JPS6087207A - Deramatic drug for external use containing extract of aloe and its preparation - Google Patents
Deramatic drug for external use containing extract of aloe and its preparationInfo
- Publication number
- JPS6087207A JPS6087207A JP58197175A JP19717583A JPS6087207A JP S6087207 A JPS6087207 A JP S6087207A JP 58197175 A JP58197175 A JP 58197175A JP 19717583 A JP19717583 A JP 19717583A JP S6087207 A JPS6087207 A JP S6087207A
- Authority
- JP
- Japan
- Prior art keywords
- aloe
- yeast
- extract
- fermentation
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は、発酵法によって得られたアロエ抽出液を含有
する皮膚外用剤及びその製造方法に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an external skin preparation containing an aloe extract obtained by a fermentation method and a method for producing the same.
アロエ抽出物は従来から皮膚外用剤に配合されているが
、それらは主として(1)アロエ内部組織の粘液主成分
である多糖類と他の水溶性成分を捕集し、アロイン、ア
ロエエモジン等のアントラキノン系の配糖体を除去した
粉末又はその水溶液、(2)同じ内部組織の中でも内鞘
の柔細胞組織の液汁中に含まれるアロイン、アロエエモ
ジンを多く含んだ抽出液そして(1)及び(2)を含ん
だ抽出物である。Aloe extracts have traditionally been incorporated into external skin preparations, but they mainly (1) collect polysaccharides, which are the main components of the mucus in the internal tissues of aloe vera, and other water-soluble components, and contain anthraquinones such as aloin and aloe emodin; (2) an extract containing a lot of aloin and aloe-emodin contained in the sap of parenchyma of the inner sheath among the same internal tissues, and (1) and (2) It is an extract containing.
これらの製造方法は、破断、圧搾、溶剤抽出、濃縮、濾
過、洗浄、再抽出及び精製工程等の多くの工程を含み、
短時間で目的物を容易に得ることは困難である欠点を有
する。These manufacturing methods include many steps such as breaking, squeezing, solvent extraction, concentration, filtration, washing, re-extraction and purification steps,
It has the disadvantage that it is difficult to easily obtain the desired product in a short time.
本発明者らは、当該植物の抽出方法を鋭意研究した結果
、当該植物の生葉全体を破砕圧搾した生汁及び圧搾糟の
単独又は混合物に、糖類及び酵母を加え、発酵させたの
ち、発酵液を濾過して、抽出液を得る方法(以下発酵抽
出法と記す)が極めて有効であることを見出した。この
方法は破砕圧搾9発酵そして濾過工程から成り、迅速且
つ短時間で当該抽出液を製造することができる。又本発
明は、アロエ生葉全部位を使用することも可能であり、
この場合、葉緑素、アミノ酸、ステロイド及びミネラル
等の有用成分をも同時【こ抽出することが可能である。As a result of intensive research on the extraction method of the plant, the present inventors added sugars and yeast to the raw juice obtained by crushing and pressing the whole fresh leaves of the plant and the pressed rice alone or in a mixture, fermented it, and then added the fermented liquid. It has been found that a method of obtaining an extract by filtration (hereinafter referred to as fermentation extraction method) is extremely effective. This method consists of crushing, pressing, 9 fermentation, and filtration steps, and can produce the extract quickly and in a short time. In addition, in the present invention, it is also possible to use all parts of fresh aloe leaves,
In this case, it is possible to simultaneously extract useful components such as chlorophyll, amino acids, steroids, and minerals.
本発明の方法によれば、常温、好ましくは25゜〜35
℃にて早くて2時間、平均2〜4時間で抽出がほぼ完了
する。According to the method of the present invention, at room temperature, preferably from 25° to 35°
The extraction is almost completed in 2 hours at the earliest, and 2 to 4 hours on average at ℃.
原料になる当該植物はユリ科アロエ属のものであればよ
く、キダチアロエ、ケープアロエそしてアロエベラ等の
一種又は数種の混合物が用いられる。The plant used as the raw material may be any member of the genus Aloe of the family Liliaceae, and one type or a mixture of several types of Aloe aloe, Cape aloe, Aloe vera, etc. can be used.
