JPS60178362A - Ph measuring ink composition and tester formed by using the same - Google Patents
Ph measuring ink composition and tester formed by using the sameInfo
- Publication number
- JPS60178362A JPS60178362A JP3378684A JP3378684A JPS60178362A JP S60178362 A JPS60178362 A JP S60178362A JP 3378684 A JP3378684 A JP 3378684A JP 3378684 A JP3378684 A JP 3378684A JP S60178362 A JPS60178362 A JP S60178362A
- Authority
- JP
- Japan
- Prior art keywords
- water
- ink composition
- polymer compound
- measurement
- indicator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
Abstract
Description
【発明の詳細な説明】
発明の技術分野
本発明は、溶液とくに尿、血液、リンパ液などの体液の
ｐＨを測定するだめの検査体を形成するのに適したイン
キ組成物ならびにそれを用いて形成された検査体に関す
る。DETAILED DESCRIPTION OF THE INVENTION Technical Field of the Invention The present invention relates to an ink composition suitable for forming a test body for measuring the pH of a solution, particularly a body fluid such as urine, blood, lymph, etc. Regarding the tested specimen.
発明の技術的背鼠ならびにその問題点
溶液のｐｎを迅速簡単かつ正確に知ることは、多くの化
学環境のもとでめられている。また溶液とくに尿などの
体液のｐＨを知ることは、体液中に蛋白質が存在するか
否かを正確に知ることの手助けとなるほか、腎孟炎、膀
胱炎などを引ぺ起こす細菌銀の可能性を確認することの
手助けとなる。Technical background of the invention and its problems It is difficult to quickly, easily and accurately know the pn of a solution in many chemical environments. In addition, knowing the pH of solutions, especially body fluids such as urine, helps to accurately determine the presence or absence of proteins in body fluids, as well as the possibility of bacterial silver that can cause nephritis, cystitis, etc. This helps in confirming the gender.
従来溶液のｐＩ（は、複数のｐＨ指示薬を含む水溶液を
ろ紙などの吸水性支持体に含浸して製造されたｐＨ試験
紙が広く用いられてきた。たとえば特公昭３ｇ７．２１
１２００号公報には、ｐＨ指示薬組成物を含む溶液に吸
収性相持体を含浸してなるｐＨ試験片が提案されている
。ところがこの試験片は、製造工程が多く工程管理上不
利で製造コストも高くなっていた。そこで製造工程が簡
素化でき大量生産に適したｐＨ試験片も提案されている
。Conventionally, pH test paper manufactured by impregnating a water-absorbing support such as filter paper with an aqueous solution containing multiple pH indicators has been widely used. For example, the pI of a solution has been widely used.
Japanese Patent No. 1200 proposes a pH test piece in which an absorbent carrier is impregnated in a solution containing a pH indicator composition. However, this test piece required many manufacturing steps, which was disadvantageous in terms of process control and resulted in high manufacturing costs. Therefore, pH test pieces that can simplify the manufacturing process and are suitable for mass production have also been proposed.
たとえば、特公昭’ｌｌｌ−，２３９！；ｊ号公報には
、複数のｐＨ指示薬と吸着性粉末を支持体上に貼着して
なるｐＨ試験片が提案されており、また実開昭！”）−
７７７６７号公報には、ｐＨ指示薬を含むｐＨ測定用イ
ンキ組成物を支持体上に印刷して設けたｐＨ測定領域を
有するｐＨ試験片も提案されている。しかしながら、こ
のようなｐＨ試試片片は、以下のような問題点があった
。For example, Tokko Sho'lll-, 239! ; Publication No. J proposes a pH test piece consisting of a plurality of pH indicators and adsorbent powder adhered to a support, and also published by Jitsukasho! ”)−
No. 77767 also proposes a pH test piece having a pH measurement area formed by printing a pH measurement ink composition containing a pH indicator on a support. However, such pH test pieces have the following problems.
（ａ） 試験片を被検液に浸漬した後、これを乾燥する
と一旺発色された色の退色現象が顕著に認められる。(a) When a test piece is immersed in a test liquid and then dried, a noticeable fading phenomenon of the developed color is observed.
（ｂ） 試験片を被検液に浸漬した際に、指示薬が被検
液中に溶出することがあり、鮮明な呈色が得にくくなる
ことがある。(b) When the test piece is immersed in the test liquid, the indicator may be eluted into the test liquid, making it difficult to obtain clear coloration.
（ｅ） 試験片を被検液に浸漬した際に、呈色に時間が
かかる。(e) It takes time for the test piece to develop color when it is immersed in the test liquid.
本発明者らは、上記問題点を解決するため研究測定用イ
ンキ組成物を用いて、これを支持体上に塗布することに
よ−て、−挙に上記問題点が解決されることを見出した
。In order to solve the above-mentioned problems, the present inventors have found that the above-mentioned problems can be solved by using an ink composition for research measurement and coating it on a support. Ta.
