JPS5868659A - Ion selective electrode - Google Patents
Ion selective electrodeInfo
- Publication number
- JPS5868659A JPS5868659A JP56166470A JP16647081A JPS5868659A JP S5868659 A JPS5868659 A JP S5868659A JP 56166470 A JP56166470 A JP 56166470A JP 16647081 A JP16647081 A JP 16647081A JP S5868659 A JPS5868659 A JP S5868659A
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- ion
- selective
- conductive material
- plasticizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920003023 plastic Polymers 0.000 claims abstract description 8
- 239000004033 plastic Substances 0.000 claims abstract description 8
- 239000004020 conductor Substances 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 abstract description 38
- 239000004014 plasticizer Substances 0.000 abstract description 9
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 abstract description 3
- ZFMQKOWCDKKBIF-UHFFFAOYSA-N bis(3,5-difluorophenyl)phosphane Chemical compound FC1=CC(F)=CC(PC=2C=C(F)C=C(F)C=2)=C1 ZFMQKOWCDKKBIF-UHFFFAOYSA-N 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 229920000915 polyvinyl chloride Polymers 0.000 abstract description 2
- 239000004800 polyvinyl chloride Substances 0.000 abstract description 2
- 108010067973 Valinomycin Proteins 0.000 abstract 1
- FCFNRCROJUBPLU-UHFFFAOYSA-N compound M126 Natural products CC(C)C1NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=O FCFNRCROJUBPLU-UHFFFAOYSA-N 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- FCFNRCROJUBPLU-DNDCDFAISA-N valinomycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O FCFNRCROJUBPLU-DNDCDFAISA-N 0.000 abstract 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 229910001414 potassium ion Inorganic materials 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 238000005259 measurement Methods 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
- G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は特定のイオン濃度を選択的に測定するためのイ
オン選択性電極に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an ion-selective electrode for selectively measuring the concentration of specific ions.
イオン選択性電極は従来よシ液中−の特定のイオンの濃
度を選択的に定着できるという特色があシ、これまでも
、特定イオンの濃度のモニタ、水質分析など広い分計に
おいて使われてきた。Conventionally, ion-selective electrodes have the characteristic of being able to selectively fix the concentration of specific ions in a liquid, and have been used in a wide range of applications, such as monitoring the concentration of specific ions and analyzing water quality. Ta.
これは、例えば陽イオン選択性を極の場合には対象とす
る陽イオンの活11a+と陽イオン選択性電極が示す電
位Eとの間には
E−B@+2.303(RT/ZF)loga” ・
=・・−(t)のような、また、陰イオン選択性電極の
場合には対象とする隘イオンの活鎗畠−と自イオン選択
性電極が示す電位Eとの間には
B −E”−2,303(RT/ZF) log a−
″ ・−−−−−(2)のような油層の対数と電位とが
比例する関係が成立し、電位の測定値から目的とするイ
オンの活量が簡単に計算できるからである。For example, in the case of a cation-selective electrode, the difference between the active 11a+ of the cation and the potential E shown by the cation-selective electrode is E-B@+2.303(RT/ZF)loga. ”・
=...-(t), and in the case of an anion-selective electrode, there is a difference between B -E and the potential E shown by the target ion-selective electrode. ”-2,303 (RT/ZF) log a-
This is because a relationship such as (2) in which the logarithm of the oil layer is proportional to the potential is established, and the activity of the target ion can be easily calculated from the measured value of the potential.
なお前記(1)式及び(2))弐において、Rは気体定
数、Tは給体温度、ZFiイオン価、FJ”j7アラデ
一定数 Heは系の標準電極電位である。In the above equations (1) and (2)), R is a gas constant, T is a feed temperature, a ZFi ion valence, FJ''j7 is an Alade constant, and He is a standard electrode potential of the system.