発酵抽出法に使用される糖類は、グル篤コース、・フル
クトース等の六炭糖類、ンヨ糖、麦芽糖等の二糖類、そ
れ以上の多糖類等で、酵母によりアルコール発酵が可能
な糖類であればよく、それら糖類のうちの一種又は数種
の混合物であってもよい。The sugars used in the fermentation extraction method include glucose, hexose such as fructose, disaccharides such as sugar and maltose, and higher polysaccharides, as long as they can be fermented with alcohol by yeast. Often, it may be one kind or a mixture of several kinds of these saccharides.
使用する糖の量は、アルコール転換量で10〜15%の
範囲になる様な量が好ましく、あまり稀薄であると抽出
がうまく進行しなかったり、当該抽出液の腐敗の原因と
もなる。逆にあまり高濃度になると酵母自身を失活させ
る結果となるので、これも好ましくない。The amount of sugar used is preferably such that the alcohol conversion amount is in the range of 10 to 15%; if it is too dilute, the extraction may not proceed well or the extract may spoil. On the other hand, if the concentration is too high, the yeast itself will be deactivated, which is also not preferable.
発酵抽出法に必要なもう一つの原料である酵母は、サツ
力ロミセスセレビシアエ属等のアルコール発酵を起こす
酵母であり、ビール酵母、製ノ(ン用の生イースト及び
ドライイースト等でもよく、これらの一種又は数種の混
合物であってもよい。Yeast, which is another raw material required for the fermentation extraction method, is a yeast that causes alcohol fermentation, such as the genus Satsuriromyces cerevisiae, and may also be beer yeast, fresh yeast for fermentation, dry yeast, etc. , one kind or a mixture of several kinds thereof may be used.
本発明は、通常の抽出法と比較して極めて迅速且つ短時
間で当該抽出液を製造することが可能であり、通常の抽
出法では得られない発酵代謝物をも含有することを特徴
とする。又発酵抽出法により得られた抽出液と発酵前の
アロエ生汁を比較すると、後者が非常に特異臭が強く、
化粧品添加物として不適当であるのに対し、発酵抽出液
は、はとんど特異臭がな(化粧品添加物等として有用で
ある。The present invention is characterized in that the extract can be produced extremely quickly and in a short time compared to normal extraction methods, and it also contains fermentation metabolites that cannot be obtained by normal extraction methods. . Furthermore, when comparing the extract obtained by the fermentation extraction method with the raw aloe juice before fermentation, the latter has a very strong specific odor.
While it is unsuitable as a cosmetic additive, the fermented extract has almost no distinctive odor (it is useful as a cosmetic additive, etc.).
以下に実施例を挙げる。Examples are given below.
し実施例1」
キダチアロエの新鮮な生葉I K9をジューサーで破砕
圧搾し、約750gの粘性の生汁を得た。また器内に角
化表皮の切片を主とし、粘性の生汁を含んだ繊維状の糟
200gを得た。Example 1 Fresh leaves of Kidachialoe I K9 were crushed and squeezed using a juicer to obtain about 750 g of viscous raw juice. In addition, 200 g of fibrous ooze containing mainly keratinized epidermis sections and viscous raw juice was obtained in the vessel.
〔イ〕 生汁750gに蜂蜜759を加えてよく撹拌し
、これに製パン用ドライイースト2(1’を加え撹拌し
、30〜35℃に保つと約20公租度で発酵が始まり、
約3時間にて発酵が完了した。常温にて24時間放置し
たのち濾過し、アロエ抽出液580gを得た。抽出液は
更に50〜60℃にて2時間放置し、酵母を失活させ、
冷蔵庫中に保持し、析出した沈澱物を濾過し、575g
のアロエ抽出液(5)を得た。この抽出液(へ)の性状
を第1表に記した。[B] Add honey 759 to 750 g of raw juice, stir well, add bread-making dry yeast 2 (1') and stir, and keep at 30-35°C. Fermentation will start at about 20 degrees centigrade.
Fermentation was completed in about 3 hours. After being left at room temperature for 24 hours, it was filtered to obtain 580 g of aloe extract. The extract was further left at 50 to 60°C for 2 hours to inactivate the yeast.
