JPS59122949A - Method and apparatus for measuring breathing capacity of animal - Google Patents
Method and apparatus for measuring breathing capacity of animalInfo
- Publication number
- JPS59122949A JPS59122949A JP57230992A JP23099282A JPS59122949A JP S59122949 A JPS59122949 A JP S59122949A JP 57230992 A JP57230992 A JP 57230992A JP 23099282 A JP23099282 A JP 23099282A JP S59122949 A JPS59122949 A JP S59122949A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
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- Hematology (AREA)
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- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
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- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は動物の呼吸能を測定するだめの方法及び装置に
係し、特にマウス等の小動物の呼吸能を測定するために
好適な呼吸能測定方法及び装置に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method and apparatus for measuring the respiratory capacity of animals, and more particularly to a method and apparatus for measuring respiratory capacity suitable for measuring the respiratory capacity of small animals such as mice.
動物の呼吸能の測定に関して、呼吸数と呼吸量が考えら
れるが、現在床〈実施されているものとしては、犬、ウ
サギ、サル、ネコ、ブタ等の比較的大きな動物に対して
、麻酔下で切開した気管にサーミスタ等の熱測定素子の
応用による流速計、又は圧力の変化を測定する素子の応
用による流量計を挿入して測定する方法及び装置がある
、しかしながらこれらの方法および装置では、長時間の
測定は不可能であシ、又麻酔下における気管の切開を必
要とする非生理的条件を採用するため人為的な影響は免
かれえない。この様な条件下では正常な生理機能に対す
る薬物の呼吸能に及ばず影響等の測定は不可能である。When it comes to measuring the respiratory capacity of animals, respiratory rate and respiratory volume can be considered, but the current method is to measure relatively large animals such as dogs, rabbits, monkeys, cats, and pigs under anesthesia. There are methods and apparatuses for measuring by inserting a flowmeter using a heat measuring element such as a thermistor or a flowmeter using an element for measuring changes in pressure into the trachea that has been incised. However, these methods and apparatuses It is not possible to measure over a long period of time, and since non-physiological conditions are employed, requiring incision of the trachea under anesthesia, artificial effects cannot be avoided. Under such conditions, it is impossible to measure the effects of drugs on normal physiological functions, as they do not affect respiratory performance.
又、比較的大きな動物を使用するために、一度に多くの
測定が不可能であり、更に、これに要する動物の費用も
多額なものとなる。Furthermore, since relatively large animals are used, it is not possible to carry out many measurements at once, and furthermore, the cost of the animals required for this is large.
本発明の目的はかかる従来技術による測定方法および装
置の欠点を除去し、安価にしかも正確に動物の呼吸能を
測定することができる方法及び装置を得ることである。The object of the present invention is to eliminate the drawbacks of the measuring methods and devices according to the prior art and to provide a method and device that can inexpensively and accurately measure the respiratory capacity of animals.
本発明による動物の呼吸能測定方法は、動物の少くとも
鼻および口を含む頭部を一定の容積を有する容器で覆い
、この容器内の動物の呼吸によって発生する微少な圧力
の変化又は音波を測定することによシ動璽の呼吸能を求
めることを特徴としておシ、その方法は極めて簡単であ
り且つ安価に実施することができると同時にその測定結
果も満足すべきものである。The method for measuring the respiratory capacity of an animal according to the present invention involves covering the animal's head, including at least the nose and mouth, with a container having a certain volume, and measuring minute pressure changes or sound waves generated by the animal's breathing inside the container. The method is very simple and can be carried out at low cost, and the measurement results are also satisfactory.
