JPS5869806A - Cosmetic lotion containing stable collagen - Google Patents
Cosmetic lotion containing stable collagenInfo
- Publication number
- JPS5869806A JPS5869806A JP16769481A JP16769481A JPS5869806A JP S5869806 A JPS5869806 A JP S5869806A JP 16769481 A JP16769481 A JP 16769481A JP 16769481 A JP16769481 A JP 16769481A JP S5869806 A JPS5869806 A JP S5869806A
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- lotion
- cosmetic lotion
- cosmetic
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Abstract
Description
【発明の詳細な説明】
本発明は新規なコラーゲン含有化粧用ローションに関す
る。更に詳しくは長期間保存後も可溶性天然コラーゲン
が変性、凝集、沈澱を起こさずしかもそれを適用しても
皮膚刺激性の低いコラーゲン含有化粧用ローションに関
するものである。可溶性天然コラーゲンは幼若動物又は
動物胎児の皮膚の結合組織よシ直接抽出して得られ、分
子間および分子内架橋結合を有しない未変化の天然コラ
−ダンである。従来皮膚の生理的老化過程は真皮の結合
組織において未変化の可溶性コラーゲンが分子間および
分子内架橋結合の生成に伴い不溶性コラ−ダンに変化し
、不溶性コラ−ダンの含量が高くなシ、その結果皮膚の
弾性が低下し湿潤性が失われ、しわが増加すると言われ
ている。この可溶性天然コラーゲンについては皮膚を透
過して結合組織の可溶性コラーゲンの消失を阻止し又は
可溶性コラーゲンを補給してその弾性を増加させしわを
予防するという考え方の下に皮膚保護剤（特公昭５２−
８３８４）として用いられてきた。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel collagen-containing cosmetic lotion. More specifically, the present invention relates to a collagen-containing cosmetic lotion whose soluble natural collagen does not undergo denaturation, aggregation, or precipitation even after long-term storage, and which causes low skin irritation when applied. Soluble natural collagen is obtained by directly extracting the connective tissue of the skin of young animals or animal fetuses, and is unchanged natural collagen having no intermolecular or intramolecular crosslinks. Conventionally, in the physiological aging process of the skin, unchanged soluble collagen in the connective tissue of the dermis changes to insoluble collagen due to the formation of intermolecular and intramolecular cross-links. As a result, the elasticity of the skin decreases, moisture is lost, and wrinkles increase. This soluble natural collagen is used as a skin protective agent (Japanese Patent Publication No. 1983-1983) based on the idea that it penetrates the skin and prevents the loss of soluble collagen in connective tissues, or replenishes soluble collagen to increase its elasticity and prevent wrinkles.
8384).
近年可溶性コラ−ダンに関する研究が進み、その構造、
性状が明らかになるにつれ上記の考え方には疑問がもた
れむしろ可溶性天然コラーゲンについてその優れた保水
効果が注目されはじめておシ、この保水効果を利用した
化粧用クリーム、化粧用乳液および化粧用ローションが
一部において研究されている現状にある。しかしながら
化粧用ローションの如く水系化粧料においては、可溶性
天然コラーゲンを単にそのまま各種の化粧料に混合した
だけでは溶解性の減少、加水分解、経口凝集沈澱等の問
題を生じ、著しく不安定である。例えば可溶性コラ−ダ
ンの等電点はＰＨ値５，８であシ弱酸性領域では容易に
凝集沈澱を生じ、またアルコールを用いた場合はコラー
ゲンが変性をうけ凝集、沈澱を促進し、カチオン活性剤
またはアニオン活性剤などの界面活性剤はコラーゲンと
複合体を形成したりコラーダン分子に変性を起こし、濁
シを生じたシ経日凝集をおこし実用に供七難い。In recent years, research on soluble colladan has progressed, and its structure,
As the properties of soluble natural collagen became clearer, the above idea became questionable, and the excellent water-retaining effect of soluble natural collagen began to attract attention. Currently, it is being researched in the department. However, in aqueous cosmetics such as cosmetic lotions, if soluble natural collagen is simply mixed into various cosmetics, problems such as decreased solubility, hydrolysis, and oral aggregation and precipitation will occur, making it extremely unstable. For example, the isoelectric point of soluble colladan is PH value 5.8, and it easily aggregates and precipitates in a slightly acidic region.Also, when alcohol is used, collagen is denatured, promoting aggregation and precipitation, and cationic activity. Surfactants such as surfactants or anionic surfactants form complexes with collagen or cause denaturation of colladan molecules, causing aggregation over time that produces cloudy spots, making them difficult to use in practice.
