JPS58208666A - Chemical manupulator - Google Patents
Chemical manupulatorInfo
- Publication number
- JPS58208666A JPS58208666A JP9259682A JP9259682A JPS58208666A JP S58208666 A JPS58208666 A JP S58208666A JP 9259682 A JP9259682 A JP 9259682A JP 9259682 A JP9259682 A JP 9259682A JP S58208666 A JPS58208666 A JP S58208666A
- Authority
- JP
- Japan
- Prior art keywords
- reagent
- reactor
- mixer
- nozzle
- constant temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
- G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00495—Centrifuges
- G01N2035/00504—Centrifuges combined with carousels
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【発明の詳細な説明】
この発明にケミカルマニピュレータに関し、特に、マイ
クロリッターオーターの試料の配合、冷却、加熱等の分
析工程を自動化するための新規な改良に関するものであ
る、
従来、用いられているマイクロリッターオーダーの分析
工程は憧めて複雑なもので、その大部分を研究者の手作
業によって行なっていた。[Detailed Description of the Invention] The present invention relates to a chemical manipulator, and in particular, to a novel improvement for automating analysis processes such as sample mixing, cooling, and heating in a microliter auto, which have been conventionally used. The analysis process for microliters is extremely complex, and much of it is done manually by researchers.
この発明に以上の欠点をすみゃ炉に除去するための極め
て効果面な手段全提供すること？目的とするもので−特
に、１ｇ１転自在ＶＣ設けられ反応容器？もつＩ！ｌ！
１転テーブル？備え友遠心分離装置と、試薬吐出ノズル
２工び乾燥用吸引ノズルに有し上下動自在Ｖｃ歿けられ
たノズル上下装置と、恒温槽ｐよびミキサとを有し上下
動目在Ｖｃ設けられた恒温槽及びミキサ上下装置と全有
し、遠ＩＬ？分離装置に対してノズル上下装置および恒
温槽及びミキサ上下装置を上下動させるようにした調成
である。The present invention provides highly effective means for eliminating the above-mentioned drawbacks in Sumya furnaces. What is the purpose of - in particular, a reaction vessel equipped with 1 g and 1 rotatable VC? Motsu I! l!
1 turn table? It is equipped with a centrifugal separator, two reagent discharge nozzles, a drying suction nozzle and a nozzle vertically movable Vc, a nozzle vertically movable device, a constant temperature bath P and a mixer, and a vertically movable scale Vc. Completely equipped with constant temperature chamber and mixer up/down device, far IL? This is a preparation in which the nozzle up/down device, constant temperature bath, and mixer up/down device are moved up and down relative to the separation device.
以下、区間と共にこの発明によるケミカルマニピュレー
タの好適な一笑嬢例について詳細に説明する、
図ｔ１１］ＶＣ，ｓ・いて符汚１で示されるものは遠心
分離装置であり、この遠心分離装置１の駆動軸２１Ｃは
覆Ｏの反応容器３をそのｌｉｔ端部に肩する回転テーブ
ル４が回転可能に装着されている。＠記、駆動＠２のほ
ぼ中央部には検出円板５が設けられ、この検出円板５の
一蝙に全体がコ字型をなす回転位置出レセンサ６とＴＬ
会するように配Ｖされており回転テーブル４の回転位置
全構出することができると共に、＠記反応容器３に第１
図の笑緋および点蔵で示されるように矢印Ａの万１５Ｊ
ｌこ１Ｉ１２Ｉ動目任に設Ｖすられている。Hereinafter, a preferred example of the chemical manipulator according to the present invention will be explained in detail together with sections. A rotary table 4 is rotatably mounted on the shaft 21C, and the rotary table 4 supports the covered reaction vessel 3 at its lit end. ＠Note, a detection disc 5 is provided approximately at the center of the drive @ 2, and a rotational position output sensor 6 and a TL, each having a U-shape as a whole, are mounted on one side of the detection disc 5.
