JPS5935148A - Automatic chemical analyzer - Google Patents
Automatic chemical analyzerInfo
- Publication number
- JPS5935148A JPS5935148A JP14544682A JP14544682A JPS5935148A JP S5935148 A JPS5935148 A JP S5935148A JP 14544682 A JP14544682 A JP 14544682A JP 14544682 A JP14544682 A JP 14544682A JP S5935148 A JPS5935148 A JP S5935148A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- measurement
- reagent
- incubation time
- reaction tubes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【発明の詳細な説明】
〔発明の技術分野〕
本発明は、測定条件が項目毎に相違する多項目の化学分
析に最適な自動化学分析装置に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Technical Field of the Invention] The present invention relates to an automatic chemical analyzer that is optimal for chemical analysis of multiple items in which measurement conditions differ for each item.
従来よシ被検体例えば生体の診断には、画像診断と生体
の検体そのものを分析するものとに大別さｎるが、形態
の病変の結果を診断するよシ機能検査の診断が優位にな
り、機能や形態が変化する以前の検体内の血液、細胞状
態を診断する方向に進んでいる。例えば人血清の成分を
分析する自動生化学分析装置は、近年測定項目及び患者
の増加に伴い検体検査の件数も増加の一途をたどってい
る。自動生化学分析装置では微量の変化量を調べるため
に対応すべく種々の方式が開発さ扛てきた。Conventionally, diagnosis of a living body, for example, can be roughly divided into image diagnosis and analysis of the living body specimen itself, but diagnosis of functional tests has become predominant in diagnosing the results of morphological lesions. , progress is being made in the direction of diagnosing the state of blood and cells within a specimen before their function or form changes. For example, automatic biochemical analyzers that analyze the components of human serum have been used in recent years to increase the number of sample tests performed as the number of measurement items and patients increases. Various methods have been developed for automatic biochemical analyzers to examine minute changes.
例えば■検体項目を高速に測定するもの、■多項目を同
時に測定するもの、■多項目を１検体づつ測定するもの
、■測定条件の異なる方式の測定項目を自動測定するも
の等が検体検査体制の用途に応じて使用さｎている。最
近、測定に抗原抗体反旧法を利用したＥＩＡ（酵素免疫
測定法）等の開発が促進されているが、従来よシ複雑な
測定方式のため、又、項目によυ測定条件が異るため？
７１．とんど用手法測定である。前記酵素免疫測定法に
は、競争結合法９均一測定法、サンドイッチ測定法。For example, sample testing systems include ■ those that measure sample items at high speed, ■ those that measure multiple items at the same time, ■ those that measure multiple items one sample at a time, and ■ those that automatically measure measurement items using different measurement conditions. It is used depending on the purpose. Recently, the development of EIA (enzyme-linked immunosorbent assay), etc., which uses the antigen-antibody assay for measurement, has been promoted. ?
71. This is a method of measurement that is used most of the time. The enzyme immunoassay method includes competitive binding method, 9 homogeneous assay method, and sandwich assay method.
抗体測定法、イムノエンザイモメトリー等があり、そｎ
ぞｎ測定ステップが異なる。There are antibody measurement methods, immunoenzymometry, etc.
The measurement steps are different.
以下、前記酵素免疫測定法のうち均一測定法における測
定ステップを第１図（α）乃至第１図（Ｃ）をも参照し
て説明する。Hereinafter, the measurement steps in the uniform measurement method of the enzyme immunoassay method will be explained with reference to FIG. 1(α) to FIG. 1(C).
