JPS5982838A - Contact medium of probe for utrasonic tomographic apparatus - Google Patents
Contact medium of probe for utrasonic tomographic apparatusInfo
- Publication number
- JPS5982838A JPS5982838A JP19415382A JP19415382A JPS5982838A JP S5982838 A JPS5982838 A JP S5982838A JP 19415382 A JP19415382 A JP 19415382A JP 19415382 A JP19415382 A JP 19415382A JP S5982838 A JPS5982838 A JP S5982838A
- Authority
- JP
- Japan
- Prior art keywords
- gel
- probe
- contact medium
- thickness
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は超音波診断装置用探触子の接触媒体に関するも
のである。さらに、本発明は含水率７０％以上で実質的
に気泡を含まず、針入度が３０ｍｍ以下のゲル硬度を有
する厚さ５ｍｍ以上の高分子含水ゲルからなる超音波診
断装置用探触子の接触媒体に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a contact medium for a probe for an ultrasonic diagnostic device. Furthermore, the present invention provides a probe for an ultrasonic diagnostic device made of a polymer hydrogel with a thickness of 5 mm or more, which has a water content of 70% or more, is substantially free of air bubbles, and has a gel hardness with a penetration depth of 30 mm or less. It concerns the contact medium.
近年、人体内の器官の異常の有無や皮膚、皮下組織の検
査、あるいは胎児心拍動や血流の脈動等の検出に超音波
診断装置が普及し多くの医療機関で手軽に使用されるよ
うになった。この診断装置を用いて検査を行う際には通
常、探触子と人体の皮膚の間での超音波の減衰を防ぐた
め水、植物油、鉱物油、グリセリン、流動パラフィン、
あるいは無定形のゲルを塗りつけたり、自己粘着性のフ
ィルムを当てたりしている。水や油、流動パラフィン等
の液体を塗布する場合は接触媒体としての厚味はせいぜ
い１〜２ｍｍまでであり、油や流動パラフィン等の場合
は診断後被診断者の皮膚からきれいにぬぐい取る必要が
ある。また接触媒体として厚さを必要とする場合は水浸
法と称してプラスチック製の水袋に水を入れでこれを被
診断者の測定部位に当てているが、この場合使用する水
は超音波の■エコーを防ぐため脱気水を用いる必東があ
り、また氷袋を用いる場合水がこぼれるおそれがある。In recent years, ultrasonic diagnostic equipment has become popular and easily used in many medical institutions to detect abnormalities in organs within the human body, examine the skin and subcutaneous tissues, and detect fetal heartbeats and blood flow pulsations. became. When performing tests using this diagnostic device, water, vegetable oil, mineral oil, glycerin, liquid paraffin, etc. are usually used to prevent ultrasound from attenuating between the probe and the human skin.
Alternatively, they smear an amorphous gel or apply a self-adhesive film. When applying a liquid such as water, oil, or liquid paraffin, the thickness of the contact medium is at most 1 to 2 mm, and in the case of oil or liquid paraffin, it must be wiped cleanly from the skin of the patient after diagnosis. be. In addition, when a thick contact medium is required, the water immersion method is used, in which water is placed in a plastic water bag and applied to the measurement area of the patient. ■It is necessary to use degassed water to prevent echoes, and there is a risk of water spilling if ice bags are used.
無定形のゲルを用いる場合は厚みの調節は水や油より広
範囲で可能であるがせいぜい１〜２ｃｍ位に止まる。し
かも探触子の移動により崩れやすく厚みを一定に出来な
いし、診断後にはぬぐい去る必要がある。自己粘着フィ
ルムの場合は厚みは一定になり診断後容易に剥離出来る
が厚みはせいぜい１ｍｍ以下である。When using an amorphous gel, the thickness can be adjusted over a wider range than with water or oil, but it is limited to about 1 to 2 cm at most. Moreover, it tends to crumble due to the movement of the probe, making it impossible to maintain a constant thickness, and it must be wiped off after diagnosis. In the case of a self-adhesive film, the thickness is constant and can be easily peeled off after diagnosis, but the thickness is at most 1 mm or less.
これに対し、本発明にまる超音波診断装置用探触子の接
触媒体は含水率７０％以上で弾性があり、針入度が３０
ｍｍ以下のゲル硬度を有する含水ゲルであり探触子と皮
膚の間に挿入することにより超音波の減衰をほぼ完全に
防止することが出来、しかも診断時に接触媒体を単に皮
膚の上に乗せるだけで皮膚との密着性も良く、診断後も
洗い流すことなく単に取り外せば良い。したがって被診
断者に不快感を全く与えることなく診断が可能である。In contrast, the contact medium of the probe for ultrasonic diagnostic equipment according to the present invention has a water content of 70% or more, is elastic, and has a penetration depth of 30%.
