JPS61120060A - Fully automatic and continuous analysis instrument - Google Patents
Fully automatic and continuous analysis instrumentInfo
- Publication number
- JPS61120060A JPS61120060A JP24074884A JP24074884A JPS61120060A JP S61120060 A JPS61120060 A JP S61120060A JP 24074884 A JP24074884 A JP 24074884A JP 24074884 A JP24074884 A JP 24074884A JP S61120060 A JPS61120060 A JP S61120060A
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- JP
- Japan
- Prior art keywords
- liquid
- reagent
- line
- probe
- latex
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は粒度分布ラテックス免疫測定法の分析装置に関
するものである。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an analyzer for particle size distribution latex immunoassay.
従来、血清等の体液から特定物質濃度を測定するため抗
原抗体反応を用いた種々の免疫測定法がある。ラテック
ス免疫検定法は定性的試験等に用いられていたが、ラテ
ックス粒子の改善、粒子カウンターの精度間上等によシ
、またその簡便さ、安価、安全性等の利点もあシ、定量
的測定に用いられつつある。しかし手操作により、多く
の試料を処理することは多大の時間と人手を必要とする
等の欠点がある。そこで今日、このラテックス免疫測定
法を利用して多数の被検体中の特定物質濃度を求めるま
でを全自動的に連続して実施可能な自動分析装置の開発
が望まれている。Conventionally, there are various immunoassay methods that use antigen-antibody reactions to measure the concentration of specific substances from body fluids such as serum. The latex immunoassay method has been used for qualitative tests, etc., but it has advantages such as improving latex particles and improving the accuracy of particle counters, as well as its simplicity, low cost, and safety. It is being used for measurements. However, there are drawbacks such as the fact that processing many samples manually requires a large amount of time and manpower. Therefore, there is currently a demand for the development of an automatic analyzer that can continuously and fully automatically determine the concentration of a specific substance in a large number of specimens using this latex immunoassay method.
本発明の目的は、上記要請を満足する短時間で多くの被
検液を処理可能で、かつ被検液中の特定物質濃度を正確
にしかも迅速且つ高感度に算出可能で経済的な自動連続
分析装置を提供することにある。The purpose of the present invention is to satisfy the above-mentioned requirements, to be able to process a large number of test liquids in a short period of time, to calculate the concentration of a specific substance in the test liquid accurately, quickly, and with high sensitivity, and to be an economical automatic continuous process. Our objective is to provide analytical equipment.
上記目的は、被検容器を保持する部材を有する送り装置
と、被検液、試薬液の各々から定量を注入および／また
は注出する装置と、注出された液を受容する受容部材を
有しかつ振盪機能を有する免疫反応装置と、この受容さ
れた液の定量を注入するプローブを有する測定試料注入
装置と、この注入された液中に存在するラテックス粒子
の粒度分布または濃度を検出する検出装置と、前記検出
されたデータから被検液中の特定物質濃度を算出する算
出装置とを有する分析装置と、この分析装置を総合的に
作動制御する電子的制御手段とからなる全自動連続分析
装置によシ達成される。The above object has a feeding device having a member for holding a test container, a device for injecting and/or dispensing a fixed amount from each of a test liquid and a reagent solution, and a receiving member for receiving the dispensed liquid. and an immunoreaction device having a shaking function, a measurement sample injection device having a probe for injecting a fixed amount of the received liquid, and a detection device for detecting the particle size distribution or concentration of latex particles present in the injected liquid. Fully automatic continuous analysis consisting of an analyzer, a calculation device that calculates the concentration of a specific substance in the test liquid from the detected data, and an electronic control means that comprehensively controls the operation of this analyzer. This is achieved by the device.