従って商品価値の高いコラーゲン含有化粧用ローション
の製剤化は実質的に不可能であったといえる。Therefore, it can be said that it has been virtually impossible to formulate a collagen-containing cosmetic lotion with high commercial value.
本発明は上記の如き化粧用ローションにおける問題点を
解決すると共に従来に無い優れた化粧用ローションを得
んものと鋭意研究した結果ついに本発明を完成するに到
った。The present invention has been made to solve the above-mentioned problems in cosmetic lotions and to provide an excellent cosmetic lotion that has not been seen before, and as a result of intensive research, the present invention has finally been completed.
本発明は塩類およびまたは保湿剤からなる可溶化安定剤
０．５〜１０重量％、水７５〜９５重量％を含有する化
粧料成分中に、ＰＨ値４〜１０の範囲において分子量１
０−３０万の可溶性天然（未処理）コラ−ダンを０．１
〜５重量％含有することを特徴とする安定な化粧用ロー
ションに関するもので、皮膚に適用することにょシ皮膚
角質層に適゛度な潤いを与え皮膚をなめらか（平滑）に
しはシを与えることを目的とする。The present invention is applied to a cosmetic ingredient containing 0.5 to 10% by weight of a solubilizing stabilizer consisting of salts and/or a humectant, and 75 to 95% by weight of water, with a molecular weight of 1 at a pH value of 4 to 10.
0-300,000 soluble natural (unprocessed) colladan at 0.1
It relates to a stable cosmetic lotion characterized by containing ~5% by weight, and when applied to the skin, it moisturizes the stratum corneum of the skin to an appropriate degree, making the skin smooth and firm. With the goal.
本発明の目的の一つは前述の如き問題を解決し可溶性天
然コラーゲンの化粧料系での安定化を図ることにある。One of the objects of the present invention is to solve the above-mentioned problems and to stabilize soluble natural collagen in cosmetic systems.
本発明の化粧用ローションとは通常の整肌栄養化粧水の
他、収れん化粧水拭き取シ化粧水、シエーゾローション
、？ディローション液状・やツク等をいう。本発明に適
用されるコラーゲンは可溶性天然（未処理）コラ−ダン
で分子量１０〜３０万のものである。通常可溶性天然コ
ラーゲンは幼若動物または動物胎児の皮膚、骨、朧など
の結合組織よシ直接抽出して得られる分子間および分子
内架橋結合を有せず又コラ−ダンのポリ被プテド鎖が酸
アルカリまたは酵素で分解をうけていないものである。What is the cosmetic lotion of the present invention? In addition to the usual skin conditioning and nourishing lotion, there is also an astringent lotion, a wiping lotion, a siezo lotion, and a lotion. Delotion liquid, etc. The collagen used in the present invention is soluble natural (unprocessed) colladan with a molecular weight of 100,000 to 300,000. Normally, soluble natural collagen is obtained by direct extraction from connective tissues such as the skin, bones, and fetuses of young animals or animal fetuses. It has not been degraded by acid or alkali or enzymes.
