JPS6013254A - Detection of contamination for flow through type analyzer - Google Patents
Detection of contamination for flow through type analyzerInfo
- Publication number
- JPS6013254A JPS6013254A JP58121392A JP12139283A JPS6013254A JP S6013254 A JPS6013254 A JP S6013254A JP 58121392 A JP58121392 A JP 58121392A JP 12139283 A JP12139283 A JP 12139283A JP S6013254 A JPS6013254 A JP S6013254A
- Authority
- JP
- Japan
- Prior art keywords
- contamination
- electrode
- degree
- standard solution
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
- G01N27/4165—Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
Description
【発明の詳細な説明】
イ、産業上の利用分野
本発明は、フロースル型分析装置の流路内の汚れ検出方
法に関する。DETAILED DESCRIPTION OF THE INVENTION A. Field of Industrial Application The present invention relates to a method for detecting contamination in a flow path of a flow-through type analyzer.
口 従来技術
フロースル型電極を使用した分析装置は、一端が試料吸
引ポンプに、他端がサンプリングノズルにパイプにより
連通ずるセル内にセンサ電極を浸清し、サンプリングノ
ズルから吸引した試料をセルを通して廃液槽に搬送する
過程でセンサ電極によりＰＨやイオン濃度を連続的に測
定するものである。Conventional technology Analyzers using flow-through type electrodes immerse the sensor electrode in a cell that is connected to a sample suction pump at one end and a sampling nozzle at the other end via a pipe, and the sample sucked from the sampling nozzle is passed through the cell to waste liquid. During the process of transporting to the tank, the pH and ion concentration are continuously measured using sensor electrodes.
このような分析装置によってｆｆｌｌｌ間の分析作業を
行なうと、ノズル、パイプ、電磁ブｆ、及び電極槽 等
の流路構成要素の内面やセンサ電極の表面に試料が付着
して汚染して検出ミスを生じるという不都合がある。When performing analysis between ffllll using such an analyzer, samples may adhere to the inner surfaces of flow path components such as nozzles, pipes, electromagnetic tubes, and electrode tanks, and the surfaces of sensor electrodes, resulting in contamination and detection errors. This has the disadvantage of causing
従来、このような不都合を解消するため、一定時間継続
して分析を行なうと、流路内に洗浄液を流して汚れを洗
節するようにしていた。Conventionally, in order to eliminate such inconveniences, a cleaning solution was flowed into the channel to wash away the dirt after continuous analysis for a certain period of time.
しかし、このような手法によると、汚染が軽微な場合に
も洗節を行なうことになるため、センサ７［極が強酸性
や強アルカリ性の洗浄液に曝され。However, according to such a method, washing is performed even when the contamination is slight, so that the electrodes of the sensor 7 are exposed to a strongly acidic or strongly alkaline cleaning solution.
その寿命を縮めるという問題があった。There was a problem of shortening its lifespan.
ハ１発明の目的
本発明は、このような問題に鑑み流路内及びセンサ電極
の汚染の程度を簡単な手法により的確に検出することが
できる汚れ検出方法を提案することを］］的とする６
二、発明の構成
すなわち１本発明の特徴とするところは、分析作業の開
始に先立って行なわれる標準液による校正時のセンサ心
極の電位差応答により汚染の程度を定量的に検出するよ
うにした点にある。C1 Purpose of the Invention In view of the above-mentioned problems, an object of the present invention is to propose a contamination detection method that can accurately detect the degree of contamination in a flow path and a sensor electrode using a simple method. 6 2. Structure of the Invention: 1. The feature of the present invention is that the degree of contamination is quantitatively detected by the potential difference response of the sensor core during calibration with a standard solution performed prior to the start of analysis work. That's the point.
ホ、実施例
そこで、以下に本発明の詳細を実施例に基づいて説明す
る。E. EXAMPLES The details of the present invention will now be explained based on examples.
第１図は、本発明が適用されるフロースル型分析装置の
一例を示す構成図であって、図中符号１は、一端が試料
吸引ポンプ２を介して廃液槽３に、他端がサンプリング
ノズル４に連通ずる電極槽で、分析対象に応じたセンサ
電極５を浸漬して構成されている。６は１校正作業時に
電極５の電位差応答速度を検出する微分回路で、これか
らの出力は微分出力測定回路７を介して汚れ表示器８に
入力して汚染の程度を定量的に表示し、同時に基準信号
発生器９からの要洗浄レベル設定信号が人力する比較回
路１０に入力して汚染が進行したる。なお、図中符号１
２．１３は、切り換え弁１４を介してそれぞれサンプリ
ングノズルに連通する２種類の濃度を持つ標準液Δ、Ｂ
を収容した標準液槽を、１５は、仕νＪ用空気層を形成
する空気取込み用の電磁ノ゛Ｃをそれぞれ示している。FIG. 1 is a configuration diagram showing an example of a flow-through type analyzer to which the present invention is applied, and reference numeral 1 in the figure indicates that one end is connected to a waste liquid tank 3 via a sample suction pump 2, and the other end is connected to a sampling nozzle. It is constructed by immersing a sensor electrode 5 according to the object to be analyzed in an electrode tank communicating with the electrode tank 4. 6 is a differential circuit that detects the potential difference response speed of the electrode 5 during one calibration operation, and the output from this is inputted to the contamination indicator 8 via the differential output measurement circuit 7 to quantitatively display the degree of contamination, and at the same time A cleaning level setting signal from the reference signal generator 9 is input to a manually operated comparison circuit 10, and contamination progresses. In addition, the code 1 in the figure
2.13 are standard solutions Δ and B having two different concentrations, each communicating with the sampling nozzle via the switching valve 14.