又、本発明による動物の呼吸能測定装置は、動物の少く
とも鼻および口を含む頭部が出るようになった前部開口
を有して動物の体部を収容するようになった容器と、そ
の前部開口から出ている動物の頭部を憶うようにこの容
器に取付けられた前部容器と、この前部容器内の動物の
呼吸によって発生する微少な圧力の変化又は音波を測定
するためにこの前部容器に取付けられたセンサと、前部
容器内に空気等の気体を定常的に導入するための装置と
を有することを特徴としておシ、その構造は極めて簡単
であり、安価に製造することができ、しかも動物の呼吸
能を正確に測定することができる。The apparatus for measuring respiratory performance of an animal according to the present invention also includes a container configured to accommodate the body part of the animal and having a front opening through which the head of the animal, including at least the nose and mouth, comes out. , a front container attached to this container so as to memorize the animal's head coming out of its front opening, and measuring minute pressure changes or sound waves generated by the animal's breathing inside this front container. The device is characterized by having a sensor attached to the front container in order to do this, and a device for steadily introducing gas such as air into the front container, and its structure is extremely simple. It can be manufactured at low cost and can accurately measure the respiratory capacity of animals.
次に、添付図面を参照して本発明の好適実施例を説明す
る。Next, preferred embodiments of the present invention will be described with reference to the accompanying drawings.
第１図は本発明による動物の呼吸能測定方法を実施する
ための呼吸能測定装置の概要を示すものであシ、マウス
等の実験用の動物を入れるための筒状の容器１と、この
容器１の先端に取付けられた前部容器２とを有する。FIG. 1 shows an outline of a respiratory performance measuring apparatus for carrying out the method for measuring animal respiratory performance according to the present invention. It has a front container 2 attached to the tip of the container 1.
筒状の容器１は、中に入れられた動物に強いストレスが
かからない程度に半拘束的に収容できるような形状と寸
法とを有し、好適には外部から観察上、透明なグラスチ
ックやガラス等の素材で作られる。この容器の形状は筒
状は限定されることなく、他の形状とすることもできる
。The cylindrical container 1 has a shape and dimensions that allow the animals placed there to be housed in a semi-restrictive manner without being subjected to strong stress, and is preferably made of transparent plastic or glass that can be observed from the outside. Made of materials such as. The shape of this container is not limited to a cylindrical shape, and may have other shapes.
上記容器１の他の態様として、動物の生理的機能に大き
な影響を及ぼさずかつ動物を半拘束的に収容できる装置
でおれば、同様に本発明の目的を達成し得るものであシ
、この様な態様においては、動物への薬物投与、動物の
***に処するために、適当な開口部を必要箇所に設けた
容器、あるいは容器全体を網目状としだものを用いるこ
とができる。この容器１の先端はほぼ円錐形の肩部３を
形成しておシ、その先端には動物の鼻および口を含む頭
部を出すための開口５が形成されている。又、この筒状
の容器°１の後端は動物を出し入れするための開口６を
有し、この後端の壁部には動物の尾を出すための切シ込
み８が軸線方向に開口６から形成されでいる。上記切り
込み８はマウス等薬物の尾静脈投与が可能とされる動物
の場合に特に設けられるものであシ、その他の動物につ
いては特に必要としない。そして、この開口６は動物を
前方に押し込むための脱着可能な閉塞部材即ち栓９によ
って閉塞されている。この栓９の挿入部の寸法は図示す
るように切シ込み８よシ短かくなっている。As another aspect of the container 1, the object of the present invention can be similarly achieved if it is a device that does not significantly affect the physiological functions of the animal and can accommodate the animal in a semi-restricted manner. In various embodiments, a container provided with appropriate openings at necessary locations for drug administration to animals and animal excretion, or a container with a mesh-like structure as a whole may be used. The tip of the container 1 forms a substantially conical shoulder 3, and an opening 5 is formed at the tip for exposing the animal's head, including its nose and mouth. Further, the rear end of this cylindrical container °1 has an opening 6 for taking the animal in and out, and the wall of this rear end has a notch 8 extending in the axial direction into the opening 6 for letting the animal's tail out. It is formed from. The above-mentioned incision 8 is especially provided in the case of animals such as mice that allow administration of drugs through the tail vein, and is not particularly necessary for other animals. This opening 6 is then closed by a removable closing member or stopper 9 for pushing the animal forward. The dimensions of the insertion portion of this plug 9 are shorter than the notch 8 as shown in the figure.