Keep it in the refrigerator, filter the precipitate, and weigh 575g.
An aloe extract (5) was obtained. The properties of this extract are shown in Table 1.
第 1 表
〔口〕 糟200gに精製水100gを加え、ミキサー
にて粉細しだ液に蜂蜜2(lを加え、よく撹拌し、これ
に製パン用土イースト5gを添加し、30〜35℃に保
つと約20分で発酵が始まり、約2時間で発酵が完了し
た。前記〔イ〕と同様の操作をし、アロエ抽出液(B)
125 flを得た。Table 1 [Mouth] Add 100 g of purified water to 200 g of rice cake, add 2 (l) of honey to the powdered soybean liquid using a mixer, stir well, add 5 g of yeast for bread making, and heat at 30-35℃. Fermentation started in about 20 minutes and completed in about 2 hours when kept at
Obtained 125 fl.
この抽出液の)の性状を第2表に記した。The properties of this extract are shown in Table 2.
第 2 表
「実施例2」
カリブ海沿岸地方産Aloe ferox Mille
r (アロエベラ近縁種)450fJとキダチアロエ4
50!、合計900gを実施例1と同様の操作をして、
生汁750gと糟145gを得た。この両者を混合し、
これにハトムギ糟75g及び製パン用ドライイースト2
0gを加え35〜40℃に保つと約2.5時間で発酵が
完了した。Table 2 "Example 2" Aloe ferox Mille from the Caribbean coast region
r (related to Aloe vera) 450fJ and Kidachi Aloe 4
50! , a total of 900 g was subjected to the same operation as in Example 1,
750 g of raw juice and 145 g of lees were obtained. Mix these two,
Add to this 75g of pearl barley rice and 2 ounces of dry yeast for bread making.
When 0g was added and kept at 35-40°C, fermentation was completed in about 2.5 hours.
以下実施例1〔イ〕と同様の操作をし、アロエ抽出液(
C1780gを得た。この抽出液(qの性状を第3表に
記した。Hereinafter, the same operation as in Example 1 [A] was carried out, and the aloe extract (
1780 g of C was obtained. The properties of this extract (q) are listed in Table 3.
次に、上記実施例で得られたアロエ抽出液イ)。Next, the aloe extract a) obtained in the above example.
CB) 、 (C)をそれぞれ用いて、以下の成分を配
合しクリームを製造した。これをクリーム1.クリーム
2、クリーム3とする。CB) and (C) were used to prepare a cream by blending the following ingredients. Cream 1. Let's call them cream 2 and cream 3.
クリーム配合成分 重量係
ステアリン酸 100
モノステアリン酸グリセリン 2.0
ポリオキシエチレン七チルエーテル 10ミリスチン酸
オクチルドデシル 3.0スクワラン 5.0
セタノール 20
アロエ抽出液 15.0
グリセリン 80
水酸化カリウム 02
(精製水によって全量を100%とする)比較のため、
同一条件でアロエ抽出液を含まないクリームを作成し、
これを比較クリームとした。Cream ingredients Stearic acid 100 Glyceryl monostearate 2.0 Polyoxyethylene heptyl ether 10 Octyldodecyl myristate 3.0 Squalane 5.0 Setanol 20 Aloe extract 15.0 Glycerin 80 Potassium hydroxide 02 (with purified water) For comparison (assuming the total amount is 100%),
Create a cream without aloe extract under the same conditions,
This was used as a comparison cream.
クリーム1.2.3及び比較クリームにつき化粧品の具
備すべき重要な第一要素である使用感テストを下記のご
と〈実施した。即ち、毎日朝夕1回、5日間顔面右側に
クリーム1.2.3の中の1点、左側に比較クリームを
使用した。尚、パネルは各群20〜40才の女性20名
を対象とした。その結果を第4表に示す。A usability test, which is an important first element that cosmetics should have, was conducted on Cream 1.2.3 and the comparative cream as follows. That is, one of the creams 1, 2, and 3 was used on the right side of the face and the comparison cream was used on the left side of the face for 5 days once a day in the morning and evening. The panel consisted of 20 women aged 20 to 40 in each group. The results are shown in Table 4.