The V is arranged so that the entire rotational position of the rotary table 4 can be exposed, and the first
15J of arrow A as shown by Ehi and Tenzo in the figure.
It has been set up for the purpose of 1I12I movement.
１ 前記Ａｌｂ分ｍ分車装置土部位置Ｖｃは
試薬吐出ノズル７および乾燥用吸引ノズル８とｔ有する
保持板９を有するノズル上下装置１０が配設されており
、この保持板９は一体に設けられｔ支軸１１が保持筒体
１２に摺動自在に設けられ、電磁プランジャ１′５の作
動により軸１１が矢印Ａの方間に上下動する調成である
。1 The soil portion position Vc of the Alb minute wheel device is provided with a nozzle up/down device 10 having a reagent discharge nozzle 7, a drying suction nozzle 8, and a holding plate 9, and this holding plate 9 is integrally provided. A support shaft 11 is slidably provided on the holding cylinder 12, and the shaft 11 is adjusted to move up and down in the direction of arrow A by the operation of an electromagnetic plunger 1'5.
さらに、前記遠心分離装置１の下部位置にに恒温槽１４
ＲＪ：びミキサ１５とをその周端部に有する保持板１６
を備えた恒温槽及びミキサ上下装置１７が配設され、こ
の保持板１６ｖｒ−一体に設けら几た支軸１８が電磁プ
ランジャ１９？有する保持筒体２０内に矢印Ｂの方間ｖ
ｃｊ？いて上下動自在に設けられていると共に、前記篭
６ブランジヤ１９？作動さぜることにより保持板１６か
矢印Ｂの方間に２いて上下動できる＃４灰である。同、
駆動軸２、＠！１１および１８とに同−中心線上に位置
している、
前記試薬吐出ノズル７には試薬送ｇ装置２１〃１ら送ら
れた試襖がμｊのオーターで吐出され一前記乾燥用吸引
ノズル８に冷却装置２２に接続されｔコンデンｔ２５に
接続さｎると共に、このコンデンサ２３の出力に真空ポ
ンプ２４Ｖｃ接続さｆている、前記恒温槽１４ｔｒｉ温
度制両装置２５に接続されて一定温度に制御されて２す
、シーケンスコントローラ２６７）−らの出力制御信号
に前記真空ポンプ２４、遠Ｉｕ分ＪｌｌＥ装置１の回転
駆動モータ１ａ恒温憎及びミキサ上下装置１７の電（Ｂ
プランジャ１９、試薬送液装置２１およびノズルを下装
置１０の電・セブランジャ１３ｉＣ供帽きれ、各々？制
御している。Furthermore, a constant temperature bath 14 is installed at the lower part of the centrifugal separator 1.
RJ: A retaining plate 16 having a mixer 15 at its peripheral end.
A constant temperature bath and a mixer up/down device 17 are provided, and an electromagnetic plunger 19 ? In the holding cylinder 20 having a direction v of arrow B
cj? The basket 6 plunger 19 is provided so as to be movable up and down. It is a #4 ash that can be moved up and down by moving the holding plate 16 in the direction of arrow B. same,
Drive shaft 2, @! The reagent discharge nozzle 7, which is located on the same center line as the reagent discharge nozzle 11 and 18, discharges the sample sent from the reagent supply device 21 1 at a rate of μj, and then passes through the drying suction nozzle 8. The constant temperature chamber 14 is connected to a cooling device 22, is connected to a condenser 25, and is connected to a vacuum pump 24Vc to the output of the condenser 23, and is controlled to a constant temperature by being connected to a temperature control device 25. 2, sequence controller 267) - the vacuum pump 24, the constant temperature rotary drive motor 1a of the remote control device 1, and the electric power (B) of the mixer up/down device 17.
Are the plunger 19, the reagent liquid feeding device 21 and the nozzle removed from the lower device 10? It's in control.
