JPS6027859A - Automatic erythrocyte sedimentation rate meter - Google Patents
Automatic erythrocyte sedimentation rate meterInfo
- Publication number
- JPS6027859A JPS6027859A JP13613383A JP13613383A JPS6027859A JP S6027859 A JPS6027859 A JP S6027859A JP 13613383 A JP13613383 A JP 13613383A JP 13613383 A JP13613383 A JP 13613383A JP S6027859 A JPS6027859 A JP S6027859A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- sample
- tube
- specimen
- sedimentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004062 sedimentation Methods 0.000 title claims abstract description 89
- 210000003743 erythrocyte Anatomy 0.000 title abstract description 9
- 210000004369 blood Anatomy 0.000 claims abstract description 130
- 239000008280 blood Substances 0.000 claims abstract description 130
- 238000002347 injection Methods 0.000 claims description 40
- 239000007924 injection Substances 0.000 claims description 40
- 239000007788 liquid Substances 0.000 claims description 4
- 230000007246 mechanism Effects 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 238000007664 blowing Methods 0.000 claims 1
- 238000005070 sampling Methods 0.000 abstract description 14
- 238000000034 method Methods 0.000 abstract description 9
- 230000009471 action Effects 0.000 abstract description 2
- 238000010241 blood sampling Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 description 9
- 230000003287 optical effect Effects 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 6
- 238000001802 infusion Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 239000013049 sediment Substances 0.000 description 4
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 230000003394 haemopoietic effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 241000257465 Echinoidea Species 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は赤血球沈降速度（以下血沈と略記する）を自動
的に測定するいわゆる自動血沈計と組合せて使用し、自
動化の程度を更に高める装置に関する。すなわち自動血
沈計にセラ１−された多数の血沈測定管（以下単に血沈
管と略記する）に多数の血液検体をそれぞれ順次所定回
を自動的に注入する装置に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a device that is used in combination with a so-called automatic hematopoietic sedimentator that automatically measures the erythrocyte sedimentation rate (hereinafter abbreviated as hematopoietic sedimentation rate) to further increase the degree of automation. That is, the present invention relates to an apparatus for automatically injecting a large number of blood samples in sequence and predetermined times into a large number of blood sediment measuring tubes (hereinafter simply referred to as blood sedimentation tubes) installed in an automatic hematological sedimentometer.
血沈の測定は、血沈管内に血液柱を形成させ、これを垂
直に立てて所定時間経過ごとの赤血球の沈降長を、通常
は目視により測定している。ところで、中規模以上の病
院では毎日の検体数が多く、これら多数の検体を目視に
より沈降距離を読みとることは、時間的、肉体的、精神
的に大きな負担となっている。この負担を軽減するため
に、種々の方式の自動血沈ｈ１がいくつか発表されてい
る。Blood sedimentation is measured by forming a blood column in a blood sedimentation tube, standing it vertically, and measuring the sedimentation length of red blood cells every predetermined time period, usually visually. Incidentally, hospitals of medium or larger size handle a large number of specimens every day, and reading the sedimentation distances of these many specimens by visual inspection poses a large time, physical, and mental burden. In order to reduce this burden, several automatic blood sedimentation h1 methods of various types have been announced.
その自動血沈計の１例を次に述べる。第１図および第２
図はそれぞれその外観図および正面図であるが、１０１
は血沈管取付台座であって、これを多数円周状に自沈管
取付台１０２上に配置させている。血沈管取付台１０２
の周辺には適当間隔で適当本数の支柱１０３を鉛直に固
定し、その上部に円板状の血沈管固定板１０４を設置′
Ｊである。この固定板には血沈雪取（＝Ｊ台座１０１と
相対応して血沈管固定具を設置）、血沈管１０５の下端
を取ト１台座１０１に押し当て、血沈管上部を相対応す
る血沈管固定具にセットすることにより、検体は血沈性
・下端から洩れることなく鉛直に保持され、血沈測定に
供されるようになっている。１０６は光源ボックスであ
り、長い直線状のフィラメントを有する光源ランプが納
められている。１０７は受光器ボックスであり、受光器
としてイメージセンサが収められている。An example of such an automatic blood sedimentation meter will be described below. Figures 1 and 2
The figures are an external view and a front view, respectively, and 101
is a blood sedimentation tube mounting pedestal, and a large number of these are arranged in a circumferential manner on the scuttling tube mount 102. Blood sedimentation tube mounting stand 102
An appropriate number of pillars 103 are vertically fixed at appropriate intervals around the periphery, and a disk-shaped blood sedimentation tube fixing plate 104 is installed on top of the pillars 103.
It is J. On this fixing plate, a blood sedimentation tube (a blood sedimentation tube fixture is installed in correspondence with the J pedestal 101), the lower end of the blood sedimentation tube 105 is pressed against the G1 pedestal 101, and the upper part of the blood sedimentation tube is connected to the corresponding blood sedimentation tube. By setting the sample in the fixture, the sample is held vertically without leaking from the lower end and is used for blood sedimentation measurement. A light source box 106 houses a light source lamp having a long linear filament. Reference numeral 107 is a light receiver box in which an image sensor is housed as a light receiver.