発明の目的ならびにその概要
本発明は従来技術に伴なう欠点を解決しようとするもの
であって、以下のような目的を有している。OBJECTS OF THE INVENTION AND SUMMARY OF THE INVENTION The present invention attempts to solve the drawbacks associated with the prior art and has the following objects.
（８）優れた感度および指示性能を有するｐＨ検査体な
らびにそのためのインキ組成物を提供すること。(8) To provide a pH tester having excellent sensitivity and indicating performance and an ink composition therefor.
（ｂ） −旺得られた色の乾燥後における退色があまり
認められないｐＩ（検査体ならびにそのためのインキ組
成物を提供すること。(b) - To provide a pI (test specimen and an ink composition therefor) in which the obtained color shows little fading after drying.
本発明に係るｐＨ測定用インキ組成物は、ｐＨ指示薬、
り級アンモニウム塩またはアミン塩、結合剤および吸水
性粉末からなる試薬組成物が、溶媒好ましくは非水溶媒
中に溶解あるい（ま分散されて形成されている。また本
発明に係るｐＨ検査体は、上記組成のｐＨ測定用インキ
組成物を支持体上に塗布してなるｐＨ測定領域を有して
いる。The ink composition for pH measurement according to the present invention includes a pH indicator,
A reagent composition comprising a grade ammonium salt or amine salt, a binder, and a water-absorbing powder is dissolved or dispersed in a solvent, preferably a non-aqueous solvent. has a pH measurement area formed by coating a support with a pH measurement ink composition having the above composition.
３、発明の詳細な説明
以下に、まず、本発明に係るｐ）（検査体を形成するに
際して用いられるｐＨ測定用インキ組成物について具体
的に説明する。3. Detailed Description of the Invention Below, first, the ink composition for pH measurement used in forming the test object (p) according to the present invention will be specifically described.
イ）原理
ｐＨによって色調の変わる指示薬を好ましくは複数種組
合わせて、被検液のｐＨを指示薬の色調を判別すること
によって測定する。b) Principle Preferably, a plurality of types of indicators whose color tone changes depending on the pH are combined, and the pH of the test liquid is measured by determining the color tone of the indicators.
口） ｐＨ指示薬
被検液の水素イオン濃度に応じて色調の変化する指示薬
であればどのような指示薬も使用できる。pH indicator: Any indicator can be used as long as it changes color depending on the hydrogen ion concentration of the test solution.
また複数種の指示薬を適当に選択または組合せることに
よって、広い範囲のｐＨ領域を測定することもできる。Furthermore, by appropriately selecting or combining a plurality of types of indicators, it is also possible to measure a wide pH range.
たとえば、ｐＨ指示薬としてメチルフッドとブロモチモ
ールブルーとを組合わせて用いれば、ＰＨ’〜りの範囲
で良好なｐＨの判定が可能である。For example, if a combination of methyl hood and bromothymol blue is used as a pH indicator, it is possible to accurately determine the pH in the range of PH' to -2.
ｐＨ指示薬は、インキ組成物の固形分に対してｏ、ｏｉ
〜ｏ、ｒ重量％の量で存在することが好ましい。The pH indicator is o, oi with respect to the solid content of the ink composition.
Preferably present in an amount of ~o,r% by weight.
ノー）≠級アンモニウム塩またはアミン塩試薬組成物中
にψ級アンモニウム塩を適量配合することによって、−
旺発色された色の経時的な退色現象が大きく抑制され、
かつ鮮明な色が得られる。No) By blending an appropriate amount of ψ class ammonium salt into the ≠ class ammonium salt or amine salt reagent composition, -
The fading phenomenon of brightly developed colors over time is greatly suppressed,
And vivid colors can be obtained.
弘級アンモニウム塩としては、アルキルトリメチルアン
モニウム塩、アルキルジメチルベンジルアンモニウム塩
、サパミン型アンモニウム塩などが用いられる。これら
のうち、アルキルジメチルベンジルアンモニウムＪｊＸ
ｂ″−特に好ましい。As the high grade ammonium salt, alkyltrimethylammonium salt, alkyldimethylbenzylammonium salt, sapamin type ammonium salt, etc. are used. Among these, alkyldimethylbenzylammonium JjX
b″-particularly preferred.
なお≠級アンモニウム塩の代わりに、陽イオン型界面活
性剤として知られている第１級アミン塩、第２級アミン
塩および第３級アミン塩あるいはポリエチソングリコー
ルも使用できる。Note that instead of the ≠-grade ammonium salt, primary amine salts, secondary amine salts, and tertiary amine salts or polyethison glycol, which are known as cationic surfactants, can also be used.
これらの≠級アンモニウム塩またはアミン塩は、インキ
組成物の固形分に対して０．Ｏｒ −／重Ｍｋ％の量で
存在することが好ましい。These ≠ grade ammonium salts or amine salts have a content of 0.0% based on the solid content of the ink composition. Preferably it is present in an amount of % Or − /weight Mk.