さらに、削６己試架吐出ノズル７にａ長手形状の試薬供
給バイブ藻３０が装着ちれ、前自己珠狩叛１６の１ｔｉ
１部にａテーバ広３１が設けられている、このテーバ木
３１ぽ第２図に示されるように一面にテーバ部３２を有
して２！１ｌｌ−前記保持板１６が上昇して第２図のＡ
の状態から第２図のＢの状態になると、前ｄ己テーバ部
３２が反応容器６の外向部に接合するため、反応容器３
はテーバ部３２に沿って傾斜する。この状態で同時に前
記保持板９が下降してくるため前記試薬供給バイブ５０
の先端部が反応容６３の内側部３ａに接合し、試薬供給
バイ１３０〃）ら供給される数μｊと云う単位の試薬に
通常に試薬供給パイプ３０の先端で表面張力により球状
となって落下しないが、球状になった試薬が反応容器３
の内側、部３ａに接し、内側部３ａを流下して底部に導
かれる４１１成である。Furthermore, a long-shaped reagent supply vibe 30 is attached to the sample rack discharge nozzle 7, and the 1ti
As shown in FIG. 2, this Theber wood 31, which has a Taber wide 31 in one part, has a Taber part 32 on one side as shown in FIG. A of
When the state changes from the state to the state shown in FIG.
is inclined along the tapered portion 32. In this state, the holding plate 9 is lowered at the same time, so the reagent supply vibe 50
The tip of the pipe 30 is joined to the inner part 3a of the reaction chamber 63, and the reagent in units of several μj supplied from the reagent supply pipe 130 normally falls into a spherical shape due to surface tension at the tip of the reagent supply pipe 30. However, the spherical reagent is in the reaction container 3.
411 is in contact with the inner part 3a, flows down the inner part 3a, and is guided to the bottom part.
以上のような構成に２いて−この発明によるケミカルマ
ニピュレータを作動させる場合について述べると、試薬
連数装置２１から送られた試薬にｔ研プランジャ１３が
作動して保持板９が降下し、試薬吐出ノズル７の試薬供
嬬バイ１体３０が反応谷ａ３の内側部３ａに接した状態
で反応容器５円にμｂ卑位で注入される。さらに、回転
テーブル４Ｖｃ設けら几た他の反応容器３に試薬ケ注入
する場合ｖｃニ、シーケンスコントローラ２６刀）うの
制御９汚により回転駆動モータ１ａ全所定角度回転させ
て他の反応容器３？ｆ″試薬吐出ノズル７ｖｃ対応した
位置迄回転移動させる、この状態で再び電磁プランジャ
１３？作動させると、保持板９か師下し前述と同様の動
作により試薬吐出ノズル７カ）ら反応各５３１ＣμＥ率
位の試薬が注入され４゜さらに、＠記反応容器３内の水
分？除去する場合ＶＣは回転駆動モータ１ａｉ作動させ
て回転テーブル４を回転させ、反応容器３ヶ乾燥用吸引
ノズルａ Ｉｃ 対ｉ した位置に位置さぜ電磁プラン
ジャ１３を作動させると一保持板９が呻下して乾燥用吸
引ノズル８が反応容器３に密層し、遠心分離後の反応容
器３内の液体ｔコンデンサ２３ｖｃＪ：ｐＨｉ云し真空
ポンプ２４で吸い取るものである。In the case where the chemical manipulator according to the present invention is operated with the above-described configuration, the T-type plunger 13 is activated by the reagent sent from the reagent serialization device 21, the holding plate 9 is lowered, and the reagent is discharged. The reagent supply vial 30 of the nozzle 7 is injected into the reaction vessel 5 yen at a μb base level while being in contact with the inner side 3a of the reaction valley a3. Furthermore, when injecting the reagent into another reaction container 3 equipped with a rotary table 4Vc, the rotation drive motor 1a is rotated at a predetermined angle by the control 9 of the sequence controller 26). When the electromagnetic plunger 13 is operated again in this state, the holding plate 9 moves down and the same operation as described above causes a reaction of 531 CμE for each from the reagent discharge nozzles 7vc). Furthermore, when removing water in the reaction container 3, the VC operates the rotary drive motor 1ai to rotate the rotary table 4, and connects the three reaction containers with drying suction nozzles a Ic and i. When the electromagnetic plunger 13 is operated at the position shown in FIG. It is called pHi and is sucked out by a vacuum pump 24.
