JPS60132562A - Dose form capsule - Google Patents

Dose form capsule

Info

Publication number
JPS60132562A
JPS60132562A JP59230476A JP23047684A JPS60132562A JP S60132562 A JPS60132562 A JP S60132562A JP 59230476 A JP59230476 A JP 59230476A JP 23047684 A JP23047684 A JP 23047684A JP S60132562 A JPS60132562 A JP S60132562A
Authority
JP
Japan
Prior art keywords
capsule
cap
capsules
compartments
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59230476A
Other languages
Japanese (ja)
Other versions
JPH0673539B2 (en
Inventor
フリツツ・ヴイツトヴエル
ルイス・エス・ジロウ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of JPS60132562A publication Critical patent/JPS60132562A/en
Publication of JPH0673539B2 publication Critical patent/JPH0673539B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
    • B29C65/58—Snap connection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/114—Single butt joints
    • B29C66/1142—Single butt to butt joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/13—Single flanged joints; Fin-type joints; Single hem joints; Edge joints; Interpenetrating fingered joints; Other specific particular designs of joint cross-sections not provided for in groups B29C66/11 - B29C66/12
    • B29C66/131—Single flanged joints, i.e. one of the parts to be joined being rigid and flanged in the joint area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/13—Single flanged joints; Fin-type joints; Single hem joints; Edge joints; Interpenetrating fingered joints; Other specific particular designs of joint cross-sections not provided for in groups B29C66/11 - B29C66/12
    • B29C66/131—Single flanged joints, i.e. one of the parts to be joined being rigid and flanged in the joint area
    • B29C66/1312—Single flange to flange joints, the parts to be joined being rigid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B29C66/2422—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being circular, oval or elliptical
    • B29C66/24221—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being circular, oval or elliptical being circular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B29C66/2424—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain
    • B29C66/24241—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain forming a triangle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B29C66/2424—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain
    • B29C66/24243—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain forming a quadrilateral
    • B29C66/24244—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain forming a quadrilateral forming a rectangle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
    • B29C66/53461—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/542—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining hollow covers or hollow bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/543—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining more than two hollow-preforms to form said hollow articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/63—Internally supporting the article during joining
    • B29C66/636—Internally supporting the article during joining using a support which remains in the joined object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/545—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles one hollow-preform being placed inside the other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Fertilizers (AREA)
  • Packages (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

【発明の詳細な説明】 本発明は鈎に医薬用の固体物質、クリーム状物質葦たは
孜状物質のためのイ史カプセルの投与形ｔｐＭに関する
。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a capsule dosage form tpM for pharmaceutical solid substances, cream-like substances or turmeric substances.

本発明の抜与ノ１〉態は互いに理詰ちれた２　（１６１
またｅユそれ以上のカプセルからなっている。カプセル
間の連結部はダイ成形技術によりカプセルと同時に製造
することができ、そしてカプセル目体の材料と同じ材料
で製造することができる。The first aspect of the present invention is logically consistent with the other (2) (161
It also consists of more capsules. The connections between the capsules can be manufactured simultaneously with the capsules by die-molding techniques and can be made of the same material as the capsule eye.

カプセルには、その中に異なる医薬を収納するために各
々のカプセルの内部に二つまたはそれ以上の分離しえな
い区画を形成することができる。The capsules can be formed with two or more inseparable compartments within each capsule for housing different medicaments therein.

分割可能なカプセルおよび区画に仕切ったカプセルの両
方共多数の単位投与量または）々ツケージとして１■」
時に成形することができる。Both divisible capsules and compartmentalized capsules can be used in multiple unit doses or as separate packages.
Can be molded at times.

先行挟ｔＦＪの一系用の硬カプセルは軸巌方向に接合し
うる円筒形のキャップ３よびボディ部分によって形成延
れた１詞の光填区画のみ′（ｆ−有する一単位からなっ
ている。先行技術による浸漬成形力法による製造上のｔ
ｔｔｌＪ限のためｅＣ１先行技術ｅ仁よるカプセルは製
造プロセス中に互いに結びつけることができない。The hard capsule for the first series of FJs consists of one unit having only one light-filling section formed by a cylindrical cap 3 and a body part that can be joined in the axial direction. Manufacturing t by the immersion forming force method according to the prior art
Due to the ttlJ limitation, the capsules according to the prior art eC1 cannot be bonded to each other during the manufacturing process.

錠剤が患者が錠剤ケ複数個の小片に破断することによシ
投与景を選択できる一つの方法であることは知られてい
る。It is known that tablets are one way in which a patient can select the administration mode by breaking the tablet into multiple pieces.

不発１月によれば、医薬が互いに反応しあって不適当な
製品を生ずる可能性があるので、錠剤まｌヒは従来技術
のカプセル中で組み合わせることができないような二様
またはそれ以上の医薬の組合せを行なうことができる。According to J.D., tablet tablets contain two or more drugs that cannot be combined in prior art capsules because the drugs may react with each other resulting in an unsuitable product. A combination of these can be used.

本発明によれば、患者によりのみ込まれる小単位部分に
分割可能なカプセルの投与形態が得られる。The present invention provides a capsule dosage form that is divisible into small unit portions that are swallowed by the patient.

それＶこ加えで、本発明によイシは、二檎濠たはそれ以
上の異な／）囚り？ミが光填されるカプセルケ提供ずゐ
ことがでさる。In addition to that, the present invention allows two or more different /) captivity? It is possible to provide a capsule that is filled with light.

本発明の物品は水の名イ１量の少ない殿粉、ゼラチン葦
たは殿杓帥轟体のような颯水性里合体をダイ成形するこ
吉によシ形成することができる。The articles of the present invention can be formed by die-molding a starch, gelatin reed, or a hydrophilic agglomerate such as starch with a small amount of water.

本発明は殊にこのようなダイ成形されたカプセル、殊に
射出成形されたカプセルの構造および形態に関するもの
である。The invention particularly relates to the structure and form of such die-molded capsules, especially injection-molded capsules.

本発明は接合可能なキャップ部分およびボディ部分から
なる複数個の小単位部分を鳴する分割可能な硬カプセル
の投与形態であって、前記ボディ部分が共に薄板状の連
結部を鳴し、前記連結部が前記ボディ部分と共ｅこ一体
に成形され且つ前記連結部が殊に医薬投与のだめのカプ
セルを小単位に分熱するようにさらに破断可能になって
いることを特急とする候カプセルの長鳥形態？提供うる
ものでるる。The present invention provides a splittable hard capsule dosage form comprising a plurality of subunit parts consisting of a cap part and a body part which can be joined together, the body parts together forming a lamellar connecting part, and the connecting parts A special feature of the long capsule is that the part is integrally molded with the body part, and the connecting part is further breakable so as to divide the capsule into small units, especially for the administration of medicine. form? What we can provide.

不発ψＪは、さらに、キ七ツブ部分およびボディ部分か
らなる区画に仕切られた儲い殻体紫肩するカプセルの投
与形態であって、前記ボディ部分が医薬の投与のために
接合濱れたときにＨＩＪ記ボデボディび前記キャップの
内部に行に一系用の二つまたはそれ以上の区画？形成す
るようにその内部に一体に成形された一つまたはそれ以
上の仕切り−ｗ有していることを舶徴とするカプセルの
投与形態を提供する。The non-exploded ψJ is further a dosage form of a round-shelled capsule divided into compartments consisting of a horn part and a body part, which when said body part is joined for the administration of the medicament. Is there two or more compartments for one line in a row inside the HIJ body and the cap? A capsule dosage form is provided having one or more partitions integrally molded therein to form a capsule.

本発明は、また、接合可能なキャップ部分およびボディ
部分からなる複数個の理詰されたカプセルを有する硬カ
プセルパッケージの投与形態であって、前記カプセルが
相互の連結部を有し、前記連結部が前記カプセルと共に
一体に成形延れ、前記連結部がカプセルを付に医薬投与
のための個々のカプセルに分１ｌｔｃｈするようにさら
に破面ｂ」能であることを特徴とする鋏カプセルパッケ
ージの投与形態を提供する。The present invention also provides a dosage form of a hard capsule package having a plurality of packed capsules consisting of a cap part and a body part which can be joined together, the capsules having an interconnection part, and wherein the capsules have an interconnection part; administration of a scissor capsule package, characterized in that the capsule is molded integrally with the capsule, and the connecting part is further capable of breaking the capsule into individual capsules for pharmaceutical administration. Provide form.

