JPS58192812A - Elastin for cosmetic and its composition - Google Patents
Elastin for cosmetic and its compositionInfo
- Publication number
- JPS58192812A JPS58192812A JP7435382A JP7435382A JPS58192812A JP S58192812 A JPS58192812 A JP S58192812A JP 7435382 A JP7435382 A JP 7435382A JP 7435382 A JP7435382 A JP 7435382A JP S58192812 A JPS58192812 A JP S58192812A
- Authority
- JP
- Japan
- Prior art keywords
- elastin
- cosmetic
- elastase
- skin
- ethylene oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
この発明は化粧用エラスチンおよびその組成物に関する
ものである。DETAILED DESCRIPTION OF THE INVENTION This invention relates to cosmetic elastin and compositions thereof.
近年、スキンクリームなどの化粧品に皮膚成分の１つで
あるコラーゲンムコ多糖類およびエラスチンを配合し、
化粧品のテクスチャーの改善、使用感の向上、エモリエ
ント効果の附与や、皮膚の保護、改善作用を有し、皮膚
ＩＣなじみ易い化粧品の開発が注目されている。In recent years, collagen mucopolysaccharides and elastin, which are skin ingredients, have been added to cosmetics such as skin creams.
The development of cosmetics that improve the texture of cosmetics, improve the feeling of use, provide emollient effects, protect and improve the skin, and are easily compatible with skin IC is attracting attention.
それら成分のうち、コラーゲンは、皮膚、血管など結合
組織を構成する生簀なタンパク質であり、生体中で常に
伸縮がくり返される結合組織、たとえば大動脈、項靭帯
などｉζ多量−こ含有されている。Among these components, collagen is a vital protein that constitutes connective tissues such as the skin and blood vessels, and is contained in large amounts in connective tissues that constantly undergo expansion and contraction in living organisms, such as the aorta and nuchal ligament.
また、結合組織中にはコンドロイチン硫酸、デルマタン
硫鍍、ヒアルロン酸などのいわゆるムコ多糖類と呼ばれ
る成分が存在する。これらムコ多糖類は水分の保持に重
要な役割をしており、加令と共番こムコ多糖類の含量は
減少することか知られている。ａｔこ、エラスチンは、
ゴム様の伸縮性を示すタンパク質であり、組織の弾力性
に関与するタンパク質である。皮膚中にも１．５〜５％
含有され皮膚の張り、若々しさに関与している。エラス
チンも、加令と゛共に皮膚などの結合組織中で変性をう
け、含量も減少することが知られている（ＦｒａＩＪｉ
ｒａｎｃｅＪ、／ｌ６５２（ｖｏｌ １０＊１）２７（
１９８２））。Furthermore, components called so-called mucopolysaccharides such as chondroitin sulfate, dermatan sulfate, and hyaluronic acid are present in the connective tissue. These mucopolysaccharides play an important role in water retention, and it is known that the content of mucopolysaccharides decreases with aging. At this, elastin is
It is a protein that exhibits rubber-like elasticity and is involved in tissue elasticity. 1.5-5% in the skin
It is involved in the firmness and youthfulness of the skin. It is known that elastin also undergoes degeneration in connective tissues such as skin with age, and its content decreases (FraIJi
ranceJ, /l652(vol 10*1)27(
1982)).
しかし、エラスチンは不溶性タンパク質であり、そのま
−では化粧品に応用することができないため、可溶化し
て水浴液としてから応用する必要がチン可溶化時に昶曹
の汚染が高い頻度で起る。However, since elastin is an insoluble protein and cannot be applied to cosmetics as it is, it is necessary to solubilize it and use it as a water bath solution, which often causes contamination with soda when solubilizing elastin.
