JPS5949807A - Method for suppressing propagation of microorganisms on membrane separator - Google Patents

Abstract

PURPOSE:To prevent the detrioration of a membrane stock material and to suppress the propagation of microoranisms by flowing a liquid contg. a prescribed concn. of a sterilizer to the permeation side of a membrane while flowing a liquid contg. no sterilizer at a prescribed rate from a concd. liquid to permeated liquid side through the membrane. CONSTITUTION:A liquid contg. no sterilizer is passed at 0.001cm<3>/cm<2>/min through the selective permeable membrane of a membrane separator which seperates a liquid to a permeated liquid and a concd. liquid. A liquid contg. a chlorine sterilizer at 10-1,000ppm effective chlorine concn. is flowed to the permeation side of the membrane. The propagation of microorganisms is thus suppressed without deterioration of the membrane stock material by the seterilizer.

Description

【発明の詳細な説明】 本発明は選択透過膜を用いた分Ｉ’１１装置における微
生物の増繁殖を防止・抑制する方法に関するものである
。最近選択透過１ニーＡ￥利用した水処理技術は急速な
進歩を遂げ、海水の淡水化、食品・医薬・醗酵等におけ
る有１ｒＴＩｉ物のｒ々縮、超純水の製造、産業廃水の
処理及びｄｉ　Ｒ塗料の回収等に数多く利用されていう
。これら選択透１ｔ４＋　Ｉ＋味は、水の溶解物質或い
はコ１イ１′状に分１ｆ（（した極めて微小な分子集合
体り・１■効成分として分離濃縮し、または飲料用とし
て或いは上、ｒ用、医療用として重用なＩを純水を４＋
）　６　ｒ、−めＷ水の精製に用いられる。かかる週択
熔過Ｈ（ｌは、分１′＋１の対象とする物質の大きさや
性状によって限夕１１ｆｆｌ過膜と逆浸透膜に大別され
るが、いずれの膜を用いる場合であっても食品・医薬・
（Ｈａ　ｎ＋　、Ｉ　業などに千６ける分離、濃Ｐｊ４
に適用するに際し、対象原液中に存在するイ改生物が処
理中妊増３〆１し、製品を汚染したり膜性能を低ドさせ
たり、更には増殖σ）極めて顕著な場合には微生物が分
離装置を汚染し、閉塞させ長期的運転を不可能罠したり
する。一般に食品・醗酵・医薬工業分野では殺薗液を使
ってこのような微生物を死滅させたり、生育を阻止する
方法を用いているが、多くの場合それらＭ、１剤はＰｓ
、構造材料を変質させ膜性能を低下させるため、これら
工業分野での膜分離の応用が制限されていた。一方、こ
れらの工業分野での膜分離においては、濃縮液側では溶
解成分の濃度が高いため微生物の増殖はそれはとでもな
いが、透過液側では溶解成分の濃度が低くかえって微生
物の増殖は顕著で、それが原因となって分離装置の濃縮
操作を中断せざるを得７よい場合が非常に多い。従って
透過液側の微生物増殖抑制手段の開発が必要となる。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for preventing and suppressing the proliferation of microorganisms in a minute I'11 apparatus using a selectively permeable membrane. Recently, water treatment technology using selective permeation has made rapid progress, including desalination of seawater, reduction of 1rTIi substances in foods, medicines, fermentation, etc., production of ultrapure water, treatment of industrial wastewater, etc. It is said to be widely used for collecting diR paint. These selective liquids 1t4 + I + taste are dissolved in water or extremely minute molecular aggregates in the shape of a coil 1', separated and concentrated as active ingredients, or used for beverages or 4+ pure water for I, which is important for medical and medical purposes
) 6 r, -me W Used for water purification. Such weekly selective filtration H (l is divided into 11 ffl filtration membranes and reverse osmosis membranes depending on the size and properties of the target substance, but regardless of which membrane is used, Food/Medicine/
(Han+, I industry, etc., 1,600 degrees of separation, concentrated Pj4
When applied to the treatment, the bioorganisms present in the target stock solution may increase during the treatment, contaminating the product, reducing membrane performance, or even causing microbial growth (in extremely severe cases). It can contaminate and block the separation equipment, making long-term operation impossible. Generally, in the food, fermentation, and pharmaceutical industries, a method is used to kill such microorganisms or inhibit their growth using a sanitizing solution, but in many cases, these M and 1 agents are Ps.
However, the application of membrane separation in these industrial fields has been limited because it alters the structural materials and reduces membrane performance. On the other hand, in membrane separation in these industrial fields, the concentration of dissolved components is high on the concentrate side, so the growth of microorganisms is not a problem, but on the permeate side, the concentration of dissolved components is low, so the growth of microorganisms is conspicuous. In many cases, this causes the concentration operation of the separation device to be interrupted. Therefore, it is necessary to develop means for suppressing microbial growth on the permeate side.