グイ成形例えば射出成形においては、成形される飼料が
成形プロセス中に熱可塑性物質の性質＋Ｃがし且つ成形
月相がその寸法全変化しないで迅速に射出することがで
きるように成形型の中で迅速に硬化する仁とが肝要であ
る。非常に多数のグイ加圧成プレ品の和′度が非常に伏
い限度以内に保たれなりればならないので、後者はル槻
な倭因である。Gui molding For example, in injection molding, the feed to be molded has the property of thermoplastic material +C during the molding process and inside the mold so that the molding phase can be quickly injected without changing its dimensions completely. It is important to have a hardening layer that hardens quickly. The latter is a major cause, since the sum of the very large number of press-formed products must be kept within very narrow limits.

本発明はまた上記のカプセル投与形態であって、射出成
形によ、！Ｉｌｌ　（’ｌ）　５〜２５重が％（親水性
重合体組成物に幻して計１４．）の水分を有する親水性
重合体組成物またはこのような重合体の混合物、そして
セラチン組成物から形成する場合Ｃ（は１０〜２０浜批
％（セラチン組成物に対して計ｎ）の水分を肩するｍＪ
記七ラうン組成吻、オ６よび／または（ｌｉ）　ｓ〜２
５嵐輩％（ｗ粉組成物に対して計算）の水分を有する殿
粉または殿粉組成物から形成されることを特徴とするカ
プセル投与形態ケ提供する。The present invention also provides a capsule dosage form as described above, by injection molding! Ill ('l) from a hydrophilic polymer composition or a mixture of such polymers having a water content of 5 to 25% by weight (total 14.0% by weight of the hydrophilic polymer composition), and from a seratin composition. When formed, mJ absorbs 10 to 20% of water (total n for the seratin composition).
Recording seven composition proboscis, o6 and/or (li) s~2
A capsule dosage form is provided, characterized in that it is formed from a starch or a starch composition having a water content of 5% (calculated on the flour composition).

本発明によれば、好ましいカプセルは殿粉を射出成形す
ることによ勺製造される。According to the invention, preferred capsules are manufactured by injection molding starch.

親水性物質、例えば、水を含むセラチンの射出成形は欧
州特許出願公開第９２９０８号に記載されている。Injection molding of hydrophilic substances, such as ceratin containing water, is described in European Patent Application No. 92908.

親水性１合体は主鎖および／または側鎖において分子群
を担持し且つ水素橋を形成しおよび／または該水素橋に
関与することができる約１０６〜１０７ダルトンの分子
質量を有する重合体である。前記親水性重合体は前記親
水性重合体組成物の５〜２５重′ｊｊｋ％の水分を有し
、そして前記親水性重合体の射出成形のための加工温度
ｌ″ｉ５０パＣから１９０℃萱での範囲内、好ましくは
８０℃から１９０″Ｇ互での範囲内でりる。Hydrophilic monomers are polymers with a molecular mass of about 106-107 daltons that carry molecular groups in the main chain and/or side chains and are capable of forming and/or participating in hydrogen bridges. . The hydrophilic polymer has a moisture content of 5 to 25% by weight of the hydrophilic polymer composition, and the processing temperature for injection molding of the hydrophilic polymer is from 50°C to 190°C. preferably within the range of 80° C. to 190″G.

親水性重合体とじてのゼラチンは酸またはアルカリで処
理されたオセイン、酸で処理きれた豚草またはアルカリ
で処理された家畜の皮革を含むイ虫々の型式のゼラチン
から製造されている。Gelatin, as a hydrophilic polymer, has been prepared from caterpillar type gelatin, including acid- or alkali-treated ossein, acid-treated ragweed, or alkali-treated livestock skin.

ｍｌ記型式の七ラテンは１０．ｔＪＯ［］〜２Ｘ１０７
ダルトンのｊｕｉ２ｄ内の分子質量または１０，０００
〜２Ｘ１０６ダルトンの範囲内の分子質量、そして１０
Ｘ１０”〜２０ｘ１０６ダルトンの範囲内の分子質量を
梅することが好′ましい。ゼラチンは該ゼラチンに対し
て計よ−した好ましくは１０〜１９凰Ｍ％、そして殊に
１２〜１８重用係の水分を有している。Seven Latin in ml format is 10. tJO[]~2X107
molecular mass in Dalton's jui2d or 10,000
molecular mass within the range of ~2X106 Daltons, and 10
Preferably, the molecular mass of the gelatin is within the range of 10" to 20" x 106 daltons.The gelatin preferably contains 10 to 19 mol%, and especially 12 to 18 mol%, based on the gelatin. Contains moisture.

すべての親水性爪体、ずなわら、含有されたセラチンは
丑だ神々の添加剤例えば欧州特許出願公開第９２９０８
　＋′３明＃ｌｉＩ首に記載され且つ前記明イ４１１岩
に示された濃度の可塑剤、潤滑剤、架橋剤および庸色剤
を含有することができる。親水性重合体は９５及に％以
内であシ好ましくは６０重賞−を越えないエキステンダ
ー例えばヒマワリ蛋白、大豆蛋白、綿実蛋白、ラッカセ
イ蛋白、ｍ＊蛋白、卵白、ナタネ蛋白。およびそのアセ
チル化誘導体、ゼラチン、架橋セラチン、ビニルアセテ
ートのような蛋白、ポリサッカライド例、ｔ　ハセルロ
ース、メチルセルロース、ヒドロキシプロピル−セルロ
ース、ヒドロキシプロピル−メチルセルロース、ヒドロ
キシメチル−セルロース、ヒドロキシエチルセルロース
、ナトリウムカルボキシメチルセルロース、寒天、アラ
ビアゴム、グアール、デキスト２ン、キチン質、ポリマ
ルトース、ポリ７ラクトース、ペクチン、アルジネート
、アルギン酸、モノザラカライド好ましくはグルコース
、フラクトース、サッカロース、オリゴサツカライド、
好フしくはフクトース、ポリビニル−ピロ９　Ｆン、”
　’）ケート、ベントナイト、刀−ホイ・−１・および
パイカーポ４−ト盆君゛４４’　ｉゐことかでさる。In all hydrophilic nail bodies, Zunawara, the contained ceratin is a divine additive such as European Patent Application Publication No. 92908
It may contain plasticizers, lubricants, crosslinking agents, and color brighteners in the concentrations listed in the +'3 Light #liI head and indicated in the above Light 411 rock. The hydrophilic polymer is within 95% and preferably does not exceed 60% extender such as sunflower protein, soybean protein, cottonseed protein, peanut protein, m* protein, egg white, rapeseed protein. and its acetylated derivatives, proteins such as gelatin, cross-linked ceratin, vinyl acetate, polysaccharides examples, t-cellulose, methylcellulose, hydroxypropyl-cellulose, hydroxypropyl-methylcellulose, hydroxymethyl-cellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, Agar, gum arabic, guar, dextrin, chitin, polymaltose, poly7-lactose, pectin, alginate, alginic acid, monosaracalide, preferably glucose, fructose, saccharose, oligosaccharide,
Preferably fuctose, polyvinyl-pyro9F,
') Kate, bentonite, sword-hui-1, and pi-carpo-4-to Bon-kun 44'i.

