JPS61137820A - Male hormone blended agent for application - Google Patents
Male hormone blended agent for applicationInfo
- Publication number
- JPS61137820A JPS61137820A JP59257457A JP25745784A JPS61137820A JP S61137820 A JPS61137820 A JP S61137820A JP 59257457 A JP59257457 A JP 59257457A JP 25745784 A JP25745784 A JP 25745784A JP S61137820 A JPS61137820 A JP S61137820A
- Authority
- JP
- Japan
- Prior art keywords
- hormone
- male
- male hormone
- action
- hair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
ａ産業上の利用分野
本発明は、男性ホルモンを皮膚に補給してその特性であ
る体毛の発毛及び精力の増強作用を示す場合におｔ・て
、極めて勝れた作用効果を示すと共に副作用と皮膚炎症
を全くおこすことがな〜・塗布用男性ホルモン混和剤に
関する。DETAILED DESCRIPTION OF THE INVENTION [a] Industrial Application Field The present invention is extremely effective when supplying male hormones to the skin to exhibit its characteristic effects of increasing body hair growth and virility. This invention relates to a topical male hormone admixture that exhibits excellent effects and causes no side effects or skin irritation.
ｂ従来の技術
眉毛、ｖ、髭、腺毛など頭髪を除く凡ゆる体毛は主とし
て男性ホルモンの支配によって生育しかつ長くならな（
・特性があるが、頭髪は主として女性ホルモンによって
支配されかつ長く生長すると℃・５ことは、関係技術分
野にお（・て既に定説となっている。禿頭が男性に有っ
て女性に無く、体毛が男性に濃く女性に薄〜・とい５古
来衆知の事実は、このホルモ／の作用原理忙よって説明
可亜である。又、男性ホルモンを補給することによって
男性の精力の増強ができることも公知である。B Conventional technology All body hair, excluding scalp hair, such as eyebrows, hair, beard, glandular hair, etc., grows mainly under the control of male hormones and does not grow long (
・Although it is a characteristic, it is already established theory in related technical fields that scalp hair is mainly controlled by female hormones and that when it grows for a long time, it is ℃ 5. The fact that men have thicker body hair and women have thinner body hair can be explained by the principle of action of this hormone.It is also known that men's virility can be increased by supplementing with male hormones. It is.
このような技術背景のなかで、男性ホルモンを主成分と
する体毛の発毛剤は若干市販されて（゛るが、何れもそ
の発毛効果は不確実であり、かつ皮膚に炎症をおこす例
が多（・などの問題点がある。Against this technological background, some hair growth agents containing male hormones as their main ingredients have been commercially available (although their hair growth effects are uncertain, and there are cases where they cause skin irritation). There are many problems such as...
又、男性に対して高単位男性ホルモンを注射し成る（・
は局所塗布をして精力増強を目的とする治療がよく行な
われている。しかし、高単位注射の副作用は強く、局所
塗布は皮膚に炎症をおこす現状にある。Also, men are injected with high-unit male hormones (・
Treatment is often performed by applying it topically to increase virility. However, high-volume injections have strong side effects, and topical application causes skin irritation.
Ｃ発明が解決しようとする問題点
以上説明した男性ホルモン利用の従来技術において、体
毛発毛剤及び精力増強剤の何れも高濃度の男性ホルモン
を使用するから一応の効果が認めらＪしるが、高濃度で
あるがための副作用酸る（・は皮膚の炎症は必至であり
、しかも体毛発毛剤、精力増強剤の何れＶＣおし・でも
認められることであるが効果が不確実である。Problems to be Solved by the Invention In the conventional techniques using male hormones as explained above, both body hair growth agents and virility enhancers use male hormones in high concentrations, so they are not effective to some extent. Due to the high concentration, the side effects are inevitable, such as skin irritation, and the effectiveness is uncertain, as is the case with both body hair growth agents and virility enhancers. .
本発明は、この男性ホルモン利用の従来技術の問題点を
解消して、顕著な効果を持ち副作用と炎症が全く無い塗
布用の男性ホルモン混和剤を１供する。The present invention solves the problems of the prior art utilizing male hormones and provides a topical male hormone admixture that is highly effective and completely free of side effects and inflammation.