Reference numeral 15 indicates an electromagnetic valve C for taking in air which forms an air layer for the work vJ.
このように構成した装置の動作を第２図に示した波形図
に基づいて説明する。The operation of the apparatus constructed in this way will be explained based on the waveform diagram shown in FIG.
分析作業に先立って切り換え弁１４により電極槽１を濃
度が低い標準液Ａに連通し、ポンプ２を作動して電極槽
１に標準液Ａを注入すると、電極５は標準ｉｌｌの濃度
に比例したレベルＬｌの信号を出力する。これが定常値
に達した時点で、第１点の校正を行なう。この第１点の
校正が終わった時点で、電磁ＪＰ１５を短時間開いてパ
イプ内に空気層を形成し、同時に切り換えゴｆ１４を濃
度が高い標準液Ｂに切り換えると、電極槽ｌ内の標準液
の濃度が階段状に変化する。これにより電極５の電位差
出力は、流路内の汚染の程度に応じた頭側、つまり汚染
の程度が低いときには急な頭像１により、また汚染の程
度が高いときには緩やかな傾斜により増大する。この電
位差ＩＩ力の増大変化は微分回路６により微分され表示
器８により表示され、同時に比較回路１０により基準信
号と比較され、基準信号よりも低いときには警報器１１
を作動して分析装置の流路内の洗浄を促す。Prior to analysis work, the electrode tank 1 is connected to the standard solution A with a low concentration by the switching valve 14, and when the pump 2 is activated and the standard solution A is injected into the electrode tank 1, the electrode 5 is proportional to the concentration of the standard ill. Outputs a signal at level Ll. When this reaches a steady value, the first point is calibrated. When this first point calibration is completed, open the electromagnetic JP15 for a short time to form an air layer in the pipe, and at the same time switch the switch go f14 to the standard solution B with a higher concentration. The concentration changes stepwise. As a result, the potential difference output of the electrode 5 is increased on the head side according to the degree of contamination in the flow path, that is, by a steep head image 1 when the degree of contamination is low, and by a gentle slope when the degree of contamination is high. This increasing change in the potential difference II force is differentiated by a differentiating circuit 6 and displayed on a display 8. At the same time, it is compared with a reference signal by a comparator circuit 10, and when it is lower than the reference signal, an alarm 11 is activated.
is activated to promote cleaning of the flow path of the analyzer.
［実施例］
試料管路系を洗浄液により洗浄した直後に４ｍＥｑ／ｕ
のカリウム！夜を第１の標準液として注入し、次に６ｍ
Ｅｑ／文のカリウム液を第２の標準液として注入したと
ころ、両標準液の切り換え時の電極出力は、はぼ垂直に
立ち上がった（第３図工）。次に、この分析装置により
ヘパリン動作検体を１００検体分析した後、上述の２種
類の標準ｌｆｋを交“互に切り換えて電極からの出力を
調べたところ、その傾斜が少し緩やかとなり、その微分
出力は、洗浄直後の微分出力の８２％となった（ ＩＩ
）。さらに、上述の検体を１００検体分析したのち、
標準液の切り換え時の微分出力を調べたところ、６３％
にまで低下した（ＩＩＩ）。このことから省路系の汚染
の度合ど微分出力とが反比例して汚染の度合を定量的に
測定できた。[Example] Immediately after cleaning the sample pipe system with a cleaning solution, 4 mEq/u
of potassium! Inject 6 m as the first standard solution, then 6 m
When a potassium solution of Eq/m was injected as the second standard solution, the electrode output when switching between the two standard solutions rose almost vertically (Fig. 3). Next, after analyzing 100 heparin action samples using this analyzer, we alternately switched the two types of standard LFK mentioned above and examined the output from the electrode.The slope became a little gentler, and the differential output was 82% of the differential output immediately after cleaning (II
). Furthermore, after analyzing 100 of the above samples,
When we investigated the differential output when switching the standard solution, it was 63%.
(III). From this, it was possible to quantitatively measure the degree of contamination in the road system by being inversely proportional to the differential output.
なお、この実施例では標ｆｉ液を低儂度から高濃度に切
り換えるようにしたが、反対に高濃度から低濃度に切り
換えても同様の作用効果があることは明白である。In this example, the standard fi liquid was switched from a low concentration to a high concentration, but it is clear that the same effect can be obtained even if the standard fi liquid is switched from a high concentration to a low concentration.