こりよシな続水住里合体ｔユヒドロキシブロビルメブー
ルセルロース７タレ−）　（ＨｐＭＣＰ）　、ホ！Ｊヒ
ニルアセアートーンタレート（ＰＶＡＰ）　、セルロー
スアセチル７タレー）　７　（ＣＡＰ）　、アクリレー
トおよびメタクリレート（Ｊｌｉｉｕｄｒａｇｉｔ）、
フタール化セ２チン、コハク化セラチン、クロトン酸お
よびシエランクである。これらの重合体は腸溶性が必要
である繍７合に好ましい。また、これらの重合体は水分
を含量しない重合体に対して割算した１５〜２２　ｕｆ
Ｕ　ｉｕ　％の水分を含有していると吉が灯葦しい。好
ましい重合体はＨＰｌ＆３Ｐ、　ＰＶＡＰおよびＣＡＰ
であ）、妹に好ましい重合体はＰＶＡＰおよびＣＡＰで
あシ、最も好ましい重合体はＰＶＡＰであシ、５〜２５
重値チ、好ましくは１５〜２２１蓋襲の水分ｔイＪする
すべてのＪ重合体（ｄ射出成形によシ製造される。Koriyoshi na Tsukimizu Sumiri Gattai t hydroxybrobyl meboul cellulose 7 sauce) (HpMCP), Ho! J hinyl acetone tallate (PVAP), cellulose acetyl 7 tally) 7 (CAP), acrylates and methacrylates (Jliiudragit),
These are phthalated ceratin, succinated ceratin, crotonic acid, and sieranc. These polymers are preferred for embroidery where enteric properties are required. Additionally, these polymers have a water content of 15 to 22 uf divided by that of polymers that do not contain water.
If it contains U iu % moisture, it will be a good luck. Preferred polymers are HPl&3P, PVAP and CAP
), the preferred polymers are PVAP and CAP, the most preferred polymers are PVAP, 5-25
All J polymers having a moisture content of 15 to 221%, preferably manufactured by injection molding.

これらの重合体のあるものは非熱可塑性でり）、そして
これらの■合イ・トを本発明によりダイ成形することが
できることは夷に驚異的である。Some of these polymers are non-thermoplastic, and it is surprising that these composites can be die formed according to the present invention.

成形温度は５０℃から１９０℃鷹での範囲内であり、そ
して成形圧力ｒ！、　６ＤＯ〜３．ＤＤＯＸＩＬＩ”Ｎ
／ｍ２の範囲内である。また、成形妊は既知の装置ケ使
用することができる。The molding temperature ranges from 50°C to 190°C, and the molding pressure r! , 6DO~3. DDOXILI”N
/m2. Also, known equipment can be used to form the mold.

好ましい１Ｌ合体はトウモロコシ、小麦、ジャガイモ、
禾およびタピオカから製造された成形可能な殿粉組成物
である。Preferred 1L combinations include corn, wheat, potato,
A moldable starch composition made from soybean flour and tapioca.

殿粉は約０〜１００係のアミロースおよび約１００〜０
チのアミロ−ペクチンを含有し、そして約０〜７０饅の
アミロースおよび約１００〜３０％のアミロはクチンを
含有することが好塘しく、そしてジャガイモ殿粉および
メイズ殿粉を含イＪしている仁とが最も好′ましい。Starch contains amylose of about 0 to 100 and about 100 to 0
and preferably about 0 to 70% amylose and about 100 to 30% amylo-pectin, and contains potato starch and maize starch. It is most preferable to have the right person.

下記の説明に」６いて「ゼラチン」または「殿粉」とい
う用暗が使用される場合、この用語は殿粉Ｉ／）発イ包
体、夏型または誘導体と、意図されたタイ成形されたカ
プセルのために各５志しうる性賀蛍有するその他の重合
体ｍは酸物と殿粉の発泡体、変型または誘導体との混合
物をも包ましでいる。In the description below, when the term ``gelatin'' or ``starch'' is used, this term is used to refer to starch shells, summer molds or derivatives, and the intended tie-forming. Other polymers, each with five possible properties for capsules, also enclose mixtures of acid and starch foams, variants or derivatives.

ハレ籾は５〜２５％、好ｉｔ、＜は１５〜２２φ、ぞし
−Ｌｉげに好−よしくは１７〜２０饅の水分金倉んでい
る。Haren paddy has a moisture content of 5 to 25%, preferably 15 to 22 φ, and preferably 17 to 20 liters of moisture.

このＩＩ摸扮は種々の添加剤、例えば、可塑剤、潤Ｎｉ
ｔ剤、架儲剤および／または着色剤ならびにエキステン
ダー葡含有することができる。This II model contains various additives, such as plasticizers, wet Ni, etc.
It may contain additives, crosslinking agents and/or coloring agents and extenders.

こλしらのずべ°Ｃの切′Ａなよ親水性ＷＩ買について
前述した物質と同じである。This material is the same as the material described above for hydrophilic materials.

殿粉の成形温度は８０〜２４０℃であり、成形圧力は６
００〜３．００［１Ｘ１０５ＮΔ２である。The molding temperature of starch is 80-240℃, and the molding pressure is 6
00-3.00[1X105NΔ2.

水ｔ＠南し且つ自由選択によりさらに添加剤を含巾する
殿粉はこれらのｔ！度および圧力の下でよく知られてい
る態様でそしてよく知られている成形装置の中で溶融せ
しめられる。These t! It is melted under temperature and pressure in a well-known manner and in well-known molding equipment.

画業用はタイ成形、すなわち、プロフィル押出成形、圧
縮成形、真空成形、熱成形、押出成形、真空成形と組み
合わせた虚合体注型によシ加工することができる。しか
しながら、射出成形が好ましい。Painting products can be processed by tie molding, ie, profile extrusion molding, compression molding, vacuum molding, thermoforming, extrusion molding, virtual coalescence casting combined with vacuum molding. However, injection molding is preferred.

本発明の利点は当業者には添付図面に関する以下の詳細
の説明を読めば明らかとなろう。The advantages of the invention will become apparent to those skilled in the art upon reading the following detailed description taken in conjunction with the accompanying drawings.

以下の説明において、本発明の実施態様を三つのカテゴ
リーにグループ分けすると便利である。In the following discussion, it may be convenient to group embodiments of the invention into three categories.

１、　分割可能なカプセル 分割可能な形態のカプセルは全部全−回でのみ込与まノ
こは叡１１−の部分に分離しその各々を態別にりむこと
かできる。ヤれ故に、当初のカプセルならびｅコ分＃Ｊ
Ｗされた小部分けの春込み易い外形になっており、そし
てその外形ｄ、址だ適用分野にス尚会さゼることかでき
る。1. Dividable Capsule A capsule in a divisible form can be divided into 11 parts and each part can be examined separately. Because of this, the original capsule lineup and e-co part #J
It has an outer shape that is easy to spring in with a small part that has been rounded, and its outer shape allows it to be used in various fields of application.

このカプセルは接合しうるキャップ部分およびボディ部
分からなシ且つその中に医薬を収納した１反＆ｉ個の連
結もれた小単位ｔイＩする分割ｎ」能な投与形態の硬カ
プセルでめつでｈｒ３ｉＪｉ＋ピボデイ部分が相互のＹ
４９板（ラメラ）状述結部を鳴し、前記連結部がｌ１ｌ
ｊ　ｕ己ポテイ部分と一体に成形され且つ削記浬紹部が
カプセルを特に医薬ケ投与するために小単位に分離する
ようにさらに破断ＢＪ能でめること全特徴とする分割可
能な投与形態の１便カプセルでろる。The capsule is a hard capsule in the form of a dosing form which consists of a cap part and a body part which can be joined together and which can be divided into a number of interconnected small units containing the medicament therein. So hr3iJi + pivot day part is mutual Y
49 lamella-like predicates, and the connecting part is l1l
A divisible dosage form which is integrally molded with the potion part and which is further characterized in that the cutting part has a breakable BJ function so as to separate the capsule into small units especially for pharmaceutical administration. It's a capsule.

また、キャップ部分はこれらを一緒に連結するラメラを
櫓することができる。また、カプセル部分の一方ケブリ
スターシートに形成し、そして他方のカプセル部分全熱
および圧力を作用させることによシシール妊れ／ζブリ
スターカバーシートにノヒ成することができる。Also, the cap portion can be strung with lamellae connecting them together. Alternatively, one of the capsule parts can be formed into a blister sheet, and the other capsule part can be formed into a seal/zeta blister cover sheet by applying total heat and pressure to the other capsule part.

このグループの一実施態椋は第１図、第２図、第５図お
よび力４図に示しである。亀１図において、２−２！ｌ
Ｓ！に沿って裁った２個のボディ１は弱い接合用ラメラ
５によシ連結されている。One embodiment of this group is shown in FIGS. 1, 2, 5, and 4. In Turtle 1 figure, 2-2! l
S! The two bodies 1 cut along are connected by a weak joining lamella 5.