また本発明化粧用ローションの効果を損うものでなけれ
ば一部熱変性などでゼラチン化したものを含んでいても
よく、またポリ〈グチドを含んだ混合物であってもよい
。性状は粉末の低溶液状ゼ、り一部など種々の形を取シ
得る。Further, as long as the effect of the cosmetic lotion of the present invention is not impaired, it may contain a gelatinized gelatinized product by heat denaturation or the like, or it may be a mixture containing poly(gutide). It can take various forms, such as powder, low-solution liquid, and liquid.
本発明に適用される可溶化安定剤と、しては、塩類とし
ては塩化ナトリウム、塩化カリウム等の中性塩、保湿剤
としてブドウ糖、ソルビトール、尿素がコラーゲンの可
溶化安定剤として最も好ましくその他に塩類としてクエ
ン酸ナトリウム、リン酸−水素ナトリウム、リン酸二水
素ナトリウム等の塩類、保湿剤としてピロリドンカルが
ン酸およヒソノ塩、クリコール類、マニトール、マルト
ース、７−ラクトース、キシリトール、ショ糖等の糖類
が挙げられる。濃度は１０％以上では皮膚に対する刺激
性が高くなシ、べとつきが現われ使用感が悪くなシまた
０、５％以下ではコラーゲンの可溶化安定化が不十分で
あるため全重量中０．５〜１０重量％が好ましい。As the solubilizing stabilizer applied to the present invention, salts such as neutral salts such as sodium chloride and potassium chloride, and humectants such as glucose, sorbitol, and urea are most preferred as collagen solubilizing stabilizers. Salts such as sodium citrate, sodium hydrogen phosphate, sodium dihydrogen phosphate, etc.; moisturizers such as pyrrolidone carboxylic acid and hysono salts, glycols, mannitol, maltose, 7-lactose, xylitol, sucrose, etc. Examples include saccharides. If the concentration is more than 10%, it will be highly irritating to the skin, it will become sticky and the feeling of use will be poor, and if it is less than 0.5%, the solubilization and stabilization of collagen will be insufficient, so it will be 0.5 to 0.5% of the total weight. 10% by weight is preferred.
本発明においては上記コラーゲンと塩類およびまたは保
湿剤からなる可溶化安定剤に水を加えた３つの成分を必
須成分とし、可溶化安定剤として塩類と保湿剤を組み合
わせて用いることが最も好ましく、かつ−領域を４〜１
ｏに保持することが必要である。自身下およびｐＨ１０
以−’Ａ膚に適用するに使用感および刺激性の点で好ま
しくなく、ｐＨ１０以上ではコラ−ダンがゼラチン化）
起こしたシ加水分解による低分子化を起こすため可溶性
天然コラーゲンの効果を失うためで最適にはＰ）（５〜
９の範囲がよい。−調整剤としてはリン酸系炭酸系の無
機酸ならびにそのアルカリ塩、クエン酸、コハク酸酒石
酸、リンゴ酸等の有機酸ならびにそのアルカリ塩を全重
量中１％程度以下で用いることが効果的である。本化粧
用ローションはその他の主な化粧料成分としてアルコー
ル類、界面活性、剤、紫外線吸収剤、種々の薬効成分、
キレート剤等を用いることができる。アルコール類はエ
チルアルコール、イソプロピルアルコール等テコ７−ｙ
ンの経日による変性、凝集、沈澱を考慮し２５重量％程
度までが使用可能な範囲である。界面活性剤としてはカ
チオン活性剤、アニオン活性剤はコラ−ダンと複合体を
形成したシコラーグン分子に変性をおこし、濁シを生じ
たり経口凝集をおこし系での安定化が不良であるため使
用を避けるべきである。エーテル系ノニオン活性剤、エ
ステル系ノニオン活性剤は使用することは可能であるが
、とくにエーテル系ノニオン活性剤が長幼であシ、３重
量％以下の使用が好ましい。紫外線吸収剤としてはウロ
カニン酸系、ペンゾンエノＺ系または安息香酸系を０．
０１〜２．００重量９ｇの範囲で用いることが好ましい
。薬効成分としてはグリチルリチン酸およびその誘導体
、グリチルレチン酸およびその誘導体アラントインなど
の抗炎症剤、ビタミンＥ、ビタミンＢ２誘導体などのビ
タミンＭ、ｒ−オリザノールの如き血行促進剤等を用い
ることも可能である。In the present invention, the three essential ingredients are the above-mentioned collagen, a solubilization stabilizer consisting of salts and/or a humectant, and water added, and it is most preferable to use a combination of salts and a humectant as the solubilization stabilizer, and - area 4-1
It is necessary to hold it at o. Below self and pH 10
(When applied to the skin, it is unfavorable in terms of feel and irritation, and at pH 10 or higher, colladan becomes gelatinized)
Optimally, P) (5 to
A range of 9 is good. - As regulators, it is effective to use phosphoric acid-based carbonic acid-based inorganic acids and their alkali salts, and organic acids such as citric acid, succinate-tartaric acid, malic acid, and their alkali salts in an amount of about 1% or less based on the total weight. be. This cosmetic lotion also contains alcohols, surfactants, agents, ultraviolet absorbers, various medicinal ingredients, and other main cosmetic ingredients.