二）結合剤
結合剤は、上記試薬類および吸水性粉末を、支持体上に
形成可能とするために用いられ、被検液中の成分および
ｐＨなどに影響を及ぼさず、しかも試薬類の溶出を防止
しかつ呈色反応を妨げないものであることが要求される
。2) Binder The binder is used to enable the above-mentioned reagents and water-absorbing powder to be formed on the support, and does not affect the components and pH of the test solution, and also does not affect the elution of the reagents. It is required that the color reaction is prevented and the color reaction is not hindered.
′このような要件を満たすｐＨ測定用インキ組成物に適
した結合剤は、ｐＨ指示薬の発色を全く妨げずしかも発
色して得られた色を安定化するという顕色効果を有する
水溶性高分子化合物と、ｐＨ指示薬の発色を妨げずしか
も試薬類の被検液中への溶出を防止するという効果を有
する皮膜形成能を有する水不溶性高分子化合物とが相合
わされて形成されていることが好ましい。'Binders suitable for pH measurement ink compositions that meet these requirements are water-soluble polymers that have a color-developing effect that does not interfere with the color development of the pH indicator at all, but also stabilizes the resulting color. It is preferable that the compound is formed by combining a water-insoluble polymer compound with a film-forming ability that does not hinder the color development of the pH indicator and also has the effect of preventing the elution of reagents into the test liquid. .
上記の水溶性高分子化合物としては、（１）かんしょデ
ンプン、ばれいしょデンプン、こんにゃく粉、フノリ、
寒天、アルギン酸ナトリウム、トロロアオイ、トンガロ
ゴム、アラビアゴム、デキストラン、Ｖパン、ニカワ、
ゼラチン、カゼイン、コラーゲンなどの天然親水性高分
子化合物、（ＩＩ）メチルセルロース、ヒドロキシプロ
ピルセルロース、ヒドロキシエチルセルロース、カルボ
キシメチルセルロースなどのセルロース誘導体、カルボ
キシメチルデンプン、ジアルデヒドデンプン誘導体など
の半合成親水性高分子化合物および（ｔｉＤポリビニル
アルコール、ポリアクリルアミド、ポリビニルピロリド
ンまたはこれらの共重合体、ポリアクリル酸ナトリウム
、ポリエチレンオキシドなどの合成高分子化合物などが
挙げられる。これらの化合物のうち、’ｌ’ｆにヒドロ
キエチルセルロースなどのセルロース誘導体およびポリ
ビニルピロリドンなどの合成高分子化合物が好藍しい。The above-mentioned water-soluble polymer compounds include (1) Kansho starch, potato starch, konnyaku powder, funori,
Agar, sodium alginate, molasses, tongarogum, gum arabic, dextran, V-pan, glue,
Natural hydrophilic polymer compounds such as gelatin, casein, and collagen; (II) Cellulose derivatives such as methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, and carboxymethyl cellulose; semisynthetic hydrophilic polymer compounds such as carboxymethyl starch and dialdehyde starch derivatives; and (tiD) synthetic polymer compounds such as polyvinyl alcohol, polyacrylamide, polyvinylpyrrolidone or their copolymers, sodium polyacrylate, and polyethylene oxide. Synthetic polymer compounds such as cellulose derivatives and polyvinylpyrrolidone are preferred.
一方上記の皮ｊ１り形成を有する水不溶性高分子化合物
トしてＨ（＋）ニトロセルロース、酢酸セルロース、エ
チルセルロース、酢酪酸セルロースなどのセルロース４
ｆｆ４ ＪｊＷ 、 （１） ホりエステル４ｆｉＪ］
Ｌアルキド樹脂、ポリウレタン樹脂、エポキシＩｉｌ脂
、アクリル樹脂、塩化ビニル樹脂、塩化ビニル共重合体
樹脂、ポリビニルブチラール、ポリ酢酸ビニルエマルジ
ョン、酢酸ビニルコポリマー（６’ｌビニル−アクリル
酸エステルなど）エマルジョン、アクリル酸エステル共
重合体エマルジョン、塩化ピニリ。On the other hand, the above-mentioned water-insoluble polymer compounds having a skin-forming structure are used, and celluloses such as H(+) nitrocellulose, cellulose acetate, ethyl cellulose, and cellulose acetate butyrate are used.
ff4 JjW, (1) Horiester 4fiJ]
L-alkyd resin, polyurethane resin, epoxy Iil resin, acrylic resin, vinyl chloride resin, vinyl chloride copolymer resin, polyvinyl butyral, polyvinyl acetate emulsion, vinyl acetate copolymer (6'l vinyl-acrylic acid ester, etc.) emulsion, acrylic Acid ester copolymer emulsion, pinylic chloride.