ｄ問題点を解決するための手段
本発明者は、以上説明した問題点を種々検討して次の考
えに基づく実験を重ねた。すなわち、発毛は皮膚組織に
おける男性ホルモン支配の生体現象であり、蛋白質であ
る毛が発育するためには、皮膚組織の健全な生活条件を
保持しながら、その発育条件を十分に整える必要がある
。dMeans for Solving the Problems The inventor of the present invention has studied various problems described above and has conducted repeated experiments based on the following ideas. In other words, hair growth is a biological phenomenon in the skin tissue dominated by male hormones, and in order for hair, which is a protein, to grow, it is necessary to maintain healthy living conditions for the skin tissue and provide sufficient conditions for its growth. .
体毛の発毛条件を十分に整えろため忙は、（１１単に男
性ホルモンを補給すればよ（・と（・５ものではなく、
皮膚に炎症をおこさずその他組織内蓄積による悪影響が
無し・程度まで男性ホルモンの濃度を低くし、（２）男
性ホルモンの作用を副腎皮質ホルモンによって増強し、
（３）来賓白質の発育にビタミンＢ２の代謝作用を適用
することの３要件が必要であることは、木発明者が先の
発明（特願昭５８−１４５７０１３）である頭髪の発毛
剤の開発研究にお（・て明らかにしたことである。本発
明者は、この３要件を併有する男性ホルモン混和剤を体
毛の発毛を目的とする皮膚に塗布するとぎ良く発毛する
と共に炎症をおこさな（・ことを確認した。If you are busy preparing the conditions for body hair growth, (11) Just supplement with male hormones (・and (・5).
It lowers the concentration of male hormones to the extent that there is no inflammation of the skin or other adverse effects due to accumulation in tissues, (2) enhances the action of male hormones with adrenal cortical hormones,
(3) The necessity of the three requirements of applying the metabolic action of vitamin B2 to the growth of guest white matter was demonstrated by the inventor Ki in his earlier invention (patent application 1457013/1982), a hair growth agent. This was revealed in development research.The present inventor has found that applying a male hormone admixture that has these three requirements to the skin where body hair is to be grown will result in good hair growth and reduce inflammation. Okosana (・I confirmed that.
又、男性の精力増強を目的として男性ホルモンを皮膚に
補給する場合に、前記３要件を併有する男性ホルモン混
和剤が、前記発毛と同原理によってすなわち皮膚組織の
健全な生活条件を保持しながら男性ホルモンが作用する
条件を設定すれば、副作用と皮膚炎症無く効果を現わす
との考えに基づ℃・て実験を重ねた。方法は、男性の局
所の皮膚に塗布することによって陰毛の発毛効果を見る
と共忙精力の増強効果を検討した。非常に精力増強効果
が有り、副作用及び炎症が全く無いことを確認した。In addition, when supplementing male hormones to the skin for the purpose of enhancing male virility, a male hormone admixture that has the above three requirements can be used according to the same principle as the above-mentioned hair growth, that is, while maintaining healthy living conditions of the skin tissue. Based on the idea that if conditions were set for male hormones to work, the drug would be effective without side effects or skin irritation, and repeated experiments were conducted at ℃. The method was to apply the product to the local skin of men to see its effect on pubic hair growth and to examine its effect on enhancing busy energy. It was confirmed that it has a very effective effect on enhancing energy and has no side effects or inflammation.
ｅ実施例１
本発明の塗布用男性ホルモン混和剤の配合実施例を次に
説明する。グミピオン酸テストステロン（男性ホルモン
）ＩＷ！ｇ、酢酸プレドニゾロン（副腎皮質ホルモン）
１．１’９、リン酸すビフラビンナトリウム（ビタミン
Ｂ、）０．５■、フラビンアデニンジヌクレオチド（ビ
タミンＢ、）００１ｍ９、マレイン酸りロルフエニラミ
１０．３■、塩酸ピリドキシン１．０■、ニコチン酸ア
ミド２、 Ｏｒｎ９、／４′ントテニＡ／ ７ 、Ｉ＋
／ コ−／ｌ／ １．０ ’７、ＤＩ。eExample 1 A formulation example of the male hormone admixture for application of the present invention will be described below. Testosterone gummy pionate (male hormone) IW! g. Prednisolone acetate (adrenocortical hormone)
1.1'9, biflavin sodium phosphate (vitamin B,) 0.5■, flavin adenine dinucleotide (vitamin B,) 001m9, rolfenirami maleate 10.3■, pyridoxine hydrochloride 1.0■, nicotine Acid amide 2, Orn9, /4' Toteni A/ 7, I+
/ Co-/l/ 1.0 '7, DI.
