JPS61207312A - Skin-beautifying cosmetic - Google Patents
Skin-beautifying cosmeticInfo
- Publication number
- JPS61207312A JPS61207312A JP4906085A JP4906085A JPS61207312A JP S61207312 A JPS61207312 A JP S61207312A JP 4906085 A JP4906085 A JP 4906085A JP 4906085 A JP4906085 A JP 4906085A JP S61207312 A JPS61207312 A JP S61207312A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- vitamin
- alkyl
- whitening
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
（発明の技術分野）
本発明は、後記特定の８−０−アルキルＬ−アスコルビ
ン酸と皮膚賦活作用を有する成分（以下、皮膚賦活成分
と称する）とを配合してなる保存安定性と美白効果の優
れた美白化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION (Technical Field of the Invention) The present invention provides a method of preparing a 8-0-alkyl L-ascorbic acid containing a specific 8-0-alkyl L-ascorbic acid and a component having a skin activating effect (hereinafter referred to as a skin activating component). This invention relates to whitening cosmetics with excellent storage stability and whitening effects.
（従来技術）
一般にシミ、ソバカス、日焼けなどに見られる皮膚の色
素沈着は、皮膚内に存在するチロシンがチロシナーゼの
作用によシ酸化されてメラニンとなり、とのメラニンが
過剰に生成することに基因するとされている。この色素
沈着を予防或いは治療することによって元の色白の肌を
維持することを目的に、従来よりＬ−アスコルビン酸と
種々の高級脂肪酸、リン酸及び硫酸とのエステル類を配
合してなる美白化粧料が提案されている。(Prior art) Skin pigmentation, which is generally seen in spots, freckles, and sunburn, is caused by the overproduction of tyrosine present in the skin, which is oxidized to melanin by the action of tyrosinase. It is said that then. In order to maintain the original fair skin by preventing or treating this pigmentation, whitening cosmetics have traditionally been made by blending esters of L-ascorbic acid with various higher fatty acids, phosphoric acid, and sulfuric acid. A fee is proposed.
しかし、これらの美白化粧料中に含有するＬ−アスコル
ビン酸のエステル類は、その保存安定性が不充分である
か、或いは保存安定性が良好であってもｔその美白効果
が充分に認められないものであった。即ち保存安定性と
美白効果とを同時に充分満足出来る美白化粧料を得るこ
とは困難でめった。However, the L-ascorbic acid esters contained in these whitening cosmetics either have insufficient storage stability, or even if they have good storage stability, their whitening effect is not fully recognized. It was something that didn't exist. That is, it is difficult and rare to obtain a skin-whitening cosmetic that satisfies storage stability and whitening effect at the same time.
また、特開昭５８−５７８７３号公報には、８−０−ア
ル牛ルＬ−アスコルビン酸の製造方法が提案されている
が、この８−０−アルキルＬ−アスコルビン酸を配合し
た化粧料の特性、すなわち保存安定性及びその美白効果
に関して何ら具体的な記載は認められない。Furthermore, JP-A-58-57873 proposes a method for producing 8-0-alkyl L-ascorbic acid; No specific description is found regarding the properties, ie, storage stability and whitening effect.
（発明の開示）
本発明者らは、上述の事情に鑑み鋭意研究した結果、特
足の８−〇−アルキルＬ−アスコルビン酸と皮膚賦活成
分とを配合してなる美白化粧料は■保存安定性が良好で
めると共に■チロシナーゼ活性阻害作用と■生成メラニ
ン淡色化作用を有し、■表皮の新陳代謝を促進して史に
美白効果を高めることを見出し本発明を完成した。(Disclosure of the Invention) As a result of intensive research in view of the above-mentioned circumstances, the present inventors have found that a whitening cosmetic containing a special 8-〇-alkyl L-ascorbic acid and a skin activating ingredient is ■ Storage stable. We have completed the present invention by discovering that it has good skin properties, 1) inhibits tyrosinase activity, 2) has an effect of lightening the melanin produced, and 2) promotes epidermal metabolism, thereby enhancing the skin whitening effect.