デン共重合体エマルジョン、エポキシ（ＩＩＪ 脂エマ
ルジョン、合成ゴムラテックスなどが挙げられる。Examples include den copolymer emulsion, epoxy (IIJ) fat emulsion, and synthetic rubber latex.
このうち、ウレタン樹脂およびポリビニルブチラール、
ｐＨ指示薬の呈色反応に悪影響を及はさないため好まし
い。Among these, urethane resin and polyvinyl butyral,
This is preferable because it does not adversely affect the color reaction of the pH indicator.
結合剤は、インキ組成物の固形分に対して認〜１ｔｒ４
合係の景で存在することが好４しい。The binder has an amount of approximately 1tr4 based on the solid content of the ink composition.
It is preferable to exist in a joint relationship.
ホ）吸水性粉末は、試薬組成物中に配合さ７１．ること
によって、被検液とｐＨ指示薬との接触を促進し、該指
示薬の呈色反応を促進する働きを自する。e) The water-absorbing powder is blended into the reagent composition71. By doing so, it acts to promote contact between the test liquid and the pH indicator and to promote the color reaction of the indicator.
このような吸水性粉末とし一〇は、水と以１’ｔ！Ｉ！
した場合に、極端な酸性あるいはアルカリ性を示すも
のは好ましくなく、しかも白色度の高いものが好ましい
。具体的には、カオリン、合成シリカ、ガラス、セルロ
ースブロック、微結晶セルロース、イオン交換セルロー
ス、イオン交換樹脂、炭酸カルシウム、炭酸マグネシウ
ム、ケイ酸アルミニウムなどが用いられうる。If you use such water-absorbing powder, 10 is water and 1't! I!
In this case, those exhibiting extreme acidity or alkalinity are not preferred, and those exhibiting high whiteness are preferred. Specifically, kaolin, synthetic silica, glass, cellulose block, microcrystalline cellulose, ion exchange cellulose, ion exchange resin, calcium carbonate, magnesium carbonate, aluminum silicate, etc. can be used.
吸水性粉末は、インキ組成物の固形分に対してｊｏ −
ｖｏ Ｍ 量％の縫で存在することが好まし−。The water-absorbing powder has a ratio of jo − to the solid content of the ink composition.
It is preferable that the thread is present in the amount of vo M%.
へ）溶媒
溶媒は、上記試薬類特に結合剤を均一かつ安定に溶解あ
るいは分散させうるものが好°まし込。このシマ件を満
たず溶媒としては、芳香族炭化水素、脂肪族炭化水素、
エステル類、アルコール類などの非水溶媒または水ある
いけと７’Ｌらの混合物が用いられる。f) Solvent The solvent is preferably one that can uniformly and stably dissolve or disperse the above reagents, especially the binder. Solvents that do not meet this requirement include aromatic hydrocarbons, aliphatic hydrocarbons,
Nonaqueous solvents such as esters and alcohols, or mixtures of water and other solvents are used.
しかしながら、ｐＨ測定用インキ組成物を支持体上に塗
布した１＆の乾燥工程を低温でしかも短時間で行なうと
いう点で非水溶媒な用することが好ましい。非水溶媒を
用いた」ん合には、残留水分に起因する試薬組成物の液
質劣化を防止できるという効果もある。However, it is preferable to use a non-aqueous solvent because the drying process of 1& in which the ink composition for pH measurement is applied onto a support can be carried out at a low temperature and in a short time. When a non-aqueous solvent is used, there is also the effect that deterioration of the liquid quality of the reagent composition due to residual moisture can be prevented.
ト）その他の成分
場合によっては、上記各成分のほかに、少量の湿潤剤た
とえは非イオン界面活性剤、隘イオン界面活性剤、陽イ
オン界面活性剤、両性イオン界面活性剤ポリエチレング
リコール類などを、ｐＨ測定用試薬組成物中に配合する
こともできる。この湿潤剤は、各試薬の分散Ｗ役立ち、
均一な試薬層の形成を促進し、水ぬれ性を向上させるこ
とができる。湿潤剤は試薬組成物の固形分に対して、Ｑ
、コ〜ｊ重Ｒチの量で存在することが好ましい。g) Other ingredients In some cases, in addition to the above ingredients, small amounts of wetting agents such as nonionic surfactants, ionic surfactants, cationic surfactants, zwitterionic surfactants, polyethylene glycols, etc. may be added. , it can also be blended into a reagent composition for pH measurement. This wetting agent helps disperse each reagent,
It can promote the formation of a uniform reagent layer and improve water wettability. The wetting agent is Q based on the solid content of the reagent composition.
, is preferably present in an amount of from 0 to 0.
１だ指示薬の呈色色調をさらに見やすくするために、た
とえばオイルイエローなどの背景色素を添加してもよ−
。To make the color tone of the indicator more visible, a background dye such as oil yellow may be added.
.