２個のキャップ２は連結されていない。第１図の分解図
である第３図においては、内容物が充填された後でしか
もキャップ２がボディ１の上に配置される前の投与形態
を示しである。第４図は第６図の側面図であってキャッ
プ２がボディ１の上に配置された後の状態を示している
。The two caps 2 are not connected. In FIG. 3, which is an exploded view of FIG. 1, the dosage form is shown after filling and before the cap 2 is placed on the body 1. FIG. 4 is a side view of FIG. 6, showing the state after the cap 2 is placed on the body 1.

第１図ないし第４図に示した実施態様はカプセル全体を
最初の状態でのみ込むことができ、そしてこの投与形態
はラメラ５ＶＣ沿って２個の７ＪＳ単位に分割してそれ
により谷小単位部分を別々にのみ込むことができるよう
にした後にのみ込むこともできる。The embodiment shown in Figures 1-4 allows the entire capsule to be swallowed in its initial state, and the dosage form is divided into two 7JS units along the lamella 5VC, thereby dividing the valley subunit portions. It can also be swallowed separately and then swallowed.

第１図ないし第４図に示した分割可能なカプセルの２１
１ｉ！ｉｆの小単位部分には、異なる医薬または同一の
医薬を充填することができる。カプセルに同一の医薬が
充填されている場合には、投与賞はカプセルを二部分に
破断することにょシ分割することができる。カプセルに
二種の異なる医薬（各小単位部分に一棟類）が充填され
ている場合には、カプセルをラメラにおいて破断するこ
とによシ所望の医業をのみ込むことができる。各々の小
単位部分の内容物を同定するために、谷小単位部分を異
なる色に着色するがまたは各小単位部分全異なる文字ま
たは模様で目」刷することができる。21 of the splittable capsules shown in Figures 1 to 4.
1i! The subunit portions of if can be filled with different or the same medicament. If the capsule is filled with the same medicament, the dosage can be divided by breaking the capsule into two parts. If the capsule is filled with two different medicines (one in each subunit), the desired medical treatment can be swallowed by breaking the capsule at the lamellae. To identify the contents of each subunit, the valley subunits may be colored in different colors or each subunit may be marked with different letters or patterns.

カプセル部分１．２および連結ラメラ５はダイ成形、好
ましくは、射用成ルにより同時に製造することができる
。連結部５はカプセル部分１および２と同じ月料からな
っている。第５図および第６図は４個の小単位部分ケ有
するカプセルの別の冥施態様をボしている。第５図は頂
部平面図であジ、そして第６図は第５図の側面図であシ
、破断できるように弱いラメラ接合部５によシ連結され
た４個のキャップ２および４個のボディ１を示している
。このカプセルの実施態様はその全体をのみ込むかまた
は３個まだは２個の小単位部分をのみ込むかまたは１個
の小単位部分のみをのみ込むことができる。また、カプ
セルの異なる小単位部分には、異なる医薬または同じ医
業を充填することができる。The capsule part 1.2 and the connecting lamella 5 can be produced simultaneously by die molding, preferably by injection molding. The connecting part 5 consists of the same monthly charge as the capsule parts 1 and 2. Figures 5 and 6 show an alternative embodiment of the capsule having four subunit parts. FIG. 5 is a top plan view and FIG. 6 is a side view of FIG. Body 1 is shown. This embodiment of the capsule can be swallowed in its entirety or can contain three or two subunits or only one subunit. Also, different subunit parts of the capsule can be filled with different medicaments or the same medicament.

第７図ないし第１２図には別の実施態様を示しである。Another embodiment is shown in FIGS. 7 to 12.

第７図ないし第１２図に使用した符号は第１図ないし第
６図に使用した符号と同じである。これらの実施態様に
おいては、ボディ部分１およびキャップ部分２は第１１
図および第１２図にろくしたように弱い接合部５にょシ
連結されている。キャップ部分２はボディ部分１と里な
シ合うことができる。また、キャップ２は連結ラメラ５
が配置されている位置に四部６を有することができそれ
によりカプセルが小単位部分に破断された後でもラメラ
５がわずかに見えるようになっている。The symbols used in FIGS. 7 through 12 are the same as those used in FIGS. 1 through 6. In these embodiments, the body part 1 and the cap part 2 are the eleventh
As shown in FIG. 1 and FIG. 12, a weak joint 5 is connected. The cap part 2 can be mated with the body part 1. In addition, the cap 2 has a connecting lamella 5
can have four parts 6 in the position where the lamellae 5 are located, so that the lamellae 5 are slightly visible even after the capsule has been broken into small unit parts.

第１６図および第１４図には、カプセルが内側部分と２
個の外側部分とを含む３個の小単位部分盆鳴し、各小単
位部分がボディ部分１およびキャップ部分２からなる別
の実施態様を示しである。第１３図および第１４図にお
いては、外側部分は三角形に形成されている。また、別
の態様とじて第１５図および亀１６図に示した外側部分
は半円形に形成されている。第１３図ないし第１６図の
実施態様においては、ボディ部分１のみが２メラ５にょ
シ連結されておシ、キャップ部分２は別個にそれぞれ形
成されている。Figures 16 and 14 show that the capsule has an inner portion and two
1 shows another embodiment of the present invention, comprising three subunit parts, each subunit part comprising a body part 1 and a cap part 2; In FIGS. 13 and 14, the outer portion is triangularly shaped. Further, as another aspect, the outer portion shown in FIGS. 15 and 16 is formed in a semicircular shape. In the embodiment shown in FIGS. 13 to 16, only the body part 1 is connected to the two membranes 5, and the cap part 2 is formed separately.

２、　区画に仕切ったカプセル 区画に仕切ったカプセルは医薬のための二つまたはそれ
以上の区画ヶ有している。このカプセルは小単位部分に
破断することはできないが、同時にのみ込むために二種
類またはそれ以上の柚傾の異なる医薬を充填することが
できる。グイ成形技術の一つの利点は区画の数ケ２個に
限定しないで適用分野に必要な数とすることができるこ
とである。2. Compartmented Capsule A compartmented capsule has two or more compartments for the medicament. The capsule cannot be broken into small unit parts, but can be filled with two or more different medicaments for simultaneous swallowing. One advantage of the gouy molding technique is that the number of compartments is not limited to two, but can be as many as required for the field of application.

この実施態様はキャップ地分七ボディ部分七からなる区
画に仕切られた投与形態の硬カプセルであって、前記ボ
ディ部分が医薬の投与のために接合部れたときに前記ボ
ディおよびＭｉＪ記キャップの内部に付に医薬のための
２個またはそれ以上の区画旬形成するようにその内部に
一体に成形された１　１１＋’］　’ｌ’　７こはでれ
以上の内鵠仕切壁全市していることｔイ９＠とする硬カ
プセルである。This embodiment is a hard capsule in a dosage form partitioned into compartments consisting of a cap, seven body parts, and a combination of said body and MiJ cap when said body parts are joined for administration of a medicament. 1 11+'] 'l' 7 or more internal partition walls integrally molded within the interior to form two or more compartments for pharmaceuticals. It is a hard capsule called t-9@.

このような区１Ｉ９１に仕切られた収カプセルｈ角１１
記ボディ部分が′＃状であシ１１４１１　［に垂面でし
がも対問した開口ｙ浦部Ｑｃ平竹な内側仕切壁を４Ｉｆ
＃え、ｉ１Ｊ記囲口ｙＪ都の谷々力稍守に医薬投与の７
こめの医薬を収納する区四Ｉ忙形成するよりにキャップ
によ）閉ざひれていること’ｔ　％　徴としている。A storage capsule h corner 11 divided into such sections 1I91
The body part has a '# shape.
# Eh, i1J record Ioku yJ Miyako's 7th day of administering medicine to Rikichokun
It is considered to be closed (by a cap) rather than forming a compartment for storing medicines.