（発明の目的）
即ち、本発明の目的は、上記の如く、保存安定性が良好
でろると共に美白効果の優れた美白化粧 ′料を提供
するにある。(Objective of the Invention) As mentioned above, the object of the present invention is to provide a skin-whitening cosmetic that has good storage stability, smooth skin, and has an excellent whitening effect.
（発明の構成）
本発明は、下記一般式
（式中、ＲはＩＲ素数１〜２２のアルキル基）で表わさ
れる８−０−アルキルＬ−アスコルビン酸と皮膚賦活作
用を有する成分とを配合することを特徴とする美白化粧
料である。。(Structure of the Invention) The present invention comprises blending 8-0-alkyl L-ascorbic acid represented by the following general formula (wherein R is an alkyl group with an IR prime number of 1 to 22) and a component having a skin activating effect. This whitening cosmetic is characterized by: .
（構成の具体的な説明）
本発明に係る８−０−アルやルＬ−アスコルビン酸は公
知の物質てらって、例えは前記特開昭５８−５７８７８
号公報に記載の製造方法等によシ賽易に＃造することが
可能である。(Specific explanation of the structure) The 8-0-alyl-L-ascorbic acid according to the present invention is a known substance, for example,
It can be easily manufactured using the manufacturing method described in the above publication.
主なる８−０−アルキルＬ−アスコルビン酸の特性及び
チロシナーゼ阻害活性率（後述する方法で廁定）を第１
表に記載する・
′、・、・ ＼
（以下金目）
不発ゝ明に係る３−０−アルキルＬ−７スコルビン酸類
は第１−表の如くほぼ同一のチロシナーゼ阻害活性率を
示し、その値はＬ−アスコルビン酸の約７／１０〜８／
１０でめる。The characteristics of the main 8-0-alkyl L-ascorbic acid and the tyrosinase inhibitory activity rate (determined by the method described below) were first determined.
The unexploded 3-0-alkyl L-7 scorbic acids listed in the table show almost the same tyrosinase inhibitory activity rate as shown in Table 1, and the value is Approximately 7/10 to 8/1 of L-ascorbic acid
It's 10.
８−０−フルキルト−アスコルビン酸ノアルキル基はそ
の炭素数が１〜２２の範囲でめればよく、水溶性乃至油
溶性を呈し、当該美白化粧料の組成に好適なものが一稙
以上選択されて通用される。The noalkyl 8-0-furkylt-ascorbic acid group has only one carbon number within the range of 1 to 22, exhibits water solubility or oil solubility, and is selected from one or more groups suitable for the composition of the whitening cosmetic. It is commonly used as
また、配合量は、美白化粧料組成物の総量を基準として
０．１〜１０．０１Ｅ量％（以下ｗｔ％と略記する）、
好ましくは１．０〜５，９ｗｔ％である。配合量がＱ、
ｌ ｗ ｔ％未満では本発明の目的とする効果に充分
でなく、ｌ Ｑ ｗ ｔ％を超えてもその増加分に見合
った効果の向上は望めず、使用時の感触が悪くなシ易い
場合や債々、の剤型を安定に保持し難い。In addition, the blending amount is 0.1 to 10.01E amount% (hereinafter abbreviated as wt%) based on the total amount of the whitening cosmetic composition,
Preferably it is 1.0 to 5.9 wt%. The blending amount is Q,
If it is less than lwt%, it is not sufficient to achieve the desired effect of the present invention, and if it exceeds lqwt%, it cannot be expected to improve the effect commensurate with the increase, and the feel during use is likely to be poor. It is difficult to maintain a stable dosage form.