A chelating agent or the like can be used. Alcohols include ethyl alcohol, isopropyl alcohol, etc.
In consideration of denaturation, aggregation, and precipitation over time, the usable range is up to about 25% by weight. As surfactants, cationic surfactants and anionic surfactants should not be used because they cause denaturation of the cicollagne molecules that form a complex with colladan, causing cloudiness and oral aggregation, and are poorly stabilized in the system. Should be avoided. Although it is possible to use ether type nonionic activators and ester type nonionic activators, it is particularly preferable to use ether type nonionic activators in an amount of 3% by weight or less. As the ultraviolet absorber, urocanic acid type, Penzone Eno Z type or benzoic acid type is used.
It is preferable to use it in a range of 0.01 to 2.00 and a weight of 9 g. As medicinal ingredients, anti-inflammatory agents such as glycyrrhetinic acid and its derivatives, glycyrrhetinic acid and its derivatives allantoin, vitamin E, vitamin M such as vitamin B2 derivatives, blood circulation promoters such as r-oryzanol, etc. can also be used.
また本発明は通常の化粧用ローションの如く香料、防腐
剤１色素、増粘剤等の化粧用原料を必要に応じて用いる
ことは言うまでもない。It goes without saying that in the present invention, cosmetic raw materials such as fragrances, preservatives, pigments, thickeners, etc., may be used as required in ordinary cosmetic lotions.
次に本発明の製造法について述べると予め油溶性化粧料
成分（薬効成分、紫外線吸収剤、界面活性剤、香料等）
を溶解したアルコールに、水溶性化粧料成分（可溶化安
定剤、−調整剤、薬効成分、防腐剤、紫外線吸収剤等）
を溶解（必要ならば加熱）した水を徐々に加え完全に混
和溶解し、次いで４０℃以下で可溶性天然コラ−ダンを
加えて化粧用ローションを得る方法が最適である。可溶
性天然コラーゲンは熱による変性を防ぐため４０００以
下の温度で加えることが必要であシ、またコラーゲンと
直接接触すること゛によシ変性凝集を起こさせるような
化粧料成分とくにアルコールとの接触を出来るだけ避け
るため上述の如く、コラーゲンを最終段階で加えること
が安定な化粧用ローションを得るために重要である。Next, to describe the manufacturing method of the present invention, oil-soluble cosmetic ingredients (medicinal ingredients, ultraviolet absorbers, surfactants, fragrances, etc.)
water-soluble cosmetic ingredients (solubilization stabilizers, conditioners, medicinal ingredients, preservatives, ultraviolet absorbers, etc.)