上記のようなｐＨ測定用インキ組成物は、支持体上に塗
布されてｐＨ１１１定領域が形成され、本発明に係る検
査体が得られる。塗布技術としては、印刷法、コーティ
ング法（たとえはロールコーティング、スプレーコーテ
ィング、ベタコーティング）などが用いられうる。本発
すＪにおいては、インキ組成物の塗布泣が比較的多くか
つ塗布址が一定であることが好ましいため、シルクスク
リーン印刷法、凹版印刷法、グラビア印刷法などによっ
て、インキ組成物を支持体上に設けることが好ましい。The ink composition for pH measurement as described above is applied onto a support to form a constant pH region of 111, thereby obtaining a specimen according to the present invention. As the application technique, a printing method, a coating method (for example, roll coating, spray coating, solid coating), etc. can be used. In J of the present invention, since it is preferable that the ink composition has a relatively large amount of coating and a constant coating area, the ink composition is applied onto the support by a silk screen printing method, an intaglio printing method, a gravure printing method, etc. It is preferable to provide the
塗布′Ｂｋは、インキ組成物の棹頷に応じて変化するが
、一般にλ〜１ｒｏｙ／ｍ’ （乾燥時）であることが
好ましい。The coating 'Bk varies depending on the strength of the ink composition, but is generally preferably λ to 1 roy/m' (dry).
支持体は、試薬組成物と反応せずしかも試薬の呈色を阻
害しないものであることが好筐しく、具体的には、たと
えば紙、合成紙、不織布捷たは合成樹脂フィルムあるい
は紙と合成１０（脂フィルムとの積層体などが用いられ
る。The support is preferably a material that does not react with the reagent composition and does not inhibit the coloring of the reagent, and specifically, for example, paper, synthetic paper, nonwoven fabric, synthetic resin film, or paper and synthetic material. 10 (a laminate with a fat film is used).
このような支持体上にｐ Ｈａ＋＋１定領域が設けられ
た本発明に係るｐＨ検査体は、スティック状、ロール状
、テープ状などの形態に形成されていてもよい。あるい
は支持体自体が被検液を採取しうるような形）ｌυたと
えはコツプ状、試験管状、皿状、トレイ状、スポイト状
に形成され、その支持体上にｐＨ測定領域を設けて、本
発明に係るｐＩ（検査体としてもよい。The pH tester according to the present invention, in which a p Ha++1 constant region is provided on such a support, may be formed in the form of a stick, a roll, a tape, or the like. Alternatively, the support itself can be formed into a shape such as a pot, test tube, dish, tray, or dropper (such that the test liquid can be sampled), and a pH measurement area is provided on the support. pI according to the invention (may also be used as a test object).
発明の効果
本発明に係るｐＨ検査体は、１級アンモニウム塩または
アミン塩ならびに特定の結合剤を含有するｐＨ測定用イ
ンキ組成物を用いて形成されているので、以下のような
効果がある。Effects of the Invention Since the pH test object according to the present invention is formed using an ink composition for pH measurement containing a primary ammonium salt or amine salt and a specific binder, it has the following effects.
ａ） ｍ’倹液中に浸漬し呈色させた後に、発色した色
の経時的な退色が少ない。a) After being immersed in the m' solution to develop color, the developed color fades less over time.
ｂ） ＰＨ測定用領域がある程度耐水性を有しておシ、
指示薬のｗｔ検検液への溶失が少ない。b) The PH measurement area has some degree of water resistance;
There is little dissolution of the indicator into the wt test sample solution.
Ｃ）呈色が迅速でかつ得られる色調が鮮明である。C) Color development is rapid and the resulting color tone is clear.
ｄ）支持体上に直接塗布好筐しくは印刷法によりＰＨ測
定用領域が形成できるため、大量生産に有利で工程も短
５ｆできる。d) Since the PH measurement area can be formed by direct coating on the support or by a printing method, it is advantageous for mass production and the process can be shortened to 5 f.
実施例／ 下記組成のｐＨ測定用インキ組成物を調製した。Example/ An ink composition for pH measurement having the following composition was prepared.
メチルレッドナトリウム塩 ０．０７ 重量部プロモメ
チールプルー Ｏ０／３
アルキルベンジルジメチル
アンモニウムクロリド ｏ、ｉｐ
（化工石けん製、サニゾール）
微結晶セルロース ３６
（無化成、アビセルＳＦ）
エチルセロンルプ ｔ。Methyl red sodium salt 0.07 Parts by weight Promomethyl blue O0/3 Alkylbenzyldimethylammonium chloride o, ip (Kakko Soap, Sanizol) Microcrystalline cellulose 36 (Non-chemical, Avicel SF) Ethylseronlupe t.