先ず、第１図（α）ＶＣ示すように、反応管１内に試料
５０μｌと緩衝液２５０μｌとを吐出する。又、一方、
前記試料の反応を知得するための基準となる標準試料と
してのキャリブレータ５０μｌと、緩衝液２５０μｌと
を反応管２内に吐出する。次に、第１図（Ａ） Ｋ示す
ように、前記反応管１．２内に試薬Ａを５０μノと緩衝
液２５０μｌとをそれぞわ一吐出して試薬Ａと前記試料
又はキャリブレータとの反応を行う。反応に際して、反
応温度９反応時間等の条件を所定に設定して行う。前記
反応終了後、第１図（Ｃ） Ｋ示すように、反応管１，
２内に試薬Ｂを５０μノと緩衝液２５０μｌとをさらに
吐出して、前記と同様に所定の反応条件下で反応を行う
。前記反応終了後、例えば１５秒経過後Ｋｉ１回目の測
定を行い、さら［３０秒経過後罠第２回目の測定を行う
。そして、反応管１で得らｎる測定データを反応管２で
得られる標準値と比較換算することによ勺試料の正確な
分析値を得ることができる。First, as shown in FIG. 1 (α) VC, 50 μl of the sample and 250 μl of the buffer solution are discharged into the reaction tube 1. Also, on the other hand,
50 μl of a calibrator, which serves as a standard sample for determining the reaction of the sample, and 250 μl of a buffer solution are discharged into the reaction tube 2. Next, as shown in FIG. 1(A)K, 50 μl of reagent A and 250 μl of buffer solution were each discharged into the reaction tube 1.2 to initiate a reaction between reagent A and the sample or calibrator. I do. During the reaction, conditions such as reaction temperature, reaction time, etc. are set to predetermined values. After the reaction is completed, as shown in FIG. 1(C) K, the reaction tube 1,
Further, 50 µl of reagent B and 250 µl of buffer solution were discharged into 2, and the reaction was carried out under the predetermined reaction conditions in the same manner as above. After the completion of the reaction, for example, 15 seconds later, the first measurement of Ki is performed, and then the second measurement of Ki is performed after 30 seconds have elapsed. Then, by comparing and converting the measured data obtained in reaction tube 1 with the standard value obtained in reaction tube 2, accurate analytical values of the sample can be obtained.
以上説明したように、試料の分析に際して前記試料Ａ、
Ｈのように２種類の試薬を使用するものの他、単一の試
薬あるいは６種類の試薬を用いるものもあシ、その各反
応条件は試薬毎に相違している。又、前記従来例では１
反応系を例に挙げて説明したが、反応系の異なる場合に
は反応時間が数時間にも及ぶものもあるため、一般に自
動測定は行なうことは困難であ）、用手法で行なわれて
いる。As explained above, when analyzing a sample, the sample A,
In addition to those that use two types of reagents like H, there are also those that use a single reagent or six types of reagents, and the reaction conditions are different for each reagent. Moreover, in the conventional example, 1
Although the explanation was given using a reaction system as an example, the reaction time may take several hours depending on the reaction system, so it is generally difficult to perform automatic measurement), so it is carried out manually. .
本発明は前記事情に鑑みてなされたものであシ、試薬分
注後のインキュベーション時間が異なる複数の検査項目
を連続的かつ自動的に測定することができる自動化学分
析装置を提供することを目的とするものである。The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an automatic chemical analyzer that can continuously and automatically measure multiple test items with different incubation times after dispensing reagents. That is.