It is a water-containing gel with a gel hardness of less than mm, and by inserting it between the probe and the skin, it can almost completely prevent attenuation of ultrasonic waves, and during diagnosis, simply place the contact medium on the skin. It also has good adhesion to the skin, so even after diagnosis, you can simply remove it without washing it off. Therefore, diagnosis can be performed without causing any discomfort to the person to be diagnosed.
また水袋を使用する場合の煩雑な脱気水の作製も不要で
ある。さらに本発明による含水ゲルは充分な強度を有し
、たとえばエコー法で断面像を得る際探触子を左右に移
動させて診断を行うが、この際ゲルが崩れる心配もない
。Further, there is no need to prepare complicated deaerated water when using a water bag. Furthermore, the hydrous gel according to the present invention has sufficient strength, and there is no fear that the gel will collapse during diagnosis by moving the probe from side to side when obtaining a cross-sectional image using an echo method, for example.
最近超音波診断装置の開発が進み診断目的に応じた接触
子が開発されている。たとえば局部の検出精度を上げる
ため多数の振動素子の位相差を利用した電子フォーカス
式の探触子が用いられる。Recently, the development of ultrasonic diagnostic equipment has progressed, and contacts have been developed depending on diagnostic purposes. For example, in order to improve local detection accuracy, an electronic focusing probe that utilizes the phase difference between multiple vibrating elements is used.
この場合探触子の先端から集域までの距離は１つの探触
子については一定であり、被診断部位の皮膚表面からの
位置が変われば従来の接触媒体では厚みの調節が困難で
あり探触子を変換する必要があった。ところが本発明の
接触媒体はゲル強度が充分強く、ゲルを切断することに
よって容易に厚みを調節することが出来、また場合によ
っては二枚重ねで使用することも可能であり、上記電子
フォーカス式の探触子を用いた診断の際にも探触子を変
えることなく接触媒体の厚みの調節により皮膚表面から
の位置の異った部位の診断が行なえる利点がある。特に
最近市販されているリアルタイム表示の動的画像を得る
ような装置では探触子１本当りの価格が高く、これを各
種取り揃えることは経済的にも大きな負担となるが、本
発明による接触媒体を用いた場合は探触子が１本でも広
範囲の診断が可能になる。In this case, the distance from the tip of the probe to the focal area is constant for one probe, and if the position of the area to be diagnosed from the skin surface changes, it is difficult to adjust the thickness using conventional contact media, I had to convert the tentacles. However, the contact medium of the present invention has a sufficiently strong gel strength, and the thickness can be easily adjusted by cutting the gel, and in some cases, it is also possible to use two sheets stacked on top of each other. Even in diagnosis using a probe, there is an advantage that diagnosis can be performed at different positions from the skin surface by adjusting the thickness of the contact medium without changing the probe. Particularly in devices that obtain dynamic images with real-time display on the market these days, the price per probe is high, and having a variety of probes is a heavy economic burden. When using a single probe, it is possible to diagnose a wide range of areas with just one probe.
さらに、本発明による接触媒体はゲル強度が充分強いた
め場合によっては探触子の先端にはめ込んで使用するこ
とも可能である。このような使用により経直腸的診断が
容易になり、かつ鮮明な画像が得られる。また、例えば
臓器内の手術を行う場合は胸部を開腹した後直接臓器表
面に本発明による接触媒体をはめ込んだ接触子を当てる
ことにより臓器内部の診断が容易に行なわれ適切な手術
が迅速に行なえる利点を有する。Furthermore, since the contact medium according to the present invention has a sufficiently strong gel strength, it can be used by fitting it into the tip of a probe in some cases. Such use facilitates transrectal diagnosis and provides clear images. Furthermore, when performing surgery inside an organ, for example, by applying a contact in which the contact medium according to the present invention is embedded directly to the surface of the organ after opening the chest, the inside of the organ can be easily diagnosed and appropriate surgery can be performed quickly. It has the advantage of
本発明の利点は上に述べた他にエコー法による診断の場
合ゲルを構成する高分子の種類と含水率の組合せを適当
に調節することによりゲル密度を皮膚の密度により近く
することが可能であり、これにより皮層と接触媒体の音
響インピーダンスの差が小さくなり、したがって皮膚面
の超音波反射率が小さくなり、より鮮明な皮膚や皮下組
織のエコー像が得られる点にある。これに対して従来の
水浸法では水、プラスチック製水袋、皮膚間の音響イン
ピーダンスの不整合のため各境界面に多重エコーが出現
し皮膚面を中心とした鮮明なエコー像を得ることは困難
であった。In addition to the above-mentioned advantages, the present invention also has the advantage that, in the case of diagnosis using the echo method, it is possible to make the gel density closer to that of the skin by appropriately adjusting the combination of the type of polymer composing the gel and the water content. This reduces the difference in acoustic impedance between the skin layer and the contact medium, and therefore reduces the ultrasonic reflectance of the skin surface, making it possible to obtain clearer echo images of the skin and subcutaneous tissue. On the other hand, in the conventional water immersion method, multiple echoes appear at each interface due to the mismatch in acoustic impedance between water, plastic water bag, and skin, making it difficult to obtain a clear echo image centered on the skin surface. It was difficult.