本発明に使用する皮膚賦活成分は、従来より知られてい
るジイソプロピルアミン ジクロロアセテート、γ−ア
ミノ酪酸、ビタミンＥ アセテート、ビタミンＥ ニコ
チネート、ビタミンＥ オロテート、朝鮮ニンジンエキ
ス、センブリエキス、ローパンテニルエチルアルコール
、ビオテ〉・等々であれはよく、好ましくはジイングロ
ビルアミンジクロロアセテート、γ−アミノ酪酸、ビタ
ミンＥ アセテート、ビタミンＥ ニコチネート、ビタ
ミンＥ オロテートからなる群から選択された少くとも
一槁でめる。The skin revitalizing ingredients used in the present invention are conventionally known diisopropylamine dichloroacetate, γ-aminobutyric acid, vitamin E acetate, vitamin E nicotinate, vitamin E orotate, Korean ginseng extract, Japanese cabbage extract, and low panthenyl ethyl alcohol. , biote, etc., preferably at least one selected from the group consisting of diingrobilamine dichloroacetate, gamma-aminobutyric acid, vitamin E acetate, vitamin E nicotinate, vitamin E orotate.
その配合量は、各成分の作用効果或いは当Ｍ美、白化粧
料の剤型などにより適宜調整されるものであるが、好ま
しくは第２表に示す配合１が好適である。The amount to be blended is appropriately adjusted depending on the effect of each component or the dosage form of the cosmetic and whitening cosmetic, but Preferably, Formulation 1 shown in Table 2 is suitable.
第２表
本発明の美白化粧料の剤型は、特に限定されるものでな
く、クリーム状、乳液状、ローシ冒ン状、パウダー状等
々の通常の化粧料の剤型を適用することが出来る。他の
成分として、香料、防腐剤、着色料、皮膚栄養剤などを
不発明の目的を達成する範囲内で適宜配合し得る。Table 2 The dosage form of the whitening cosmetic of the present invention is not particularly limited, and usual cosmetic dosage forms such as cream, emulsion, lotion, powder, etc. can be applied. . Other ingredients such as fragrances, preservatives, coloring agents, skin nutrients, etc. may be added as appropriate within the scope of achieving the object of the invention.
（発明の実施例） 以下、実施例にて本発明を説明する。(Example of the invention) The present invention will be explained below with reference to Examples.
実施例に記載の■保存安定性試験、■チロシナーゼ活性
阻害率の測定法、■メラニン形成抑制試験、■皮膚色明
度回復試験、■美白実用試験は下記の通りに実施した。1) Storage stability test, 2) Measuring method of tyrosinase activity inhibition rate, 2) Melanin formation inhibition test, 2) Skin color brightness recovery test, and 2) Whitening practical test described in the Examples were conducted as follows.
■保存安定性試験
論製直後の試料と、温度が２０°Ｃ１４６°Ｃの恒ｍ家
に８ケ月間保存した各々の試料を１記の方法にてチロシ
ナーゼ活性阻害率を測定した。(2) Storage stability test The inhibition rate of tyrosinase activity was measured using the method described in 1 above for samples immediately after production and for each sample stored in a constant temperature room at a temperature of 20°C to 146°C for 8 months.
上記、８つの試料の値を比較してチロシナーゼ活性阻害
率の低減が少ない試料は、保存安定性が良好であると評
価した。The values of the above-mentioned eight samples were compared, and the sample with a small decrease in the inhibition rate of tyrosinase activity was evaluated as having good storage stability.
■チロシナーゼ活性阻害率の測定方法
ハープ４７グーパツセイ（Ｈａｒｄｉｎｇ −ｐａｓｓ
ａｙ ）マウスメラノーマから抽出した酵素チロシナー
ゼを使用し、その酵素活性をドーノく−クロームノ４７
５ｎｍの吸光度を測定するフォトメトリー法によってし
らべた。■Measurement method of tyrosinase activity inhibition rateHarding-pass
ay) Using the enzyme tyrosinase extracted from mouse melanoma, we investigated its enzyme activity - Chromeno 47
The results were examined by photometry, which measures absorbance at 5 nm.