前記目的を達成するための本発明の概要は、試薬分注後
のインキュベーション時間が異なる検査項目を連続的に
測定し、多検体多項目の分析を行う自動化学分析装置に
おいて、複数の反応管を配置すると共に、装置内を搬送
可能に保持される複数の反応プレートと、前記各反応プ
レー）Ｋ配置される複数の反応管に対して種々の検体を
吐出すると共に、さらに１又は複数の試薬を吐出するサ
ンプリング部材と、複数の反応プレートを順次棚状に収
納し所定のインキュベーション時間恒温状態に維持する
恒温槽と、所定のインキュベーション時間経過後に恒温
槽よル搬出さ扛る反応プレートに対して分析測定を行う
測定部と、前記反応プレートの搬送移動をインキュベー
ション時間に基づいて制御するコンピュータとを有する
ことを特徴とするものである。The outline of the present invention for achieving the above object is to continuously measure test items with different incubation times after dispensing reagents, and to analyze multiple reaction tubes in an automatic chemical analyzer that performs analysis of multiple samples and multiple items. A plurality of reaction plates are arranged and held so as to be transportable within the apparatus, and each of the reaction plates is discharged with various specimens into the plurality of reaction tubes arranged, and one or more reagents are further injected into the plurality of reaction tubes. Analysis is performed on the sampling member to be discharged, the constant temperature bath in which multiple reaction plates are sequentially stored on shelves and kept in a constant temperature state for a predetermined incubation time, and the reaction plate that is carried out from the constant temperature bath after the predetermined incubation time has elapsed. The present invention is characterized in that it includes a measurement section that performs measurements, and a computer that controls transport and movement of the reaction plate based on incubation time.
以下、本発明の一実施例を図面を参照して説明する。第
２図は本発明の一実施例である自動化学分析装置の概略
斜視図である。第２図において、１は反応テーブルでア
シ、複数の反応管１αを例えば縦横に配列している。２
は搬送ベルトであシ所定域に亘って無端状に張架される
と共に、前記反応テーブル１を載置して搬送するように
なっている。尚、搬送ベルト２の駆動は後述するコンピ
ュータ１１によって制御されている。３は検体サングラ
であり、前記搬送ベルト２の駆動系路の近傍に設置さ扛
ると共に、複数の小カップ６α内に種々の検体及び標準
検体を収納している。４は検体分注ノズルであシ、図示
矢印Ａ、Ｂ方向に移動して、前記検体サングラ３よ）検
体を吸入して前記反応プレート１上の各反応管１αに順
次様々の検体を吐出するようになっている。検体を収納
した反応プレートは、搬送糸路途中の所定位置に設定し
た第１の試薬分注ノズル５．第２の試薬分注ノズル６゜
第３の試薬分注ノズル７によってそ扛ぞれの検査項目に
応じた試薬が吐出されるようになっている。Hereinafter, one embodiment of the present invention will be described with reference to the drawings. FIG. 2 is a schematic perspective view of an automatic chemical analyzer that is an embodiment of the present invention. In FIG. 2, reference numeral 1 denotes a reaction table on which a plurality of reaction tubes 1α are arranged, for example, vertically and horizontally. 2
is stretched endlessly over a predetermined area by a conveyor belt, and the reaction table 1 is placed thereon and conveyed. Note that the drive of the conveyor belt 2 is controlled by a computer 11, which will be described later. Reference numeral 3 denotes a specimen sampler, which is installed near the drive path of the conveyor belt 2 and stores various specimens and standard specimens in a plurality of small cups 6α. Reference numeral 4 denotes a sample dispensing nozzle, which moves in the directions of arrows A and B in the figure, sucks in the sample (from the sample sampler 3), and sequentially discharges various samples into each reaction tube 1α on the reaction plate 1. It looks like this. The reaction plate containing the specimen is transferred to the first reagent dispensing nozzle 5, which is set at a predetermined position in the middle of the conveying thread path. A second reagent dispensing nozzle 6 and a third reagent dispensing nozzle 7 discharge reagents according to each test item.