このようにイオン選択性電”極を用いれば、1位を測定
すゐだけで広い濃度範囲でのイオンの定量が可能となる
。tた、イオン選択性電極を用い、電極部を小型にする
ことKよシ、少量のサンプルでの測定が可能となる。こ
のようなイオン選択性電極の便利さのため、最近ではこ
れを医療用、特に血液中にとけているイオン、例えばN
a +、K+C!−などのイオンの定量に用いようと
する試みがさかんになってきている。By using an ion-selective electrode in this way, it is possible to quantify ions over a wide concentration range by simply measuring the first position.Also, by using an ion-selective electrode, the electrode part can be made smaller. This makes it possible to perform measurements with a small amount of sample.Due to the convenience of such ion-selective electrodes, they have recently been used for medical purposes, especially for measuring ions dissolved in blood, such as N.
a+, K+C! There have been many attempts to use it for quantifying ions such as -.
ところがイオン選択性電極においては、長時間使用する
と、イオン選択性の膜が劣化して膜の交換を行う必要が
あり、i九、交換の際に電極機能を回復させる必要がし
ばしば起る。特に1中性キヤリヤーをポリ塩化ビニルな
どのプラスチック中に可塑剤とともに含むようにした形
式のイオン選択性膜を有するイオン選択性電極において
は、これを血液などの分析などに用いる場合には、前記
イオン選択性膜中より前記可塑剤が優先的に抽出される
ため短寿命であった。However, when an ion-selective electrode is used for a long time, the ion-selective membrane deteriorates and the membrane needs to be replaced, and it is often necessary to restore the electrode function at the time of replacement. In particular, in an ion-selective electrode having an ion-selective membrane in which a neutral carrier is contained in a plastic such as polyvinyl chloride together with a plasticizer, when this is used for analysis of blood, etc., the above-mentioned The plasticizer was preferentially extracted from the ion-selective membrane, resulting in a short lifespan.
本発明は、以上の中性キャリヤーをイオン選択性物質と
して有する中性キャリヤー形式のイオン選択性電極の欠
点を解消することを目的とする。An object of the present invention is to eliminate the drawbacks of the above-described neutral carrier type ion-selective electrode having a neutral carrier as an ion-selective substance.
すなわち、本発明は、容器内に収納された内部基準電極
と、この電極を囲むように前記容器内に封入され良導電
性物質と、前記容器の器壁の一部を構成しプラスチック
材料、可塑剤およびイオン選択性物質を含むイオン選択
性膜とを具備し、錠前d己イオン選択性模と同材質の延
長部を設けることを特徴とするイオン選択性霜−極に係
るものである。That is, the present invention provides an internal reference electrode housed in a container, a highly conductive material sealed in the container to surround this electrode, and a plastic material or plastic material forming a part of the wall of the container. The present invention relates to an ion-selective frost-electrode, comprising an ion-selective membrane containing an ion-selective agent and an ion-selective substance, and an extension portion made of the same material as the ion-selective pattern of the lock.
本発明のイオン選択性電極においては、皮とえイオン選
択性膜の血液と接する表面から可塑剤が抽出されたとし
ても、前記延長部から前記イオン選択性膜の方へ可塑剤
が供給されることになり、結局イオン選択性模内部での
可塑剤a度の減少が妨げられ膜の劣化が抑制さ才)る。In the ion-selective electrode of the present invention, even if the plasticizer is extracted from the surface of the ion-selective membrane in contact with blood, the plasticizer is supplied from the extension to the ion-selective membrane. As a result, the decrease in the degree of plasticizer inside the ion-selective mold is prevented, and the deterioration of the membrane is suppressed.
以下、本発明を実施例によって説明する。Hereinafter, the present invention will be explained by examples.