The most suitable method is to gradually add water in which the colladan is dissolved (heated if necessary) to mix and dissolve completely, and then add soluble natural colladan at a temperature below 40°C to obtain a cosmetic lotion. Soluble natural collagen needs to be added at a temperature below 4,000°C to prevent denaturation due to heat, and should not be exposed to cosmetic ingredients, especially alcohol, that could cause denaturation and aggregation due to direct contact with collagen. In order to obtain a stable cosmetic lotion, it is important to add collagen at the final stage, as mentioned above, to avoid this as much as possible.
上記の如くして得られた本発明化粧用ローションは、分
子量１０万〜３０万の可溶性天然（未処理）コラーゲン
ｐ系への長期安定化を図シ、可溶性天然コラーゲンの有
する優れた保水効果を効果的に発揮させ得るもので従来
の保湿剤のみを用いた化粧用ローションでは得られない
しつと〕感（潤い）を皮膚角質層に与え皮膚とよくなじ
み皮膚をなめらか（平滑）にし、はシを与え得るもので
ある。The cosmetic lotion of the present invention obtained as described above exhibits long-term stabilization of the soluble natural (untreated) collagen p system with a molecular weight of 100,000 to 300,000, and exhibits the excellent water retention effect of soluble natural collagen. It gives the stratum corneum a moisturizing effect that cannot be obtained with conventional cosmetic lotions using only moisturizers, blends well with the skin, smoothes the skin, and prevents skin irritation. It is something that can be given.
次に本発明化粧用ローションの実施例を示す。Next, examples of the cosmetic lotion of the present invention will be shown.
配合割合は重量パーセントである。The blending ratio is expressed in weight percent.
実施例１ 化粧水
可溶性天然コラ−ダン ０．５ブドウ糖
５．０塩化ナトリウ
ム ０．８炭酸ナトリウム
０．０２防腐剤
０．１香料（水溶性）
微量水
９３．５８実施例２ 栄養化粧水
可溶性天然コラ−ダン ２．０ブドウ糖
３．０ソルビトール
２．０塩化ナトリウム
０．８酢゛酸ｄｅ−α−トコフェロ
ール ０．１エチルアルコール
７．０１．３−ブチレングリコール
２．０炭酸ナトリウム ゛ ０．２
防腐剤 ０．０５香料
微量水
８ ２．８ ５実
Ｍ例３ アストリンゼンドロージョン可溶性天然コラ
ーゲン ０．１ブドウ糖
β・０尿素
２．０エチルアルコール
Ｉ Ｏ，０グリセリン １．０
クエン酸 ０．０１リン酸
水素ナトリウム Ｏ０ｌウロカニン酸
０．’０５防腐剤
０．０５香料
微量水
８３．６９実施例４ 整肌化粧水
可溶性天然コラ−ダン １．０ソルビ
トール ６．０尿素
２．０塩化カリウム
０．５グリチルリチン酸ソカリウム
０．１エテルアルコール
５．０ポリオキシエチレン硬化ヒマシ油 ０．３コ
ハク酸 ０．０１コハク酸
ナトリウム ０−１１５ｐ−アミノ
安息香酸 １．０防腐剤
０．１香料
微量水、 ８３．８
４実施例５ アフターシェーブローション可溶性天然コ
ラ−ダン ０．５リン酸水素ナトリウム
０．５イソプロピルアルコール
１０．０ポリオキシエチレン硬化ヒマシ油
０．４プロピレングリコール ３．０
酒石酸 ０．１メントー
ル ０．０１防腐剤
０．０５香料
微量水
８５．４ ４実施例６ 液状パッ
ク
可溶性天然コラ−ダン ５．０１．３−
ブチレングリコール ６．０ポリエチレンダ
リコール ３．０塩化ナトリウム
１．０グリテルレン酸ステアリル
０．０５ポリオキシエチレンオレイルエーテル
０．３ポリビニールアルコール ５．０エ
チルアルコール ５．０グリセリン
１・０防腐剤
０．１香料
微量水
７４．５ ５次に本発明による化粧用ロー
ションの経時変化について述べる。Example 1 Lotion soluble natural colladan 0.5 glucose 5.0 sodium chloride 0.8 sodium carbonate