本発明の上記分析装置を構成する各装置は通常用いられ
る部材または部品で構成される駆動装置等を有している
。またこの分析装置は電子的制御手段たとえは制御用マ
イクロコンビエータ−等を介して有機的に相互に連結さ
れ、そのプログラムにそって駆動または作動される。従
って被検液容器の載置および免疫反応装置への受容部材
たとえばマイクロプレートを載置する以外は手操作を介
することなくかつ、データ計算を人為的にすることなく
一定条件に従って自動的に被検液の分析結果を得ること
ができる。Each of the devices constituting the above-mentioned analyzer of the present invention has a drive device and the like made of commonly used members or parts. The analyzers are organically interconnected via electronic control means, such as a control micro combinator, and are driven or operated according to the program. Therefore, the test is automatically performed according to certain conditions without any manual operations other than placing the test liquid container and placing the receiving member, such as a microplate, on the immune reaction device, and without artificial data calculation. Liquid analysis results can be obtained.
本発明の装置を構成している各装置について説明する。Each device constituting the device of the present invention will be explained.
送り装置は、被検液容器を多数保持し、以下述べられる
分注装置の自動シリンジのプローブの移動と同期して移
動するよう駆動装置が設けられている。The feeding device holds a large number of test liquid containers, and is provided with a driving device so as to move in synchronization with the movement of the probe of the automatic syringe of the dispensing device described below.
分注装置は各種族を所望定量注入注出するようにたとえ
ば電子的に駆動制御されるピストンとこれを収容するシ
リンダーとこれに連通接続され、各種族に浸漬されたチ
ューブとこのチューブに接続され各種族を単独にまたは
希釈して注入および／または注出し、免疫反応装置の受
容部材たとえばマイクロプレートに、最適測定用試料が
形成可能なように、各種族の投入順序、時間間隔を有し
つつ分配するよう前記受容部材と共に駆動制御されるプ
ローブとからなる自動シリンジである。The dispensing device is connected to, for example, an electronically driven and controlled piston and a cylinder housing the piston to inject and dispense a desired amount of each species, and is connected to a tube immersed in each species. Each species can be injected and/or poured out singly or diluted, and each species can be injected and/or poured into a receiving member of an immunoreaction device, such as a microplate, while maintaining the input order and time intervals for each species so that an optimal measurement sample can be formed. An automatic syringe comprising a probe actuated with said receiving member for dispensing.
本発明では、この分注装置の自動シリンジは被検液用１
本以上、試薬液用１本以上の計２本以上が各踪立して前
記のように機能しかつ制御される。In the present invention, the automatic syringe of this dispensing device has one for the test liquid.
A total of two or more tubes, one for the reagent solution and one for the reagent solution, each function and are controlled as described above.
また、この自動シリンジは各対応する液を希釈液につい
て希釈する機構を併せて有することができる。Moreover, this automatic syringe can also have a mechanism for diluting each corresponding liquid with a diluent.
従って上記試薬液用シリンジに対応する試薬液とは単な
る希釈液を含まないもので、ラテックス試薬、非特異的
免疫反応阻止試薬等の被検液に対し、緩衝効果以外の物
理化学的作用全厚える試薬を意味する。Therefore, the reagent solution corresponding to the above-mentioned reagent solution syringe is one that does not contain a mere diluent, and has a full range of physicochemical effects other than buffering effects on test solutions such as latex reagents and non-specific immune reaction blocking reagents. means a reagent that can be used
免疫反応装置は、上記分注装置により分注された被検液
、試薬液を受容する受容部材と、これを保持すると共に
振盪し、被検液と試薬液との反応を促進させるための振
盪装置等からなっている。The immunoreaction device includes a receiving member that receives the test liquid and reagent liquid dispensed by the above-mentioned dispensing device, and a receiving member that holds and shakes the receiving member to promote the reaction between the test liquid and the reagent liquid. It consists of equipment, etc.
受容部材は多数の被検液を分注可能な多数のウェルを有
するプレート等が好適であるが、多数の独立した試験管
およびその保持部材等からなるものでもよい。またこの
受容部材は前記分注装置のプローブの移動、注出および
後述する測定試料注入装置のプローブの移動、注入とタ
イミングを合わせて移動可能に設けられている。また振
盪装置も上記受用部材とプローブの動きとタイミングを
合わせ、かつ最適な測定試料が得られるよう静止と振盪
が制御される。The receiving member is preferably a plate having a large number of wells into which a large number of test liquids can be dispensed, but it may also be made of a large number of independent test tubes and their holding members. Further, this receiving member is provided so as to be movable in synchronization with the movement and injection of the probe of the dispensing device and the movement and injection of the probe of the measurement sample injection device, which will be described later. Further, the shaking device is also controlled so as to synchronize the timing with the movement of the receiving member and the probe, and to control its static and shaking so as to obtain the optimum measurement sample.