さてこの構成例の血沈自動測定装置の動作・機能は次の
通りである。光源ボックス１０６と受光器ボックス１０
７とは連絡器１０８ににって連結されており、又この受
光器ボックス１０７は支持・駆動軸１０９．１０９′で
保持されている。この支持・駆動軸１０９はモーター
１１０に連結されており、モーター１１０の回転により
、受光器ボックス１（１７およびこれに連結している光
源ボックス１０６とから構成される光学検知系１５０を
回転さ゛せる。その際、光源ボックス１０６と受光部ボ
ックス１０７との間隙に血沈管を挾むようにして回転す
るように構成しである。言いかえれば血沈管の両側に相
対向して光源ボックス１０６と受光部ボックス１０７が
配置され、かつ回転するように構成されている。光源ボ
ックス内の光源から血沈管に光を照射し、血沈管の透過
光をレンズを透過させたのち、イメージセンサで検出す
る。沈降した赤血球の上端面より上部は透明な血漿であ
るので、照射した光は透過し、受光部に到達するが、沈
降赤血球の上端面以下は不透明であるので、この部分に
照射した光は透過しない。この現象を利用し、イメージ
センサによる測光により、光の透過、不透過の境界を観
測することができるので、これを初期の白液柱面の高さ
位置との差を測定することにより血沈値を測定すること
ができる。Now, the operations and functions of the blood sedimentation automatic measuring device of this configuration example are as follows. Light source box 106 and receiver box 10
7 by a communication device 108, and this receiver box 107 is held by support/drive shafts 109, 109'. This support/drive shaft 109 is a motor
110, and the rotation of the motor 110 rotates the optical detection system 150, which is composed of the receiver box 1 (17) and the light source box 106 connected to it. It is configured to rotate so that the blood sedimentation tube is sandwiched in the gap with the light receiving section box 107. In other words, the light source box 106 and the light receiving section box 107 are arranged opposite to each other on both sides of the blood sedimentation tube, and are configured to rotate. The light source in the light source box irradiates the blood sedimentation tube with light, and the transmitted light from the blood sedimentation tube is transmitted through a lens and then detected by an image sensor.The area above the upper end surface of the sedimented red blood cells is transparent. Since it is plasma, the irradiated light passes through and reaches the light receiving part, but the area below the upper end of the sedimented red blood cells is opaque, so the irradiated light does not pass through this area.Using this phenomenon, an image sensor By photometry, it is possible to observe the boundary between light transmission and non-transmission, and by measuring the difference between this and the initial height position of the white liquid column surface, the blood sedimentation value can be measured.
そしてモーター１１０を駆動することにより、光源ボッ
クス１０６と受光部ボックス１０７とは一体となって回
転し、かつ両者の間隙に次々と血沈管が通過するように
構成されているので、セットされた多数の検体の血沈値
を自動的に測定することが５−
できる。そして、通常３０分経過後、１１）間経過後（
場合によってはさらに２時間経過後）それぞれの血沈管
について、その検***置番号と共に血沈値をプリンタ
１２５によって印字する。By driving the motor 110, the light source box 106 and the light receiving unit box 107 are rotated as a unit, and blood sedimentation tubes are configured to pass through the gap between them one after another. 5- It is possible to automatically measure the blood sediment value of a sample. Then, usually after 30 minutes, after 11) minutes (
(In some cases, after another 2 hours have passed) For each blood sedimentation tube, print the blood sedimentation value along with its sample position number.
125.
そのため、この自動血沈計の光源ボックス、受光部ボッ
クス内には、上記部品のほか血沈雪取イ」有無弁別のた
めの光源１１９および受光器１２０、また血沈雪取イ」
位置番号読みとりのための光源１２１および受光器１２
２を収めである。位置番号読みとりの方法としては、例
えば血沈管固定板１０４の一部に位置番号弁別孔１２３
をそれぞれ血沈管取付位置にり・１応して設け、作動時
に光源１２１を受光器１２２が位置番号弁別孔を間に挾
むように構成しである。Therefore, in addition to the above-mentioned parts, the light source box and light receiving box of this automatic hematology analyzer include a light source 119 and a light receiver 120 for determining the presence or absence of a blood sediment collector, as well as a blood sediment collector.
Light source 121 and light receiver 12 for reading position number
This is a total of 2. As a method for reading the position number, for example, a position number discrimination hole 123 is provided in a part of the blood sedimentation tube fixing plate 104.
are respectively provided at the blood sedimentation tube attachment position, and when activated, the light source 121 and the light receiver 122 are configured to sandwich the position number discrimination hole therebetween.
イして例えば第３図に示したＪ：うに６ケ所の位置の孔
のあけ方の組み合せによって６３個所までの位置弁別が
可能ぐある。イのほか図示はしていないが、必要な４１
様の劇時装置、マイクロコンピュータなどを装備する。For example, it is possible to discriminate up to 63 positions by combining the hole openings at the 6 positions shown in Figure 3. Although not shown in addition to A, the necessary 41
Equipped with various theatrical equipment, microcomputers, etc.
このような構成によって、前述のごとく各検体の各時間
ごとの血沈値を、検６−
***置番号とともにプリンタ １２５によって印字でき
る。With this configuration, as described above, the blood sedimentation value of each sample at each time can be printed by the printer 125 together with the sample position number.