本発明者らはかかる目的に適う手段を鋭意検討した結果
、膜の透過液側に殺菌剤を含有する液を流して膜に接触
せしめ、且つその際、濃縮液側から透過液側へ膜を介し
て殺菌剤を含有しない液を透過させることにより１１１
４　＝ｆ、材が殺菌ｆＩすにより劣下されることを防止
すへ】ことにより、上記目的が同時に達成しりりことを
見１１１シ、本発明に到達した。As a result of intensive studies by the present inventors on means suitable for this purpose, we decided to flow a solution containing a disinfectant into the permeate side of the membrane and bring it into contact with the membrane. 111 by passing a disinfectant-free solution through the
4 = f, to prevent the deterioration of the material due to sterilization fI] It was found that the above objects were achieved at the same time, and the present invention was arrived at.

即ち本発明は、 （１）選択透過膜を用い工銭イ４を」ｈ過液とｄり縮液
とに分離する膜分離装置に４、目する透過液側の微生物
の増殖を防止又は抑制御−る＆ζ当り、―縮液側から透
過敢四へ殺菌ｊ’ｉｌｌを富−Ｍ　Ｌ　７エｔ・液な透
過させつつ透過液側に殺山削を含有する液を流して微生
物の増殖を防止又は抑制することを特徴とする膜分離装
置の微生物増殖防止・抑制方法であり、また （２）　　当該殺媚剤を含ｉｉ’　Ｌ’　／、ｃい鑓の
透過−：ｂｔ　ｈ一単位膜面積当りＱ　、００１　、；
＋ｄ　／（ｉ　／　ｎｉｐ、以上である上記第１項記載
の；鵡分＞ｈｅ装置１））峨生物増殖防止・抑制方法で
あり、更に（よ （３）　　轟該殺爾剤を倉７げする液が、有効堪ネ濃度
が１０−以上１０００贈以「であｌ）層素系殺菌剤含有
液ある上記西１項叉は亀２項記載σノ膜分Ｆａ　：ｍ　
ＩＩの微生物増殖防止・抑制方法である。That is, the present invention provides: (1) a membrane separation device that uses a selectively permeable membrane to separate a filtrate into a filtrate and a filtrate; For control & ζ, sterilizing J'ill is permeated from the condensed liquid side to the permeation tank, and while the liquid is permeating through the liquid, a liquid containing sardine is flowed to the permeated liquid side to multiply microorganisms. A method for preventing and suppressing the growth of microorganisms in a membrane separation device, characterized in that it prevents or suppresses the growth of microorganisms in a membrane separation device, and (2) permeation of the aphrodisiac containing the aphrodisiac. Q per membrane area, 001;
+d/(i/nip) is a method for preventing/suppressing the proliferation of microorganisms (1)) described in item 1 above, and furthermore, (3) The liquid to be used has an effective concentration of 10 to 1,000 or more. (l) A liquid containing a stratozoon-based fungicide.The film fraction Fa as described in Section 1 or Section 2 above.
This is the method for preventing and suppressing the growth of microorganisms.

本発明に、ｔｄいて膜分離装＋ｉ＋ｉとは特に限にしな
いが、例えば逆況ｘ１１膜モジュールで隔夕）濾過膜モ
ジュールを用いた分離装置ｔが挙げられ、特に逆ｄ選膜
分離装置に本発明を適用するとき、その効果が大である
。The present invention is not particularly limited to td and membrane separator+i+i, but includes, for example, a separation device t using a filtration membrane module (with a reverse d When the invention is applied, the effect is great.