各試料０．９−を採取し、Ｌ−チロシン浴液（０，８ｑ
／＊）を１−とマツクルペイン氏の緩衝Ｍ（Ｐｎ６．８
）を１−加え、８７゛Ｃの恒温水槽中でｌＯ分間インキ
エベートした後、これにチロシナーゼ溶液（１ｑ／ｍｔ
）を０．１ ｍｌ ７Ｊｔｉえてよく撹拌し、８７°Ｃ
に保って１０分後、４７５１ｍで吸光度（Ｄｌ）を測定
する。加熱失活さゼたチロシナーゼを用いて同様に反応
させた吸光度（Ｄ２）および水のみを用いた対照試験品
の吸光度（Ｄ８）を測定し１、次式からチロシナーゼ活
性阻害率を算出する。0.9- of each sample was taken, and L-tyrosine bath solution (0.8q
/*) is 1- and Mr. Matsukurupain's buffer M (Pn6.8
) and incubate for 10 minutes in a thermostatic water bath at 87°C.
), stir well, and heat to 87°C.
After 10 minutes at 4751 m, the absorbance (Dl) is measured. The absorbance (D2) of a similar reaction using heat-inactivated tyrosinase and the absorbance (D8) of a control test product using only water are measured 1, and the tyrosinase activity inhibition rate is calculated from the following formula.
■メラニン形成抑制試験
Ｆｌ系黒色モルモット（雄、約８周令、平均体重８５０
ｆ／）の背部皮膚を刈上後、脱毛クリームによシ完全
除毛し、翌日より各試料を除毛部皮膚に毎日−回、４ｄ
当９０．２ｆｍ布し、閉塞貼布した。尚−試料に対して
動物は一５ｉｏ匹使用しもメラニン形成抑制効果の評価
は、試験開始後１ケ月後に実施し、高速分光色彩針を用
いて塗布部の明度（ＹＴ）と非塗布部の明度（Ｙｏ）と
の比の値（ＹＴ／ＹＯ）で示した。■ Melanin formation suppression test Fl black guinea pig (male, approximately 8 weeks old, average weight 850
After cutting the back skin of f/), the hair was completely removed using a hair removal cream, and from the next day, each sample was applied to the skin of the hair-removed area once a day for 4 d.
A 90.2 fm cloth was used and an occluded patch was applied. Although 15 io animals were used for each sample, the melanin formation inhibitory effect was evaluated one month after the start of the test, and the lightness (YT) of the coated area and the non-coated area were measured using a high-speed spectroscopic color needle. It is expressed as a ratio value (YT/YO) to brightness (Yo).
■皮膚色明度回復試験
被試験者２０名の背部皮膚にＵＶ−Ｂ領域の紫・外線を
最小紅斑量の２倍量照射し、１週間の後、その照射部に
試料塗布部位と非塗布部位とを設定して各々の皮膚の基
準明度（■ｏｉｌ［、ｖｏ′ｆｌＩ）を測定した。引続
いて塗布部位には試料を１日１回ずつ８ケ月間連続塗布
し、８．７．１８週間後の塗布部位及び非塗布部位の皮
膚の回復間ＩＴ（（Ｖｎ・・・値、ｖｎ′・・・値）を
測定して、第８表の判定基準により、皮膚色の回復拌幽
を実施した。■Skin color brightness recovery test The back skin of 20 test subjects was irradiated with ultraviolet/ultraviolet rays in the UV-B region at twice the minimum amount of erythema, and after one week, the irradiated areas were applied to the sample application area and the non-application area. The reference lightness (■oil[, vo'flI) of each skin was measured by setting the following values. Subsequently, the sample was continuously applied to the application site once a day for 8 months, and the IT ((Vn... value, vn ' ... value) was measured, and skin color restoration agitation was performed according to the criteria shown in Table 8.