このような区画に仕切られた硬カプセルはまた１ｊ１１
ｆｆｔｊボディス１１≦分がフリスターシートであシ月
つキャップ部分が熱」ｄよび圧力を加えることによシシ
ールもれたブリスターカバーシートであることｔ％竜と
している。A hard capsule divided into such compartments is also 1j11
It is assumed that the bodice 11≦ is a blister sheet and the cap part is a blister cover sheet that leaks by applying heat and pressure.

このグループの実施態様は第１７図および第１８図に示
しである。第゛１７図はキャップ２と内部に仕切壁５に
よｐ分＾１Ｌちれた二つの区画奮弔ブーるボディ１とを
有する区画に仕切られたカプセルの分解斜視図である。Embodiments of this group are shown in FIGS. 17 and 18. FIG. 17 is an exploded perspective view of a capsule divided into compartments having a cap 2 and a body 1 having two compartments separated by a partition wall 5 by a distance of p^1L inside.

区画の各々は異なる医薬を収納している。第１８図は第
１７図の区−に仕切られたカプセルを閉ざして１８１８
線に沿って裁った断面図でメジ、区画１１および１２の
中の異なる医薬が完全に分Ｎ＋ｈされている状態ケ示し
ている。Each compartment contains a different medication. Figure 18 shows the capsule partitioned into sections shown in Figure 17 closed and 1818
The cross-sectional view taken along the line shows that the different medicines in compartments 11 and 12 are completely separated.

集１９図は開口端部において軸線方向に雨接した２個の
キャップ２を示した本発明の別の実施態様の区画に仕切
られたカプセルの頂部平面図である。Figure 19 is a top plan view of a compartmentalized capsule of another embodiment of the invention showing two caps 2 axially in contact at the open end.

第２０図は開口端部において食接した２個のキャップ２
を示した、第１９図を２０−２０線で裁った断面図であ
る。キャップ２の内部には、一体に成形されたディスク
または仕切壁５により異ｌる医榮ケ収納ず６ン′ζめの
２１１１１１１の区画１１．１２によシ分都δれ／ζ円
筒形ポテイ１が収納されている。区画１１．１２の中に
異なる医薬を光填した後に、２個のキャップ１の各々は
区ＩＩ！１１１１，１２の中の医薬を閉じ込めるように
ボディ１の上で各各のＣ１９０端部から入れ予成に接合
ちれる。キャップ１の一力は異なる治療上の必要条件の
ために冑の＋ａ！性分泌故中で浴解する物質で製造する
ことができよう。また、他方のキャップ１およびボディ
２は腸溶性物質で製造することができよう。このように
して、一つの区画の中の医薬の一方は患者の胃の内部で
崩壊させることができ、一方他方の区画中の異なる医薬
は患者の腸管で崩壊させることができる。キャップ１お
よびボディ２の相科および／または厚さを変えることに
より各々の区画１１．１２の崩急速度を制御することが
できる。Figure 20 shows two caps 2 that are in contact at the open end.
20 is a sectional view taken along the line 20-20 of FIG. 19. FIG. The interior of the cap 2 is provided with a cylindrical pot with an integrally molded disk or partition wall 5 to accommodate different medical devices and compartments 11 and 12 of the 6th section 2111111. 1 is stored. After filling the compartments 11.12 with different medicaments, each of the two caps 1 is loaded with compartment II! 1111, 12 are inserted from each C190 end on the body 1 and pre-bonded. Cap 1's power is +a of helmet for different therapeutic requirements! It could be made with a substance that dissolves in sexual secretions. The other cap 1 and body 2 could also be made of enteric material. In this way, one of the medicaments in one compartment can disintegrate inside the patient's stomach, while a different medicament in the other compartment can disintegrate in the patient's intestinal tract. By varying the phase family and/or thickness of the cap 1 and body 2, the rate of collapse of each compartment 11, 12 can be controlled.

不発ψＪの別の一つの特徴ｅユキャツブ部、分１および
ボディ部分２を第１８図、第１９図」６よび第２０図に
杆号Ｊでボした一合領域において平滑面を形成するよう
に接合することができることである。Another feature of the unexploded ψJ is that the yukatsubu part, part 1, and body part 2 are arranged so as to form a smooth surface in the joint area marked by rod number J in Figs. 18, 19, 6, and 20. It is possible to join.

３、　カプセルパッケージ カプセルパッケージは各小単位部分を使用するために破
断することができるように連結さｉｂた２個またはそれ
以上のカプセルからなっている。カプセルパッケージは
全体をの不込むように急回されておらず、むしろ例えば
谷小単位部分を短期的にのみ込まなければならない場合
に便利な貯蔵形態を提供することを慰図したものである
。従って、相互に連結された小単位部分の数はのみ込み
易いという必扱余件のために限定きｉｔていない。カプ
セルノぞツケージは１だグループ１０分割可能なカプセ
ルおよびグループ２の区ｉ［！ｌｌに仕切られたカプセ
ルを一括）ξツクするために１史月」することができる
。3. Capsule Package A capsule package consists of two or more capsules connected together so that each subunit part can be broken for use. Capsule packages are not intended to be rapidly swallowed whole, but rather to provide a convenient storage form where, for example, a small portion must be swallowed in the short term. Therefore, the number of interconnected sub-unit parts is not limited due to the necessity of easy swallowing. Capsule number cage is 1. Capsules that can be divided into 10 groups and group 2 division i [! It is possible to take 1 month to pick up the capsules partitioned into ll at once).

この実施態様は接合可能なキャップ部分およびボディ部
分からなる被数個の連結されたカプセルを崩する投与形
態の硬カプセルノゼツケージであシ、前記カプセルが相
互の連結部を有し、前記連結部が前記カプセルと一体に
成形され且つ前記連結部が塾らにカプセルを４１に医薬
の投与のためにｉ＋？ｌｌ々のカプセルに分離するよう
に破１す［可能であることをｌ特徴とする硬カプセル）
々ツケージである。This embodiment is a hard capsule nose cage of the dosage form that collapses several connected capsules consisting of a cap portion and a body portion that can be joined, said capsules having mutual connections, and said capsules having interconnected portions; The part is molded integrally with the capsule, and the connecting part connects the capsule to 41 for administering the medicine. [Hard capsule characterized by the fact that it can be broken to separate into individual capsules]
It is a cage.

このグループの一実施悪様は第２１図および第２２図に
示しである。第２１図は軸線に沿って！ｉｔ列したカプ
セルを示した頂部平面図である。One implementation of this group is shown in FIGS. 21 and 22. Figure 21 is along the axis! FIG. 3 is a top plan view showing the capsules arranged in a row.

第２２図はラメラ５によシ迎結されたカプセルボディ１
を示した第２１図を線２２で裁った断面図である。ラメ
ラ５はカプセルボディ１と同一の材料からなシ、そして
ダイ成形技術にょシ同時に製造される。投与パッケージ
のキャップ部分２は互いに連結されていない。ボディ部
分１およびキャップ部分２０両方は耐分離徊造を構成す
るようにロック装置を備えることができる。Figure 22 shows the capsule body 1 which is joined by the lamella 5.
21 is a sectional view taken along line 22. FIG. The lamella 5 is made of the same material as the capsule body 1 and is manufactured simultaneously using die molding technology. The cap parts 2 of the dosing package are not connected to each other. Both the body part 1 and the cap part 20 can be provided with a locking device so as to constitute a separation-resistant structure.

カプセルパッケージの別の一実施態様は第２３図および
第２４図に示しである。第２３図は一つの円に沿って配
置されたカプセルユニットを示した頂部平面図である。Another embodiment of a capsule package is shown in FIGS. 23 and 24. FIG. 23 is a top plan view showing capsule units arranged along one circle.

第２４図は接合部５によ）連結されたカプセルボディを
示した、第２３図を２４−２４　ｍに沿って裁った断面
図である。FIG. 24 is a sectional view taken along line 24--24 m of FIG. 23, showing the capsule body connected (by joint 5).

接合部５はカプセルボディ１と同じ桐材で製造すること
ができる。これらの接合部５はボディ部分１と同時に製
造される。ボディ部分１およびキャップ部分２はまたロ
ック装置を備えることができる。The joint 5 can be made of the same paulownia wood as the capsule body 1. These joints 5 are manufactured at the same time as the body part 1. The body part 1 and the cap part 2 can also be provided with a locking device.