又、反応容袋６内の試料の温度全急激に上下させる場合
ｖｃは、電磁プラノジャ１９７３−作動させて保持板１
６全土昇さぜると、恒温槽１４が上昇して反応容置５が
恒温槽１４内に人つクヒ秋態となり恒温槽１４Ｖｃ設足
された温度に削記反ルＳ谷器６内の温度が一定時間内に
変更される。In addition, when the temperature of the sample in the reaction bag 6 is suddenly raised or lowered, the electromagnetic plane jar 1973 is operated and the holding plate 1
6, the constant temperature chamber 14 rises and the reaction vessel 5 enters the constant temperature chamber 14, and the temperature at which the constant temperature chamber 14Vc is set is recorded. The temperature is changed within a certain period of time.
匠って、本実ｍ１ｆｉｌによれば、反応容器３内の試料
の遠ノし分離、試薬注入、乾昧、温度変化、ｆ８−よび
ミキシング等の８ ｉ′Ｆ、に全く入手全弁することな
くシーケンスコントローラＩｃ 、Ｊ：、 ９極のて簡
単、正確に、刀）つ、目動的に行なうことができるもの
であリー従来、多くの研究者により行なわれてきた困難
な作業を迅運に行なうことがでさるよう［なった効果は
、極めて肩益なことである。、特に、μｅ卑位の試薬全
反応容器を傾針させることにより極めて容易に反応容器
内に供給するように４１ｉ！＋双した効果は絶大なもの
がある。According to Takumi M1fil, it is possible to obtain all the necessary information at 8 i'F, such as centrifugal separation of the sample in the reaction vessel 3, reagent injection, drying, temperature change, f8- and mixing. The sequence controller Ic, J:, 9-pole can be easily, accurately, and visually performed.It quickly and easily performs difficult tasks that have traditionally been performed by many researchers. [The resulting effect is extremely beneficial.] In particular, by tilting the entire reaction vessel, the 41i! + The combined effect is tremendous.
典１図はこの発明によるケミカルマニピュレータ？示す
全体慣故図で、第２図（４）（Ｂ）に費部を示す偽成因
である。
１に遠ノし分離装置、５に反応容器、５ａに内側都、Ａ
はｕ転テーブル、６は回転位置出しセンサ、７ば試薬吐
出ノズル、８は乾燥用吸引ノズ化、９は保持板、１０は
ノズル上下装置、１４に恒温槽、１５はミキサ、１６ば
保持板、１７に恒温槽及びミキサ上下装置、２１は試系
送′Ｉ′ＶＬ鋲直、２２は冷却装置、２３はコンデンサ
、２４は真空ポンプ、２５はｔｌＲ度制ｍ装置、２６は
シーケンスコントローラ、３０は試薬供１、」バイフ淳
−３１はテーバ体、５２はテーバ部である、Is Figure 1 the chemical manipulator according to this invention? In the overall conventional diagram shown in FIG. 2, (4) (B) shows the false cause. 1 is the remote separation device, 5 is the reaction vessel, 5a is the inner cap, A
1 is a U-turn table, 6 is a rotary positioning sensor, 7 is a reagent discharge nozzle, 8 is a suction nozzle for drying, 9 is a holding plate, 10 is a nozzle up/down device, 14 is a constant temperature bath, 15 is a mixer, 16 is a holding plate , 17 is a constant temperature chamber and mixer up/down device, 21 is a test system feeder, 22 is a cooling device, 23 is a condenser, 24 is a vacuum pump, 25 is a tlR system, 26 is a sequence controller, 30 is the reagent sample 1, ``Byfu Jun-31 is the Taber body, and 52 is the Taber part.