尚、皮膚の明＆（Ｖ値）は高速分光色彩計で測定して得
られ九マンセル値より算出した。また、評価は被試験者
２０名の評価点の平均値で示した。The skin brightness & (V value) was obtained by measuring with a high-speed spectrocolorimeter and calculated from the Nine Munsell value. Moreover, the evaluation was shown as the average value of the evaluation scores of 20 test subjects.
第 ８ 表
■美白夾用試験
シミ、ンパカス、日焼は等を訴える被試験者各２０名の
顔面に試料を朝夕１回ずつ８ケ月間連続塗布した後の改
善効果を調査した。評価は（インシミ、（ロ）ンバカス
、ｅ）日焼けが各々改善されたと回答した被試験者の数
で示した。Table 8 - Whitening test The improvement effect was investigated after applying the sample to the faces of 20 test subjects who complained of age spots, acne scars, sunburn, etc. once in the morning and once in the evening for 8 months. The evaluation was expressed by the number of test subjects who answered that (in spots, (lonely) bumps, and (e) sunburn were improved.
実施例１〜５、比較例１〜４
〔二層型ローション〕
下記の組成に於いて第４，５表左欄に示す通シにＬ−７
スコルビン酸の誘導体と皮膚賦活成分の種類及び配合址
を変えて、実施例、比較例でめる二層型ローシ言ンを調
製して諸試験を実態した。その結果を第４．６表の右欄
に示した。Examples 1 to 5, Comparative Examples 1 to 4 [Two-layer lotion] With the following composition, L-7 was added to the composition shown in the left column of Tables 4 and 5.
Two-layer lotion gels were prepared in Examples and Comparative Examples by changing the type and composition of the scorbic acid derivative and the skin-activating ingredient, and various tests were carried out. The results are shown in the right column of Table 4.6.
（２）調製方法
（Ａ）成分の内油耐性のものは■）成分（油相）中に、
また水浴性のものは（Ｃ）成分（水相）中に、必要に応
じて加熱して均一に溶解するＯ
次いで、ＣＢ）成分浴液、（Ｃ）成分溶液を均一に混合
撹拌分散した後、容器に充填する。(2) Preparation method (A) In the case of the internal oil resistant component, ■) In the component (oil phase),
For water-bathable products, O is added to the (C) component (aqueous phase) by heating if necessary to uniformly dissolve the O. Next, after uniformly mixing and stirring the CB) component bath solution and the (C) component solution, , fill the container.
る。Ru.
（３ン特 性
第４，５表に示すごとく比較例２〜４の従来より知られ
ているＬ−アスコルビン酸の誘導体を配合した二層型ロ
ーシロンの中には保存安定性試験、メラニン形成抑制試
験に於いて良好な結果を呈するものも見られるがヒト皮
膚を対象とした皮膚色明度回復試験、美白爽用試験に於
いては満足１−る明の員白化粧料に於いては前記諸試験
の評価力！すべて良好でるり、特に本発明に係る８−０
−エチルＬ−７スコルビン酸のみを配合した比較例１４
に対して実施例１〜４は、更に皮膚賦活成分を配合する
ことによって、ヒト皮膚に於ける美白効果を著しく向上
していることが明らかであった。(3) As shown in Tables 4 and 5, some of the two-layer L-ascorbic acid derivatives in Comparative Examples 2 to 4 were tested for storage stability and inhibited melanin formation. Although there are some products that show good results in tests, the skin color brightness recovery test on human skin and the skin whitening refreshment test are satisfactory. Evaluation power of the test! All are good, especially 8-0 related to the present invention
Comparative example 14 containing only ethyl L-7 scorbic acid
On the other hand, in Examples 1 to 4, it was clear that the whitening effect on human skin was significantly improved by further incorporating a skin activating ingredient.
実施例６〜１３ 比較例５〜２
〔スキンクリーム〕
実施例１と同様に、下記の組成に於いて種々の実施例、
比較例のスキンクリームを調製して諸試験を実施した。Examples 6 to 13 Comparative Examples 5 to 2 [Skin Cream] Similar to Example 1, various Examples with the following compositions,
A comparative skin cream was prepared and various tests were conducted.