殺−剤としては、ＨＣｌ０．　ＮａＣｌ０及びジク、ル
イソシアヌル酸ナトリウムの如き塩素系殺菌剤Ｃ有効塩
素雨Ｉｔ（ｉｏ−〜１０００１１声が好ましい）、ヨー
ドホールやポビドンヨウ素のリロきヨウ素系殺菌剤、両
性界面活性剤や陽イオン界面活性剤の如き界面活性剤、
過ホ１り素酸ソーダや過酸化水素の如き過酸化物が挙げ
られる。これらを用いるには一般に水溶液として用いら
れる。As a disinfectant, HCl0. Chlorine-based disinfectants such as NaCl0 and dichloride, sodium isocyanurate, effective chlorine rain It (preferably io-~100011), iodine-based disinfectants such as iodophor and povidone-iodine, amphoteric surfactants and cationic interfaces. Surfactants such as active agents,
Examples include peroxides such as sodium perphosphate and hydrogen peroxide. These are generally used as aqueous solutions.

また殺菌剤を含有する液と分離膜或は膜モジュールとを
接触させるＫは、膜分離操作を一旦停止してから濃縮液
や透過液を水で置換して実施してもよいが、操作として
支障のない場合は停止せずに透過液側に殺菌剤を添加す
ることによって達成することもできる。In addition, contacting the liquid containing a disinfectant with the separation membrane or membrane module may be carried out by temporarily stopping the membrane separation operation and replacing the concentrated liquid or permeated liquid with water; If there is no problem, this can also be achieved by adding a disinfectant to the permeate side without stopping the process.

かかる手段が効果的な分離）１４１とし一〇は、セルν
　−ス・エステル第４１！ｐｉ　１１１４１軍り／ミド
系分離膜、ポリベンツイミタゾｐン量分ＭＩ　Ｉｔｓ！
　ｒ　ポリベンツイミダゾール量分ｈｉｔ　ｌｌＱ　、
　、ｌ：、すＡ−ナシロン系分離膜、ポリ量分ド系分ポ
リ起、ポリスルホン系分離膜、ポリアクリロ＝、　トｕ
ル量分Ｗ膜などから選ばれる逆浸透膜や隔夕（濾過・＋
＋、４及１び架＠ポリアミド、架橋ポリ尿素、架橋ボｌ
）　＝ｉミーステル架橋フルフリルアルコール系ポリマ
ーなどから選ばれるａ金膜等が例示される。これらの分
離膜の内で、本発明に特に好適に使用Ｏｐるものとして
は、セルｐ−スエスデル系、ポリ／ミ　ド系。Such a means is effective for separation) 141 and 10 are cells ν
-Su Esther No. 41! pi 11141 Military/Mid-based separation membrane, polybenzimitazo p amount MI Its!
r polybenzimidazole amount hit llQ,
, l:, A - Nasilone-based separation membrane, poly-based separation membrane, polysulfone-based separation membrane, polyacrylo =, t u
Reverse osmosis membranes and alternating membranes (filtration, +
+, 4 and 1 cross-linked @ polyamide, cross-linked polyurea, cross-linked vol
)=i selected from Miestel cross-linked furfuryl alcohol-based polymers, etc.A gold film and the like are exemplified. Among these separation membranes, those particularly preferably used in the present invention include cell p-Suesdel type and poly/mide type.

ポリベンノイミタゾ「フン系、下す尿水系逆ａ透膜及び
隔夕１ｍ過膜が挙しｌ′られる。Polybennoimitazo ``feces type'', urinary water type reverse a-permeable membrane, and diagonal 1m permeable membrane are listed.

上記種々の***ｌの中で、詩に汎用的にＩ！／！υ透１
摸として多く１目いらｉｔ　Ｃいる自［ｒ虎１３ルｐ−
ス膜、芳香族ポリアミドＩμは従来λノン菌剤特に前記
塩素系殺菌剤に対する耐性が低いとされていたために本
発明方法の適用により曲生物の増殖抑制の効果が有効に
発現される。Among the various votes listed above, I! /! υtransparent 1
I need a lot of it as a model.
Since the aromatic polyamide Iμ has conventionally been considered to have low resistance to λ non-bactericidal agents, particularly the above-mentioned chlorine-based bactericidal agents, the application of the method of the present invention effectively exhibits the effect of inhibiting the growth of acrobacteria.