−メチオニン４．０うを軟膏基剤１００２に均質分散し
て本発明の塗布用男性ホルモン混和剤とする。この調製
には、前記各成分剤の注射用アンプル入りを用（・た。- Methionine 4.0 is homogeneously dispersed in ointment base 1002 to prepare the androgen admixture for application of the present invention. For this preparation, injection ampoules of each of the above-mentioned ingredients were used.
例えばプロピオン酸テストステロ７は１ＯｒＩＰＬ！（
ｌｅｅ）注射液のＱ、 ｌ ｃｃを用いた。°又、他の
成分剤も２ｃｃ注射液を用いたが、各注射液は油性又は
水性液である。For example, Propionate Testostero 7 is 1OrIPL! (
lee) injection solution Q, l cc was used. Further, 2 cc injection solutions were used for other component drugs, and each injection solution was an oil-based or an aqueous solution.
ｆ実施例２
次に本発明の実施例２として、実施例ＩＫおける酢酸プ
レドニゾロンの代りに酢酸コルチゾン（副腎皮質ホルモ
ン）１０ηを用い、他の物質及び量を実施例１と全く同
じとした。f Example 2 Next, as Example 2 of the present invention, 10η of cortisone acetate (adrenocortical hormone) was used instead of prednisolone acetate in Example IK, and the other substances and amounts were the same as in Example 1.
ｇ作 用
前記本発明の塗布用男性ホルモン混和剤の構成にお（・
て、主成分であるプロピオン酸テストステロン（男性ホ
ルモン）を０．ｏｏ１％ト（・５超低濃度として用℃・
るから、皮膚に炎症をおこさずまた皮膚内に蓄積するこ
とはない。酢酸プレドニゾロン（副腎皮質ホルモン）は
男性ホルモンの作用を助け、又、ピタミ／Ｂ２ （リン
酸すゼフラピンナトリウム及びフラビンアデニンジヌク
レオチド）は蛋白質の代謝作用を促進するために、皮膚
組織の健全な生活条件のなかで体毛の発毛及び精力増強
の作用を促がすことになる。以上は主役たる男性ホルモ
ン、副腎皮質ホルモン及びビタミンＢ、の作用であるカ
、前記他の成分は発毛及び精力増強作用にお−・て脇役
を果たす。マレイン酸クロルフェニラミンは副腎皮質ホ
ルモンの作用を強め、塩酸ピリドキシン、ニコチン酸ア
ミド、ノξントテニルアルココール、ＤＬ−メチオニン
は何れもビタミンＢ。g action In the composition of the above-mentioned androgen admixture for application of the present invention, (・
The main ingredient, testosterone propionate (male hormone), is 0. oo1% (・5°C for ultra-low concentration)
Therefore, it does not cause skin irritation and does not accumulate within the skin. Prednisolone acetate (adrenocortical hormone) supports the action of male hormones, and Pitami/B2 (zeflapine sodium phosphate and flavin adenine dinucleotide) promotes protein metabolism and promotes the healthy life of skin tissue. Under these conditions, it promotes body hair growth and increases virility. The above is due to the effects of the main male hormones, adrenal cortical hormones, and vitamin B, while the other ingredients play supporting roles in hair growth and virility enhancement. Chlorpheniramine maleate strengthens the action of adrenal cortical hormones, and pyridoxine hydrochloride, nicotinamide, nototenyl alcohol, and DL-methionine are all B vitamins.
の蛋白質代謝作用を強゛めることＫよって総合的に体毛
の発毛及び精力増強の作用を促がすと考えられる。It is thought that by strengthening the protein metabolic effect of K, it comprehensively promotes the effects of body hair growth and enhancement of virility.