１２４は測定位置番号表示燈であって、少なくとも血沈
管の取付可能本数の個数を設ける。１２６．１２７は電
源スィッチ、測定時間選択スイッチ等の操作のスイッチ
の類である。このような自動面沈計の出現により、従来
の目視による測定における大きな時間的、肉体的、精神
的角担が解決された。Reference numeral 124 denotes a measurement position number indicator light, which is provided in a number corresponding to at least the number of blood sedimentation tubes that can be attached. Reference numerals 126 and 127 indicate operation switches such as a power switch and a measurement time selection switch. The advent of such an automatic surface sink meter has solved the great time, physical, and mental burden of conventional visual measurements.
しかし、血沈管に血液検体を入れる操作は未だに手作業
の段階にとどまっており、特に血沈管の上端を口で吸っ
て血液検体を血沈管に吸引採取する方法がもっとも一般
的に行なわれている。ところで、この口で吸引する方法
は操作を誤まると血液が日中に入るおそれがあり、病気
感染の可能性が大きく、大変危険である。However, the operation of putting a blood sample into a blood sedimentation tube still remains at the manual stage, and the most common method is to suction the blood sample into the blood sedimentation tube by sucking the top end of the blood sedimentation tube with your mouth. . By the way, this method of suctioning with the mouth is very dangerous as there is a risk of blood getting into the body during the day if the operation is incorrect and there is a high possibility of disease infection.
このような危険防［トの観点から、またさらに一層の省
力化の立場から、血沈管への血液検体採取の自動化の要
望も強まってきた。本発明はこれらの要望に応えるため
に種々検詞の結果生まれた血液検体自動サンプリング機
能を持った自動血流計であり、以下実施例に基づき詳細
な説明する。From the viewpoint of such risk prevention and from the viewpoint of further labor saving, there has been a growing demand for automation of blood sample collection into blood sedimentation tubes. The present invention is an automatic blood flow meter having an automatic blood sample sampling function created as a result of various tests to meet these demands, and will be described in detail below based on examples.
第４図は自動サンプリング部の一実施例の外観図であり
、第５図はその部分拡大図である。多数の血液検体管（
真空採血管や、注射器で採取した血液を移し入れた試験
管にゴムキャップをしたもの、など）をセラ１〜し、順
次血液検体管（以下、検体管と略記）から採取し、自動
血流計にレットした血沈管に所定量注入する装詔である
。２０１は検体管取付板であり、検体管保持リング２０
２を有する検体管取付具２０３が多数取イ４けられてい
る。FIG. 4 is an external view of one embodiment of the automatic sampling section, and FIG. 5 is a partially enlarged view thereof. Many blood sample tubes (
Blood sample tubes (vacuum blood collection tubes, test tubes containing blood collected with a syringe and rubber caps, etc.) are sequentially collected from blood sample tubes (hereinafter referred to as sample tubes), and the blood is collected using an automatic blood flow system. This is a device for injecting a predetermined amount into a blood sedimentation tube. 201 is a sample tube mounting plate, and a sample tube holding ring 20
A large number of sample tube fittings 203 having 2 and 4 parts are installed.
なお、検体管取付具２０３はビン２０４を介して検体取
（Ｎｌ板２０１に取り（ｔ １．、Ｊられており、ビン
２０４を軸とじて検体管はは望鉛直面内で回転できるよ
うに（−・である。そしてこの検体管保持リング２０２
に、それぞれ検体管２０５を取りつける。なお第４図に
おいては多数の検体管類を−７ン図示することは鮒ＬＪ
大部分を甲に点線で示しｌこ。The sample tube fitting 203 is used to collect the sample via the bottle 204 (t1., J), so that the sample tube can rotate in the vertical plane with the bottle 204 as the axis. (-.And this sample tube holding ring 202
A sample tube 205 is attached to each. In addition, in Figure 4, the large number of specimen tubes is shown in a -7n diagram.
Most of it is indicated by a dotted line on the instep.
検体管取付板２０１は支社２２６で支えられ、ブ［ｌグ
ラマによって馴初されるモーターによって回転するよう
になっている。The sample tube mounting plate 201 is supported by a branch 226 and is adapted to be rotated by a motor that is started by a grapher.
２０６は検体様取部構成ブロックであり、ピストン動作
のように前後に移動しうる採取釘等保持具２−０７が設
けられ、この先端には送気１１２０８と採取針２０９と
が設けられている。送気針２０８にはチューブが接続さ
れ、チューブの他端はプログラマで制御される送気ポン
プ２１３に接続される。採取針２０９にもチューブ２１
５が接続され、検体様取部構成ブロック２０６から外部
へ出ており、自動血流計の検体注入部に接続される。Reference numeral 206 is a component block for the specimen sample collection section, which is provided with a collection nail holder 2-07 that can move back and forth like a piston action, and an air supply 11208 and a collection needle 209 are provided at the tip of this holder 2-07. . A tube is connected to the air supply needle 208, and the other end of the tube is connected to an air supply pump 213 controlled by a programmer. The tube 21 is also connected to the collection needle 209.
5 is connected to the outside from the specimen sampling section configuration block 206, and is connected to the specimen injection section of the automatic blood flow meter.