上記のようにして形成された測定試料は測定試料注入装
置により定量が注入される。この装置は前述した分注装
置の自動シリンジと同様の機構を有し、希釈手段を有す
る構造でもよい。従ってこの注入された測定試料は必要
ならば適宜希釈されるがこの希釈操作も同装置で可能で
ある。あるいは、この注入装置により注入された試料を
好適な移送手段により検出装置へ移送されるが、この検
出装置内部に希釈手段を設けてもよい。A fixed amount of the measurement sample formed as described above is injected by a measurement sample injection device. This device has a mechanism similar to the automatic syringe of the dispensing device described above, and may have a structure including dilution means. Therefore, the injected measurement sample is appropriately diluted if necessary, and this dilution operation is also possible with the same device. Alternatively, the sample injected by the injection device is transferred to the detection device by suitable transfer means, and dilution means may be provided inside the detection device.
この検出装置は、電気抵抗式、光学式等、適用できる任
意方式のラテックス粒子検出器とこれに接に、ヒされラ
テックス粒子の粒度分布または濃度を換算測定する装置
とを含む。This detection device includes a latex particle detector of any applicable type, such as an electrical resistance type or an optical type, and a device that converts and measures the particle size distribution or concentration of the latex particles.
検出装置により検出されたデータは、この装置と連結さ
れた算出装置に移送される。算出装置は通常ノデータ処
理用コンピューターでよく、これによう自動的に被検液
中の所望の特定物質濃度が算出され、次いでプリントア
ウトされる。The data detected by the detection device is transferred to a calculation device connected to this device. The calculation device may be a normal data processing computer, which automatically calculates the concentration of the desired specific substance in the test liquid and then prints it out.
本発明の装置の実施例を第１図に従って説明する。送り
装置１はサンプルラック１１とサンプルラック駆動装置
１２等からなる。サンプルラック１１は被検液用試験管
を２０〜５０個保持できる直径１．０〜２．０１の穴１
３が同心円上に設けである。サンプルラック駆動装置１
２はサンプルラック１１の円心の真下に位置し、制御用
コンピューターの指示によシ目的試料を被検液用自動シ
リンジ３のプローブ３１の真下に移動させる。分注装置
２は被検液用自動シリンジ３と非特異的免疫反応阻止用
試薬等の試薬用自動シリンジ４とラテックス試薬用シリ
ンジ５とからなる。該自動シリンジ３は被検液用プロー
ブ３１とその保持部材３２と、プローブ３１の駆動装置
２３と、被検液用シリンダー３４と、同ピストン３５と
、ピストン駆動装［３６と、切替バルブ３７と、この駆
動装置３８と、希釈液用ピストン３９と、同シリンダ３
１０と、同駆動装置３１１と、プローブ３１とシリンダ
３４と切替バルブ３７とシリンダ３１０とを接続連通し
希釈液容器３１３に至るチューブ３１２等からなる。プ
ローブ３１は駆動装置３３により上下、南北に移動され
る。またこの自動シリンジ３は５〜１００μ！の被検液
及び希釈液を定量注入、注出できる。切替バルブ３７を
駆動制御することによシ、必要に応じて被検液を希釈す
ることができる。試薬用自動シリン：）４はプローブ４
１と、この保持部材４２と、切替バルブ４３と、バルブ
駆動装置４４と、ピストン４５と、シリンダー４６と、
このピストン駆動装置４７と、プローブ４１と切替バル
ブ４４とシリンダー４６を接続連通させて試薬容器４９
に至るチューブ４８等からなる。この自動シリンジ４は
試薬容器から試薬を５〜１００μ！定量注入し、プロー
ブ４１から後述するウェル６１に注出される。ラテック
ス試薬用自動シリンジ５はプローブ５１と、プローブ保
持部材５２と、切替バルブ５３と、バルブ駆動装置５４
と、ピストン５５と、シリンダー５６と、ピストン駆動
装置５７と、プローブ５１と切替バルブ５３とシリンダ
ー５６とを接続連通させてラテックス試薬用容器５９に
至るチューブ、５８等からなる。この自動シリンジ５は
容器５９からラテックス試薬を５〜１００μｌの定量注
入し、プローブ５１からウェル６１に定量注出する。An embodiment of the apparatus of the present invention will be described with reference to FIG. The feeding device 1 includes a sample rack 11, a sample rack driving device 12, and the like. The sample rack 11 has holes 1 with a diameter of 1.0 to 2.01 that can hold 20 to 50 test tubes for test liquids.