カリウムイオン選択性電&を図面によって説明すれば、
略筒状の容器1・l内に収納δれた鎖−塩化銀よりカる
内部基準電極12がこの電極を前記容器内の先端部で区
割して支持する遮壁13によって支持され、容器内で前
記電極を囲むように封入された内部電解質であるKC/
よりなる導電性物質14と容器の器壁の一部を構成し、
容器の先端に貼着した中性キャリヤーであるパリノマイ
シンをOT塑剤であるジオクチルアジペートとと4.に
プラスチック中に固定し九カリウムイオン選択性膜15
と前記内部基準電極12管外部に導出するリード線16
よりなるイオン選択性電極において、前記イオン選択性
膜15が導電性物質14と接する容器の内側に突出して
前記イオン選択性膜と同材質の延長部17が設けられた
構造になっている、かかる構造を有する本発明のカリウ
ムイオン選択性電極は、実際の測定を行なったところ、
K+の濃度範囲10−’M〜5x10−sMにおいてネ
ルンスト応答を示り、血清中での寿命は6か月であった
。これに対し従来の形式のカリウムイオン選択性電極で
は1〜2か月程度の寿命である。If you explain potassium ion selective electron & with a drawing,
An internal reference electrode 12 from a chain-silver chloride body housed in a substantially cylindrical container 1.l is supported by a shielding wall 13 that partitions and supports this electrode at the tip of the container. An internal electrolyte KC/
constitutes a part of the wall of the container with a conductive substance 14 consisting of
4. The neutral carrier palinomycin attached to the tip of the container is mixed with the OT plasticizer dioctyl adipate. nine potassium ion-selective membranes fixed in plastic to 15
and the internal reference electrode 12 and a lead wire 16 led out to the outside of the tube.
The ion-selective electrode has a structure in which the ion-selective membrane 15 protrudes inside a container in contact with the conductive substance 14 and is provided with an extension portion 17 made of the same material as the ion-selective membrane. When the potassium ion selective electrode of the present invention having the structure was actually measured,
It exhibited a Nernstian response in the K+ concentration range of 10-'M to 5x10-sM and had a lifespan of 6 months in serum. In contrast, conventional potassium ion selective electrodes have a lifespan of about 1 to 2 months.
以上のように1本発明の電極は血液分析にお・いて長崎
命を有するため、本発明の電極を用いれは従来ひんばん
に行なう必要のあった電極の交換も少なくてすみ、娯測
定の回数も減少できる利点がある。As mentioned above, since the electrode of the present invention has a Nagasaki life in blood analysis, using the electrode of the present invention reduces the need for electrode replacement, which conventionally had to be done frequently, and the number of recreational measurements. It also has the advantage of being able to reduce
図面は、本発明の実施例のイオン選択性′fIL極の断
面図である。
11−一容器、12・・・内部基準電極、13・・・遮
壁、14・・・導電性物質、15・・・イオン選択性膜
、16・・・リード線、17・・・延長部。The drawing is a cross-sectional view of an ion-selective 'fIL pole according to an embodiment of the present invention. DESCRIPTION OF SYMBOLS 11-1 container, 12... Internal reference electrode, 13... Shielding wall, 14... Conductive substance, 15... Ion selective membrane, 16... Lead wire, 17... Extension part .
Claims (1)
に前記容器内に封入されえ導電性物質と前記容器の器壁
の一部を構成しプラスチック材料、可履剤およびイオン
選択性物質を含むイオン選択性膜とを具備し、前記イオ
ン選択性膜が前記導電性物質と接する@に前記イオン選
択性膜と同材質の延長部を設けることを特徴とするイオ
ン選択性電極。A conductive material that is housed in a container and is sealed in the container so as to surround the specific internal reference electrode and the t-pole, and a plastic material, a lubricant, and an ion-selective material that constitute a part of the wall of the container. An ion-selective electrode comprising: an ion-selective membrane comprising: an ion-selective membrane comprising: an extension portion made of the same material as the ion-selective membrane at a portion where the ion-selective membrane contacts the conductive substance;
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56166470A JPS5868659A (en) | 1981-10-20 | 1981-10-20 | Ion selective electrode |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56166470A JPS5868659A (en) | 1981-10-20 | 1981-10-20 | Ion selective electrode |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5868659A true JPS5868659A (en) | 1983-04-23 |
Family
ID=15831986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56166470A Pending JPS5868659A (en) | 1981-10-20 | 1981-10-20 | Ion selective electrode |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5868659A (en) |
-
1981
- 1981-10-20 JP JP56166470A patent/JPS5868659A/en active Pending
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