0.02 preservative
0.1 fragrance (water soluble)
trace water
93.58 Example 2 Nutritional lotion Soluble natural colladan 2.0 Glucose 3.0 Sorbitol 2.0 Sodium chloride
0.8 de-α-tocopherol acetate 0.1 Ethyl alcohol
7.01.3-Butylene glycol
2.0 Sodium carbonate ゛ 0.2
Preservative 0.05 fragrance
trace water
8 2.8 5 Actual M Example 3 Astringent Lotion Soluble Natural Collagen 0.1 Glucose
β・0 urea
2.0 ethyl alcohol
I O,0 Glycerin 1.0
Citric acid 0.01 Sodium hydrogen phosphate O0l Urocanic acid 0. '05 preservative
0.05 fragrance
trace water
83.69 Example 4 Skin conditioning lotion Soluble natural colladan 1.0 Sorbitol 6.0 Urea
2.0 potassium chloride
0.5 Sopotassium glycyrrhizinate
0.1 ether alcohol
5.0 Polyoxyethylene hydrogenated castor oil 0.3 Succinic acid 0.01 Sodium succinate 0-115p-aminobenzoic acid 1.0 Preservative
0.1 fragrance
Trace water, 83.8
4 Example 5 Aftershave Lotion Soluble Natural Colladan 0.5 Sodium Hydrogen Phosphate 0.5 Isopropyl Alcohol
10.0 Polyoxyethylene hydrogenated castor oil
0.4 Propylene glycol 3.0
Tartaric acid 0.1 Menthol 0.01 Preservative
0.05 fragrance
trace water
85.4 4 Example 6 Liquid Pack Soluble Natural Colladan 5.01.3-
Butylene glycol 6.0 Polyethylene dalycol 3.0 Sodium chloride
1.0 Stearyl glycerulinate
0.05 polyoxyethylene oleyl ether
0.3 Polyvinyl alcohol 5.0 Ethyl alcohol 5.0 Glycerin 1.0 Preservative
0.1 fragrance
trace water
74.5 5 Next, the change over time of the cosmetic lotion according to the present invention will be described.
表の説明
表は米発明による化粧用ローションの経時変化を本発明
で用いている可溶化安定剤を使用しない同一処方の化粧
用ローション（本発明化粧用ローションから可溶化安定
剤のみを除いたもの）の経時変化と比較したものである
。表１、表２、表３、表４表５および表６はそれぞれ実
施例１ 、’２ 、３４．５および６の化粧用ローショ
ンの外観性状の経時変化を示す。Explanation of the table This table shows the change over time of the cosmetic lotion according to the US invention, and the cosmetic lotion with the same formulation without the solubilizing stabilizer used in the present invention (the cosmetic lotion of the present invention with only the solubilizing stabilizer removed). ) compared with the change over time. Tables 1, 2, 3, 4, 5 and 6 show changes over time in the appearance and properties of the cosmetic lotions of Examples 1, '2, 34.5 and 6, respectively.
表中、−〜升の記号は化粧用ローションの外観性状の変
化をコラ−ダンの変性の程度によシ表わした。In the table, symbols from - to square represent changes in the appearance and properties of cosmetic lotions depending on the degree of modification of colladan.