前部ｂｇｒ２９′に筒状の容器１の先端に一定容積の室
１０を形成するように脱着可能に取付けられておシ、好
適には容器１と同様に透明なプラスチック等で作られか
つ動物の前頭部を収容するに十分な大きさのものが良い
。It is removably attached to the front bgr 29' so as to form a chamber 10 of a constant volume at the tip of the cylindrical container 1, and is preferably made of transparent plastic or the like like the container 1 and is made of animal material. It should be large enough to accommodate the front of the head.
この前部容器２には、動物の呼吸によって発生する室１
０内の微少な圧力の変化又は音波を測定するだめのコン
デンサマイクロホン等のセンサ１１が取付けられている
。又、この前部容器２には室１０内に空気等の気体を定
常的に導入及び排出するための入口管１２および出口管
１３が設けられ、ポンプ１４によって圧縮された気体は
圧力調整、流量調整、脈動防止装置１５によって調整さ
れて入口管１２から室１０内に入シ、出口管１３から外
部に導ひかれて調整弁、流量計装置１６等を介して排出
される。これらの装置１２゜１３．１４，１５．１６の
作動によって、室１０内に定常的な気体の流れを維持し
、呼吸能測定に対する外気の影響を排除することができ
る。又、入口管１２と出口管１３とは図示された対向す
る位置に限定されることなく他の位置に取り付けること
ができる。This front container 2 contains a chamber 1 generated by the animal's breathing.
A sensor 11, such as a condenser microphone, is attached to measure minute changes in pressure or sound waves within the sensor. The front container 2 is also provided with an inlet pipe 12 and an outlet pipe 13 for steadily introducing and discharging gas such as air into the chamber 10, and the gas compressed by the pump 14 is controlled by pressure adjustment and flow rate. The liquid enters the chamber 10 from the inlet pipe 12 after being regulated by the regulating and pulsating prevention device 15, is led to the outside from the outlet pipe 13, and is discharged via the regulating valve, flowmeter device 16, etc. The operation of these devices 12, 13, 14, 15, 16 makes it possible to maintain a constant flow of gas within the chamber 10 and to eliminate the influence of outside air on the respiratory performance measurements. Further, the inlet pipe 12 and the outlet pipe 13 are not limited to the illustrated opposing positions, but can be installed in other positions.
センサ１１によって検出された圧力変化又は音波は増幅
器１７を介してレコーダ１８に記録される。又、周波数
−電圧変換装置１９により変換された電圧もまだレコー
ダ１８に同時に記録される。Pressure changes or sound waves detected by the sensor 11 are recorded via an amplifier 17 on a recorder 18 . Also, the voltage converted by the frequency-to-voltage converter 19 is still recorded on the recorder 18 at the same time.
次に、第１図に示された装置によって動物の呼吸能を測
定する方法を説明する。Next, a method for measuring the respiratory capacity of an animal using the apparatus shown in FIG. 1 will be explained.
先づ、筒状の容器１から栓９を取り除き、マウス等の実
験用の動物を、その尾が切り込み８から外に出るように
容器１内に入れ、前部容器２の開口５から鼻および口が
出る程度に栓９を押し込む。First, remove the stopper 9 from the cylindrical container 1, place an experimental animal such as a mouse into the container 1 with its tail coming out through the notch 8, and insert the nose and nose through the opening 5 of the front container 2. Push in the stopper 9 until the opening comes out.
次に、センサ１１や入口管１２および出口管１３が装着
された前部容器２を容器１の前部に装着してポンプ１４
を始動する。かくして、空気は圧力調整、流量調整、脈
動防止装置１５により調整されて、適量の空気が前部容
器２の室１０内に送給され、調整弁、流量計装置１６に
よって室１０内の雰囲気が一定に調整される。このとき
、実験上必要に応じて空気以外の気体（薬物や生体異物
を含む気体、炭酸ガス、−酸化炭素、酸素など）、又は
、空気と空気以外の気体との混合気体を使用するととも
できる。このようにして、実験用の動物の呼吸による室
１０内の圧力の変化又は動物の呼吸による音波をセンサ
１１によって検知し、増幅器１７および周波数−電圧変
換装置１９を介してレコーダ１８に記録させる。このと
き、必要に応じて、容器１の切シ込み８から外部に出て
いる動物の尾に注射等の薬物投与をして所望の実験を行
うことができる。このようにして行った実験結果の一例
が第２図に示されている。Next, the front container 2 equipped with the sensor 11, the inlet pipe 12, and the outlet pipe 13 is attached to the front of the container 1, and the pump 14 is attached to the front part of the container 1.