本発明の接触媒体は高分子物質の含水ゲルから構成され
ており、尚分子物質の１成分としては充分なる強度と保
水性を持ち、含水率が７０％以上の含水ゲルが得られる
なら有機高分子物質か無機高分子物質かを問わない。た
とえばポリアクリルアミド、ポリヒドロキジエチルメタ
クリレート、ポリビニルアルコール（他のモノマーとの
共重合体を含む）、ポリビニルピリジン、ポリビニルピ
ロリドン、ポリビニルベンジルトリメチルアンモニウム
クロライド、ポリアクリル酸（またはＮａ塩、ＮＨ４塩
）、ポリアクリル酸エステル、ポリスチレンスルホン酸
、ポリエチレングリコール、ポリエチレンオキサイド（
またはそのエステル）、ホリリシン、ポリグルタミン酸
、ポリアミノスチレン、スチレン−無水マレイノ酸（ま
たはＮａ塩、ＮＨ４塩）共重合体、酢酸ビニル−無水マ
レイン酸（またはＮａ塩、ＮＨ４塩）共重合体、酢酸ビ
ニル−クロトン酸（またはＮａ塩、ＮＨ４塩）共重合体
、イソブテン−無水マレイン酸（またはＮａ塩、ＮＨ４
塩）共重合体等の有機合成高分子、カルボキシメチルセ
ルロース、ヒドロキシエチルセルロース。The contact medium of the present invention is composed of a hydrogel of a polymer substance, and has sufficient strength and water retention as a component of the molecular substance, and if a hydrogel with a water content of 70% or more can be obtained, an organic It does not matter whether it is a molecular substance or an inorganic polymer substance. For example, polyacrylamide, polyhydroxydiethyl methacrylate, polyvinyl alcohol (including copolymers with other monomers), polyvinylpyridine, polyvinylpyrrolidone, polyvinylbenzyltrimethylammonium chloride, polyacrylic acid (or Na salt, NH4 salt), polyacrylic acid ester, polystyrene sulfonic acid, polyethylene glycol, polyethylene oxide (
or its esters), folyricin, polyglutamic acid, polyaminostyrene, styrene-maleinoic anhydride (or Na salt, NH4 salt) copolymer, vinyl acetate-maleic anhydride (or Na salt, NH4 salt) copolymer, vinyl acetate - Crotonic acid (or Na salt, NH4 salt) copolymer, isobutene - Maleic anhydride (or Na salt, NH4 salt)
salt) organic synthetic polymers such as copolymers, carboxymethyl cellulose, hydroxyethyl cellulose.