又、本発明の混和剤を例えば眉毛の発毛のために盾部に
塗布すると離れた位置にある捷が顕著に生長し、成るい
は陰毛を発毛する目的で男性の局所に塗布すると明らか
に精力増強の効果が現われると共に両下肢の発毛をｒ４
認した。これは吸収作用によって塗布位置から若干廃れ
た位置に効果を示すことが確認できたことになる。Furthermore, when the admixture of the present invention is applied to the shield area for the purpose of eyebrow hair growth, for example, the hairs located at distant locations grow significantly, or when applied to the local area of men for the purpose of pubic hair growth. The effect of increasing energy appears and hair growth on both lower limbs is R4.
Approved. This confirms that the absorption effect is effective at a position slightly removed from the application position.
本発明の塗布用男性ホルモン混和剤の濃度は軟膏基剤１
００を中忙男性ホルモン１■すなわち０．００１％であ
るが、先の発明である頭髪の発毛剤における精製水４１
中に女性ホルモン０、２１１９丁なわち０．０００００
５％の濃度に比べると濃厚である。したがって、前記頭
髪の発毛剤にお（・では女性ホルモンの蓄積を考慮する
必要は全くなかったが、本発明の男性ホルモン混和剤の
場合は男性ホルモンの蓄積を考慮して無目的、広範囲か
つ長期の使用はすべきでな（・。The concentration of the male hormone admixture for application of the present invention is 1
00 is a medium-sized male hormone 1 ■, or 0.001%, but purified water 41 in the hair growth agent of the previous invention
There are 0.2119 female hormones in it, which is 0.00000
It is richer than the 5% concentration. Therefore, in the hair growth agent mentioned above, there was no need to take into consideration the accumulation of female hormones, but in the case of the androgen admixture of the present invention, the accumulation of male hormones was taken into consideration, and the use of non-purposeful, wide-ranging and It should not be used for long periods (・.
ｈ発明の効果
本発明の塗布用男性ホルモノ混和剤は、体毛の発毛作用
及び男性の精力増強作用を顕著に示す条件Ｋ ：ｔ６’
ｙ・て、副作用及び皮膚の炎症を現わすことが全く無（
・ことを確認した。h Effects of the Invention The androgenic hormone admixture for application of the present invention exhibits remarkable effects on body hair growth and male virility enhancement under conditions K: t6'
Y・There are no side effects or skin irritation (
·It was confirmed.
次に適用例とその効果を説明する。Next, an example of application and its effects will be explained.
（１１４５才の女、眉に本混和剤の耳掻き１杯量を１日
１回塗布、むづむづした感じを塗布個所に覚えた。約１
か月で眉に発毛、同時に吸収作用によって捷の生長を認
めた。尚、目下４か月の塗布を継続中、炎症全くなし。(11 A 45-year-old woman applied one earpick of this mixture to her eyebrows once a day, and felt a tingling sensation in the area where it was applied.Approx.
Within a month, hair grew on the eyebrows, and at the same time, hair growth was observed due to absorption. In addition, I have been using the drug for 4 months now, and there has been no inflammation at all.
＋２１５５才の男、精力増強を目的として小豆大の量を
毎日１回局所に塗布、約３年続けた。+21 A 55-year-old man applied a pea-sized amount topically once a day for the purpose of increasing his virility for about 3 years.
陰毛の発毛と併せて精力増強を確認したが、同時に吸収
作用として両下肢の発毛を認めた。Increased virility was confirmed along with pubic hair growth, but at the same time, hair growth was observed on both lower legs as an absorption effect.
又、その間に１回の塗布量を増したときは、畢丸部に鈍
痛を５つたえたが、前記の正規塗布量では鈍痛なく、又
、炎症は３年間を通じて全くなし。Also, when the amount of application was increased during that time, I experienced five dull pains in the furrow area, but with the regular application amount, there was no dull pain, and there was no inflammation at all over the three years.
＋３１４０才の女、外陰部無毛症、直接局所忙塗布し約
３か月で発毛が認められた。+31 A 40-year-old woman with vulvar alopecia experienced hair growth after about 3 months of direct topical application.