通常、分離膜ｆぺの膜モジユール内の微生物の殺菌或は
増慣抑制法としては膜分離操作を停止させ、Ｍ縮液側及
び透過液側に殺准剤含有液を導入するか、或は膜分離操
作を行いつつ、濃縮液側及び透過液側に希薄な殺１夷剤
Ｓ竹液を常時注入するかのいずれかの方法がとられてい
る。Usually, as a method for sterilizing or suppressing the growth of microorganisms in the membrane module of the separation membrane FPE, the membrane separation operation is stopped and a liquid containing a quasiicide is introduced into the M condensate side and the permeate side, or One of the methods used is to constantly inject dilute monocide S bamboo liquid into the concentrate side and the permeate side while carrying out the membrane separation operation.

然しく・ずれの方法で、ら・つても、Ｍ１剤が膜ＪＰｔ
造月利を変質させるため、殺菌剤濃度を低く保つ必要が
あり、（例えばＪａ素系殺萌剤の場合、有効堪木譲ｊＷ
が１０１１−以下好ましくは１１＋ｌ朋以下）殺菌の効
果は十分でない。However, in both cases and in different ways, the M1 agent
In order to change the yield, it is necessary to keep the concentration of the fungicide low (for example, in the case of Ja-based sprouticide, the effective
is 1011- or less, preferably 11+1 or less) The sterilization effect is not sufficient.

本発明方法によれば、殺菌剤に対して耐性が低い膜素材
に効果がより発現される。According to the method of the present invention, the effect is more pronounced on membrane materials that have low resistance to disinfectants.

１／ｉ哨剤を含有しない液の透過液は、膜素材、殺菌剤
の種類、濃度及び対象徴生物の種類によって適宜選定さ
れるので、特に限定する一２要はないが通常、殺菌剤を
含有する液のＲ調剤濃度が、例えば有効塩素として２０
１−乃至１　（１００ｐｐｍの液を用いた場合、単位膜
面積当りｏ、、ｏ　ｏ　１ｄ／ｃｒＩｔ／Ｉｎ１ｎ以上
、好ましくはｏ、ｏ　ｏ　２ＣＴＩ／ｃｔｌ／殺菌効果
が減少するので、通常ｏ、ｏ　８７　／　ｃｒｌ／ｍｉ
ｎ以下である、 殺菌剤は前記のｐｔ、＋　＜　１１．４１出し・ｚ、）
ことがＱぎるが、特ニ塩素系殺菌剤Ｇ１５１ｉＹ　＋’
＋ｎ　ｉ’＋’ｌ　７Ｊ’−ジＥ　！＋＋ｌｉ　Ｃ人手
しやすいこと、殺菌効果も低τＪ　）隻で顕著であるこ
とから一般に最も多くチ！用化され〔いる。ｎ・かる塩
素系殺菌剤の有効Ｉｌｌ　Ｘ　ｉｐ度は対象とする微生
物の種類により殺菌剤に対する耐性が異るので、限定す
ることが出来ないか１Ｉｆｉ　′７Ｋ　、食品・醗醇工
業で用いられている有効塩素ａ　ｕｙは、１゜Ｖ−以上
である。一方、有効塩素−Ｉ蜆があまり高すぎると、微
生物以外の物矧、例えば透過液に含まれている有価物や
膜以夕ｌのモジュール構成材料を劣化させ好中しくない
。通常１０００卿以下である。The permeated liquid that does not contain a 1/i surveillance agent is selected appropriately depending on the membrane material, the type and concentration of the disinfectant, and the type of anti-symbol organism, so there is no need to specifically limit the permeate, but it usually does not contain a disinfectant. If the R preparation concentration of the liquid contained is, for example, 20% as available chlorine,
1- to 1 (When using 100 ppm solution, o, o o 1d/crIt/In1n or more per unit membrane area, preferably o, o o 2CTI/ctl/Since the bactericidal effect decreases, usually o, o 87/crl/mi
n or less, the bactericidal agent has the above pt, + < 11.41 out・z,)
However, the special dichlorine disinfectant G151iY +'
+n i'+'l 7J'-jiE! ++li CIt is generally the most common because it is easy to handle and the sterilization effect is low (τJ). It has been put to use. The effective level of chlorine-based disinfectants cannot be limited because resistance to the disinfectant varies depending on the type of microorganisms targeted. The available chlorine auy is 1°V- or more. On the other hand, if the available chlorine-I content is too high, substances other than microorganisms, such as valuable substances contained in the permeate and the module constituent materials of the membrane, are degraded, which is undesirable. Usually less than 1000 sir.