へ、効果
以上、説明したように本発明によれば、２種類の標準液
の切り換え時に発生ずるセンサ出力の微分値により汚染
の程度を定量的にＡ１１ｌ定するようにしたので、電極
を含む管路系を適切な時期に洗浄することができ、過度
な洗浄による電極のノｆ命の短縮や分析ミスの発生を未
然に防止して信頼性の高い分析装置を実現することがで
きる。As described above, according to the present invention, the degree of contamination is determined quantitatively by the differential value of the sensor output generated when switching between two types of standard solutions, so that the tube containing the electrode The tract system can be cleaned at an appropriate time, and a highly reliable analytical device can be realized by preventing shortening of electrode life and occurrence of analysis errors due to excessive cleaning.
第１図は、本発明の方法が適用された装置の一一例を示
す構成図、第２図は、同上装置の動作を示す波形図、第
３図工、Ｉｌ、ＩＩＩは、それぞれ流路系の汚染と゛上
極電位差出力の関係を示す説明図である。
１・・・・電極槽 ２・・・・ポンプ
３・・・・廃液槽 ４・・・・サンプリングノズル５・
・・・センサ電極 １２．１３・・・・標準液槽出願人
株式会社 島津製作所
代理人 Ｊ１゛理士 西 川 慶 拍
回 木 村 勝 彦
竿／コ
悶ｑ■Ｃ
＄３回FIG. 1 is a configuration diagram showing an example of a device to which the method of the present invention is applied, FIG. 2 is a waveform diagram showing the operation of the same device, and FIG. 3 is a flow path system. FIG. 2 is an explanatory diagram showing the relationship between contamination and the output of the upper electrode potential difference. 1... Electrode tank 2... Pump 3... Waste liquid tank 4... Sampling nozzle 5.
...Sensor electrode 12.13...Standard liquid tank Applicant Shimadzu Corporation Agent J1゛Physician Kei Nishikawa Time Katsuhiko Kimura/Ko agon ■C $3 times
Claims (1)
ンサ電極を浸漬してなるフロースル型分析装置にそれぞ
れ濃度が異なる標準液を交互に注入し、−・力の標準液
から他方のｇ準液に切り換えたときに発生する前記電極
からの出力信号の微分値をめ、この値に基づいて前記分
析装置の汚染のＰ１度を判定するフロースル型分析装置
の汚れ検出方法。Standard solutions with different concentrations are alternately injected into a flow-through type analyzer, which consists of a sensor electrode immersed in an electrode tank in which a sample flow path is formed from one end to the other. (g) A method for detecting contamination of a flow-through type analyzer, in which the differential value of the output signal from the electrode generated when switching to a quasi-liquid is calculated, and the P1 degree of contamination of the analyzer is determined based on this value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58121392A JPS6013254A (en) | 1983-07-04 | 1983-07-04 | Detection of contamination for flow through type analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58121392A JPS6013254A (en) | 1983-07-04 | 1983-07-04 | Detection of contamination for flow through type analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6013254A true JPS6013254A (en) | 1985-01-23 |
Family
ID=14810056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58121392A Pending JPS6013254A (en) | 1983-07-04 | 1983-07-04 | Detection of contamination for flow through type analyzer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6013254A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0281194A2 (en) * | 1987-03-03 | 1988-09-07 | Yokogawa Europe B.V. | Method and device for testing ion sensitive electrodes and system for monitoring of an ion concentration |
| EP0419769A2 (en) * | 1989-09-29 | 1991-04-03 | Mettler-Toledo AG | Method for continuously monitoring an electrode system for potentiometric measurements |
| CN108431599A (en) * | 2015-12-22 | 2018-08-21 | 雷迪奥米特医学公司 | Detect the method that whether there is grumeleuse in fluid specimen sample analysis instrument |
| JP2019184301A (en) * | 2018-04-04 | 2019-10-24 | キヤノンメディカルシステムズ株式会社 | Autoanalyzer |
-
1983
- 1983-07-04 JP JP58121392A patent/JPS6013254A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0281194A2 (en) * | 1987-03-03 | 1988-09-07 | Yokogawa Europe B.V. | Method and device for testing ion sensitive electrodes and system for monitoring of an ion concentration |
| EP0419769A2 (en) * | 1989-09-29 | 1991-04-03 | Mettler-Toledo AG | Method for continuously monitoring an electrode system for potentiometric measurements |
| CN108431599A (en) * | 2015-12-22 | 2018-08-21 | 雷迪奥米特医学公司 | Detect the method that whether there is grumeleuse in fluid specimen sample analysis instrument |
| JP2018534579A (en) * | 2015-12-22 | 2018-11-22 | ラジオメーター・メディカル・アー・ペー・エス | Method for detecting the presence or absence of clots in a liquid sample analyzer |
| CN113156098A (en) * | 2015-12-22 | 2021-07-23 | 雷迪奥米特医学公司 | Method for detecting the presence of a clot in a liquid sample analyzer |
| US11226328B2 (en) | 2015-12-22 | 2022-01-18 | Radiometer Medical Aps | Method of detecting the presence or absence of a clot in a liquid sample analyzer |
| JP2019184301A (en) * | 2018-04-04 | 2019-10-24 | キヤノンメディカルシステムズ株式会社 | Autoanalyzer |
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