８は恒温槽であシ、前記搬送ベルト２の末端部近傍に配
置さｎると共に、複数の反応グレート１を棚状に収納し
て恒温度を維持するようになっている。前記恒温槽８に
おける前記搬送ベルト２の搬送方向に沿った前後には昇
降機９，１０が設けら牡ると共に、図示Ｃ，Ｄ方向に沿
って昇降可能となっている。尚、昇降機９，１０は図示
しないピックアップ機構を有し、前記反応グレート１を
恒温槽８に出入させるようになっている。前記コンピュ
ータ１１は、各測定項目に応じたインキュベーション時
間に基づいて、前記反応プレート１の搬送移動と、恒温
槽内に格納さ扛る時間とを制御する。１２は測定部であ
シ、前記恒温槽８内で所定のインキュベーション時間格
納された反応プレート１は、前記測定部１２において、
例えば比色測定が行なわれるようになっている。尚、図
示してはいないが、測定の終了した反応プレート１はそ
の後洗浄、乾燥さ扛て次の測定に備えるよう罠なってい
る。Reference numeral 8 denotes a constant temperature oven, which is disposed near the end of the conveyor belt 2, and a plurality of reaction grates 1 are housed in a shelf shape to maintain a constant temperature. Lifts 9 and 10 are provided at the front and back of the thermostatic chamber 8 along the conveyance direction of the conveyor belt 2, and are movable up and down along directions C and D in the figure. Incidentally, the elevators 9 and 10 have a pick-up mechanism (not shown), and are configured to move the reaction grating 1 into and out of the constant temperature bath 8. The computer 11 controls the transportation and movement of the reaction plate 1 and the time during which it is stored in the constant temperature bath, based on the incubation time corresponding to each measurement item. Reference numeral 12 denotes a measuring section, and the reaction plate 1 stored in the thermostatic chamber 8 for a predetermined incubation time is placed in the measuring section 12.
For example, colorimetric measurements are being carried out. Although not shown, the reaction plate 1 after the measurement is washed and dried to prepare for the next measurement.
以上のように構成さｆした自動化学分析装置の作用につ
いて説明する。先ず、搬送ベルト２の移動に伴って搬送
される反応プレート１は、検体分注ノズル４の設定位置
下方に停止して、複数の反応管１α内に種々の検体が吐
出される。この際、反応テーブル１上の少なくとも−の
反応管１αには標準検体が吐出される。検体を収納した
反応プレート１は、搬送ベルト２ＫＱって移動し、次に
試薬の分注を受けるた怜に停止する。ここで、第１．第
２、第３の試薬分注ノズル５，６．７を介して、反応プ
レート１上の各反応管１αに対して同一の試薬が所定量
吐出される。その後、反応グレート１は搬送ベルト２に
沿ってさらに移動し、搬送ベルト２の末端部に設けた昇
降機９上に載置される。The operation of the automatic chemical analyzer configured as above will be explained. First, the reaction plate 1, which is transported as the transport belt 2 moves, stops below the set position of the specimen dispensing nozzle 4, and various specimens are discharged into the plurality of reaction tubes 1α. At this time, the standard specimen is discharged into at least the negative reaction tube 1α on the reaction table 1. The reaction plate 1 containing the specimen moves along the conveyor belt 2KQ, and then stops in time to receive the reagent dispensed. Here, the first. A predetermined amount of the same reagent is discharged into each reaction tube 1α on the reaction plate 1 through the second and third reagent dispensing nozzles 5, 6.7. Thereafter, the reaction grate 1 moves further along the conveyor belt 2 and is placed on an elevator 9 provided at the end of the conveyor belt 2.