以上の組成物を充分にホモミキサーで微細分散させた後
、スクリーン印刷法により、厚み２３０μｍの白色ポリ
スチレンシート上に一辺がｊｍｍの四角形となるように
印刷した。用いたスクリーン版はｌＯＯメツシュ、レジ
ストおよびスクリーン秒の厚みの合計け１３０μｍであ
った。After sufficiently finely dispersing the above composition using a homomixer, it was printed on a white polystyrene sheet having a thickness of 230 μm to form a rectangular shape having a side of j mm by screen printing. The screen plate used had a total thickness of 130 μm, including the thickness of the lOO mesh, the resist, and the screen thickness.
得られた印刷物を＆ｊ’Ｃで３０分乾燥後、スティック
状に断裁してｐＨ測定用検査体を得た。The obtained printed matter was dried at &j'C for 30 minutes and then cut into stick shapes to obtain test pieces for pH measurement.
これらのスティックを、既知のｐＨ溶液で試験した。各
石ｉ水素イオン濃度で認められた着色は次のようであっ
た。 ｐＨｊ 橙 色
ｐＨ４黄色
ｐＨ７黄緑色
ｐＨｒ 緑色
ｐＨ９Ｙｔ 色
呈色は、均一かつ鮮明であり、ｐＨｊ〜りの 範囲で容
易に判別できるものてあった。また、色素等などの被検
体液中の溶出は認められず、浸漬後、室内でユＯ分間放
１鼠しても色調は変らず、数時間放置して試薬層が乾燥
してもｐ Ｈｊ 以外は殆んど同じ色調を維持していた
。These sticks were tested with known pH solutions. The coloration observed in each stone at different hydrogen ion concentrations was as follows. pHj Orange pH 4 Yellow pH 7 Yellow-green pHr Green pH 9 Yt The coloration was uniform and clear, and could be easily distinguished within the range of pHj to 2. In addition, no elution of pigments or other substances from the test body fluid was observed, and the color tone did not change even if the mouse was left indoors for one minute after immersion, and even after the reagent layer was left to dry for several hours, the pH remained unchanged. Other than that, the color tone remained almost the same.
また、検査される尿のような溶液でも正確にｐＨを測定
できる。筐たこの検査体を長期保存（／年６ケ月）して
も呈色性能に変化はなく、安駕であった。In addition, the pH can be accurately measured even in solutions such as urine to be tested. Even after long-term storage (6 months/year) of the specimen tested by Kakitoko, there was no change in coloring performance, which was poor.
また、上記のｐＨ測測用用インキ組成物 安定で、調製
後ｌケ月経過後でも、再分散させるだけで印刷可能で、
得られた検査体は同様に艮好な性能を有して込だ。In addition, the above ink composition for pH measurement is stable and can be printed by simply redispersing it even after one month has passed after preparation.
The test specimen obtained also showed excellent performance.
実施例コ
実施例／のｐＨ測測用用インキ組成物訃いて、ヒドロキ
シエチルセルロースをポリビニルピロリドン（ＧＡＦ社
製に−２０）に、そしてポリビニルブチラール樹脂をウ
レタン樹脂（大日本インキ製、パンデックス・Ｔ−！ｔ
７０）に代えた以外は実施例／と同様にしてｐＨ測定用
検査体を製造した。Ink composition for pH measurement of Example/Example/Example/Example/Example/Example/Ink composition for pH measurement -!t
A test body for pH measurement was manufactured in the same manner as in Example except that 70) was replaced.
得られたｐＨ測定用検査体はｐＨｊ〜りの範囲で実施例
／と同様、鮮明でかつ安定な呈色を示した。The obtained test specimen for pH measurement showed clear and stable coloration in the pH range of 2 to 2, as in Example.
く比較例／＞（四級アンモニウム塩の効果）実施例１の
ｐＨ測定用インキ組成物におりて、サニゾールを配合し
なり以外は実’Ｊｊｊｉｉ例／と同様にして検査体を製
造した。Comparative Example (Effect of quaternary ammonium salt) A specimen was produced in the same manner as in Example 1, except that Sanizol was added to the pH measuring ink composition of Example 1.
この検査体を被検溶液に浸漬後、発色した色の経時変化
はつぎのようになった。After this specimen was immersed in the test solution, the color developed over time changed as follows.
ｐＨ浸漬直後 征漬後２０分経過時
ｊ 橙色 橙色
６ 橙黄色 橙 色
７ 黄緑色 黄 色
ざ゛緑色 黄色
タ 青色 黄色
呈色後試薬層が乾いていくにしたがって特にアルカリ性
領域での退色が著しかった。Immediately after pH immersion 20 minutes after immersion Orange Orange 6 Orange Yellow Orange 7 Yellow-green Yellow Dark green Yellow Ta Blue After yellow coloring, as the reagent layer dried, fading was especially remarkable in the alkaline region.
く比較例λ〉（水溶性高分子化合物結合剤の効果）下記
組成のｐＨ測定用インキ組成物を実施例１と同様にして
調製した後支持体上に印刷して、ｐＨ測測用用検査体製
造した。Comparative Example λ〉 (Effect of water-soluble polymer compound binder) An ink composition for pH measurement having the following composition was prepared in the same manner as in Example 1, and then printed on a support and tested for pH measurement. The body was manufactured.