したがって、エラスターゼの消毒法としてエチレンオキ
サイドガスを用いたところ、エラスターゼの活性を低下
させることなく、確実−こ消毒が可能になり、濾過滅菌
法よりずっと簡便であることが分った。また、エラスチ
ン溶解中にたとえ細菌などが汚染したとしても、菌数が
急速に増加しないようにすれば、臭気愉質の発生もなく
、衛生的−なエラスチン溶液が得られることが判明した
。この汚染生菌の数の増加を抑制する方法として、エラ
スターゼ活性を抑制しない程度のメチルパラベン、エチ
ルパラベン、プロピルパラベン、ブチルパラベンなどの
パラベン＠またはその混合物を工″ラスチン溶解液中に
存在させる方法が有効であることも判明した。Therefore, when ethylene oxide gas was used as a method for disinfecting elastase, reliable disinfection was possible without reducing the activity of elastase, and it was found to be much simpler than the filter sterilization method. It has also been found that even if bacteria become contaminated during elastin dissolution, as long as the number of bacteria is prevented from rapidly increasing, a sanitary elastin solution can be obtained without generating any unpleasant odor. As a method to suppress the increase in the number of contaminating living bacteria, there is a method in which parabens such as methylparaben, ethylparaben, propylparaben, butylparaben, or mixtures thereof are present in the Rustin solution to an extent that does not suppress elastase activity. It was also found to be effective.
したがって、エチレンオキサイドガス消毒したエラスタ
ーゼ、オートクレーブもしくは沸騰消毒をおこなったエ
ラスチン溶液、そして溶解時のパラベン類の防腐剤の使
用の組合ゼにより、細菌類の汚染のない、グレードの高
い化粧用エラスチンの製造が可能になった。したがって
、この発明は以上の結果から完成するに到ったものであ
る。Therefore, by combining elastase sterilized with ethylene oxide gas, elastin solution sterilized in an autoclave or boiling, and the use of paraben preservatives during dissolution, high-grade cosmetic elastin is produced without bacterial contamination. is now possible. Therefore, this invention has been completed based on the above results.
エラスターゼのエチレンオキサイドガスによる消毒では
、エラスターゼ粉末を厚さ０．０６ｍのポリエチレン袋
に入れてシールし、これを更に大きなスタフレン袋に入
れ、大きな袋にエチレンオキサイドガスを充満さゼシー
ルして室温に放置し島放置時間が３時間から１８時間ま
で経過しても、エラスターゼのエラスチン溶解能は殆ん
ど低下せず、しかも完全な消毒ができた。To disinfect elastase with ethylene oxide gas, put elastase powder into a 0.06 m thick polyethylene bag, seal it, put it into a larger Staphlen bag, fill the larger bag with ethylene oxide gas, seal it, and leave it at room temperature. Even when the island was left for 3 to 18 hours, the ability of elastase to dissolve elastin hardly decreased, and moreover, complete disinfection was achieved.
また防腐剤であるパラベン類で生菌数の増加を抑制する
には、パラベン濃ｔを０．０１〜０．２％とすれば、エ
ラスターゼ活性を阻害することもないが、望ましい濃度
範曲は０．０５〜０．１５優である。In addition, in order to suppress the increase in the number of viable bacteria using parabens, which are preservatives, if the paraben concentration is set to 0.01-0.2%, it will not inhibit elastase activity, but the desirable concentration range is It is 0.05 to 0.15 excellent.
このようにして製造されたエラスチンをスキンクリーム
＠、乳液類に混合すると、化粧品のテクスチャーが改善
され、皮膚に水分を附与するモイスチャー効果が強調さ
れる。また可溶化エラスチンは角質内に滲透し表皮を滑
らかＩこする効果がある。更に、毛髪用化粧品に応用し
た場合、損傷した毛髪にエラスチンは吸着し毛髪のトリ
ートメント疹こ効果がでる。When the elastin produced in this way is mixed into skin creams and emulsions, the texture of the cosmetics is improved and the moisturizing effect of adding moisture to the skin is emphasized. In addition, solubilized elastin penetrates into the stratum corneum and has the effect of smoothing the epidermis. Furthermore, when applied to hair cosmetics, elastin is adsorbed to damaged hair, resulting in a hair treatment rash effect.