以下実施例により本発明な史１ｃ詳細に説明する、 実施例１ （１）　　分離膜モジュール 膜木拐として酢酸セルｌ＝−”Ｘを用いたＡｂｃｏｒ　
Ｉｎｃ、（Ｕ、Ｓ、Ａ）製のチューブラ−型逆浸透モジ
ュール（Ａｓ−１の７型） （２）　　分喘対家液 １０ｗｔ％グルコース「有水溶液 （３）　　運転方法 グルツース水溶液をポンプにより昇圧し、モジュール入
口圧力４４ｋｇ／ｄＧ、モジュール出口圧力４０ゆ／　
ｃｒｌ　Ｇ　、モジュール出側濃縮液流ｔ２１　／　ｍ
ｉｎ　、濃縮液温度３５℃の条件で１日当り２２時間連
続運転した。然る後逆浸遺操作を停止し、モジュールの
濃縮液側及び透過液側を浄化した水道水で３０分間通水
洗浄した後、濃縮液側に浄化した水道水をモジュール出
入口平均圧力３ゆ／ｃｒ／ＩＧ、（単位膜面積当りの透
水量実測値０．００３２禰／ｄ／ｍ１ｎ）流量２１　／
　ｍｉｎ、　　で通液し、一方送過液側は、Ｐ　Ｈ６，
ｓ　（塩酸添加）、千オ硫酸ナトリウム水浴液による滴
定によって測定された有効塩素濃度３００１１１ｆｌの
Ｎａ０１Ｏ水溶液を通赦し、３０分曲Ｒ菌した。殺１ｎ
後（濃縮液側及び透過液側を再び浄化水道水で約４０分
間通液洗浄した。上記操作を７ｒＸ　Ｉコ繰り返し実施
し、連続６０日間運転した。受ジＪ本膜モジュール運転
の＾縮性りしは以ドのｔｔＵ　（であった。The history of the present invention will be explained in detail with reference to examples below. Example 1 (1) Abcor using acetic acid cell l=-"X as a separation membrane module membrane membrane
Tubular type reverse osmosis module (As-1 type 7) manufactured by Inc., (U, S, A) (2) Dispersion versus home solution 10 wt% glucose "aqueous solution (3) Operation method Pressurize the glucose aqueous solution with a pump. The module inlet pressure is 44 kg/dG, and the module outlet pressure is 40 kg/dG.
crl G, module outlet concentrate flow t21/m
Continuous operation was performed for 22 hours per day at a concentrated liquid temperature of 35°C. After that, the reverse immersion operation was stopped, and the concentrated liquid side and the permeated liquid side of the module were washed with purified tap water for 30 minutes, and then the purified tap water was poured into the concentrated liquid side at an average pressure of 3 Yu/min at the module entrance and exit. cr/IG, (measured water permeability per unit membrane area 0.0032 m/d/m1n) flow rate 21/
The liquid is passed through at PH6, on the other hand, on the sending liquid side
s (hydrochloric acid added), a Na01O aqueous solution with an effective chlorine concentration of 300,111 fl measured by titration with a sodium periosulfate water bath solution was passed through, and R bacteria were incubated for 30 minutes. Murder 1n
After washing (the concentrated liquid side and the permeated liquid side were washed again with purified tap water for about 40 minutes). The above operation was repeated 7 times and operated for 60 consecutive days. Rishi was the following ttU (.

運転日数　透　水　イ１　透過水水質 Ｃ日　）　　　　　（Ａ’／Ｉｌｌゾ川Ｌ）　　用（り
ｙしｒ＋−スｗｔ％）０日（スタート）　　　　　　１
４．ｇ　　　　　　　　　ｏ、ｏ　　９２１日　　　　
　　１３．７　　　　０．０９５１０日　　　　　　　
１　２．９　　　　０．０９６２０日　　　　　　　１
　２，７　　　　　　Ｑ、０　９　９３０日　　　　　
　　１　２．５　　　　０．０９８６０日　　　　　　
１　２．４　　　　０．１　００６０日間運転後、濃縮
液側′及び透過級側共微生物の顕著な増殖は酌められ／
、ｒ、かった。Number of operating days Water permeation I1 Permeated water quality C days) (A'/Ill River L) (Ryshir+-S wt%) 0 days (start) 1
4. go o, o 921 days
13.7 0.09510 days
1 2.9 0.09620 days 1
2,7 Q, 09 930 days
1 2.5 0.09860 days
1 2.4 0.1 After 60 days of operation, significant growth of co-microorganisms on the concentrate side and the permeate side was considered/
, r, it was.