第 4 表 クリーム1.2.3及び比較クリームの使用感テスト (パネル数20名) 但し、有効係は下記式により計算した。Table 4 Usability test of cream 1.2.3 and comparative cream (Number of panels: 20 people) However, the effective ratio was calculated using the following formula.
次に、実施例1〔イ〕で得られたアロエ抽出液(A)を
用いて下記の成分の化粧水を作成した。Next, a lotion containing the following ingredients was prepared using the aloe extract (A) obtained in Example 1 [A].
化粧水成分 重量係
グリセリン 2゜
1.3−ブチレングリコール 3゜
アロエ抽出液(ハ)) 30.0
エタノール 4.0
゛(精製本によって全量を100%とする〕また、比較
化粧水として上記成分よりアロエ抽出液(A)を除いた
ものを作成した。Lotion ingredients Weight: Glycerin 2゜1.3-butylene glycol 3゜Aloe extract (c)) 30.0 Ethanol 4.0゛ (The total amount is 100% depending on the purification book) Also, as a comparison lotion, the above ingredients A sample was prepared by removing the aloe extract (A).
クリームと同様の方法により、女性パネル15名につき
、使用感テストを実施した。その結果を第5表に示す。A usability test was conducted on a panel of 15 women using the same method as for the cream. The results are shown in Table 5.
第 5 表 抽出液含有化粧水及び比較化粧水の 使用感テスト (パネノI/!a15名) 但し、有効係は下記式により計算した。Table 5 Extract-containing lotion and comparative lotion Usability test (Paneno I/!a 15 people) However, the effective ratio was calculated using the following formula.
、同 代理人 鎌 1) 文 二, same agent Kama 1) sentence 2
Claims (2)
を破砕、圧搾して得られた生汁及び圧搾糟の単独又は混
合物に、糖類及び酵母を加えて発酵させ、その発酵液を
濾過したアロエ抽出液を含有する皮膚外用剤。(1) Saccharides and yeast are added to the raw juice obtained by crushing and pressing the entire fresh leaves of one or more plants of the genus Aloe of the family Liliaceae, either alone or in a mixture, and fermented by adding sugars and yeast, and producing the fermented liquid. A topical skin preparation containing filtered aloe extract.
破砕、圧搾し、得られた生汁及び圧搾糟の単独又は混合
物に糖類及び酵母を加えて発酵させたのち、その発酵液
を濾過することから成るアロエ抽出液の製造方法。(2) Crush and press the whole fresh leaves of one or more plants of the genus Aloe of the Liliaceae family, add sugars and yeast to the obtained raw juice and pressed pulp alone or in a mixture, and ferment the resulting fermented liquid. A method for producing an aloe extract comprising filtering.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58197175A JPS6087207A (en) | 1983-10-19 | 1983-10-19 | Deramatic drug for external use containing extract of aloe and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58197175A JPS6087207A (en) | 1983-10-19 | 1983-10-19 | Deramatic drug for external use containing extract of aloe and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6087207A true JPS6087207A (en) | 1985-05-16 |
JPH0520407B2 JPH0520407B2 (en) | 1993-03-19 |
Family
ID=16370043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58197175A Granted JPS6087207A (en) | 1983-10-19 | 1983-10-19 | Deramatic drug for external use containing extract of aloe and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6087207A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6287241A (en) * | 1985-10-11 | 1987-04-21 | Lion Corp | Oil droplet-in-water type emulsion composition |
JP2004196664A (en) * | 2002-12-16 | 2004-07-15 | Yakult Honsha Co Ltd | Humectant and cosmetic comprising the same |
JP2005008532A (en) * | 2003-06-17 | 2005-01-13 | Eau De Vie Japon:Kk | Humectant and skin cosmetic and food and drink for beauty culture comprising the same humectant formulated therein |
CN104306322A (en) * | 2014-11-22 | 2015-01-28 | 沈阳源康医疗器械有限公司 | Cordyceps-militaris-ingredient contained eye cream and preparing method of cordyceps-militaris-ingredient contained eye cream |