上記採取針保持具２０７は非採取時には後退しており、
採取時のみ前進し、送気針２０８と採取針２０９の先端
が検体管のゴムキャップ２１０を貫入するようになって
いる。必要な動作は図示してはいないが、マイクロコン
ピュータで制御される。The collection needle holder 207 is retracted when not collecting data,
The air supply needle 208 and the tips of the collection needle 209 are moved forward only during collection, so that the tips of the air supply needle 208 and the collection needle 209 penetrate the rubber cap 210 of the sample tube. Although necessary operations are not shown, they are controlled by a microcomputer.
次に自動血流計の試料注入部の例について説明する。第
６図は第１図、第２図について一例として説明した方式
の自動血流計に試料注入部が付加された構成例、第７図
、第８図は試料性入部機構の拡大説明図である。血沈管
取付台１０２はモーターによって間欠的に回転するよう
に構成され、こ９−
れには多数の自沈管ホルダー３０１が設けられ−Ｃおり
、この部分に空の血沈管１０５をセットする。血沈管ホ
ルダー３０１にはゴムキャップ３０２、受ＩＪ台（中心
部に注入針が貫通できるための孔を有する）３０３、お
よびこれらを上方に押しトけるためのスプリング３０４
が設けられでいる。ゴムキャップ３０２の底部は適当な
厚さとなっていて、注入側が容易に員入りやすいよう、
しかし血液検体注入後注入１１が抜き去られた後、血液
検体が洩れ出ないようになっている。 ３０５は注入品
構成ブロックＣあり、これには血沈管ホルダー３０１を
血液検体注入時に固定するためのクランプ３０６、一端
に注射器３０７を右Ｊる注入レバー３０８、血液注入１
ノベル検出器３０９を先端にもつレベル検出器取付柱３
１０などが設けられている。ごの注入品構成ブ［−１ツ
ク３０５は、自動血流計の注入部取付はベース３１１上
に、血沈管向って前進後３ｐが可能な状態で取り飼けら
れる。待機状態のとぎは注入品構成ブ１」ツク３０５は
後退の位置にあり、注入的には前進してクランプ３０６
が血沈管ホルダー３０１を保持するよう−１０＝
構成される。Next, an example of a sample injection section of an automatic blood flow meter will be explained. Figure 6 is a configuration example in which a sample injection section is added to the automatic blood flow meter of the type explained as an example in Figures 1 and 2, and Figures 7 and 8 are enlarged explanatory diagrams of the sample injection mechanism. be. The blood sedimentation tube mount 102 is configured to be rotated intermittently by a motor, and is provided with a large number of scuttling tube holders 301 in which empty blood sedimentation tubes 105 are set. The blood sedimentation tube holder 301 includes a rubber cap 302, an IJ receiving stand 303 (having a hole in the center for an injection needle to pass through) 303, and a spring 304 for pushing these upwards.
is provided. The bottom of the rubber cap 302 has an appropriate thickness so that the injection side can be easily inserted.
However, after the blood sample is injected and the inlet 11 is removed, the blood sample is prevented from leaking out. Reference numeral 305 indicates an infusion component block C, which includes a clamp 306 for fixing the blood sedimentation tube holder 301 during blood sample injection, an injection lever 308 for holding a syringe 307 at one end, and a blood injection 1
Level detector mounting column 3 with novel detector 309 at the tip
10 etc. are provided. The infusion product component block 305 is mounted on the base 311 for mounting the injection part of the automatic blood flow meter in a state in which it can be moved forward toward the blood sedimentation tube. In the standby state, the clamp 305 that constitutes the injected product is in the retracted position, and when injected, it moves forward and clamps 306.
-10= is configured to hold the blood sedimentation tube holder 301.
次に上記のような試料注入部が付加された自動血沈計と
、さきに説明した白液検体自動サンプリング（以下、サ
ンプラーと略記）とを組合せ、本発明の目的を実現させ
る場合の動作機能を説明する。まず自動血沈計とサンプ
ラーとを電気的に接続し、また自動血沈計試利注入部の
注入針とサンプラーの採取針とをチコーブ２１５で接続
する。この状態を第９図に示した。そしてサンプラーに
検体管をセット、２１５また自動面沈計には空の血沈管
を少くとも検体管の数だけセットし、電源を入れる。光
学検知系１５０が回転をはじめると共に、血沈管取付台
１０２が回転し、最初に検体が注入されるべき血沈管が
試料注入部の位置に来たところで停止する。このとき注
入品構成ブロック３０５は後退の位置にあり、また注入
レバー３０８は下降の位置にあり、注入針３０７は下方
を向いており、トレイン受（プ冊３１２の方に向ってい
る。この間に一方サンプラーの検体管取付板２０１も回
転し、最初に採取されるべき検体管が採取針２０９の対
向位置まできたところで停止上する３、検体管回転用レ
バー２１１がピン２１２を軸として約９０°の適当角度
？″′数回１１復回転運動ｔ）、第５図に示したごどく
この作用にすって検体管２０５が９０°強鉛直面内で数
回回転転倒さけられ、検体託・内の血液検体が混和・均
一化される。その後、適当時間、検体管回転用レバー２
１１は第５図実線Ｃ・示した位置７−停庄Ｊる。Next, we will combine the automatic hematology analyzer with the sample injection unit as described above and the automatic white liquid sample sampling (hereinafter abbreviated as sampler) described earlier to realize the operational functions for realizing the purpose of the present invention. explain. First, the automatic hematology sedimentation meter and the sampler are electrically connected, and the injection needle of the automatic hematology sedimentation meter sample injection section and the sampling needle of the sampler are connected by the chicobe 215. This state is shown in FIG. Then, set sample tubes in the sampler, set at least as many empty blood sedimentation tubes as the number of sample tubes in the automatic sedimentation meter, and turn on the power. As the optical detection system 150 begins to rotate, the blood sedimentation tube mount 102 rotates and stops when the blood sedimentation tube into which the sample is first injected reaches the position of the sample injection part. At this time, the infusion component block 305 is in the retracted position, the injection lever 308 is in the lowered position, and the injection needle 307 is facing downward and toward the train receiver 312. On the other hand, the sample tube mounting plate 201 of the sampler also rotates, and when the sample tube to be collected first reaches the position opposite the collection needle 209, it stops and lifts up. The sample tube 205 is rotated several times in the vertical plane at an angle of 90 degrees to avoid overturning, as shown in Figure 5. The blood sample is mixed and homogenized.After that, the sample tube rotation lever 2 is pressed for an appropriate period of time.