start. In this way, the air is regulated by the pressure adjustment, flow rate adjustment, and pulsation prevention device 15, and an appropriate amount of air is fed into the chamber 10 of the front container 2, and the atmosphere in the chamber 10 is adjusted by the regulating valve and flowmeter device 16. Constantly adjusted. At this time, a gas other than air (gas containing drugs or xenobiotics, carbon dioxide, carbon oxide, oxygen, etc.) or a mixture of air and a gas other than air may be used as necessary for the experiment. . In this way, changes in the pressure within the chamber 10 caused by the breathing of the experimental animal or sound waves caused by the breathing of the animal are detected by the sensor 11 and recorded by the recorder 18 via the amplifier 17 and the frequency-voltage converter 19. At this time, if necessary, a desired experiment can be carried out by administering a drug such as an injection to the animal's tail, which is exposed through the incision 8 of the container 1. An example of the experimental results conducted in this manner is shown in FIG.
第２図に示されたグラフは第１図に示された装置を使用
して実験用のマウスに呼吸抑制作用を有する薬物（ペン
タシミ７ ） ： １０ｍｇ／ Ｉ Ｄｉ／／ｋ１９を
尾静豚よシ投与した場合の呼吸能の変化を示したもので
ある。ことで、縦軸は呼吸数の変化を表し、横軸は前述
の薬物投与前から投与後に至る時間を表す。図中、グラ
フ（イ）は呼吸パターン（呼吸の深さ、呼吸数など）を
表し、グラフ（ロ）は呼吸パターンに対応した呼吸数の
時間的変化を表し、薬物がし→の時点で投与されると、
図から容易に理解されるように、直ちに呼吸数が大きく
変動すると同時に急激に減少し、２分、６分と時間の経
過につれて徐々に回復することが明瞭に測定された。The graph shown in Fig. 2 shows that a drug with a respiratory depressant effect (Pentashimi 7): 10 mg/I Di//k19 was administered to experimental mice using the apparatus shown in Fig. 1. This figure shows changes in respiratory ability when administered. Thus, the vertical axis represents the change in respiratory rate, and the horizontal axis represents the time from before to after administration of the drug. In the figure, the graph (a) represents the breathing pattern (breathing depth, breathing rate, etc.), and the graph (b) represents the temporal change in the breathing rate corresponding to the breathing pattern. When it is done,
As can be easily understood from the figure, it was clearly measured that the respiratory rate immediately fluctuated greatly and at the same time rapidly decreased, and then gradually recovered as time elapsed, such as 2 minutes and 6 minutes.
次に第６図に示した本発明の他の実施例を説明する。Next, another embodiment of the present invention shown in FIG. 6 will be described.
第６図に示された実施例では、動物は筒状の容器２１内
に拘束されてはいるが、第１図に示された前部容器２を
有せず、筒状の容器２１内の圧力の変化又は音波が測定
されるようになっている。In the embodiment shown in FIG. 6, the animal is restrained within the cylindrical container 21 but does not have the front container 2 shown in FIG. Changes in pressure or sound waves are to be measured.
容器２１は第１図に示された容器１とほぼ同様に通常は
透明なプラスチック等で作られておシ、その先端はほぼ
円錐形の肩部２２を形成しており、その先端には動物の
頭部を出すための開口２３が形成されている。この開口
２３は第１図の開口５のように鼻および口を含む頭部の
みを出すようにすることもできる。この容器２１の後端
は動物を出し入れするだめの開口２４を有し、この後端
の壁部には第１図に示された切り込み８と同様な切シ込
み２５が開口２４から軸線方向に形成されている。そし
て、この開口２４は動物を前方に押し込むだめの栓２６
によって閉塞されている。The container 21 is generally made of transparent plastic or the like, similar to the container 1 shown in FIG. An opening 23 is formed for exposing the head of the head. This opening 23 can also be designed to expose only the head including the nose and mouth, like the opening 5 in FIG. The rear end of this container 21 has an opening 24 through which animals can be taken in and taken out, and a notch 25 similar to the notch 8 shown in FIG. It is formed. This opening 24 is a stopper 26 for pushing the animal forward.
is blocked by.