昇降機９は図示しないピックアップ機構にょル前記反応
プレート１を恒温槽８内の例えば最下段の棚部に格納す
る。恒温槽８内に格納された反応プレート１は、コンピ
ュータ１１に制御されて測定項目に応じた所定のインキ
ュベーション時間恒温状態に維持さ扛る。尚、反応管１
αに分注される試薬は、一般にインキュベーション時間
が項目及び反応系によシ異なる為、恒温槽８内に格納し
た反応グレート１を所定時間後に取シ出して、搬送ベル
ト２を逆転させて、再度試薬分注位置に設定し、試薬の
分注を行うようＫしてもよい。最初の反応プレート１を
恒温槽８に格納した後、次の反応グレート１が搬送ベル
ト２に沿って搬送さ扛、前記と同様にして検体及び試薬
が分注される。この際、例えば最初の反応グレート１に
収納した検体と同一検体のものに対して他の項目の測定
を行う場合には、前記試薬分注位置において、他の測定
項目に応じた試薬が分注さ扛る。そして、前記と同様に
して昇降機９ｖｃ反応グレート１を導き、恒温槽８内の
２段目の棚部に前記反応グレート１を格納する。以下、
同様にして、順次多検体多項目の分析のための反応グレ
ート１が恒温槽８内のそれぞｎ異なる棚部に格納される
。一方、恒温槽８内罠格納された反応グレート１のイン
キュベーション時間は測定項目毎に相違しておシ、反応
プレート１を測定部１２へ導く順番は、必ずしも恒温槽
８内への格納部とは限らない。測定項目によっては、数
時間もインキュベーション時間を要するものもある。本
発明では、搬送ベルト２の搬送系路とは独立して、恒温
槽８内の格納部を棚状としたため、恒温槽８内への格納
順序に拘わらず、恒温槽８よシ任意の反応プレート１を
取〕出すことができるようになっている。測定項目に応
じた所定のインキュベーション時間は、恒温槽８内への
格納順序と対応付けてコンピュータ１１に先しめ設定し
ておけば、インキュベーション時間の経過した順に、反
応プレート１を恒温槽８よ勺取勺用して測定部１２に導
出することができる。即ち、コンピュータ１１の制御に
基づいて、昇降機１０が所定の棚部に上昇移動し、反応
プレートをピックアップした後下降して、測定部１２に
案内する搬送ベルトに送シ田丁ことができる。恒温槽８
より取シ出さ扛た反応プレート１は順次測定部１２にお
いて、例えば分光測定が行なわれ、種々の検体について
の測定データを標準検体についてのデータと比較換算す
ることによう、多検体多項目についての分析を連続して
得ることができる。The elevator 9 uses a pickup mechanism (not shown) to store the reaction plate 1 on, for example, the lowest shelf in the thermostatic chamber 8 . The reaction plate 1 stored in a constant temperature bath 8 is controlled by a computer 11 and maintained at a constant temperature for a predetermined incubation time depending on the measurement item. In addition, reaction tube 1
Since the incubation time for the reagent dispensed into α generally varies depending on the item and reaction system, the reaction grade 1 stored in the thermostatic chamber 8 is taken out after a predetermined time, the conveyor belt 2 is reversed, You may set it to the reagent dispensing position again and press K to dispense the reagent. After the first reaction plate 1 is stored in the thermostatic chamber 8, the next reaction plate 1 is conveyed along the conveyor belt 2, and the specimen and reagent are dispensed in the same manner as described above. At this time, for example, when measuring other items on the same sample stored in the first reaction grade 1, the reagent corresponding to the other measurement item is dispensed at the reagent dispensing position. Explode. Then, the elevator 9vc reaction grate 1 is guided in the same manner as described above, and the reaction grate 1 is stored on the second shelf in the thermostatic chamber 8. below,
Similarly, reaction grades 1 for analysis of multiple samples and multiple items are sequentially stored in n different shelves in the thermostatic chamber 8. On the other hand, the incubation time of the reaction plate 1 stored in the thermostatic chamber 8 is different for each measurement item, and the order in which the reaction plates 1 are led to the measurement section 12 does not necessarily differ from the storage section in the thermostatic chamber 8. Not exclusively. Some measurement items require incubation time of several hours. In the present invention, the storage section in the thermostatic oven 8 is made into a shelf-like structure independent of the conveyance path of the conveyor belt 2, so that any reaction can be carried out from the thermostatic oven 8 regardless of the order of storage in the thermostatic oven 8. Plate 1 can be taken out. If the predetermined incubation time corresponding to the measurement item is set in advance in the computer 11 in correspondence with the order of storage in the thermostatic chamber 8, the reaction plates 1 can be placed in the thermostatic chamber 8 in the order in which the incubation time has elapsed. The data can be extracted and delivered to the measurement unit 12. That is, under the control of the computer 11, the elevator 10 moves upward to a predetermined shelf, picks up the reaction plate, and then descends to transfer it to a conveyor belt that guides it to the measuring section 12. Constant temperature bath 8
The reaction plate 1 taken out from the sample is sequentially subjected to, for example, spectroscopic measurement in the measurement section 12, and measurement data for various samples are compared and converted with data for standard samples. Analysis can be obtained continuously.