3 are arranged on concentric circles. Sample rack drive device 1
2 is located directly below the center of the sample rack 11, and moves the target sample directly below the probe 31 of the automatic syringe 3 for test liquid according to instructions from the control computer. The dispensing device 2 includes an automatic syringe 3 for a test liquid, an automatic syringe 4 for a reagent such as a reagent for inhibiting a non-specific immune reaction, and a syringe 5 for a latex reagent. The automatic syringe 3 includes a test liquid probe 31, its holding member 32, a drive device 23 for the probe 31, a test liquid cylinder 34, a piston 35, a piston drive device [36], and a switching valve 37. , this drive device 38, the diluent piston 39, and the same cylinder 3.
10, a driving device 311, a tube 312 connecting and communicating the probe 31, cylinder 34, switching valve 37, and cylinder 310 to a diluent container 313, and the like. The probe 31 is moved up and down and north and south by a drive device 33. Also, this automatic syringe 3 has a diameter of 5 to 100μ! Capable of injecting and dispensing a fixed amount of test liquid and diluted liquid. By driving and controlling the switching valve 37, the test liquid can be diluted as necessary. Automatic syringe for reagents:) 4 is probe 4
1, this holding member 42, a switching valve 43, a valve driving device 44, a piston 45, a cylinder 46,
The piston drive device 47, the probe 41, the switching valve 44, and the cylinder 46 are connected and communicated with each other to form a reagent container 49.
It consists of a tube 48 etc. leading to . This automatic syringe 4 dispenses 5 to 100 microns of reagent from the reagent container! A fixed amount is injected and poured out from the probe 41 into a well 61 which will be described later. The automatic syringe 5 for latex reagents includes a probe 51, a probe holding member 52, a switching valve 53, and a valve driving device 54.
, a piston 55, a cylinder 56, a piston drive device 57, a tube 58 connecting and communicating the probe 51, switching valve 53, and cylinder 56 to a latex reagent container 59, etc. This automatic syringe 5 injects a fixed amount of 5 to 100 μl of latex reagent from a container 59 and discharges the latex reagent into a well 61 from a probe 51 .
免疫反応装置６は８×１２に配列されたウェル６１を有
するマイクロプレート６２と、マイクロプレート６２を
水平に振盪させ、かつ最少フェル単位で東西南北に移動
する駆動装置６３等からなる。このマイクロプレート６
２は上述した分注装置から被検液、試薬液をウェル６１
にプローブ３１．４１．５１から順次分注される。The immunoreaction device 6 includes a microplate 62 having wells 61 arranged in an 8×12 array, a drive device 63 that shakes the microplate 62 horizontally, and moves it north, south, east, west, and the like in the minimum fell unit. This microplate 6
2, the test liquid and reagent liquid are supplied to the well 61 from the above-mentioned dispensing device.
The probes are sequentially dispensed from probes 31, 41, and 51.
測定試料、注入装置７は、プローブ７１と、この保持部
材７２と、プローブ７１と、上下東西に移動させる駆動
装置７３と、切替バルブ７４と、バルブ駆動装置７５と
、シリンダー７６と、ピストン７７と、ピストン駆動装
置７８と、プローブ７１と切替バルブとシリンダーを接
続連通させ検出装置８にウェル３１で形成されプローブ
７１で定量注入された測定試料を定量移送するチューブ
７９等からなる。The measurement sample and the injection device 7 include a probe 71, this holding member 72, the probe 71, a drive device 73 for moving it up and down, east and west, a switching valve 74, a valve drive device 75, a cylinder 76, and a piston 77. , a piston drive device 78, and a tube 79 that connects and communicates the probe 71, the switching valve, and the cylinder to the detection device 8, and transfers the measurement sample formed in the well 31 and injected by the probe 71 in a fixed amount.