メチルレッドナトリウム塩 θ、０７重月一部プロモチ
モールブルー ０．３０
エチルセルロース ｊ
（パーキュレス製 Ｎ−ｊｔＯ）
微結晶セルロース ３６
（旭化成、アビセル５Ｆ）
ｎ−ブチルアルコール タ
トルエン ＳＯ
得られた検査体を、被検体液中に浸漬した後発色するま
でに袈した時間は約１分であり、しかも１１、、−３分
で退色現象が認められた。Methyl red sodium salt θ, 07 Juzuki part promothymol blue 0.30 Ethyl cellulose j (Percules N-jtO) Microcrystalline cellulose 36 (Asahi Kasei, Avicel 5F) n-Butyl alcohol Tatoluene SO The obtained test specimen was The time it took for color to develop after being immersed in the sample solution was about 1 minute, and discoloration was observed after 11, -3 minutes.
出願人代理人 猪 股 清Applicant's agent Kiyoshi Inomata
Claims (1)
結合剤および吸水性粉末からなる試薬組成物が、溶媒中
に溶解あるいは分散されてなることを特徴とするｐＨ測
定用インキ組成物。 λ、結合剤が、顕色効果を有する水溶性高分子化合物と
、皮膜形成能を有する水不溶性高分子化合物とからなる
特許請求の範囲第７項に記載のインキ組成物。 ３、顕色効果を有する水溶性高分子化合物が、ヒドロキ
シエチルセルロースまたはポリビニルピロリドンである
特許請求の範囲第２項に記載のインキ組成物。 弘 皮膜形成能を有する水不溶性高分子化合物が、ウレ
タン樹脂またはポリビニルブチラール樹脂である特許請
求の範囲第２項に記載のインキ組成物。 ｔ−ｐＩ（指示薬、弘級アンモニウム塩またはアミン塩
、結合剤および吸水性粉末からなる試薬組成物が溶媒中
に溶解あるいは分散されてなるｐＨ測定用インキ組成物
を、支持体上に塗布してなるｐＨ測定用領域を有するこ
とを特徴とするｐＨ測定用検出体。 ｔ、結合剤が、顕色効果を有する水溶性高分子化合物と
、皮膜形成能を有する水不溶性高分子化合物とからなる
特許請求の範囲第５項に記載の検出体。 ７、顕色効果を有する水溶性高分子化合物が、ヒドロキ
シエチルセルロースまたはポリビニルピロリドンである
特許請求の範囲第６項に記載の検出体。 ｒ、皮膜形成能を有する水不溶性高分子化合物が、ウレ
タン樹脂またはポリビニルブチラール樹脂である特許請
求の範囲第６項に記載の検出体。[Claims] /, pH indicator, high grade ammonium salt or amine salt,
An ink composition for pH measurement, characterized in that a reagent composition comprising a binder and a water-absorbing powder is dissolved or dispersed in a solvent. 8. The ink composition according to claim 7, wherein the binder comprises a water-soluble polymer compound having a color developing effect and a water-insoluble polymer compound having a film-forming ability. 3. The ink composition according to claim 2, wherein the water-soluble polymer compound having a color developing effect is hydroxyethyl cellulose or polyvinylpyrrolidone. Hiroshi The ink composition according to claim 2, wherein the water-insoluble polymer compound having film-forming ability is a urethane resin or a polyvinyl butyral resin. An ink composition for pH measurement, in which a reagent composition consisting of t-pI (indicator, a high-grade ammonium salt or amine salt, a binder, and a water-absorbing powder) is dissolved or dispersed in a solvent, is coated on a support. A detecting body for pH measurement characterized by having a pH measurement region: t. A patent in which the binder comprises a water-soluble polymer compound having a color developing effect and a water-insoluble polymer compound having a film-forming ability. Detector according to claim 5. 7. Detector according to claim 6, wherein the water-soluble polymer compound having a color developing effect is hydroxyethyl cellulose or polyvinylpyrrolidone. r. Film formation. 7. The detection object according to claim 6, wherein the water-insoluble polymer compound having the above-mentioned ability is a urethane resin or a polyvinyl butyral resin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3378684A JPH0623764B2 (en) | 1984-02-24 | 1984-02-24 | Ink composition for pH measurement and inspection body formed using the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3378684A JPH0623764B2 (en) | 1984-02-24 | 1984-02-24 | Ink composition for pH measurement and inspection body formed using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60178362A true JPS60178362A (en) | 1985-09-12 |
| JPH0623764B2 JPH0623764B2 (en) | 1994-03-30 |
Family
ID=12396151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3378684A Expired - Lifetime JPH0623764B2 (en) | 1984-02-24 | 1984-02-24 | Ink composition for pH measurement and inspection body formed using the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0623764B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62258665A (en) * | 1986-05-06 | 1987-11-11 | ダイセル化学工業株式会社 | Deodorant composition |