本発明は前記実施例に限定さ扛るものではなく、本発明
の要旨の範囲内で種々の変形例を包含することは言うま
でもない。例えば、酵素免疫測定に際しては、恒温槽８
と測定部１２との間の反応プレート１の搬送糸路途中に
、分離分注ノズルを配置することもできる。即ち酵素免
疫測定では、一定量の酵素標識抗体と測定子べき抗原と
−と反応させ、ついで過剰の酵素標識抗体を同相上に不
溶化した十分量の抗原で取シ除く。そして、測定子べき
抗原の量に応じて上清に残る酸素活性が変化するもので
ある。従って、この上清を前記分離分注ノズルで吸引し
、他の反応グレート１に吐出してこれを前記測定部１２
に導けばよい。又、前記実施例においては、多項目の測
定に際して同一温度条件の下で恒温槽８内に格納したが
、測定項目によっては温度条件が異なるものもあるため
、恒温槽８を２種以上の温度に設定維持できるようにし
てもよい。この他、試薬分注６分元測定をも測定温度条
件下で行なえるように、配置場所を異にして、２，６の
温度に対応できるように分注ノズル又は測定部を複数設
置してもよい。It goes without saying that the present invention is not limited to the embodiments described above, but includes various modifications within the scope of the gist of the present invention. For example, when performing enzyme immunoassay,
A separation/dispensing nozzle can also be arranged in the middle of the conveyance path of the reaction plate 1 between the measuring section 12 and the measuring section 12 . That is, in enzyme immunoassay, a certain amount of enzyme-labeled antibody is reacted with the antigen to be measured, and then excess enzyme-labeled antibody is removed with a sufficient amount of insoluble antigen on the same phase. The oxygen activity remaining in the supernatant changes depending on the amount of antigen to be measured. Therefore, this supernatant is sucked by the separation/dispensing nozzle, discharged to the other reaction grade 1, and transferred to the measurement section 12.
You can lead to In addition, in the above embodiment, when measuring multiple items, the thermostatic oven 8 was stored under the same temperature conditions, but since some measurement items may have different temperature conditions, the thermostatic oven 8 may be stored at two or more temperatures. It may be possible to maintain the settings. In addition, multiple dispensing nozzles or measurement units are installed in different locations to accommodate 2 and 6 temperatures, so that reagent dispensing and 6-minute measurements can be performed under measurement temperature conditions. Good too.
以上説明したように、この発明によると、多検体多項目
の分析測定に際して項目毎に異なるインキュベーション
時間をそｎぞれ確保しながらも連続的に測定を行うこと
ができる自動化学分析装置を提供することができる。従
って、従来より用手法で行っていた測定に関して操作者
の負担を大幅に軽＄、することができる。As explained above, according to the present invention, there is provided an automatic chemical analyzer that can carry out continuous measurements while ensuring different incubation times for each item when analyzing and measuring multiple samples and multiple items. be able to. Therefore, it is possible to significantly reduce the burden on the operator regarding measurements that have conventionally been performed manually.
第１図（ａ）〜（Ｃ）は酵素免疫測定法のうちの均一測
定法の測定ステップを示す概略説明図、第２図は本発明
の一実施例である自動化学分析装置の櫃略斜祝図である
。
１・・・反応プレート、１α・・・反応管、 ２・・
・搬送ベルト、 ４・・・検体分注ノズル、 ５，６
．７・・・試薬分注ノズル、 ８・・・恒温槽、
９．１０・・・昇降機、ｉｉ・・・コンピュータ、
１２・・・測定部。FIGS. 1(a) to (C) are schematic illustrations showing the measurement steps of a homogeneous assay method of enzyme immunoassay, and FIG. 2 is a schematic diagram of an automatic chemical analyzer according to an embodiment of the present invention. It is a congratulatory map. 1... Reaction plate, 1α... Reaction tube, 2...