−変化なし
± コラーゲンわずかに凝集
十 コラ−ダン凝集
廿 コラ−ダン凝集沈澱
化粧水 室温 −−一−−−−
４５°Ｃ−−−−−−−
抜き化粧水室温 士 士 十 甘 甘 甘 什４５°
Ｃ士 士 十 廿 丑 丑 丑表２
栄養化粧水室温 −−−一−−−
４５°Ｃ−−−−−−−
ジョン ４５°Ｃ−−−−−−−−，１
表４
検 体 保存 経 時 変 化
条件１日３日１０日３０日ω日９０日１８０日整肌化粧
水 室温 −−−一−−−
４５°Ｃ−−−−−−−
整肌化粧水 室温 士 士 十 ＋＋ 升 甘
甘４５°Ｃ士 士 十 丑 ＋ ＋
升４５-No change±Collagen slightly agglomerated 10 Colladan flocculated 10 Colladan flocculated and precipitated lotion Room temperature -1 45°C--- Lotion removed at room temperature 45°
Table 2 Nutrient lotion room temperature --- 1 --- 45°C --- 45°C ---------, 1 Table 4 Specimen preservation Change over time Conditions 1 day 3 days 10 days 30 days ω days 90 days 180 days Skin conditioning lotion Room temperature −−−1−−− 45°C−−−−−− Skin conditioning lotion Room temperature Expert 10 ++ Masu sweet
Sweet 45°C Shishi Ten Ox ＋ ＋
45 squares
Claims (1)
５〜１０重量％、水７５〜９５重量％を含有する化貝料
成分中に、…値４〜１ｏの範囲において分子量１０〜３
ｏ万の可溶性天然（未処理）コラ−ダンを０．１〜５重
量％含有せしめることを特徴とする安定なコラーゲン含
有化粧用ローション。 ２、 塩類が塩化ナトリウム、塩化カリウム、クエン酸
ナトリウム、リン酸−水素ナトリウム、またはリン酸二
水素ナトリウムである特許請求の範囲第１項記載の安定
なコラーゲン含有化粧用ローション。 ３、保湿剤がブドウ糖、ソルビ）−ル、ｆｌ、ピロリド
ンカルボン酸およびその塩、グリコール類、マニトール
、マルトース、フラクトース、キシリトール、又はショ
糖である特許請求の範囲第１項記載の安定なコラ−ダン
含有化粧用ローション。 ４、薬剤を含有せしめた特許請求の範囲第１項記載の安
定なコラ−ダン含有化粧用ローション０ ５、 アルコールを含有せしめた特許請求の範囲第１項
記載の安定なコラーゲン含有化粧用ローション。 ６、紫外線吸収剤０．０１〜２．００重量％を含有せし
めた特許請求の範囲第１項記載の安定なコラーゲン含有
化粧用ローション。[Claims] 1. Solubilization stabilizer consisting of salts and/or humectants 0.
In the chemical shell material component containing 5 to 10% by weight and 75 to 95% by weight of water,...with a molecular weight of 10 to 3 in the range of 4 to 1o.
A stable collagen-containing cosmetic lotion characterized by containing 0.1 to 5% by weight of soluble natural (unprocessed) colladan. 2. The stable collagen-containing cosmetic lotion according to claim 1, wherein the salt is sodium chloride, potassium chloride, sodium citrate, sodium hydrogen phosphate, or sodium dihydrogen phosphate. 3. The stable collagen according to claim 1, wherein the humectant is glucose, sorbyl, fl, pyrrolidone carboxylic acid and its salts, glycols, mannitol, maltose, fructose, xylitol, or sucrose. Cosmetic lotion containing Dan. 4. The stable collagen-containing cosmetic lotion according to claim 1, which contains a drug. 5. The stable collagen-containing cosmetic lotion according to claim 1, which contains alcohol. 6. The stable collagen-containing cosmetic lotion according to claim 1, which contains 0.01 to 2.00% by weight of an ultraviolet absorber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16769481A JPS5869806A (en) | 1981-10-20 | 1981-10-20 | Cosmetic lotion containing stable collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16769481A JPS5869806A (en) | 1981-10-20 | 1981-10-20 | Cosmetic lotion containing stable collagen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5869806A true JPS5869806A (en) | 1983-04-26 |
| JPH029561B2 JPH029561B2 (en) | 1990-03-02 |
Family
ID=15854491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16769481A Granted JPS5869806A (en) | 1981-10-20 | 1981-10-20 | Cosmetic lotion containing stable collagen |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5869806A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6089410A (en) * | 1983-10-20 | 1985-05-20 | Shiseido Co Ltd | Cosmetic |