第１図に示されたセンサ１１とほぼ同様なセンサ２７が
容器２１の側部に設けられて、動物の呼吸による体の体
積の変動に起因する容器２１内の圧力の変化又は呼吸に
よる音波を測定するようになっている。このセンサ２７
に結合されたものは第１図に示されたものと同様な増幅
器１１、レコーダ１８および周波数−電圧変換装置１９
である。A sensor 27, substantially similar to the sensor 11 shown in FIG. It is designed to be measured. This sensor 27
Coupled to are an amplifier 11, a recorder 18 and a frequency-to-voltage converter 19 similar to that shown in FIG.
It is.
第６図に示された測定装置によっても、第１図に示され
たと同様な結果が得られることが判明している。It has been found that similar results to those shown in FIG. 1 can be obtained with the measuring device shown in FIG.
以上の如く、本発明による動物の呼吸能測定方法及び装
置によると、動物の通常の生理的条件下で、動物に特別
に手を加えることなく動物の呼吸能を容易にしかも長時
間にわたって正確に測定することができる。特に薬物の
投与前から投与後を通じて連続的に呼吸能を把握するこ
とができる。As described above, according to the method and apparatus for measuring the respiratory capacity of an animal according to the present invention, it is possible to easily and accurately measure the respiratory capacity of an animal over a long period of time under the normal physiological conditions of the animal without any special handling of the animal. can be measured. In particular, respiratory ability can be continuously monitored from before to after drug administration.
また、本発明はほとんどの小動物に対して特に効果的で
あシ、特に、実験動物として多く利用されているマウス
およびラットの他、ウサギ、ハムスター、モルモット等
の比較的小さな動物の呼吸能測定に好適である。In addition, the present invention is particularly effective for measuring the respiratory performance of most small animals, such as mice and rats, which are often used as experimental animals, as well as relatively small animals such as rabbits, hamsters, and guinea pigs. suitable.
尚、第１図および第２図に示された実施例においては、
センサＩＬ ２７はコンデンサマイクロホンで、あると
して説明されているが、歪デージ、測定ができるセンサ
を適宜使用することができる。In addition, in the embodiment shown in FIGS. 1 and 2,
Although the sensor IL 27 is described as being a condenser microphone, any sensor capable of measuring distortion can be used as appropriate.
さらに、上記センサの取付位置は呼吸能を感度良く正確
に測定できるならば、どのような位置でもよく、例えば
又、第６図に示したセンサ２７を栓２６に設けることに
よシその取扱いを更に便利にすることができる。Furthermore, the above-mentioned sensor may be installed at any position as long as the respiratory capacity can be measured accurately and sensitively.For example, by installing the sensor 27 shown in FIG. It can be made even more convenient.
さらに、１８はレコーダとして説明されているが、単に
呼吸数として測定する場合にはプリンタでもよい。Further, although the reference numeral 18 is described as a recorder, it may be a printer if the respiration rate is simply measured.
第１図は本発明の実施例を示す一部断面概略図、第２図
は第１図に示された測定装置を使用してマウスの呼吸能
を°測定した実験結果の一例を示すグラフ、第６図は本
発明の他の実施例を示す一部す断面概略図である。
１．２・・・容器、 ３・・・肩部、５．６・・
・開口、 ８・・・切り込み、９・・・栓、
１０・・・室、１１・・・センサ、
１２・・・入口管、１３・・・出口管、 １８・
・・レコーダ。
代理人 浅 村 皓
外４名
牙１ 図
牙３図FIG. 1 is a partially cross-sectional schematic diagram showing an embodiment of the present invention; FIG. 2 is a graph showing an example of experimental results obtained by measuring the respiratory capacity of mice using the measuring device shown in FIG. 1; FIG. 6 is a schematic partial cross-sectional view showing another embodiment of the present invention. 1.2... Container, 3... Shoulder, 5.6...