CN104352422A (en) * | 2014-11-22 | 2015-02-18 | 沈阳源康医疗器械有限公司 | Eye cream containing cordyceps militaris component and preparation method of eye cream |
CN104434759A (en) * | 2014-11-22 | 2015-03-25 | 沈阳源康医疗器械有限公司 | Eye cream containing ingredient of cordyceps militaris and preparation method thereof |
CN104523555A (en) * | 2014-11-22 | 2015-04-22 | 沈阳源康医疗器械有限公司 | Eye cream containing cordyceps militaris ingredient, and preparation method thereof |
CN104758202A (en) * | 2015-03-09 | 2015-07-08 | 胡建华 | A detergent containing plant extract products and a preparing method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS527062A (en) * | 1975-07-07 | 1977-01-19 | Sanyo Electric Co Ltd | Open show case |
JPS5244375A (en) * | 1975-10-06 | 1977-04-07 | Nissan Diesel Motor Co Ltd | Link mechanism |
JPS5345376A (en) * | 1976-10-04 | 1978-04-24 | Sumitomo Chemical Co | Method of producing high molecular polyolefin resin sheet or film |
JPS55145607A (en) * | 1979-04-28 | 1980-11-13 | Lion Corp | Aloin-containing composition |
JPS5697209A (en) * | 1980-01-08 | 1981-08-05 | Hideo Shibata | Dandruff removing lotion |
JPS5742326A (en) * | 1980-07-25 | 1982-03-09 | Oreal | Stable o/w type emulsion |
JPS5815918A (en) * | 1981-07-21 | 1983-01-29 | Lion Corp | Preparation of physiologically active substance from aloe |
-
1983
- 1983-10-19 JP JP58197175A patent/JPS6087207A/en active Granted
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS527062A (en) * | 1975-07-07 | 1977-01-19 | Sanyo Electric Co Ltd | Open show case |
JPS5244375A (en) * | 1975-10-06 | 1977-04-07 | Nissan Diesel Motor Co Ltd | Link mechanism |
JPS5345376A (en) * | 1976-10-04 | 1978-04-24 | Sumitomo Chemical Co | Method of producing high molecular polyolefin resin sheet or film |
JPS55145607A (en) * | 1979-04-28 | 1980-11-13 | Lion Corp | Aloin-containing composition |
JPS5697209A (en) * | 1980-01-08 | 1981-08-05 | Hideo Shibata | Dandruff removing lotion |
JPS5742326A (en) * | 1980-07-25 | 1982-03-09 | Oreal | Stable o/w type emulsion |
JPS5815918A (en) * | 1981-07-21 | 1983-01-29 | Lion Corp | Preparation of physiologically active substance from aloe |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6287241A (en) * | 1985-10-11 | 1987-04-21 | Lion Corp | Oil droplet-in-water type emulsion composition |
JPH0576336B2 (en) * | 1985-10-11 | 1993-10-22 | Lion Corp | |
JP2004196664A (en) * | 2002-12-16 | 2004-07-15 | Yakult Honsha Co Ltd | Humectant and cosmetic comprising the same |
JP2005008532A (en) * | 2003-06-17 | 2005-01-13 | Eau De Vie Japon:Kk | Humectant and skin cosmetic and food and drink for beauty culture comprising the same humectant formulated therein |
CN104306322A (en) * | 2014-11-22 | 2015-01-28 | 沈阳源康医疗器械有限公司 | Cordyceps-militaris-ingredient contained eye cream and preparing method of cordyceps-militaris-ingredient contained eye cream |
CN104352422A (en) * | 2014-11-22 | 2015-02-18 | 沈阳源康医疗器械有限公司 | Eye cream containing cordyceps militaris component and preparation method of eye cream |
CN104434759A (en) * | 2014-11-22 | 2015-03-25 | 沈阳源康医疗器械有限公司 | Eye cream containing ingredient of cordyceps militaris and preparation method thereof |
CN104523555A (en) * | 2014-11-22 | 2015-04-22 | 沈阳源康医疗器械有限公司 | Eye cream containing cordyceps militaris ingredient, and preparation method thereof |
CN104758202A (en) * | 2015-03-09 | 2015-07-08 | 胡建华 | A detergent containing plant extract products and a preparing method thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH0520407B2 (en) | 1993-03-19 |
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