検出装置８は希釈装置８１と、ラテックス粒子を検出す
る電気抵抗式検出器８２と、この検出器８２からの情報
をラテックス粒度分布として換算する換算装［８３等か
らなる。検出装置８は直径０．６〜３０μｍまでの粒子
を０．１μｍ以下の単位で粒度分布を測定できる能力を
有する。The detection device 8 includes a dilution device 81, an electrical resistance detector 82 for detecting latex particles, and a conversion device [83, etc.] for converting information from the detector 82 as a latex particle size distribution. The detection device 8 has the ability to measure the particle size distribution of particles having a diameter of 0.6 to 30 μm in units of 0.1 μm or less.
検出装置８からのデータは、算出装置であるデータ処理
用コンピューターに移送され、被検液中の所望特定物質
濃度に換算される。The data from the detection device 8 is transferred to a data processing computer, which is a calculation device, and is converted into a desired specific substance concentration in the test liquid.
上述した各構成装置と、これを駆動制御する制御用コン
ピューターとこの付属装置は、１６ビツトのデーターパ
スにより結ばれている。矢印はデータの送受方向を示す
。Each of the above-mentioned component devices, the control computer that drives and controls them, and the attached devices are connected by a 16-bit data path. Arrows indicate the direction of data transmission and reception.
次に本装置を用いて被検液を分析し、測定結果を得るま
での、本装置を構成する各装置のメカニカル・タイミン
グの具体例を第２図に示した。Next, FIG. 2 shows a specific example of the mechanical timing of each device constituting this device until the test liquid is analyzed using this device and a measurement result is obtained.
第２図の符号は第１図の符号と同一である。以下この例
を説明する。The symbols in FIG. 2 are the same as those in FIG. This example will be explained below.
マイクロプレート６２が免疫反応装置６にセットされ、
サンプルランク１１０穴１３に被検液の入った試験管が
セットされ、ラテックス試薬以外の試薬が容器４９に、
ラテックス試薬が容器５９に収容されると本装置の分析
が開始される。第２図に示したように各装置は１５秒を
１サイクルとして駆動制御される。マイクロプレート６
２は１２行８列の９６のウェルからなり、１行８個のウ
ェルが大きなサイクルとして使用される。まず、１行目
に自動シリンジ３のプローブ３１によ）被検液を２分間
で分注し、次の２分間で自動シリンジ４によって所望の
試薬が１行目に同時に自動シリンジ３によって２行目に
被検液が分注され、４分経過する。次の２分間で、自動
シリンジ５によつ又１行目にラテックス試薬が、２行目
に自動シリンジ４によって所望の試薬が、３行目に自動
シリンジ３によって被検液が各々同期して分注される。A microplate 62 is set in the immunoreaction device 6,
A test tube containing a test liquid is set in the hole 13 of the sample rank 110, and reagents other than the latex reagent are placed in the container 49.
When the latex reagent is placed in the container 59, the analysis of this apparatus is started. As shown in FIG. 2, each device is driven and controlled with one cycle of 15 seconds. Microplate 6
2 consists of 96 wells arranged in 12 rows and 8 columns, and each row of 8 wells is used as a large cycle. First, the test liquid (using the probe 31 of the automatic syringe 3) is dispensed into the first line in 2 minutes, and in the next 2 minutes, the desired reagent is dispensed into the first line by the automatic syringe 4 into two lines at the same time. The test liquid is dispensed into the eye, and 4 minutes have passed. In the next 2 minutes, the latex reagent is added to the automatic syringe 5 in the first line, the desired reagent is added to the second line by the automatic syringe 4, and the test liquid is added to the third line by the automatic syringe 3. Dispensed.