| EP0301203A2 (en) * | 1987-07-27 | 1989-02-01 | FAVINI S.r.l. | Pocket tester for paper and fabrics |
| WO1998007027A1 (en) * | 1996-08-13 | 1998-02-19 | Litmus Concepts, Inc. | pH AND AMINE TEST ELEMENTS AND APPLICATIONS TO DIAGNOSIS OF VAGINAL INFECTIONS |
| US7306764B2 (en) * | 2003-03-24 | 2007-12-11 | Precision Laminates Inc. | Wetness indicator |
| JP2009265086A (en) * | 2008-03-31 | 2009-11-12 | Rengo Co Ltd | Health testing material for animal |
| WO2010117520A3 (en) * | 2009-03-31 | 2011-01-27 | Illinois Tool Works Inc. | Reversible color-changing sanitizer-indicating nonwoven wipe |
| US8772185B2 (en) | 2010-10-15 | 2014-07-08 | Illinois Tool Works Inc. | Reversible color-changing ink formulations and nonwoven wipes |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477921A1 (en) * | 2002-03-05 | 2003-09-12 | James A. Profitt | Absorbing organic reagent into diagnostic test devices by formation of amine salt complexes |
-
1984
- 1984-02-24 JP JP3378684A patent/JPH0623764B2/en not_active Expired - Lifetime
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62258665A (en) * | 1986-05-06 | 1987-11-11 | ダイセル化学工業株式会社 | Deodorant composition |
| EP0301203A2 (en) * | 1987-07-27 | 1989-02-01 | FAVINI S.r.l. | Pocket tester for paper and fabrics |
| WO1998007027A1 (en) * | 1996-08-13 | 1998-02-19 | Litmus Concepts, Inc. | pH AND AMINE TEST ELEMENTS AND APPLICATIONS TO DIAGNOSIS OF VAGINAL INFECTIONS |
| US5897834A (en) * | 1996-08-13 | 1999-04-27 | Litmus Concepts, Inc. | pH test elements |
| US5910447A (en) * | 1996-08-13 | 1999-06-08 | Litmus Concepts, Inc. | pH and amine test to diagnosis of vaginal infections |
| US6099801A (en) * | 1996-08-13 | 2000-08-08 | Litmus Concepts, Inc. | pH and amine test elements and applications to diagnosis of vaginal infections |
| US6200817B1 (en) | 1996-08-13 | 2001-03-13 | Litmus Concepts, Inc. | PH and amine test elements and applications to diagnosis of vaginal infections |
| US7306764B2 (en) * | 2003-03-24 | 2007-12-11 | Precision Laminates Inc. | Wetness indicator |
| JP2009265086A (en) * | 2008-03-31 | 2009-11-12 | Rengo Co Ltd | Health testing material for animal |
| CN102414363A (en) * | 2009-03-31 | 2012-04-11 | 伊利诺斯工具制品有限公司 | Reversible color-changing sanitizer-indicating nonwoven wipe |
| WO2010117520A3 (en) * | 2009-03-31 | 2011-01-27 | Illinois Tool Works Inc. | Reversible color-changing sanitizer-indicating nonwoven wipe |
| US8772186B2 (en) | 2009-03-31 | 2014-07-08 | Illinois Tool Works Inc. | Reversible color-changing sanitizer-indicating nonwoven wipe |
| US8772184B2 (en) | 2009-03-31 | 2014-07-08 | Illinois Tool Works Inc. | Reversible color-changing sanitizer-indicating nonwoven wipe |
| EP2952626A1 (en) * | 2009-03-31 | 2015-12-09 | Illinois Tool Works Inc. | Reversible color-changing sanitizer-indicating nonwoven wipe |
| EP3150760A1 (en) * | 2009-03-31 | 2017-04-05 | Illinois Tool Works, Inc. | Reversible color-changing sanitizer-indicating nonwoven wipe |
| US9861245B2 (en) | 2009-03-31 | 2018-01-09 | Illinois Tool Works, Inc. | Reversible color-changing sanitizer-indicating nonwoven wipe |
| US8772185B2 (en) | 2010-10-15 | 2014-07-08 | Illinois Tool Works Inc. | Reversible color-changing ink formulations and nonwoven wipes |
| CN105040463A (en) * | 2010-10-15 | 2015-11-11 | 伊利诺斯工具制品有限公司 | Reversible color-changing ink formulations and nonwoven wipes |
| US9475952B2 (en) | 2010-10-15 | 2016-10-25 | Illinois Tool Works Inc. | Reversible color-changing ink formulations and nonwoven wipes |
| EP3093387A1 (en) * | 2010-10-15 | 2016-11-16 | Illinois Tool Works, Inc. | Reversible color-changing polymeric article |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0623764B2 (en) | 1994-03-30 |
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