メチルセルロース等の有機半合成高分子、でんぷん、グ
アーガム、カラギーナン、寒天、アルギン酸、デキスト
ラン、アミロース、ブルラン、セラチン等の有機天然高
分子、ポリケイ酸ナトリウム等の無機高分子が挙げられ
る。これらの中で実用上、ポリアクリルアミド、ポリヒ
ドロキシエチルメタクリレート，ポリビニルアルコール
（他のモノマーとの共重合を含む）、ポリアクリル酸エ
ステル、ポリビニルピロリドン、酢酸ビニル−無水マレ
イン酸（またはＮａ塩、ＮＨ４塩）共重合体、イソブテ
ン−無水マレイン酸（またはＮａ塩、ＮＨ４塩）共重合
体、カルボキシメチルセルロース、ヒドロキシエチルセ
ルロース、でんぷん、グアーガム、カラギーナン、寒天
、アルギン酸、デキストラン、プルラン、ゼラチン、ポ
リケイ酸ナトリウム等が好ましい。これらの高分子は単
独でも、あるいは他の高分子や、無機物との混合物や低
分子による架橋物、グラフト物等としても使用可能であ
り、また、高分子の重合度や、共重合組成、置換度等は
特に限定されるものではない。Examples include organic semi-synthetic polymers such as methylcellulose, organic natural polymers such as starch, guar gum, carrageenan, agar, alginic acid, dextran, amylose, bullulan, and ceratin, and inorganic polymers such as sodium polysilicate. Among these, polyacrylamide, polyhydroxyethyl methacrylate, polyvinyl alcohol (including copolymerization with other monomers), polyacrylic acid ester, polyvinylpyrrolidone, vinyl acetate-maleic anhydride (or Na salt, NH4 salt) ) copolymer, isobutene-maleic anhydride (or Na salt, NH4 salt) copolymer, carboxymethyl cellulose, hydroxyethyl cellulose, starch, guar gum, carrageenan, agar, alginic acid, dextran, pullulan, gelatin, sodium polysilicate, etc. are preferred. . These polymers can be used alone, or in mixtures with other polymers or inorganic substances, or as crosslinked or grafted products with low molecules. The degree etc. are not particularly limited.
本発明の接触媒体の製造方法は含水率が７０％以上で実
質的に気泡を含まず、針大度が３ｍｍ以下のゲル硬度を
有する厚さ５ｍｍ以上の含水ゲルが得られるならば如何
なる方法でもよく、製造方法が特に限定されるものでは
ない。たとえば、ポリアクリルアミドやポリビニルアル
コール等の水溶液への放射線照射、でんぷん等の水溶液
中でのアクリル酸エステルや酢酸ビニル等のセリウム塩
でのグラフト共重合、ジアルデヒド、エピクロルヒドリ
ン、ジビニル化合物等の低分子橋かけ剤によるポリビニ
ルアルコール、ポリアクリルアミド。The method for producing the contact medium of the present invention may be any method as long as it can obtain a hydrous gel having a water content of 70% or more, substantially free of air bubbles, a needle size of 3 mm or less, and a gel hardness of 5 mm or more. Well, the manufacturing method is not particularly limited. For example, radiation irradiation of aqueous solutions such as polyacrylamide and polyvinyl alcohol, graft copolymerization with acrylic esters and cerium salts such as vinyl acetate in aqueous solutions such as starch, and low molecular bridges such as dialdehydes, epichlorohydrin, and divinyl compounds. Polyvinyl alcohol and polyacrylamide with coating agents.
デキストラン、プルラン等の高分子の三次元網状化、ア
クリルアミド、ヒドロキシエチルメタクリレート等のモ
ノマーの固相重合による三次元網状化、ポリビニルベン
ジルトリメチルアンモニウムクロライド等のポリアニオ
ンとポリスチレンスルホン酸等のポリアニオンとの結合
、アルギン酸、カラギーナン等の金金属塩によるゲル化
、イノブテン−無水マレイン酸（またはＮａ塩、ＮＨ４
塩）共重合体等の変性架橋、寒天等のゲル等が列挙され
る。Three-dimensional network formation of polymers such as dextran and pullulan, three-dimensional network formation by solid phase polymerization of monomers such as acrylamide and hydroxyethyl methacrylate, bonding of polyanions such as polyvinylbenzyltrimethylammonium chloride and polyanions such as polystyrene sulfonic acid, Gelation with gold metal salts such as alginic acid and carrageenan, inobutene-maleic anhydride (or Na salt, NH4
Modified crosslinks such as salt) copolymers, gels such as agar, etc. are enumerated.
本発明の含水ゲルには主体となる高分子物質以外に短繊
維や繊維状物、無機物等の補強材を添加しでもよく、ま
た可塑剤やゲル化等、消泡剤等を添加してもよい。ただ
し、本発明の目的を達成するためには含水ゲルは超音波
に対して均質であることが必要であるため、これらの添
加物は含水ゲル中での分散は出米るだけ均一にし、含水
ゲル中に密度差を生ぜしめないようにする必要がある。In addition to the main polymeric substance, the hydrogel of the present invention may contain reinforcing materials such as short fibers, fibrous substances, and inorganic substances, and may also contain plasticizers, gelling agents, antifoaming agents, etc. good. However, in order to achieve the purpose of the present invention, the hydrogel needs to be homogeneous to ultrasonic waves, so these additives should be dispersed as uniformly as possible in the hydrogel, and It is necessary to avoid creating density differences in the gel.