・Opening, 8...notch, 9...stopper,
10... Room, 11... Sensor,
12... Inlet pipe, 13... Outlet pipe, 18.
...Recorder. Agent Asamura Kōgai 4 people 1 picture 3 figures
Claims (4)
積を有する容器で覆い、この容器内の動物の呼吸によっ
て発生する微少な圧力の変化又は音波を測定することに
よシ動物の呼吸能を求めることを特徴とする動物の呼吸
能測定方法。(1) The animal's head, including at least its nose and mouth, is covered with a container having a certain volume, and the animal's head is measured by measuring minute pressure changes or sound waves generated by the animal's breathing inside the container. A method for measuring the respiratory capacity of an animal, characterized by determining the respiratory capacity.
て、該動物が自由に呼吸出来るように少くともその鼻お
よび口を含む頭部を前記容器の前端から出し、該動物の
体部を前記容器内に緩く固定するように前記容器の後端
を閉塞し、この容器内の動物の呼吸によって発生する微
少な圧力の変化又は音波を測定することにより動物の呼
吸能を求めることを特徴とする動物の呼吸能測定方法。(2) Place the animal in a relatively narrow container with a certain volume, protrude at least the head, including the nose and mouth, from the front end of the container so that the animal can breathe freely, and the body of the animal. is loosely fixed in the container, and the rear end of the container is closed, and the respiratory capacity of the animal is determined by measuring minute pressure changes or sound waves generated by the animal breathing inside the container. A method for measuring the respiratory capacity of animals.
になった前部開口を有して該動物の体部を収容するよう
になった容器と、 前記前部開口から出ている動物の頭部を覆うように前記
容器に取付けられた前部容器と、該前部容器内の動物の
呼吸によって発生する微少な圧力の変化又は音波を測定
するためにこの前部容器に数句けられたセンサと、 前記前部容器内に空気等の気体を定常的に導入するだめ
の装置とを有することを特徴とする動物の呼吸能測定装
置。(3) a container adapted to accommodate the body parts of the animal, having a front opening through which the head of the animal, including at least the nose and mouth, emerges; A front container is attached to the container so as to cover the animal's head, and a few tubes are attached to this front container to measure minute pressure changes or sound waves generated by the breathing of the animal in the front container. 1. A respiratory performance measuring device for an animal, characterized in that the device comprises: a sensor that is blown into the front container; and a device that steadily introduces a gas such as air into the front container.
になった前部開口と、動物を出し入れするだめの後部開
口とを有して該動物の体部を収容する−ようになった容
器と、 動物を前記容器の前方に弱く拘束できる程度に前記後部
開口を閉塞するだめの閉塞部材と、前記容器内の動物の
呼吸によって発生する微少な圧力の変化又は音波を測定
するために、この容器に取付けられたセンサとを有する
ことを特徴とする動物の呼吸能測定装置。(4) It has a front opening through which the head of the animal including at least its nose and mouth comes out, and a rear opening through which the animal can be taken in and taken out, and the body part of the animal is housed therein. a container for measuring minute changes in pressure or sound waves generated by the breathing of the animal in the container; , and a sensor attached to the container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57230992A JPS59122949A (en) | 1982-12-28 | 1982-12-28 | Method and apparatus for measuring breathing capacity of animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57230992A JPS59122949A (en) | 1982-12-28 | 1982-12-28 | Method and apparatus for measuring breathing capacity of animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59122949A true JPS59122949A (en) | 1984-07-16 |
| JPH0310078B2 JPH0310078B2 (en) | 1991-02-12 |
Family
ID=16916530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57230992A Granted JPS59122949A (en) | 1982-12-28 | 1982-12-28 | Method and apparatus for measuring breathing capacity of animal |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59122949A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5099792A (en) * | 1991-04-08 | 1992-03-31 | Battelle Memorial Institute | Interchangeable whole-body and nose-only exposure system |