11 is located at the position 7 shown by the solid line C in FIG.
このとぎ勿論検体管も第５図実線で・′示しＩ、＝横転
やへ士向七＼の状態とイＴる。次に１λ；数多１等保持
ｉ−！ ２（１７が前進し、ｊス気１（−２０８おＪ、
び採取針２０９が検体管ゴムキＡ７ツゾ２１０を貫通Ｊ
る３、送気ポンプ２１３が動作し、送気釦 ２０８を通
って空気が検体管中に送られ、血液検体２１４は、採取
ｉ１２０９、接続ヂコーーグ２１５、自動血沈計の注入
１１を通ってドレイン受皿３１２へと流れ、血液検体の
流路が共洗いされる。At this point, of course, the specimen tube is also shown by the solid line in Figure 5. Next, 1λ; holds the first rank in number i-! 2 (17 moves forward, j su ki 1 (-208 o J,
The sampling needle 209 penetrates the specimen tube rubber cap A7 210 J
3, the air supply pump 213 operates, air is sent into the sample tube through the air supply button 208, and the blood sample 214 is passed through the collection i 1209, the connection dicoug 215, and the injection 11 of the automatic hematology analyzer into the drain tray. 312, and the blood sample flow path is washed together.
適当に共洗いされた後、送気ポンプ２１３が−［１（学
才する。After being properly co-washed, the air pump 213 becomes -[1 (school age).
次に自勅面）宛ｔ１側の３１人♀１３０７が鉛面面内で
１８０°回転し、注入１（は」一方を向く。注入品構成
ブロック３０５が醋’）イＬｌｙ Ｔクランプ３０６が
血沈管取付台−３０１を保持する。ついで注入レバー３
０８が上昇し、注入針３０７はゴムキャップ３０２を貫
入する（第７．８図）。サンプラー側の送気ポンプ２１
３が再び作動し、検体管中の血液検体が、前記と同じ経
過を通って血沈管１０５に送られる。血液検体の血沈管
への注入量は、血液注入レベル検出器３０９によって監
視されており、血液レベルが徐々に上冒し、所定停止レ
ベルへの到達を血液注入レベル検出器３０９によって検
出し、送気ポンプ２１３を停止させ、血液検体の注入を
停止する。血液注入レベル検出器としては一対の光源と
光検出器とを、血沈管を挾んで配置するようにし、血沈
管内血液の上昇によって、光源から光検出器への照射光
の遮断を検出するのが便利である。血沈管に血液検体が
注入されたことは、光学検知系１５０の回転・通過によ
って検知され、該血沈管の位置番号が記憶されるととも
に、該血沈管について計時が開始される。さらに第１０
図のように検体管２０５に、例えば太線と細線との組合
せから構成される縞模様配列のＩＤ（検体弁別）チュー
ブ２３４１３−
をつＩＪるどともに、検体管［１１転用レバー２１１の
適当イｆ位置に例えばバーコートリーダーなど光学的読
取り駁間の検出端２３０をｈ）目Ｊ、この１ツバ−２１
１の約１７７４回転による検体管の引越しの際にＩＯチ
ｊ−ブ２３４の縞模様配列を検出端２３５がなぞること
により、検体番号を識別、記憶させ、これど自動血沈計
の血沈管位防番号とを組合ローＣ記憶させることにより
、検体の取り違えを防ぐことが口Ｆ能となる。どくに最
近は病院にお１．する診掠のシステムがオンライン化さ
れ、臨床検査のデータ！プオンライン化されるＩノ向（
” ｉｊＬんでおり、）−記のＪ、うな方法をとること
により、このような２１１に対応することができる。Next, the 31 person ♀ 1307 on the t1 side addressed to the t1 side rotates 180 degrees in the vertical plane, and the injected product component block 305 faces one side. Holds the pipe mount-301. Next, injection lever 3
08 is raised and the injection needle 307 penetrates the rubber cap 302 (Fig. 7.8). Air pump 21 on the sampler side
3 is activated again, and the blood sample in the sample tube is sent to the blood sedimentation tube 105 through the same process as described above. The amount of blood sample injected into the blood sedimentation tube is monitored by a blood injection level detector 309, and when the blood level gradually rises to a predetermined stop level, the blood injection level detector 309 detects that the blood level gradually rises and reaches a predetermined stop level. The pump 213 is stopped and the injection of the blood sample is stopped. As a blood injection level detector, a pair of light source and a photodetector are arranged to sandwich a blood sedimentation tube, and the blockage of the irradiated light from the light source to the photodetector is detected by the rise of blood in the blood sedimentation tube. It's convenient. Injection of the blood sample into the blood sedimentation tube is detected by rotation and passage of the optical detection system 150, the position number of the blood sedimentation tube is stored, and time measurement is started for the blood sedimentation tube. Furthermore, the 10th
As shown in the figure, attach an ID (sample discrimination) tube 23413- in a striped pattern, for example, consisting of a combination of thick lines and thin lines, to the sample tube 205, as well as attach it to the sample tube [11 Place the detection end 230 between the optical reading device, such as a bar coat reader, at the