本発明の含水ゲルの水分率は、含水ゲル中を超音波が通
過する際超音波の減衰をなるべく防ぎ、ゲルと皮膚との
密度差をより小さくするため出来るだけ高い方が好まし
く、少くともゲル重量全体の７０％以上は必要であり、
好ましくは８０％以上である。含水率が７０％より低い
場合は超音波の吸収係数が大きくなり、また皮膚の含水
率（約７０％以上）との差が大きくなって皮膚と含水ケ
ルの界面での超音波の吸収、反射が起り、鮮明な画像が
得られにくくなる。含水率の上限はゲル硬度により決ま
り、用いる高分子によって異なる。The moisture content of the hydrogel of the present invention is preferably as high as possible in order to prevent attenuation of ultrasonic waves as much as possible when the ultrasonic waves pass through the hydrogel, and to further reduce the difference in density between the gel and the skin. At least 70% of the total weight is required,
Preferably it is 80% or more. When the water content is lower than 70%, the absorption coefficient of ultrasound increases, and the difference with the water content of the skin (approximately 70% or more) increases, causing absorption and reflection of ultrasound at the interface between the skin and the water-containing membrane. occurs, making it difficult to obtain a clear image. The upper limit of water content is determined by gel hardness and varies depending on the polymer used.
たとえば、ポリビニルアルコールの場合は製法により異
なるが約９５％、寒天ゲルの場合はほぼ９７％が限界で
ある。For example, in the case of polyvinyl alcohol, the limit is about 95%, although it varies depending on the manufacturing method, and in the case of agar gel, the limit is about 97%.
本発明の含水ゲルは超音波診断装置用接触子の接触媒体
として使用することを目的としているため、ゲル中に気
泡を含むことは極力避けねばならない。気泡が大きい場
合、あるいは多い場合はたとえばエコー法診断装置に用
いる場合擬エコーとなり、Ａモード法では異常パルス、
Ｂモード法ではコーストとなり、また超音波の散乱、吸
収減衰の原因ともなる。Since the hydrogel of the present invention is intended to be used as a contact medium for a contactor for an ultrasonic diagnostic device, the inclusion of air bubbles in the gel must be avoided as much as possible. If the bubbles are large or there are many, for example, when used in an echo method diagnostic device, it will result in a false echo, and in the A-mode method, it will cause abnormal pulses,
In the B-mode method, this causes coasting, which also causes scattering and absorption attenuation of ultrasound waves.
本発明の含水ケルの特徴は、従来の接触媒体と異なり、
超音波診断中綴触媒体の形状が変わらず、また必要に応
じてゲルを切断することにより厚さを適当に調節して１
つの探触子で皮膚表面からの深度の異なる幾つかの部位
を診断することが可能であり、さらに適当に成型するこ
とにより探触子の先端にはめ込むことも可能である点に
存する。The characteristics of the hydrous Kel of the present invention are different from conventional contact media,
The shape of the ultrasound diagnostic midsection catalyst body remains unchanged, and the thickness can be adjusted appropriately by cutting the gel as necessary.
It is possible to diagnose several sites at different depths from the skin surface with one probe, and furthermore, it is possible to fit it into the tip of the probe by appropriately molding it.
したがって、これらの目的を達成するためにはゲルの強
度は充分強い必要があり、ゲルの強度の代表特性として
針入度で表わしたゲル硬度で表現すれば、少くとも針入
度３０ｍｍ以下、であることが必要であり、好ましくは
２０ｍｍ以下である。針入度が３０ｍｍより大きい場合
はゲルの強度が弱く、厚さ５ｍｍ以上の含水ゲル成型物
を得ることが困難であったり、探触子を走査した場合崩
れたり、厚さを調節するための切断が不能であったりし
て本発明の目的を達することが出来ない。ここで針入度
は直径１０ｍｍの表面平滑な鋼鉄製プランジャーをゲル
の表面に当て、室温で全荷重１５０ｇをかけた時に１分
後にプランジャーの先端が沈下する距離（ｍｍ）で表示
する。Therefore, in order to achieve these objectives, the strength of the gel must be sufficiently strong, and if expressed in terms of gel hardness expressed in terms of penetration as a representative characteristic of gel strength, it is necessary to have a penetration of at least 30 mm or less. It is necessary that the diameter is 20 mm or less, and preferably 20 mm or less. If the penetration is greater than 30 mm, the strength of the gel is weak, and it may be difficult to obtain a hydrogel molded product with a thickness of 5 mm or more, or it may collapse when scanning with a probe, or it may be difficult to obtain a hydrogel molded product with a thickness of 5 mm or more. The object of the present invention cannot be achieved because cutting is impossible. Here, the penetration is expressed as the distance (mm) at which the tip of the plunger sinks after 1 minute when a smooth steel plunger with a diameter of 10 mm is applied to the surface of the gel and a total load of 150 g is applied at room temperature.