二種の異なる医薬を組み合わせるためのカプセルパッケ
ージの別の実施ｊン様ｒ第２５図および第２６図にボし
である。第２５図は接合部５によシ連結されたカプセル
盆ボした頂部平面図である。第２６図は第２５図を２６
−２６ｍに沿って裁った断面図であシ、ダイ成形によシ
同時に形成されたカプセルボティ部分１を示している。Another implementation of a capsule package for combining two different medicines is shown in Figures 25 and 26. FIG. 25 is a top plan view of the capsule tray connected by the joint 5. Figure 26 is the same as Figure 25.
This is a sectional view taken along the line -26m, showing the capsule body part 1 formed simultaneously by die molding.

キャップ部分２は連結芒れていない。カプセルは互いに
Ｖ４接したボディ部分の中に二抛の医薬を充填すること
ができるように二列に配置された形態で示しである。The cap portion 2 is not connected. The capsules are shown arranged in two rows so that two medicaments can be filled into the body portions V4 to each other.

グリスターパッケージは医薬およびその他の安全性の高
い製品を充填するだめの既知のパッケージの形態である
。本発明の別の一つの特徴はブリスターに医薬を充填し
た後に熱および圧力を加えることによシー緒にシールさ
れるブリスターシートおよびカバーシートのブリスター
パンケージ構成部分から硬カプセルを形成できることで
ある。本発明においては、ブリスターパッケージ栴成部
分は水溶性で必シ且っ食用の萩水性皇合体から製造され
る。Glister packaging is a known form of packaging for filling pharmaceuticals and other high-security products. Another feature of the invention is that hard capsules can be formed from the blister pan cage components of a blister sheet and cover sheet that are sealed together by applying heat and pressure after filling the blister with the medicament. In the present invention, the blister package forming part is made from water-soluble and indispensably edible Hagi water-based material.

第２７図はカプセルブリスターパッケージの一実！態様
の頂部平面図でろシ、別個の区画１１．１２，１３．１
４・・・・・・を有するブリスターシート１０を示して
いる。第２８図は医薬を収納したブリスター区画１１，
１２，１３．１４・・・・・・をシールするように圧力
および熱葡加えることによシカバーシート１５がシール
されたブリスターシート１０を示した、第２７図を２８
−２８線で裁った断面図である。カバーシート１５とブ
リスターシート１０との接合部には、ブリスター区画１
３．１４・・・川の分離線を形成するように穴１６紮形
成することが、できる。第２９図、第６０図、第３１図
および第３２図は第２７図および第２８図に使用された
符号と同じ杓−号葡使用してカプセルフリスターパンケ
ージの別の火ＪＡｒＪ）Ｋ！４Ｊｋを示している。Figure 27 is a capsule blister package! In a top plan view of the embodiment, the filter, separate compartments 11.12, 13.1
A blister sheet 10 having 4... is shown. FIG. 28 shows a blister compartment 11 containing medicines,
27 to 28 showing the blister sheet 10 with the cover sheet 15 sealed by applying pressure and heat to seal 12, 13, 14...
It is a sectional view taken along the -28 line. A blister compartment 1 is provided at the joint between the cover sheet 15 and the blister sheet 10.
3.14... It is possible to form 16 holes to form a river separation line. Figures 29, 60, 31 and 32 use the same numbers as those used in Figures 27 and 28 to separate the capsule frister pancakes. 4Jk is shown.

第２９図およびん３０図には、ブリスターシート１０オ
□よびカバーシート１５が対称の区画１３．１４荀治し
ている慣用のカッセルの形態の細長い横断ｍｉ　’ｃ　
Ｍするカプセルフリスターパッケージを示しである。FIGS. 29 and 30 show an elongated cross section in the form of a conventional cassette in which the blister sheet 10 and the cover sheet 15 cover symmetrical sections 13.14.
This figure shows a Capsule Frister package.

第３１図および第６２図には、省々の区画１１．１２が
内部に異なる医薬を収納するだめの小単位部分１７．１
８，１９．２０にそれぞれさらに区分されているカプセ
ルフリスターパッケージを丞してるる。In Figures 31 and 62, the various compartments 11.12 are shown as small unit parts 17.1 containing different medicines therein.
We carry Capsule Frister packages which are further divided into 8, 19 and 20 respectively.

本発明のすべτのカプセルの実施態様はカプセル拐科が
可塑化装置の中で溶ルｌされ次いで成りヒ型の中に射出
される射出成形機匝よシ製造することができる。成形型
が開かれるときに、膜力部分が放出もれる。本発明のカ
プセルを製造するために、フイ次ムキャスチング、射出
＆［、圧縮成形、吹出成形、深絞シ成形法およびその他
のグイ成形技術もまた使用することができる。All capsule embodiments of the present invention can be manufactured using an injection molding machine in which the capsule material is melted in a plasticizer and then injected into a mold. When the mold is opened, the membrane force part leaks out. Molding, injection molding, compression molding, blow molding, deep drawing and other molding techniques can also be used to produce the capsules of the present invention.

本発明はまたカプセル部分を接合する場合にカプセルの
シールおよび接合を含むことができる。接合されたカプ
セル部分のシールまたは結合によシカプセルの分離およ
び不正操作をさらに阻止し且つカプセルを液密、蒸気密
および気密にする付加的な固定が得られる。The invention may also include sealing and joining the capsule when joining the capsule parts. The sealing or bonding of the joined capsule parts provides additional fixation that further prevents separation and tampering of the capsule and renders it liquid-tight, vapor-tight and gas-tight.

本発明によ＃）製造されたカプセルは医薬を投与する目
的ならびに色素、化学薬品、香辛料、植物用の肥料の組
合わせ、保繰物質を含む肥料、種子、化粧品、農業製品
等の正確な量？投与するために使用することができる。Capsules manufactured according to the present invention are used for the purpose of administering medicines as well as precise quantities of dyes, chemicals, spices, combinations of plant fertilizers, fertilizers containing storage substances, seeds, cosmetics, agricultural products, etc. ? Can be used to administer.

この明細書に開示した事項が本発明を例示する目的のた
めのみであシ且つ本発明が特許請求の範囲内に該当する
すべての変型および同等の変更を仮台していることｔ理
月１すべきである。The matter disclosed in this specification is for the purpose of illustrating the invention only, and the invention is intended to cover all modifications and equivalent changes that fall within the scope of the claims. Should.