この間、第２図に示したように、各構成装置は駆動制御
される。以下同様に、２行目にラテックス試薬が３行目
に、これ以外の試薬が４行目に被検液が２分間で分注さ
れる。１行目のウェルはラテックス試薬分注時から６分
後、振盪装置６３によシラテックス反応が完了する。測
定試料注入装置７のプローブ７１によりこの反応液は注
入され、同試料は検出装置８に移送される。従って本装
置駆動時から１０分後、１行目の８体の被検液から粒度
分布の測定が開始され１２分後光了し、この間およびこ
の後データ処理され、プリンターによシ、プリントアウ
トされる。１２分後２行目８体の被検液がプローブ７１
によシ同様に注入され、処理される。以下同様に９６番
目までの被検液を処理すると、３４分で９６体の被検液
が分析される。プリンターにより全被検液の所望物質の
濃度が打ち出されるまで３６分である。During this time, as shown in FIG. 2, each component device is driven and controlled. Similarly, the latex reagent is dispensed in the second line, the third line is the other reagents, and the test liquid is dispensed in the fourth line in 2 minutes. Six minutes after dispensing the latex reagent to the wells in the first row, the silatex reaction is completed by the shaking device 63. This reaction liquid is injected by the probe 71 of the measurement sample injection device 7, and the sample is transferred to the detection device 8. Therefore, 10 minutes after the device is started, measurement of particle size distribution starts from the test liquids of the 8 specimens in the first row, and after 12 minutes the measurement is completed.During this time and after that, the data is processed, sent to the printer, and printed out. be done. After 12 minutes, the test liquid from the 8 bodies in the second row reaches the probe 71.
It is injected and processed in the same way. If the test liquids up to the 96th sample are processed in the same manner, the test liquids of 96 bodies will be analyzed in 34 minutes. It takes 36 minutes for the printer to print out the concentration of the desired substance in all the test liquids.
なお本実施例では被検液用自動シリンジ１本であるが、
これを２本以上にすることもできる。また、試薬用プロ
ーブも移動可能とすることができる。ラテックス試薬用
自動シリンジを２本以上、ラテックス試薬以外の同［ま
たは異種の試薬用の自動シリンジを２本以上設け、処理
能力を高め、かつ被検液の処理範囲を拡大することも可
能である。In this example, one automatic syringe for the test liquid was used, but
It is also possible to have two or more. Further, the reagent probe can also be made movable. It is also possible to increase processing capacity and expand the processing range of test liquids by installing two or more automatic syringes for latex reagents and two or more automatic syringes for the same or different types of reagents other than latex reagents. .
また、本装置はラテックス試薬即ち之テックスを抗原、
抗体等を感作する担体として用いた試薬での免疫測定装
置に好適であるが、ラテックス以外の担体に抗原、抗体
等を感作した試薬での測定も可能である。In addition, this device uses a latex reagent, i.e., the latex, as an antigen,
Although it is suitable for an immunoassay device using a reagent used as a carrier to sensitize antibodies, etc., it is also possible to perform measurements using reagents in which carriers other than latex are sensitized with antigens, antibodies, etc.
本発明の装置を用いることＫより、多くの被検液を短時
間で、かつ信頼度の高いラテックス免疫測定結果を得る
ことができる。By using the apparatus of the present invention, highly reliable latex immunoassay results can be obtained for a large number of test liquids in a short time.
第１図は本発明の装置の実施例説明図である。
矢印はデータの送受方向を示す。第２図は本装置ｋ Ｔ
ｋ成する各装置のメカニカル・タイミングの具体例を示
したものである。
■・・・送り装置、１１・・・サンプルラック、１２・
・・サンプルラック駆動装置、１３・・・試験管保持穴
、２・・・分注装置、３・・・被膜液用自動シリンジ、
４・・・試薬用自動シリンジ、５・・・ラテックス試薬
用シリンジ、７・・・測定試料注入装置、３１，４１，
５１．７１・・・プローブ、３２，４２，５２．７２・
・・プローブ保持部材、３３．７３・・・プローブ駆動
装置、３５，３９，４５゜５５．７７・・・ピストン、
３４，３１０．４６，５６．７６・・・シリンダー、３
６，３１１．４７，５７．７８・・・ピストン駆動装置
、３７，４３，５３．７４・・・切替バルブ、３３．３
８，４４，５４，７５・・・切替パルプ駆動装置、３１
２．４８，５８．７９・・・チューブ、３１３・・・希
釈液容器、４９・・・試薬液容器、５つ・・・ラテック
ス試薬容器、６・・・送り装置、６１・・・ウェル、６
２・・・マイクロプレー・ト、６３・・・駆動装置、８
・・・検出装置、８１・・・希釈装置、８２・・・検出
器、８３・・−換算装置（ほか３名）FIG. 1 is an explanatory diagram of an embodiment of the apparatus of the present invention. Arrows indicate the direction of data transmission and reception. Figure 2 shows this device kT
This figure shows a specific example of the mechanical timing of each of the devices that make up the system. ■... Feeding device, 11... Sample rack, 12...