本発明の含水ゲルの大きさは特に限定されないが、厚さ
は５ｍｍ以上が好ましく、それ未満では皮膚や皮下組織
のエコー像を得る際鮮明な画像が得られず、またゲルを
切断して厚み調節を行う際も厚みの範囲が狭く不便であ
る。通常１〜１０ｃｍの厚さが使用上便利である。The size of the water-containing gel of the present invention is not particularly limited, but the thickness is preferably 5 mm or more; if it is less than 5 mm, a clear image cannot be obtained when obtaining an echo image of the skin or subcutaneous tissue, and the thickness may be reduced by cutting the gel. When adjusting the thickness, the range of thickness is narrow, which is inconvenient. A thickness of 1 to 10 cm is usually convenient for use.
なお、本発明の含水ゲルを長期間保存した場合、かびや
バクテリヤが付着し、これらが繁殖するおそれがあるの
で、含水ゲル製造時に予め防腐剤や防塵剤等の添加が好
ましい。また特に臓器等の診断に用いることを考慮して
細菌感染を防ぐためガス殺菌や放射線殺菌等を行うこと
が望ましい。Note that when the hydrogel of the present invention is stored for a long period of time, there is a risk that mold and bacteria may adhere and propagate, so it is preferable to add preservatives, dustproofing agents, etc. in advance during the production of the hydrogel. In addition, especially considering use in diagnosis of organs, etc., it is desirable to perform gas sterilization, radiation sterilization, etc. to prevent bacterial infection.
本発明の接触媒体の使用態様としてはエコー法による超
音波診断用探触子にのみ使用されるのではなく、ドップ
ラー法による胎児モニターや血圧計用の探触子にも使用
可能である。The contact medium of the present invention can be used not only in ultrasonic diagnostic probes using the echo method, but also in probes for fetal monitors and blood pressure monitors using the Doppler method.
以下に実施例により、本発明をさらに説明する。The present invention will be further explained below with reference to Examples.
実施例１
アクリルアミドモノマー１５０ｇおよびＮ、Ｎ−メチレ
ンビスアクリルアミド８ｇを含む水溶液１０００ｍｌを
調製し、この液に５％ジメチルアミノプロピオニトリル
水溶液１００ｍｌと１％渦硫酸カリウム１００ｍｌを加
えて気泡を含まぬように注意しながらよく混合し、直ち
にたて１０ｃｍ、よこ１５ｃｍ、深さ１０ｃｍの容器に
流し込んで４０℃、１０時間反応させた。ゲル化後容器
より収り出し、蒸留水で表面を洗滌し、付着水を拭い取
った後、超音波診断装置用探触子と皮膚との間の接触媒
体として用いてエコー法Ｂモード法により乳腺の断面像
を撮影したところ、皮膚と接触媒体との境界線の巾は狭
く、凝エコーもない鮮明な画像が得られた。Example 1 1000 ml of an aqueous solution containing 150 g of acrylamide monomer and 8 g of N,N-methylenebisacrylamide was prepared, and 100 ml of a 5% dimethylaminopropionitrile aqueous solution and 100 ml of 1% vortex potassium sulfate were added to this solution to avoid air bubbles. The mixture was mixed well while paying attention to the following, and immediately poured into a container measuring 10 cm in length, 15 cm in width, and 10 cm in depth, and reacted at 40° C. for 10 hours. After gelation, it is taken out of the container, the surface is washed with distilled water, and the adhering water is wiped off, and then it is used as a contact medium between the probe for an ultrasound diagnostic device and the skin, and it is processed using the echo method B-mode method. When a cross-sectional image of the mammary gland was taken, the width of the border between the skin and the contact medium was narrow, and a clear image without coagulation echoes was obtained.
なお、ゲルの厚さは８ｃｍ、ゲルの含水率は８６％、ゲ
ルの硬度は針入度５ｍｍ以下であった。The thickness of the gel was 8 cm, the water content of the gel was 86%, and the hardness of the gel was 5 mm or less in penetration.