比較例１ 実施例１において、殺菌の際モジュールのの縮液側の水
道水をモジュール出入口平均圧力ｏ、２　ｋｙ　／　ｃ
ｒｌ　Ｇ以Ｆ、流Ｊ４ｔ′２１　／　ｍｉｎで通液する
仙は全く同様の操作を行ったところ、２日後（逆浸透運
転延時間４４時間後）の透水量は２９　ｅ　／ｍ’／’
　ｌ、透過水中のグルコース濃度は１、ｚｗｔ％であっ
た。２日後運転を中止し、膜を取出し調べたところ、Ｎ
ａｃｌｏによって劣化し、非常に脆くなっていた、 比較例２ 実施例１において、逆浸透の濃縮操作を１日当り２３時
間連続運転し、殺菌操作を実施しないまま浄化した水道
水ｔ”ｔｏ分間通液洗浄し、再び逆浸透運転を行った他
は、全く同様の操作を行った。この操作を繰り返し実施
した結果以下の如くであった。Comparative Example 1 In Example 1, when sterilizing the tap water on the condensation side of the module, the average pressure at the module inlet and outlet was o, 2 ky/c.
rl G to F, when the same operation was performed on the cell which flows at a flow rate of J4t'21/min, the water permeation amount after 2 days (after 44 hours of reverse osmosis operation) was 29 e/m'/'
The glucose concentration in the permeate water was 1.zwt%. Two days later, the operation was stopped and the membrane was taken out and examined, and N
Comparative Example 2 In Example 1, the reverse osmosis concentration operation was operated continuously for 23 hours per day, and purified tap water was passed through for minutes without sterilization. Exactly the same operation was performed except for washing and performing reverse osmosis operation again.The results of repeating this operation were as follows.

運転日数　透　水　性　透過氷水質 Ｃ日　）　　　　　　（１／ｍし’ＨＲ）　　　　（グ
ルコース濃度チ）スタート　　　＋　５．１　　　　０
．１０２１日　　　１４．０　　　０．１１０ １０１：１　　１２．８　　　０．１１２２０日　　　
１２．６　　　０．１１３２０日間の運転後の１１へ性
能は実施例と比較して著しい差はなかったが、透溝水は
微生物を含有した白濁液であった。七ジュールの透過水
側を分解し−（観察したところ透溝水の流路−Ｑ　Ｅ、
る面ｊ圧管の周囲には繊維状のｅ’ｊ！カーーー而に牛
面・としていた。Number of operating days Water permeability Permeation ice water quality C days) (1/m HR) (Glucose concentration CH) Start + 5.1 0
．． 1021 days 14.0 0.110 101:1 12.8 0.11220 days
12.6 0.11 After 20 days of operation, there was no significant difference in performance compared to the example, but the channel water was a cloudy liquid containing microorganisms. The permeated water side of 7 joules was decomposed - (I observed the flow path of the permeated water - Q E,
There is a fibrous e'j! around the surface j pressure tube. He was wearing a cow-face.

実施例 逆浸透膜素材として、ポリマーの主鎖にベンツイミダシ
ロン環を有する＋＋５リヘノノイミクン［１ンを用いた
チューブラ−型１；ジユールを使用（Ｍ効Ｍ面Ｎｌｔ　
１．２６　ｍ’　）　Ｌ　ｆ、−仙）Ｊｌ、実施例１と
同一の条件でグルコースの（、′Ｉｉ縮４・■作な行っ
た。EXAMPLE As a reverse osmosis membrane material, tubular type 1 using ++5 lihenonomikun [1] having a benzimidacilone ring in the main chain of the polymer;
1.26 m') Lf, -X)Jl, Glucose (,'Ii) production was carried out under the same conditions as in Example 1.