４８図１用のｈｉＪ身（なｉ兄ゆ」 第１図、第２図、第３図および第４図は分割ν」能な備
カプセルのグループの一笑施態様を示した図、第５図お
よび第６図は４個の小単位部分をイ〕するカプセルの別
の実施態様を示した図、椙７し１ないし第１２図はボデ
ィ部分およびキャップ部分が弱い接合部によシ連結され
た別の実施慝様を示し／ヒ図、紀１３図および第１４図
はカプセルが内相リバ１（分と２個の外側部分とをイｊ
する３個の小単位部分葡俯えた別の実施態様を示した図
、２＋’、　１ｓ図＊ｓ　ｘヒｈ＝　１６　ｕｉｔ外１
ｔｔｔｌ　部＋）　カ千円形に形成された別の実施態様
を示した図、第１７図はギヤツブ部分上仕切壁によシ分
離された２個の区画を冶するボディとを鳴する区画に仕
切られたカプセルの分解斜視図、第１８図１閉ざされた
状態の第１７図の区画に仕切られたカプセルを１８−１
８＆！に沿って裁った断面図、第１９図は開口端部にお
いて衝接した２個のキャップを示した不発明の区画に仕
切られたカプセルの別の態様を不しだ図、第２０図は一
口端部において衝接した２個のキャップを下した第１９
図を２０−２０線で裁った断面図、第２１図は軸線に沿
って整列したカプセルを示したｍ部平面図、第２２図は
ラメラにより連結されたカプセルボディを示した、第２
１図を２２−２２　＋１１ｉ！に沿って裁った断面図、
第２３図は一つの円に沿って配置されたカプセルユニッ
トを示した頂部平面図、第２４図は接合部によシ連結さ
れたカプセルボディを示した、第２３図を２４−２４　
線に沿って裁った断面図、第２５図は接合部によって連
結されたカプセルを示したカプセル／′！ツケージの頂
部平面図、第２６図はダイ成形によル同時に成形された
カプセルボディを示した、第２５区を２６−２６線に沿
って裁つ７’Ｃ〜１面図、第２７図は別１１んのブリス
ター区画葡殉するブリスターシートｆニア１ζしたカプ
セルブリスターパッケージの一実施態様の頂部平面図、
第２８図は医薬を収納したブリスター区画ヶシールする
ように圧力および熱を力１１えることによシカバーシー
トがシールされたブリスターシートを示した。第２７図
ケ２ａ−２８−線に沿って裁つ／ヒ断面図、第２９図、
第３０図、第６１図および第６２図はカプセルフリスタ
ーパッケージの別の実施態様ケ示した図である。48 Figures 1, 2, 3, and 4 are diagrams showing a laughing embodiment of a group of divided capsules, and Figure 5. and FIG. 6 shows another embodiment of the capsule having four subunit parts, and FIGS. 7 to 12 show the body part and the cap part connected by a weak joint. An alternative embodiment is shown in Figures 13 and 14, in which the capsule has an inner portion and two outer portions.
A diagram showing another embodiment of three small unit parts, 2+', 1s diagram*s
Figure 17 is a diagram showing another embodiment formed in a 1000-circle shape, with a gear part partitioned into a body that defines two compartments separated by an upper partition wall and a compartment that sounds. An exploded perspective view of the capsule in the closed state, FIG. 18-1.
8&! FIG. 19 is a cross-sectional view of another embodiment of the inventive compartmentalized capsule showing two caps abutting at the open end; FIG. No. 19, where the two caps that collided at the mouth end were lowered.
21 is a cross-sectional view taken along the line 20-20, FIG. 21 is a plan view of the m section showing the capsules aligned along the axis, and FIG. 22 is the second section showing the capsule bodies connected by lamellae.
1 figure 22-22 +11i! A cross-sectional view cut along the
23 is a top plan view showing capsule units arranged along a circle; FIG. 24 is a top plan view showing capsule bodies connected by joints; FIG.
A cross-sectional view taken along the line, Figure 25, shows capsules connected by joints /'! Figure 26 is a plan view of the top of the cage, and Figure 26 shows the capsule body molded at the same time by die molding. A top plan view of one embodiment of a capsule blister package with 11 blister compartments and blister sheets near 1ζ;
Figure 28 shows a blister sheet in which the cover sheet has been sealed by applying pressure and heat 11 to seal the blister compartment containing the medicament. Fig. 27 - Cross-sectional view cut along line 2a-28-, Fig. 29,
FIGS. 30, 61 and 62 illustrate alternative embodiments of capsule frister packages.

１・・・ボディｒ５Ｌ〜分、２・・・キャップ部分、５
・・・ラメラ（接合部）、１０・・・ブリスターシート
、１１．１２，１３．１４・・・ブリスター区画、１５
・・・カバーシート、１６・・・穴、１７．１８．１９
．２０・・・小単位部分。1...Body r5L ~ minute, 2...Cap part, 5
... Lamella (junction), 10... Blister sheet, 11.12, 13.14... Blister section, 15
...Cover sheet, 16...Hole, 17.18.19
．． 20...Small unit part.

４’９Ｆｉｉ’ｌ・出願人　ワーナーーランバート・コ
ンパニー化　埋　人　ラＰ用１±　山　下 し１面の浄書（内容に変更なし） ＦＩＧ、　１ ＦＩＧ、　６ ＦＩＧ　７ ＦＩＧ　８ ＦＩＧ　ｌｏ ５ ＦｌＧ、１ｌ ＦＩＧ、　１２ ＦＩＧ　＋３ ＦＩＧ　１４ ＦＩＧ　＋５ ５　９ ＦＩＧ　＋６ ＦＩＧ、　１９ ＦＩＧ、２○ ＦＩＧ　２１ ＦＩＧ、２２ ＦＩＧ、　２３ ＦｌＧ、２４ ＦＩＧ、　２７ ＦｌＧ２８ ＦｌＧ、２９ ＦｌＧ、３０ ＦＩＧ、　３１ ＦｌＧ、３２ 手続補正書（方式） 昭和６（）年　１　ＪＪ２５日 特許庁長官　志　賀　学　殿 １、事件の表示 昭和５９年特許願第２３０４７６号 ２、発明の名称 投与形態のカプセル ３、補正をする者 事１４との関係　特許出願人 名称　ワーナーーランパ′−ト・コンパニー６・“１ｉ
ｊＩ″−ｎｊｏＩ”　イ、１，１ヶ。１１ゆ、、−１゜
およ、□１□ｌ補正の内容 別紙のとおシ下記の書＠全提出します。4'9Fii'l・Applicant: Warner-Lambert Compagnie, buried person, 1± for LAP, engraving of page 1 (no changes in content) FIG, 1 FIG, 6 FIG 7 FIG 8 FIG lo 5 FlG, 1l FIG, 12 FIG +3 FIG 14 FIG +5 5 9 FIG +6 FIG, 19 FIG, 2○ FIG 21 FIG, 22 FIG, 23 FlG, 24 FIG, 27 FlG28 FlG, 29 FlG, 30 FIG, 31 F lG, 32 Procedural amendment (Method) Manabu Shiga, Commissioner of the Japan Patent Office, 1 JJ 25, 1982, 1, Indication of the case, Patent Application No. 230476 of 1982, 2, Title of the invention: Capsule 3, Administration form, Article 14 of the person making the amendment. Related Patent Applicant Name Werner-Lampert Company 6 “1i
jI″-njoI” I, 1,1 piece. 11 Yu,, -1゜, □1□l Contents of the amendment Please submit the following document @ in its entirety.

１、委任状およびその訳文 ２、　図面浄書（内容に変更なしλ 以上1. Power of attorney and its translation 2. Drawing engraving (no changes to the content) that's all

Claims (1)