実施例２
加熱溶解した１２％ポリビニルアルコール（クラレ製Ｐ
ＶＡ−１１７）水溶液４００ｍｌを滅菌処理した、たて
１０ｃｍ、よこ１０ｃｍ、深さ１０ｃｍの容器に入れ、
これに加野溶解した５％ホウ酸水溶液２００ｍｌを添加
し、気泡が入らぬように緩やかに混合し、室温で２時間
放置してゲル化させた。得られた含水ゲルは含水率９０
．３％で、ゲル硬度は針入度で１０ｍｍであった。この
ゲルを厚さ２ｃｍに切り実施例１と同様の使用法で乳腺
の断面像を撮影した場合実施例１と同様に鮮明な画像が
得られた。Example 2 Heat-dissolved 12% polyvinyl alcohol (Kuraray P
VA-117) Pour 400 ml of the aqueous solution into a sterilized container measuring 10 cm long, 10 cm wide, and 10 cm deep.
To this was added 200 ml of a 5% aqueous solution of boric acid dissolved in Kano, mixed gently so as not to introduce air bubbles, and allowed to stand at room temperature for 2 hours to gel. The obtained hydrogel has a water content of 90
．． 3%, the gel hardness was 10 mm in terms of penetration. When this gel was cut to a thickness of 2 cm and a cross-sectional image of the mammary gland was photographed using the same method as in Example 1, a clear image was obtained as in Example 1.
実施例３
滅菌処理した２％塩化カリウム水溶液６００ｍｌをたて
１５ｃｍ、よこ２０ｍｌ、深さ１０ｃｍの容器に流し込
み、これに滅菌処理した３％カラギーナン水溶液５００
ｍｌを少しずつ、泡が立たぬように緩く攪拌しなから加
え、全部加え終った後、室温で１枚成置してゲル化させ
た。得られた含水ゲル（厚さ３．６ｃｍ、含水率９５％
、針入度８ｍｍ）をたて１０ｃｍ、よこ５ｃｍの大きさ
に切断し、探触子の接触媒体として用いて右上腕部に存
在する静脈１を市販の超音波診断装置によりエコー断層
像としてブラウン管に作成し、カメラ撮影を行ったとこ
ろ鮮明なのう腫状塊が認められた。Example 3 Pour 600 ml of a sterilized 2% potassium chloride aqueous solution into a container measuring 15 cm long, 20 ml wide and 10 cm deep, and pour 500 ml of a sterilized 3% carrageenan aqueous solution into the container.
ml was added little by little while stirring gently to prevent bubbles from forming, and after all the addition was complete, one sheet was left at room temperature to gel. The resulting hydrogel (thickness: 3.6 cm, water content: 95%)
, penetration depth 8 mm) was cut into a piece measuring 10 cm vertically and 5 cm horizontally, and using it as a contact medium for the probe, vein 1 in the right upper arm was recorded as an echo tomogram using a commercially available ultrasonic diagnostic device on a cathode ray tube. When the tumor was photographed with a camera, a clear cystic mass was observed.
特許出願人 株式会社クラレ 代埋入 弁理士 本多 堅Patent applicant: Kuraray Co., Ltd. Substitute Patent Attorney Ken Honda
Claims (1)
３０ｍｍ以下のゲル硬度を有する厚さ５ｍｍ以上の高分
子含水ゲルからなる超首波診断装置用探触子の接触媒体
。A contact medium for a probe for an ultra-neck wave diagnostic device, which is made of a polymer hydrous gel with a thickness of 5 mm or more, which has a water content of 70% or more, is substantially free of air bubbles, and has a gel hardness with a penetration depth of 30 mm or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19415382A JPS5982838A (en) | 1982-11-04 | 1982-11-04 | Contact medium of probe for utrasonic tomographic apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19415382A JPS5982838A (en) | 1982-11-04 | 1982-11-04 | Contact medium of probe for utrasonic tomographic apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5982838A true JPS5982838A (en) | 1984-05-14 |
| JPH0221252B2 JPH0221252B2 (en) | 1990-05-14 |
Family
ID=16319796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19415382A Granted JPS5982838A (en) | 1982-11-04 | 1982-11-04 | Contact medium of probe for utrasonic tomographic apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5982838A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS611162U (en) * | 1984-06-08 | 1986-01-07 | 株式会社日立メディコ | Ultrasonic inspection device probe |
| JPS61149128A (en) * | 1984-12-21 | 1986-07-07 | カネボウ株式会社 | Transparent viscous composition for ultrasonic diagnosis |
| JPS62155819U (en) * | 1986-03-25 | 1987-10-03 | ||
| JPS63192424A (en) * | 1987-02-04 | 1988-08-09 | ヘキスト合成株式会社 | Bolus for ultrasonic diagnosis |