The detection end 235 traces the striped pattern arrangement of the IO tube 234 when the sample tube is moved by about 1774 rotations of 1, identifying and storing the sample number, which is used to prevent the blood sedimentation tube position of the automatic hemodiameter. By memorizing the numbers and numbers, it is possible to prevent sample mix-ups. Dokuni recently went to the hospital. The medical examination system has been made online and clinical test data has been uploaded! I-direction that will be online (
211 can be handled by taking the method shown in J.
さて、１本の血沈管への血液検体の注入が終ｒすると、
自動血沈８１側では注入レバー３０８が下降して注入針
３０７が血沈管ホルタ−３０１から抜ける。Now, once the blood sample has been injected into one blood sedimentation tube,
On the automatic blood sedimentation tube 81 side, the injection lever 308 is lowered and the injection needle 307 is removed from the blood sedimentation tube holter 301.
次に注入品構成ブロック３０５が後退し、注入レバー３
０８が１８０°回転して注射側が下向きとなり、トレイ
ン受け■３１２の方面へ向く。一方、勺ンプラー側は、
採取釘等保持Ｒ２０７が１ｖｃ退し、採取劃−１４＝
等２０８．２０９が検体管２０５のゴムキャップから抜
は出る。Next, the infusion component block 305 is retracted, and the infusion lever 3
08 is rotated 180 degrees so that the injection side faces downward and faces toward the train receiver ■312. On the other hand, the Tsunepura side,
The sampling nail etc. holding R207 retreats by 1vc, and the sampling nail etc. 208, 209 is removed from the rubber cap of the specimen tube 205.
以上で先ず最初のサンプリングの一工程が完了する。再
び、自動血沈計の血沈管取付台１０２とサンプラーの検
体管取付板２０１が回転し、それぞれ新しい血沈管と検
体管について既）ホと同様の動作が行なわれ、次々とく
り返してゆく。その間光学検知系１５０は回転し、新し
く血液検体が注入された血沈管の位置番号の記憶と計時
を行なう。ただし、血液検体注入中の血沈管付近にまで
光学検知系１５０が回転して近づいた時は、これを認識
して自動的に停止させ、注入終了、注入構成ブロック３
０５が後退したのち、光学検知系１５０が再び回転をは
じめる」；うに構成することはいうまで′心ない。The first step of sampling is thus completed. The blood sedimentation tube mounting base 102 of the automatic blood sedimentation meter and the sample tube mounting plate 201 of the sampler are rotated again, and the same operations as in (e) are performed for new blood sedimentation tubes and sample tubes, respectively, and are repeated one after another. During this time, the optical detection system 150 rotates to memorize the position number of the blood sedimentation tube into which the blood sample has been newly injected and to measure time. However, when the optical detection system 150 rotates and approaches the vicinity of the blood sedimentation tube where the blood sample is being injected, it recognizes this and automatically stops the injection, and the injection configuration block 3
05 retreats, the optical detection system 150 starts rotating again.'' Needless to say, it is unconscionable to configure the optical detection system 150 in this manner.
而してそれぞれの血沈管について、３０分、１時間、必
要あれば２時間経過するごとに血沈値を、位置番号とと
もに、さらに前述の検体ＴＤ機能をもたせた場合は検体
番号もともに、自動的にプリントアウトする。For each blood sedimentation tube, the blood sedimentation value is automatically displayed every 30 minutes, 1 hour, or 2 hours if necessary, together with the position number, and if the above-mentioned sample TD function is provided, the sample number is also automatically displayed. print out.
なお上記の実施例では、血沈管下端に装着したゴムキャ
ップ３０２の下端面から注入ｉ１３０７を輿入させ、血
液検体を注入する方式であったが、側面から注入する方
式もある。この場合の例を第１１図、第１２図に示す。In the above embodiment, the injection i1307 is introduced from the lower end surface of the rubber cap 302 attached to the lower end of the blood sedimentation tube, and the blood sample is injected, but there is also a method in which the blood sample is injected from the side. Examples of this case are shown in FIGS. 11 and 12.