Claims (1)
ブル全層する遠心分離装置と、この回転テーブルの回転
位置全検出するためのｌＩｌ！１転位置出転位出出と、
前♂己遠心分離装置の上部位置に設けられ試薬吐出ノズ
ルｊ１？よび乾燥用吸引ノズルとを有すると共に前記遠
心分離装置の方向に往仮移動目仕に設けられたノズル上
下装置と、前記遠心分離装置の下部位置ｖｃ設けられ恒
温槽２よびミキサーと′に肩すると共にその支＠刀同に
移動自在に設け、られた恒温槽及びミキサー上下装置と
一前記ノノル上下裂直、遠心分ｌｌ！袈直２よび恒温槽
及びミキサー上下装置の作１ｔｌｌ’に制御する友めの
シーケンスコントローラと、＠配試薬吐出ノズルに設け
られ友長手形状のバイブ本と、前記恒温槽及びミキサー
上下装置ＶＣ設けらｎたテーバ体とを備７１、前記恒温
槽及びミキサー上下装置が上昇した場合、このテーバ体
が前記反応容器全傾斜させ、＠記バイブ体が反応容器の
ＦＦ３壁に接合しパイプ体〃）らの試薬が反応容器内に
供給されるようｖｃ構成したことを％俤とするケミカル
マニピュレータ。Reaction vessel with tilt a? It has a centrifugal separator for all layers of a rotary table equipped with a rotary self-control IC, and a lIl! for detecting all rotational positions of this rotary table. 1-transition position/transposition/output,
The reagent discharge nozzle j1 is installed at the top of the front self-centrifugation device. and a suction nozzle for drying, and a nozzle up-and-down device provided with a temporary moving mechanism in the direction of the centrifugal separator, and a lower position vc of the centrifugal separator, which is located on the constant temperature bath 2 and the mixer. At the same time, it is movably installed on its support, with a thermostatic chamber and mixer vertical device, and a vertically split, centrifugal section! A companion sequence controller that controls the construction of the pedestal 2, a constant temperature bath, and a mixer up/down device, a vibrator in a vertical shape provided at the reagent discharge nozzle, and a VC device for the constant temperature bath and mixer up/down device. When the constant temperature bath and the mixer vertical device are raised, this Taber body tilts the entire reaction vessel, and the vibrator body is joined to the FF3 wall of the reaction vessel and the pipe body A chemical manipulator having a vc configuration such that reagents are supplied into a reaction vessel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9259682A JPS58208666A (en) | 1982-05-31 | 1982-05-31 | Chemical manupulator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9259682A JPS58208666A (en) | 1982-05-31 | 1982-05-31 | Chemical manupulator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58208666A true JPS58208666A (en) | 1983-12-05 |
| JPH0330822B2 JPH0330822B2 (en) | 1991-05-01 |
Family
ID=14058826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9259682A Granted JPS58208666A (en) | 1982-05-31 | 1982-05-31 | Chemical manupulator |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58208666A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4753892A (en) * | 1986-06-26 | 1988-06-28 | Coombs David H | Process for forming a continuous solution gradient |
| JPH04330270A (en) * | 1991-04-30 | 1992-11-18 | Shimadzu Corp | Micro-manipulator |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6351950B2 (en) * | 2013-10-22 | 2018-07-04 | キヤノンメディカルシステムズ株式会社 | Automatic analyzer and dispenser |
| ES2891850T3 (en) * | 2015-11-25 | 2022-01-31 | Siemens Healthcare Diagnostics Products Gmbh | Procedure for transferring a volume of liquid into an analysis device |
-
1982
- 1982-05-31 JP JP9259682A patent/JPS58208666A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4753892A (en) * | 1986-06-26 | 1988-06-28 | Coombs David H | Process for forming a continuous solution gradient |
| JPH04330270A (en) * | 1991-04-30 | 1992-11-18 | Shimadzu Corp | Micro-manipulator |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0330822B2 (en) | 1991-05-01 |
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