| JPS63302834A (en) * | 1987-06-04 | 1988-12-09 | Yotsukaichi Gosei Kk | Contact medium of probe for ultrasonic diagnosis and preparation thereof |
| JPH0271731A (en) * | 1988-09-06 | 1990-03-12 | Terumo Corp | Acoustic coupler incorporated with holder and manufacture thereof |
| US5265614A (en) * | 1988-08-30 | 1993-11-30 | Fujitsu Limited | Acoustic coupler |
| WO1994012105A1 (en) * | 1992-12-02 | 1994-06-09 | Shiseido Company, Ltd. | Contact medium for probe of ultrasonic diagnostic apparatus |
| JPH0661210U (en) * | 1993-02-04 | 1994-08-30 | アトム株式会社 | Ultrasonic transducer mounting sheet for patient monitoring equipment |
| JP2001057787A (en) * | 1999-06-11 | 2001-02-27 | Nikon Corp | Vibration actuator device |
| JP2006078400A (en) * | 2004-09-10 | 2006-03-23 | Ntt Neomeit Chugoku Corp | Coupling medium for ultrasonic flaw detection |
| JP2021053053A (en) * | 2019-09-30 | 2021-04-08 | 富士フイルム株式会社 | Hydrogel for ultrasonic probe, ultrasonic probe with hydrogel and ultrasonic diagnostic apparatus |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5563636A (en) * | 1978-11-06 | 1980-05-13 | Koyo Sangyo Co | High molecular gel containing water for ultrasoniccwave diagnosis |
| JPS5949750A (en) * | 1982-09-13 | 1984-03-22 | 株式会社クラレ | Contact medium of ultrasonic diagnostic probe |
-
1982
- 1982-11-04 JP JP19415382A patent/JPS5982838A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5563636A (en) * | 1978-11-06 | 1980-05-13 | Koyo Sangyo Co | High molecular gel containing water for ultrasoniccwave diagnosis |
| JPS5949750A (en) * | 1982-09-13 | 1984-03-22 | 株式会社クラレ | Contact medium of ultrasonic diagnostic probe |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS611162U (en) * | 1984-06-08 | 1986-01-07 | 株式会社日立メディコ | Ultrasonic inspection device probe |
| JPS61149128A (en) * | 1984-12-21 | 1986-07-07 | カネボウ株式会社 | Transparent viscous composition for ultrasonic diagnosis |
| JPH0226496B2 (en) * | 1984-12-21 | 1990-06-11 | Kanebo Ltd | |
| JPS62155819U (en) * | 1986-03-25 | 1987-10-03 | ||
| JPH0345651B2 (en) * | 1987-02-04 | 1991-07-11 | Hekisuto Gosei Kk | |
| JPS63192424A (en) * | 1987-02-04 | 1988-08-09 | ヘキスト合成株式会社 | Bolus for ultrasonic diagnosis |
| JPS63302834A (en) * | 1987-06-04 | 1988-12-09 | Yotsukaichi Gosei Kk | Contact medium of probe for ultrasonic diagnosis and preparation thereof |
| US5265614A (en) * | 1988-08-30 | 1993-11-30 | Fujitsu Limited | Acoustic coupler |
| JPH0271731A (en) * | 1988-09-06 | 1990-03-12 | Terumo Corp | Acoustic coupler incorporated with holder and manufacture thereof |
| JPH0696011B2 (en) * | 1988-09-06 | 1994-11-30 | テルモ株式会社 | Manufacturing method of acoustic coupler with holder |
| WO1994012105A1 (en) * | 1992-12-02 | 1994-06-09 | Shiseido Company, Ltd. | Contact medium for probe of ultrasonic diagnostic apparatus |
| JPH0661210U (en) * | 1993-02-04 | 1994-08-30 | アトム株式会社 | Ultrasonic transducer mounting sheet for patient monitoring equipment |
| JP2001057787A (en) * | 1999-06-11 | 2001-02-27 | Nikon Corp | Vibration actuator device |
| JP4736161B2 (en) * | 1999-06-11 | 2011-07-27 | 株式会社ニコン | Vibration actuator device |
| JP2006078400A (en) * | 2004-09-10 | 2006-03-23 | Ntt Neomeit Chugoku Corp | Coupling medium for ultrasonic flaw detection |
| JP2021053053A (en) * | 2019-09-30 | 2021-04-08 | 富士フイルム株式会社 | Hydrogel for ultrasonic probe, ultrasonic probe with hydrogel and ultrasonic diagnostic apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0221252B2 (en) | 1990-05-14 |
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