注入時ど共洗い時の場合の注入Ｈの回転が水平面内で９
０°回転覆るほかは、動作は第７図、第８図の場合どほ
ぼ同じであるので、あらためて詳細に説明Ｊるまでもイ
τいど思わ４′する１、なお上記の例においては、採取
Ｈから注入層に至る経路中に残存する前の血液検体の排
出は、次に採取すべき検体による共洗いのみによって行
なう方法であったが、これは例えば第１３図に示した」
、うに検体採取部構成ブ［］ツク ２０６が回転するよ
うに（第１３図では９０°回転）構成し、そのえ１向方
向に空の検体管２１６を配昭し、送気１１、採取１１を
これに川入せしめて−Ｈ送気ポンプを作動さ氾、送気に
よって採取針から注入１１に至る経路中の旧検体を追い
出したのち、次の採取すべき検体の採取作動を行なわせ
、共洗いを開始するようにしてもよい。The rotation of injection H in the case of co-washing during injection is 9 in the horizontal plane.
Other than the 0° rotation, the operation is almost the same in Figures 7 and 8, so it would be difficult to explain in detail again.In the above example, The blood sample remaining in the path from collection H to the injection layer was discharged only by co-washing with the sample to be collected next, as shown in Figure 13, for example.
, the sea urchin sample collection unit configuration block 206 is configured to rotate (rotated by 90 degrees in FIG. 13), and the empty sample tube 216 is distributed in one direction, and the air supply 11 and the collection 11 are rotated. The -H air supply pump is activated, and the old specimen in the path from the collection needle to the injection 11 is expelled by air, and then the next specimen to be collected is collected. Co-washing may be started.
あるいは検体容器数イ１板２０１の特定位置に空の検体
容器を取り付け、一つの検体の採取終了ごとにこの空の
検体容器が検体様取部構成ブロック２０６の対向位置に
まで回転してきて、この空容器を利用して旧検体を追い
出すように構成してもよい。Alternatively, an empty sample container is attached to a specific position on the sample container plate 201, and each time one sample is collected, the empty sample container is rotated to a position opposite to the sample collection block 206. It may also be configured to use an empty container to remove old samples.
以上の説明においては採取針と送気側に２本の注射針を
用いる例で説明したが、同軸二重構造の注射針を用いて
もよい。また検体採取時の検体管の向きは、横転や）下
向きに限られるものではなく、完全倒立でもにい。In the above explanation, an example is given in which two injection needles are used for the collection needle and the air supply side, but a coaxial double-structured injection needle may also be used. Also, the orientation of the specimen tube when collecting the specimen is not limited to upside down or facing down, but can also be completely upside down.
以上詳述したように本発明によれば、
■血沈管への採取を全く自動的に行なうことができるの
で、感染のおそれが全くなく、従来法にくらべ安全性が
格段に向上する。As described in detail above, according to the present invention, (1) Collection into blood sedimentation tubes can be performed completely automatically, so there is no risk of infection, and safety is significantly improved compared to conventional methods.
■人による動作は、検体管と血沈管の取付けと、スイッ
チ作動のみでよく、著しく省力化に役立つ。■The only human operations required are attaching the sample tube and blood sedimentation tube and operating the switch, which greatly reduces labor.
■検体ＴＤが容易に実現でき、検体の取り違えをなくす
ことも可能となるので、診断の信頼性を高めると共に、
今後の病院のオンライン１７−
化にも容易に対応でさるＪ、うになる。■Sample TD can be easily achieved and it is possible to eliminate sample mix-ups, increasing the reliability of diagnosis and
It will be easy to adapt to the future of online hospitals.
など大きなメリッ］〜が期待でき、実用に供しｒその効
果甚だ大である。We can expect great benefits such as... and the effects will be enormous when put into practical use.