【特許請求の範囲】 （１）接合’ｆｉＪ能なキャップ部分およびボディ部分
からなる複数個の連結された小単位部分を有する分割可
能な投与ル態の硬カプセルであって、前記ボディ部分が
相互の連結部ケ有し、前記連結部が前＋ｉ３ボディ部分
と一体に成形され且つ前記連結部がカプセルを小単位部
分に分離するようにさらに破断可能であることを特徴と
する分割可能な投与形態の鋏カプセル。 （２）　前記キャップ部分が相互の連結部を有している
ことをｑ″！ｒ徴とするｌ特許請求の範囲第１項に記載
の分割ＢＪ能な硬カプセル。 （３）　前記ボディ部分が相互の連結部を壱し且つ前記
キャップ部分が相互のラメラ連結部を鳴していることを
特徴とする特許請求の範囲第１項に記載の分割可能な硬
カプセル。 （４）　Ｒ＋Ｊ　ｉｉｄカプセル部分の一方がブリスタ
ーシートでオシ且つ他方のカプセル部分が熱および圧力
を加えるこ七によシシールちれたブリスターカバーシー
トであることケ特徴とする特許請求の範囲第１項に記載
の分割可能な硬カプセル。 （５）接合可能なキャップ部分およびボディ部分からな
る複数個の連結されたカプセルを有する。Ｊツケージ形
の投与形態の硬カプセルであって、前記カプセルが相互
の連結部を有し、前記連結部が前記カプセルと一体に成
形され且つ前記連結部がカプセルを個々のカプセルに分
離するようにさらに破断可能であることを特徴とする特
許請求の範囲第１埃に記載のパッケージ形の投与形態の
硬カプセル。 （６）　前記カプセル部分の一方がブリスターシートで
あり且つ油力のカプセル部分が熱および圧力τ力ｌえる
ことによシシールされたブリスターカバーソートである
ことに’ｌな徴とする特目′ｒ請求の範囲第５項に記載
の硬カプセルノ七ツケージ。 （７）　キャップ部分およびボディ部分からなる投与形
態の区画に仕切られ／こ破カプセルであって、￥３ｉｌ
韻ボディ部分が医薬の投与のために接合８れたときに前
記ボディ部分およびｎｉＪ記キャップＩＩｊ分の内ｎ１
Ｓに弔に医薬のノこめの２個またはそれ以上の区画音形
成するようにその内部に一体に成形された１個またはそ
れ以上の内ｔｌｉ１１仕切壁イ仕切壁上ていることを特
徴とする区画に仕切られた硬カプセル。 （８）　ｔｊ１＋　Ｍ己キャップ部分および／址たをま
ボディ部分がｔＷいラメラｅ（より相互に連結されｔ　
ｒ２ｉＪ記連赤占部が破ロノ１自Ｊｈｉニであることを
特徴とする特許許藺求の範囲第１項から第５項までの各
項および第７項のいずれか１項に記載の投与形態の硬カ
プセル。 （９）キャップ部分およひボディ部分からなる投−布形
態の区画に仕切られた硬カプセルであってＳ　６ｉ＋記
ボデボディが接合されたときにＤｉｔ記ボデボ１４部分
び前記キャップ部分の内部に医薬のための２個またはそ
れ以上の区画音形成するように内部に一体に成形された
１個またはそれ以上の内側仕切壁を有している乙さを特
徴とする’４：Ｊ’　請求の範囲第７項または第８項に
記載の投与形態の区画に仕切られた硬カプセル。 （１０〕前記ボデイ部分が軸線に垂直であυ且り対向し
た開口端部に平行な内側仕切壁を備えた管状部材でメシ
、前記ＨＦｊＤ　５’１部の各々がキャップによシ閉ざ
されて内部に区画を形成していることをｌ１萼徴とずる
特肝ｍｌ求の範囲第９項にｂピ載の区画に仕切られたイ
便カプセル。 （　１　１　）　ｆ３Ｊ記ボデイ都分がブリスターシー
トでアシ且つ前記キャップ部分が熱および圧力を加える
ことによ夛シールされたブリスターカバーシートである
ことを特徴とする特ｉ″［請求の範囲第９項に記載の区
画に仕切られたイ吠カプセノレ　。 （１２）　８ｉ１記投与形態のカプセルが５〜２５虚組
％（親水性重合体組成物に刻してｄ［′ノ１ンの水分を
鳴ずる親水性重合体組成物またｈこのような重合体の混
合物、そしてセラチン組成物から形成する場合には１０
〜２　０　Ｍ　Ａｔ％（セラチン組成物に対して剖ｔＶ
．）の水分を有する七うテン組成物且つ／また１１５〜
２５皿Ｍ．チ（殿粉組成物に対して計′＃．）の水分を
有する殿粉または殿粉組成物から射出成形によ如製造さ
れていることを特徴とする特＋１＋−請求の範囲第１項
から＄１０項までのいずれか１　ＪＪ｛に記載の分割可
能な硬カプセル。 （１６）殿粉組成物から製造されていること葡４’ｒ鰍
とする％肝請求の範囲第１２項にｍｌ載の分割可能な硬
カプセル。 （１４）医薬投与の目的なわびに色素化学系品、香辛料
、稙物用の肥料の組合わせ、保ｈ！１！物負を言む肥料
、硬子、化粧品、農業製品忙正確に定１を投与するだめ
の特δｆｂｎ求の範囲多１１１唄から第１３項までのい
づれか１項に記載の分割可能な硬カプセルの使用。 （１５）医薬、色素、化学薬品、香辛料、肥料、イ皇子
、化粧品゛または農業製品を言獅していることを特徴と
する特ｌｆ請求の範囲第１項から第１４項までのいずれ
か１項に記載の投与形態のカプセル。Scope of Claims: (1) A hard capsule in the form of a divisible dosage unit having a plurality of connected sub-unit parts consisting of a cap part and a body part which can be joined, wherein the body parts are mutually connected. a splittable dosage form, characterized in that said linkage is integrally molded with the front+i3 body part and that said linkage is further rupturable to separate the capsule into subunit parts. scissors capsule. (2) The split BJ capable hard capsule according to claim 1, wherein the cap portion has a mutual connection portion as a q″!r feature. (3) The body portion is The splittable hard capsule according to claim 1, characterized in that the cap portion has a mutual connecting portion and the cap portion connects the mutual lamellar connecting portion. (4) R+J iid capsule portion The splittable hard disk according to claim 1, wherein one of the capsule parts is a blister sheet and the other capsule part is a blister cover sheet that is sealed by applying heat and pressure. Capsule. (5) A hard capsule in the form of a J-cage dosage form having a plurality of connected capsules consisting of a cap part and a body part which can be joined, the capsules having mutual connections, Packaged dosage form according to claim 1, characterized in that a connecting part is molded integrally with the capsule and that the connecting part is further breakable to separate the capsule into individual capsules. (6) One of the capsule parts is a blister sheet, and the oil capsule part is a blister cover sort sealed by applying heat and pressure. Special Features'r Seven hard capsule cages according to claim 5. (7) A capsule divided/broken into dosage form compartments consisting of a cap part and a body part, costing ¥3il.
When the body parts are joined together for the administration of a medicament, said body part and the cap IIj part n1
S is characterized by two or more compartments of the medicinal compartment having one or more internal partitions integrally molded therein so as to form a partition wall. Hard capsule divided into compartments. (8) tj1+ M's cap part and/or body part are tW thin lamellae (more interconnected and t
The administration according to any one of paragraphs 1 to 5 and paragraph 7 of the patent application, characterized in that the r2iJ record is HARONO1JJHINI. Hard capsule in the form. (9) A hard capsule partitioned into a capsule-shaped compartment consisting of a cap portion and a body portion, in which when the S6i+ body body is joined, there are 14 body portions and the inside of the cap portion. '4:J' characterized by a wall having one or more internal partition walls integrally molded therein to form two or more compartments for the A compartmentalized hard capsule of the dosage form according to paragraph 7 or 8. (10) The body part is a tubular member having an inner partition wall perpendicular to the axis and parallel to the opposing opening ends, and each of the HFjD 5' parts is closed by a cap. A capsule divided into the compartments listed in b in the range of characteristic liver ml, which is characterized by the formation of compartments inside the calyx. and the cap portion is a blister cover sheet sealed by applying heat and pressure. (12) Capsules of the dosage form 8i1 may contain 5 to 25% imaginary composition (a hydrophilic polymer composition in which the hydrophilic polymer composition contains d 10 when formed from a mixture of polymers and a seratin composition.
~20 M At% (at tV for the Seratin composition)
．． ) and/or 115~
25 dishes M. The invention is characterized in that it is produced by injection molding from a starch or a starch composition having a water content of Any one of items up to $10 JJ { The divisible hard capsule described in 1 JJ {. (16) Dividable hard capsules in ml according to claim 12, which are manufactured from a starch composition. (14) For the purpose of pharmaceutical administration, a combination of pigment chemical products, spices, and fertilizers for growing crops, h! 1! The splittable hard capsule described in any one of paragraphs 111 to 13 of the range of characteristics δfbn required for accurately administering a certain amount of fertilizers, corns, cosmetics, and agricultural products. use. (15) Any one of claims 1 to 14, characterized in that it refers to medicines, pigments, chemicals, spices, fertilizers, cosmetics, or agricultural products. Capsules of the dosage form described in Section 1.
JP59230476A 1983-11-04 1984-11-02 Dosage form capsules Expired - Lifetime JPH0673539B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54879483A 1983-11-04 1983-11-04
US548794 1983-11-04
US64166484A 1984-08-17 1984-08-17
US641664 1984-08-17

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Publication Number Publication Date
JPS60132562A true JPS60132562A (en) 1985-07-15
JPH0673539B2 JPH0673539B2 (en) 1994-09-21

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BE (1) BE900950A (en)
CH (1) CH661878A5 (en)
DE (1) DE3438656A1 (en)
FR (1) FR2554418B1 (en)
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CH661878A5 (en) 1987-08-31
BE900950A (en) 1985-04-30
FR2554418A1 (en) 1985-05-10
GB8427523D0 (en) 1984-12-05
JPH0673539B2 (en) 1994-09-21
FR2554418B1 (en) 1989-11-24
IT1178193B (en) 1987-09-09
GB2148841B (en) 1987-07-01
DE3438656A1 (en) 1985-05-23
GB2148841A (en) 1985-06-05
IT8449110A0 (en) 1984-11-02

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