その結果を第６．７表右欄に示した。The results are shown in the right column of Table 6.7.
（２）調製方法
（４）成分の内油耐性のものはω）成分中に、また水溶
性のものはΩ成分中に混合し、のフ成分とΩ成分を各々
均一に加熱溶解して温度を８０″ＯＫする。(2) Preparation method (4) Mix the oil-resistant components in the ω component, and the water-soluble components in the Ω component, and uniformly heat and dissolve each of the F component and the Ω component. OK to 80″.
次いで、（Ｂ）成分中に（Ｃ）成分を注入撹拌混合した
後、撹拌しながら温度を３０℃迄冷却する。Next, component (C) is poured into component (B) and mixed with stirring, and then the temperature is cooled to 30° C. while stirring.
（３）特 性
第６，７表に示す如く、比較例６，７に対して本発明の
美白化粧料で１６実施例８〜１８は諸試験に於いて全て
良好な結果を示し、美白効果も優れていることは明らか
でめった。(3) Properties As shown in Tables 6 and 7, 16 Examples 8 to 18 of the whitening cosmetics of the present invention all showed good results in various tests compared to Comparative Examples 6 and 7, and had whitening effects. It is clear that it is also excellent.
また、特に実施例１２，１ｇに於いては（ｇ＠施例５に
関しても同様）、アルキル基がメチル、エチル、インプ
ロピルでろる水浴性の８−０−アルキルＬ−アスコルビ
ン酸とアルキル基がミリスチル、オレイル、ベヘニルで
ある油浴性の８−〇−アルキルＬ−アスコルビン酸とを
配合することによって一段と優れた保存安定性及び美白
効果を示した。In addition, especially in Example 12, 1g (the same applies to g@Example 5), the alkyl group is a water-bathable 8-0-alkyl L-ascorbic acid in which the alkyl group is methyl, ethyl, or impropyl. By blending with oil-bathable 8-alkyl L-ascorbic acids such as myristyl, oleyl, and behenyl, even better storage stability and whitening effect were exhibited.
（発明の効果）
以上配紙の如く、本発明の美白化粧料は従来のＬ−アス
コルビン酸の射４４４−を氏合せる美白化粧料に比較し
て保存安定性及び美白効果に於いて顕著に優れているこ
とは明らかでおる。(Effects of the Invention) As described above, the whitening cosmetic of the present invention is significantly superior in storage stability and whitening effect compared to the conventional whitening cosmetic containing L-ascorbic acid. It is clear that
特に、本発明に係る水浴性と油浴性の８−〇−アルキル
Ｌ−アスコルビン酸の両方と皮膚賦活成分を含有する組
成物からなる美白化粧料は更に一段と優れた効果を呈す
ることが紹められた。In particular, it was introduced that the whitening cosmetic composition of the present invention, which is composed of a composition containing both water-bathable and oil-bathable 8-0-alkyl L-ascorbic acid and a skin activating ingredient, exhibits even more excellent effects. It was done.
Claims (2)
る３−Ｏ−アルキルＬ−アスコルビン酸と皮膚賦活作用
を有する成分とを配合することを特徴とする美白化粧料
。(1) 3-O-alkyl L-ascorbic acid represented by the following general formula ▲ Numerical formula, chemical formula, table, etc. ▼ (In the formula, R is an alkyl group having 1 to 22 carbon atoms) and a component that has a skin activating effect A whitening cosmetic characterized by containing the following.