手続ネ…正書 昭和６０年１０月１１日Procedure Ne…Authentic book October 11, 1985
Claims (1)
以下及びビタミンＢ＿２２０ｍｇ以下を主成分として軟
膏基剤１００ｇに均質分散することを特徴とする塗布用
男性ホルモン混和剤。Male hormone 20mg or less, adrenal cortical hormone 20mg
An androgenic hormone admixture for application, characterized in that the following and vitamin B_220mg or less are homogeneously dispersed in 100g of an ointment base.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59257457A JPS61137820A (en) | 1984-12-07 | 1984-12-07 | Male hormone blended agent for application |
| DE19853538612 DE3538612A1 (en) | 1984-12-07 | 1985-10-30 | ANDROGEN MIXTURE FOR APPLICATION |
| FR8517865A FR2574293A1 (en) | 1984-12-07 | 1985-12-03 | COMPOSITION CONTAINING ANDROGEN FOR LOCAL APPLICATION |
| CA000496832A CA1256380A (en) | 1984-12-07 | 1985-12-04 | Andreogen agent for application to the skin for body hair growth and enhancement of vitality in males |
| GB08529933A GB2167957B (en) | 1984-12-07 | 1985-12-04 | Androgen mixture for stimulating hair growth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59257457A JPS61137820A (en) | 1984-12-07 | 1984-12-07 | Male hormone blended agent for application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61137820A true JPS61137820A (en) | 1986-06-25 |
Family
ID=17306594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59257457A Pending JPS61137820A (en) | 1984-12-07 | 1984-12-07 | Male hormone blended agent for application |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS61137820A (en) |
| CA (1) | CA1256380A (en) |
| DE (1) | DE3538612A1 (en) |
| FR (1) | FR2574293A1 (en) |
| GB (1) | GB2167957B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0256472A3 (en) * | 1986-08-11 | 1988-09-07 | Lion Corporation | Cosmetic agent for application to skin |
| EP1806131A3 (en) | 1996-07-22 | 2007-08-01 | Renovo Limited | Use of sex steroid function modulators to treat wounds and fibrotic disorders |
| AU7250301A (en) * | 2000-06-22 | 2002-01-02 | Willy Ben Moussa Ben Mohammed | Use of glucocorticosteroids for producing a medicament to treat oligotrichia |
| IL157535A0 (en) * | 2003-08-21 | 2004-03-28 | Topimed Ltd | Preparations for the prevention of skin atrophy |
| WO2006084312A1 (en) * | 2005-02-09 | 2006-08-17 | Acrux Dds Pty Ltd | Method of promoting hair growth |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5879913A (en) * | 1981-11-09 | 1983-05-13 | Taizo Ayukawa | Hair tonic composition |
| JPS5988407A (en) * | 1982-11-11 | 1984-05-22 | Shiseido Co Ltd | Hair tonic |
| JPS59172412A (en) * | 1983-03-19 | 1984-09-29 | Shiseido Co Ltd | Hair tonic |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2257223A1 (en) * | 1972-11-22 | 1974-06-12 | Fouad Dr Med Talabani | Hair growth and anti- hairloss compsn. - contg. mixts of androgen, oestrogen, corticoid and carriers |
-
1984
- 1984-12-07 JP JP59257457A patent/JPS61137820A/en active Pending
-
1985
- 1985-10-30 DE DE19853538612 patent/DE3538612A1/en not_active Withdrawn
- 1985-12-03 FR FR8517865A patent/FR2574293A1/en not_active Withdrawn
- 1985-12-04 GB GB08529933A patent/GB2167957B/en not_active Expired
- 1985-12-04 CA CA000496832A patent/CA1256380A/en not_active Expired
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5879913A (en) * | 1981-11-09 | 1983-05-13 | Taizo Ayukawa | Hair tonic composition |
| JPS5988407A (en) * | 1982-11-11 | 1984-05-22 | Shiseido Co Ltd | Hair tonic |
| JPS59172412A (en) * | 1983-03-19 | 1984-09-29 | Shiseido Co Ltd | Hair tonic |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8529933D0 (en) | 1986-01-15 |
| GB2167957B (en) | 1988-12-14 |
| CA1256380A (en) | 1989-06-27 |
| DE3538612A1 (en) | 1986-06-19 |
| FR2574293A1 (en) | 1986-06-13 |
| GB2167957A (en) | 1986-06-11 |
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