第１図及び第２図は従来の自動血沈削の外観図及び正面
図、第３図は位置番号読みとり方法の例示図、第４図及
び第５図は本発明の実施例を承り自動サンプリング部の
例示図及びその部分拡大図、第６図は本発明の実施例を
示づ試ｒ目＋入部の例示図、第７図及び第８図は同上の
左上及び右下の各部分拡大図、第９図は同、ｌこの自動
面沈泪と血液検体自動サンプリング装置の組合せを示す
本発明の例示図、第１０図は本発明に使用される検体色
・の例示図、第１１図、第１２図及び第１３図は本発明
の更に他の実施例を示す例示図である。
１０２ 血沈管取付板
１０５ 面 沈 管
３０１ 血沈管ホルダー
３０２ ゴムキレツブ
３０３ 受 け 台
１８−
３０４ スプリング
３０５Ａ 面液送り管
３０５Ｂ ビス］・ン
３０６ クランーノ
３０７ ｆｆ 人 ！ｌ
３１０ レベル検出器１１メ付（１
３１２ド１ツイン條・（〕曲
１９−
第１図Figures 1 and 2 are an external view and a front view of a conventional automatic blood grinder, Figure 3 is an illustration of a position number reading method, and Figures 4 and 5 are an automatic sampling unit according to an embodiment of the present invention. Fig. 6 is an illustrative drawing showing an embodiment of the present invention, and Fig. 6 is an illustrative drawing of the trial rth + entry part, Fig. 7 and Fig. 8 are partially enlarged views of the upper left and lower right parts of the same. Figure 9 is an exemplary diagram of the present invention showing a combination of this automatic surface sedimentation and blood sample automatic sampling device, Figure 10 is an exemplary diagram of sample color used in the present invention, Figure 11, FIGS. 12 and 13 are illustrations showing still other embodiments of the present invention. 102 Sedimentation tube mounting plate 105 side Sedimentation tube 301 Sedimentation tube holder 302 Rubber socket 303 Receiver 18- 304 Spring 305A Surface liquid feed tube 305B Bis]・N 306 Cranno 307 ff Person! l 310 with 11 level detectors (1 312 do 1 twin condition) (Track 19- Fig. 1
Claims (1)
容器と血液検体の血沈を測定する多数の血沈管の取付部
、血液を採取゛リベぎ血液検体容器からの血液検体採取
部と血液検体採取部から血沈管へ血液検体を供給する血
液検体注入部を有し、当該血液検体採取部と血液検体注
入部とが導管で接続されており、血沈管と検体容器とを
血液検体採取時に１：１に対応させ血液検体を血液検体
容器から採取するに先立ち、検体容器を回転転倒させ、
次いで検体容器中の血液検体を血沈管の所定レベルにま
で順次自動的に注入することを特徴とする自動血沈針。 ２、密閉しうる構造の検体容器が釦の貫入可能なゴムキ
ャップを備えてこの密閉容器内に送気することにより検
体が採取されることを特徴とする特訂晶求の範囲第１項
記載の自動血沈針。 ３、白液検体容器取付部に空の容器を組込むか又は別個
に空の容器を設け、検体採取に先立ち該空容器を介して
、検体採取部から注入部に至る経過内の前回採取残存検
体を排出することを特徴とする特許請求の範囲第１項な
いし第２項記載の自動血沈針。 ４．１組の光源と光検知器どを有し、血沈管への検体注
入時に血沈管が光源と光検知器との間に介在するように
構成し、検体の注入レベルを光源からの光検知器への入
射光の遮断により所定レベルにまで注入されたことと検
出することを特徴とする特許請求の範囲第１項ないし第
３項記載の自動血沈針。 ５、検体管を転倒回転させる機構に検体識別器を取付け
たことを特徴とする特許請求の範囲第１項ないし第４項
記載の自動血沈針。[Scope of Claims] 1. Mounting parts for a large number of sealed blood sample containers containing blood samples and a large number of blood sedimentation tubes for measuring blood sedimentation of the blood samples, and for collecting blood from the blood sample containers. It has a blood sample collection section and a blood sample injection section that supplies the blood sample from the blood sample collection section to the blood sedimentation tube. Before collecting the blood sample from the blood sample container, the sample container is rotated and overturned.
An automatic blood sedimentation needle is characterized in that the blood specimen in the specimen container is then automatically injected sequentially into a blood sedimentation tube up to a predetermined level. 2. The scope of the special request described in item 1, characterized in that the specimen container has a sealable structure and is equipped with a rubber cap that can be penetrated by a button, and the specimen is collected by blowing air into the sealed container. automatic blood sedimentation needle. 3. Insert an empty container into the white liquid sample container attachment part or provide a separate empty container, and prior to specimen collection, use the empty container to collect the previously collected remaining specimen from the specimen collection part to the injection part. An automatic blood sedimentation needle according to any one of claims 1 to 2, characterized in that the needle discharges blood. 4. It has one set of a light source and a photodetector, etc., and is configured so that the blood sedimentation tube is interposed between the light source and the photodetector when the sample is injected into the blood sedimentation tube, and the injection level of the sample is controlled by the light from the light source. 4. The automatic blood sedimentation needle according to claim 1, wherein injection to a predetermined level is detected by blocking incident light to the detector. 5. The automatic blood sedimentation needle according to any one of claims 1 to 4, characterized in that a specimen identifier is attached to the mechanism for inverting and rotating the specimen tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13613383A JPS6027859A (en) | 1983-07-26 | 1983-07-26 | Automatic erythrocyte sedimentation rate meter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13613383A JPS6027859A (en) | 1983-07-26 | 1983-07-26 | Automatic erythrocyte sedimentation rate meter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6027859A true JPS6027859A (en) | 1985-02-12 |
Family
ID=15168074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13613383A Pending JPS6027859A (en) | 1983-07-26 | 1983-07-26 | Automatic erythrocyte sedimentation rate meter |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6027859A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5311588U (en) * | 1976-07-13 | 1978-01-31 | ||
| JPS57107142A (en) * | 1980-12-24 | 1982-07-03 | Shigeo Suzuki | Instrument for injecting blood into pipette for blood sinking rate measurement |
-
1983
- 1983-07-26 JP JP13613383A patent/JPS6027859A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5311588U (en) * | 1976-07-13 | 1978-01-31 | ||
| JPS57107142A (en) * | 1980-12-24 | 1982-07-03 | Shigeo Suzuki | Instrument for injecting blood into pipette for blood sinking rate measurement |
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