...Sample rack drive device, 13...Test tube holding hole, 2...Dispensing device, 3...Automatic syringe for coating liquid,
4... Automatic syringe for reagent, 5... Syringe for latex reagent, 7... Measurement sample injection device, 31, 41,
51.71...probe, 32,42,52.72.
...Probe holding member, 33.73...Probe drive device, 35, 39, 45°55.77...Piston,
34,310.46,56.76...Cylinder, 3
6,311.47,57.78...Piston drive device, 37,43,53.74...Switching valve, 33.3
8, 44, 54, 75... switching pulp drive device, 31
2.48, 58.79... Tube, 313... Diluent liquid container, 49... Reagent liquid container, 5... Latex reagent container, 6... Feeding device, 61... Well, 6
2... Microplate plate, 63... Drive device, 8
...detection device, 81...dilution device, 82...detector, 83...-conversion device (and 3 others)
Claims (1)
、試薬液の各々から定量を注入および／または注出する
少なくとも２本のプローブを有する分注装置と、注出さ
れた液を受容する受容部材を有しかつ振盪機能を有する
免疫反応装置と、この受容された液の定量を注入するプ
ローブを有する測定試料注入装置と、この注入された液
中に存在するラテックス粒子の粒度分布または濃度を検
出する検出装置と、前記検出されたデータから被検液中
の特定物質濃度を算出する算出装置とを有する分析装置
と、この分析装置を総合的に作動制御する電子的制御手
段とからなる全自動連続分析装置。A feeding device having a member for holding a sample liquid container, a dispensing device having at least two probes for injecting and/or dispensing fixed amounts from each of a sample liquid and a reagent liquid, and a dispensing device having a member for holding a sample liquid and a reagent liquid, An immunoreaction device having a receiving member and having a shaking function, a measurement sample injection device having a probe for injecting a fixed amount of the received liquid, and a particle size distribution of latex particles present in the injected liquid. or an analyzer having a detection device that detects the concentration, a calculation device that calculates the concentration of a specific substance in the test liquid from the detected data, and an electronic control means that comprehensively controls the operation of the analyzer. A fully automatic continuous analyzer consisting of:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24074884A JPS61120060A (en) | 1984-11-16 | 1984-11-16 | Fully automatic and continuous analysis instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24074884A JPS61120060A (en) | 1984-11-16 | 1984-11-16 | Fully automatic and continuous analysis instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61120060A true JPS61120060A (en) | 1986-06-07 |
Family
ID=17064118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24074884A Pending JPS61120060A (en) | 1984-11-16 | 1984-11-16 | Fully automatic and continuous analysis instrument |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61120060A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01259257A (en) * | 1988-04-08 | 1989-10-16 | Toa Medical Electronics Co Ltd | Immune agglutination measuring instrument |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53104726A (en) * | 1976-12-10 | 1978-09-12 | Technicon Instr | Test method of liquid containing specific antigen ag or antibody ab |
-
1984
- 1984-11-16 JP JP24074884A patent/JPS61120060A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53104726A (en) * | 1976-12-10 | 1978-09-12 | Technicon Instr | Test method of liquid containing specific antigen ag or antibody ab |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01259257A (en) * | 1988-04-08 | 1989-10-16 | Toa Medical Electronics Co Ltd | Immune agglutination measuring instrument |
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