・Transport belt, 4... Sample dispensing nozzle, 5, 6
．． 7... Reagent dispensing nozzle, 8... Constant temperature bath,
9.10... Elevator, ii... Computer,
12...Measurement section.
Claims (1)
を連続的に測定し、多検体多項目の分析を行う自動化学
分析装置において、複数の反応管を配置すると共に、装
置内を搬送可能に保持される複数の反応プレートと、前
記各反応プレートに配置される複数の反応管に対して種
々の検体を吐出すると共に、さらに１又は複数の試薬を
吐出するサンプリング部材と、複数の反応プレートを順
・１次棚状に収納し所定のインキュベーション時間恒温
状態に維持する恒温槽と、所定のインキュベーション時
間経過後に恒温槽よシ搬出さｎる反応プレートに対して
分析測定を行う測定部と、前記反応プレートの搬送移動
をインキュベーション時間に基づいて制御するコンピュ
ータとを有することを特徴とする自動化学分析装置。In an automatic chemical analyzer that continuously measures test items with different incubation times after dispensing reagents and performs multi-specimen multi-item analysis, multiple reaction tubes are arranged and held so that they can be transported within the device. A plurality of reaction plates, a sampling member that discharges various specimens into a plurality of reaction tubes disposed on each reaction plate, and further discharges one or more reagents, and a plurality of reaction plates in order. A thermostat that is stored in a shelf and maintains the temperature at a constant temperature for a predetermined incubation time; a measuring section that performs analysis and measurement on the reaction plates that are removed from the thermostatic oven after a predetermined incubation time; An automatic chemical analysis device comprising: a computer that controls transport movement based on incubation time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14544682A JPS5935148A (en) | 1982-08-24 | 1982-08-24 | Automatic chemical analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14544682A JPS5935148A (en) | 1982-08-24 | 1982-08-24 | Automatic chemical analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5935148A true JPS5935148A (en) | 1984-02-25 |
Family
ID=15385409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14544682A Pending JPS5935148A (en) | 1982-08-24 | 1982-08-24 | Automatic chemical analyzer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5935148A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0193385A2 (en) * | 1985-02-27 | 1986-09-03 | Sherwood Medical Company | Automated microbiological testing appparatus and method |
| JPS61212766A (en) * | 1985-02-27 | 1986-09-20 | イエル・ホールディング・エス・ピー・ア | Analyzer |
| JPS61247373A (en) * | 1985-03-01 | 1986-11-04 | シヤ−ウツド・メデイカル・カンパニ− | Automatic bacteria testing apparatus |
| CN112394185A (en) * | 2019-08-19 | 2021-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Reference substance position distribution method and sample analysis system |
-
1982
- 1982-08-24 JP JP14544682A patent/JPS5935148A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0193385A2 (en) * | 1985-02-27 | 1986-09-03 | Sherwood Medical Company | Automated microbiological testing appparatus and method |
| JPS61212766A (en) * | 1985-02-27 | 1986-09-20 | イエル・ホールディング・エス・ピー・ア | Analyzer |
| JPH0588425B2 (en) * | 1985-02-27 | 1993-12-22 | Ieru Hoorudeingu Spa | |
| JPS61247373A (en) * | 1985-03-01 | 1986-11-04 | シヤ−ウツド・メデイカル・カンパニ− | Automatic bacteria testing apparatus |
| CN112394185A (en) * | 2019-08-19 | 2021-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Reference substance position distribution method and sample analysis system |
| CN112394185B (en) * | 2019-08-19 | 2024-03-22 | 深圳迈瑞生物医疗电子股份有限公司 | Reference substance position distribution method and sample analysis system |
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