その結果濃縮性能は運転スイｚ−１，時の透水性３８　
（１／ｍ”／ＨＲ）　、　Ｊ過水中６ノグ、１．コース
０１度０．０６２（ｗｔ％）に対し、６０１］運転尚の
それぞれの性能は３２　（ｅ／＋ｒ＋’／ＨＲ’）、　
０．（１７０（ｗ　ｔ％　）　　と安定した性能が得ら
れた７、また士ジュールの透過液側には微生物の増殖は
認められ１．Ｃかった。As a result, the concentration performance was 38% when the operating speed was z-1 and the water permeability was 38%.
(1/m''/HR), J overwater 6 nog, 1. Course 01 degree 0.062 (wt%), 601] operation performance of each is 32 (e/+r+'/HR'),
0. (170 (wt%)), stable performance was obtained7, and microbial growth was observed on the permeate side of the joule (1.C).

実施例３ 実施９１１２におけるポリベンツイミダゾ１７ンｉＭを
素材として用い、実施例１における殺菌剤貧有液の有効
塩素濃度及び、′殺菌時の濃縮液側の流水平均圧力を種
々変えてグルコースの濃縮操作を実施した。２０日運転
後の透過水側の微生物増殖状況を目視観察した結果を以
下に示した。Example 3 Using polybenzimidazone 17 iM in Example 9112 as a material, glucose concentration was carried out by varying the effective chlorine concentration of the disinfectant-poor liquid in Example 1 and the average pressure of the flowing water on the concentrated liquid side during sterilization. The operation was carried out. The results of visual observation of microbial growth on the permeated water side after 20 days of operation are shown below.

実施例　有効塩素濃度　濃縮液側圧力　微生物増殖の■
無（ＩＩＦ　）　　　　（ｋｙ　／ｆｆ１Ｇ　）３　　
　　　　　２　０　　　　　　　１．０　　　　　　　
　　　無４　　　　１００　　　　２．０　　　　　　
　無５　　　　　５　０　０　　　　　　　３．０　　
　　　　　　　　　無いずれの実施例においても、２０
日後のモジュールの濃縮性能に著しい変化はなかった。Example Effective chlorine concentration Concentrate side pressure Microbial growth■
None (IIF) (ky /ff1G)3
2 0 1.0
None 4 100 2.0
None 5 5 0 0 3.0
None In any of the examples, 20
There was no significant change in the concentration performance of the module after days.

特許出ｈａ人帝人株式会社 ４Patent issuer Teijin Ltd. 4

Claims (3)

【特許請求の範囲】[Claims] （１）　　選択透過膜を用いて液体を透過液と濃縮液と
に分離する膜分離装置における透過液側の微生物の増殖
を防止又は抑制するに当り、濃縮液側から透過液＋Ｉｌ
］へ殺菌剤全含有１．ない液を透過さ亡つつ透過液側に
殺菌剤を含有する液を流して微生物の増殖を防１Ｆ、又
は抑制すうことを特徴とする膜分離装置の微生物増殖防
止・抑制方法。(1) When preventing or suppressing the growth of microorganisms on the permeate side of a membrane separation device that uses a selectively permeable membrane to separate a liquid into a permeate and a concentrate, the permeate + Il is removed from the concentrate side.
] Contains all disinfectants 1. A method for preventing and suppressing the growth of microorganisms in a membrane separation device, characterized in that the growth of microorganisms is prevented or suppressed by flowing a liquid containing a bactericide to the permeated liquid side while passing through the permeated liquid. （２）　　当該殺菌剤な含竹しない液の透過、１１′が
単位膜面債当り、Ｑ　−００１ｃＪ　／　ｄ　／　＝ｎ
、以上である特許請求の範囲第１項記載の膜分離装置の
微生物増殖防止・抑制方法。(2) Permeation of the fungicide-free liquid, 11' per unit membrane surface bond, Q -001cJ / d / = n
A method for preventing and suppressing microbial growth in a membrane separation device according to claim 1, which is the above. （３）　　当該殺菌剤を含有する液が、有効塩素濃度が
１０Ｔｉｌ朋以上１０００　ｐｐ＋ｎ以丁である塩素系
殺菌剤含有液である特許請求の範囲第１項又は第２項記
載の膜分離装置の１改生物増殖防止・１（ｐ側方法。(3) The membrane separation device according to claim 1 or 2, wherein the disinfectant-containing solution is a chlorine-based disinfectant-containing solution having an effective chlorine concentration of 10 to 1000 pp+n. 1 Prevention of growth of reformed organisms 1 (p-side method.