ミン ジクロロアセテート、γ−アミノ酪酸、ビタミン
Ｅ アセテート、ビタミンＥ ニコチネート、ビタミン
Ｅ オロテートからなる群から選択された化合物の少な
くとも一種である特許請求の範囲第（１）項に記載の美
白化粧料。(2) The ingredient having a skin activating effect is at least one compound selected from the group consisting of diisopropylamine dichloroacetate, γ-aminobutyric acid, vitamin E acetate, vitamin E nicotinate, and vitamin E orotate. The whitening cosmetic according to item (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4906085A JPS61207312A (en) | 1985-03-11 | 1985-03-11 | Skin-beautifying cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4906085A JPS61207312A (en) | 1985-03-11 | 1985-03-11 | Skin-beautifying cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61207312A true JPS61207312A (en) | 1986-09-13 |
Family
ID=12820538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4906085A Pending JPS61207312A (en) | 1985-03-11 | 1985-03-11 | Skin-beautifying cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61207312A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03153609A (en) * | 1989-11-11 | 1991-07-01 | Kanebo Ltd | Skin-beautifying cosmetic |
| US5723645A (en) * | 1996-09-05 | 1998-03-03 | Pacific Corporation | Method for preparing 3-aminopropane phosphoric acid |
| EP0904772A4 (en) * | 1996-04-01 | 2000-03-29 | Kao Corp | Skin color improver |
| JP2002284626A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | External skin preparation |
| JP2002284665A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | Cosmetics |
| JP2002284625A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | Cosmetics |
| KR20020093627A (en) * | 2001-06-08 | 2002-12-16 | 가부시키가이샤 시세이도 | Method of preventing darkening of skin or inhibiting melanization of melanin monomer and polymerization inhibitor of biological dihydroxyindole compound |
| JP2011168538A (en) * | 2010-02-18 | 2011-09-01 | Kao Corp | Skin cosmetic |
| JP2019069909A (en) * | 2017-10-06 | 2019-05-09 | 静岡県公立大学法人 | Polyglycerol-containing liposome preparation |
| US10322078B2 (en) | 2014-06-10 | 2019-06-18 | Ajinomoto Co., Inc. | Cosmetic composition containing 3-O-alkyl-L-ascorbic acid or salt thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56120612A (en) * | 1980-02-27 | 1981-09-22 | Kanebo Keshohin Kk | Beautifying cosmetic |
| JPS5857373A (en) * | 1981-10-01 | 1983-04-05 | Sunstar Inc | Preparation of l-ascorbic acid derivative |
-
1985
- 1985-03-11 JP JP4906085A patent/JPS61207312A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56120612A (en) * | 1980-02-27 | 1981-09-22 | Kanebo Keshohin Kk | Beautifying cosmetic |
| JPS5857373A (en) * | 1981-10-01 | 1983-04-05 | Sunstar Inc | Preparation of l-ascorbic acid derivative |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03153609A (en) * | 1989-11-11 | 1991-07-01 | Kanebo Ltd | Skin-beautifying cosmetic |
| EP0904772A4 (en) * | 1996-04-01 | 2000-03-29 | Kao Corp | Skin color improver |
| US6197343B1 (en) | 1996-04-01 | 2001-03-06 | Kao Corporation | Skin color improver |
| US5723645A (en) * | 1996-09-05 | 1998-03-03 | Pacific Corporation | Method for preparing 3-aminopropane phosphoric acid |
| JP2002284626A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | External skin preparation |
| JP2002284665A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | Cosmetics |
| JP2002284625A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | Cosmetics |
| KR20020093627A (en) * | 2001-06-08 | 2002-12-16 | 가부시키가이샤 시세이도 | Method of preventing darkening of skin or inhibiting melanization of melanin monomer and polymerization inhibitor of biological dihydroxyindole compound |
| JP2011168538A (en) * | 2010-02-18 | 2011-09-01 | Kao Corp | Skin cosmetic |
| US10322078B2 (en) | 2014-06-10 | 2019-06-18 | Ajinomoto Co., Inc. | Cosmetic composition containing 3-O-alkyl-L-ascorbic acid or salt thereof |
| JP2019069909A (en) * | 2017-10-06 | 2019-05-09 | 静岡県公立大学法人 | Polyglycerol-containing liposome preparation |
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