| JPS6133105A (en) * | 1984-07-24 | 1986-02-17 | Shiseido Co Ltd | Skin external preparation |
| JPS627A (en) * | 1985-03-04 | 1987-01-06 | Shiseido Co Ltd | Skin external agent containing incorporated urea |
| JPH01238512A (en) * | 1988-03-18 | 1989-09-22 | Sansho Seiyaku Co Ltd | Drug for external use |
| JPH02178211A (en) * | 1988-12-28 | 1990-07-11 | Sansho Seiyaku Co Ltd | Stable external base composition |
| JP2008239507A (en) * | 2007-03-26 | 2008-10-09 | Fancl Corp | Stabilizer of triple helical structure of collagen |
| JP2015523333A (en) * | 2012-05-16 | 2015-08-13 | コシードバイオファーム カンパニー リミテッド | Cosmetic, pharmaceutical and food composition containing a crushed or extracted fish eyeball |
| JP2016077410A (en) * | 2014-10-14 | 2016-05-16 | 地方独立行政法人東京都立産業技術研究センター | Collagen solution and gel production method using it |
| JP2022535365A (en) * | 2019-05-27 | 2022-08-08 | デイタム バイオテック リミテッド | Collagen composition and use thereof |
| KR20230143550A (en) * | 2022-04-05 | 2023-10-12 | (주)뉴트리 | Composition comprising collagen with enhanced storage stability and method for preparing the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54110336A (en) * | 1978-02-16 | 1979-08-29 | Taichirou Akiyama | Skin protecting agent and production thereof |
| JPS55149369A (en) * | 1979-05-10 | 1980-11-20 | Ajinomoto Co Inc | Wetting agent composition |
-
1981
- 1981-10-20 JP JP16769481A patent/JPS5869806A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54110336A (en) * | 1978-02-16 | 1979-08-29 | Taichirou Akiyama | Skin protecting agent and production thereof |
| JPS55149369A (en) * | 1979-05-10 | 1980-11-20 | Ajinomoto Co Inc | Wetting agent composition |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6089410A (en) * | 1983-10-20 | 1985-05-20 | Shiseido Co Ltd | Cosmetic |
| JPH0456004B2 (en) * | 1983-10-20 | 1992-09-07 | Shiseido Co Ltd | |
| JPS6133105A (en) * | 1984-07-24 | 1986-02-17 | Shiseido Co Ltd | Skin external preparation |
| JPS627A (en) * | 1985-03-04 | 1987-01-06 | Shiseido Co Ltd | Skin external agent containing incorporated urea |
| JPH01238512A (en) * | 1988-03-18 | 1989-09-22 | Sansho Seiyaku Co Ltd | Drug for external use |
| JPH02178211A (en) * | 1988-12-28 | 1990-07-11 | Sansho Seiyaku Co Ltd | Stable external base composition |
| JP2008239507A (en) * | 2007-03-26 | 2008-10-09 | Fancl Corp | Stabilizer of triple helical structure of collagen |
| JP2015523333A (en) * | 2012-05-16 | 2015-08-13 | コシードバイオファーム カンパニー リミテッド | Cosmetic, pharmaceutical and food composition containing a crushed or extracted fish eyeball |
| JP2016077410A (en) * | 2014-10-14 | 2016-05-16 | 地方独立行政法人東京都立産業技術研究センター | Collagen solution and gel production method using it |
| JP2022535365A (en) * | 2019-05-27 | 2022-08-08 | デイタム バイオテック リミテッド | Collagen composition and use thereof |
| KR20230143550A (en) * | 2022-04-05 | 2023-10-12 | (주)뉴트리 | Composition comprising collagen with enhanced storage stability and method for preparing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH029561B2 (en) | 1990-03-02 |
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