| US5297502A (en) * | 1993-05-05 | 1994-03-29 | Jaeger Rudolf J | Modular reversible-flow-past nasopulmonary respiratory dosing system for laboratory animals |
| WO2003067967A1 (en) * | 2002-02-14 | 2003-08-21 | Japan Science And Technology Agency | Body temperature holding device with heart rate and respiration rate detecting function for small animals and heart rate and respiration rate measuring system for small animals using the device |
| WO2007015289A1 (en) * | 2005-08-01 | 2007-02-08 | Drug Safety Testing Center Co., Ltd. | Chamber unit, pharmacological test system for respiration system and pharmacological test method for safety |
| JP2009507516A (en) * | 2006-03-20 | 2009-02-26 | ソウル ナショナル ユニヴァーシティー インダストリー ファウンデーション | Laboratory mouse motor function analyzer |
| CN106093371A (en) * | 2016-08-16 | 2016-11-09 | 卢丽花 | A kind of operational approach of white mice experimental monitoring device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55101355U (en) * | 1979-01-09 | 1980-07-15 | ||
| JPS56125215U (en) * | 1980-02-21 | 1981-09-24 | ||
| JPS5717315U (en) * | 1980-06-30 | 1982-01-29 | ||
| JPS5719653U (en) * | 1980-07-07 | 1982-02-01 | ||
| JPS5759940A (en) * | 1980-09-29 | 1982-04-10 | Kuraray Co Ltd | Production of ethylene-vinyl alcohol copolymer resin composition and vessel |
-
1982
- 1982-12-28 JP JP57230992A patent/JPS59122949A/en active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55101355U (en) * | 1979-01-09 | 1980-07-15 | ||
| JPS56125215U (en) * | 1980-02-21 | 1981-09-24 | ||
| JPS5717315U (en) * | 1980-06-30 | 1982-01-29 | ||
| JPS5719653U (en) * | 1980-07-07 | 1982-02-01 | ||
| JPS5759940A (en) * | 1980-09-29 | 1982-04-10 | Kuraray Co Ltd | Production of ethylene-vinyl alcohol copolymer resin composition and vessel |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5099792A (en) * | 1991-04-08 | 1992-03-31 | Battelle Memorial Institute | Interchangeable whole-body and nose-only exposure system |
| US5297502A (en) * | 1993-05-05 | 1994-03-29 | Jaeger Rudolf J | Modular reversible-flow-past nasopulmonary respiratory dosing system for laboratory animals |
| WO2003067967A1 (en) * | 2002-02-14 | 2003-08-21 | Japan Science And Technology Agency | Body temperature holding device with heart rate and respiration rate detecting function for small animals and heart rate and respiration rate measuring system for small animals using the device |
| US7174854B2 (en) | 2002-02-14 | 2007-02-13 | Japan Science And Technology Agency | Body temperature holding device with heart rate and respiration rate detecting function for small animals and heart rate and respiration rate measuring system for small animals using the device |
| WO2007015289A1 (en) * | 2005-08-01 | 2007-02-08 | Drug Safety Testing Center Co., Ltd. | Chamber unit, pharmacological test system for respiration system and pharmacological test method for safety |
| US7703414B2 (en) | 2005-08-01 | 2010-04-27 | Drug Safety Testing Center Co., Ltd. | Chamber device, respiratory pharmacological test system and pharmacological safety test method |
| JP2009507516A (en) * | 2006-03-20 | 2009-02-26 | ソウル ナショナル ユニヴァーシティー インダストリー ファウンデーション | Laboratory mouse motor function analyzer |
| JP4813559B2 (en) * | 2006-03-20 | 2011-11-09 | ソウル ナショナル ユニヴァーシティー インダストリー ファウンデーション | Laboratory mouse motor function analyzer |
| CN106093371A (en) * | 2016-08-16 | 2016-11-09 | 卢丽花 | A kind of operational approach of white mice experimental monitoring device |
| CN106093371B (en) * | 2016-08-16 | 2017-10-03 | 卢丽花 | A kind of operating method of small white mouse experimental monitoring device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0310078B2 (en) | 1991-02-12 |
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