更にまたこのよう番こ製造されたエラスチンとコラーゲ
ンを共ｌこスキンクリーム、乳液などの化粧品に混合便
用すると、一層の皮膚の保護改善作用′がある。また、
このエラスチン、コラーゲンおよびムコ多糖類の３者を
スキンクリーム、乳液などの化粧品に同時に応用すると
、皮膚の主な成分を含んだ化粧品となり皮膚の保護改善
作用に一層の効果を発揮する。Furthermore, when the elastin and collagen produced in this manner are mixed and used in cosmetics such as skin creams and emulsions, they have a further effect of improving skin protection. Also,
When these three components, elastin, collagen, and mucopolysaccharides, are simultaneously applied to cosmetics such as skin creams and emulsions, the cosmetics contain the main components of the skin and are even more effective in protecting and improving the skin.
以下、この発明を実施例にて説明する。This invention will be explained below with reference to Examples.
実施例１
牛の項靭帯の表面に耐着している脂肪、筋崗、よごれな
どを除いたエラスチン原料１ｋｊｇを１０倍量の沸騰水
そ３０分間煮沸し、冷却後、切断し、ホモジナイザーも
しくは崗挽き機で粉砕した。その後、１０倍量の水で２
時間煮沸し、冷却後、エラスチンを濾布で絞って、２４
の・メチルパラベン０．１嘩を含むＭ／２０）リス緩衝
液（ｐＨ８，５）を加え、ガラスビンに入れてオートク
レーブで消毒した。Example 1 1 kg of elastin raw material from which fat, muscle, dirt, etc. adhering to the surface of the nuchal ligament of a bovine were removed was boiled in 10 times the amount of boiling water for 30 minutes, cooled, cut, and placed in a homogenizer or granite. Grinded with a grinder. After that, 2 times with 10 times the amount of water.
After boiling for an hour and cooling, squeeze out the elastin with a filter cloth for 24 hours.
M/20) Lys buffer (pH 8.5) containing 0.1% of methylparaben was added, and the mixture was placed in a glass bottle and sterilized in an autoclave.
一方、ブタ膵臓から得られたエラスターゼ（大野製薬■
製エラスターゼ活性０．３Ｕ／■）１２９をｌＯｘ１０
ｃｍ のポリエチレン袋（膜厚［１，０６Ｍ）に入れ熱
シールし、更に３０Ｘ３０ｃｍ のスタフレン袋内に
置き、エチレンオキサイドガスを６０×３０ｃｍ袋内に
充満さビ、シールし室温で８時間放置した。On the other hand, elastase obtained from pig pancreas (Ohno Pharmaceutical ■
elastase activity 0.3U/■) 129 to lOx10
The mixture was placed in a polyethylene bag (film thickness: 1.06 M), heat-sealed, and then placed in a 30 x 30 cm Staphrene bag, filled with ethylene oxide gas into the 60 x 30 cm bag, sealed, and left at room temperature for 8 hours.
このオートクレーブ消毒したエラスチン原料番こエチレ
ンオキサイド消毒したエラスターゼを加え３７ｔｌ’の
恒温娠盪機で３日間放置したところ、項靭帯エラスチン
は完全に溶解し、少量の綿状の不溶物が残った。これを
９５ｔｌ’で１０分間加熱すると、少量の新たな沈殿物
が生成した。これを冷却 後、消毒した濾過機で濾紙
を用いて濾過すると、８〜１２％のエラスチン濃度の透
明で淡黄色の僅かなタンパク臭をもつ無菌のエラスチン
溶液が得られた。Elastase sterilized with ethylene oxide was added to this autoclave-sterilized elastin raw material, and the mixture was left in a 37 tl' thermostatic shaker for 3 days, and the nuchal ligament elastin was completely dissolved, leaving a small amount of flocculent insoluble material. This was heated at 95 tl' for 10 minutes and a small amount of new precipitate formed. After cooling, this was filtered through a filter paper using a sterilized filter to obtain a clear, pale yellow, and sterile elastin solution with a slight protein odor and an elastin concentration of 8 to 12%.
このエラスチン溶液は化粧水、クリーム、毛髪用化粧品
などへの配合に適したものである。This elastin solution is suitable for inclusion in lotions, creams, hair cosmetics, and the like.
この実施例で（ま緩衝液としてＭ／２０１Ｊス緩衝液（
・ｐｉ−１８，５）を用いたが、リン酸緩衝液、グリシ
ン−塩化す） ＩＩウムーＮｍＯＨ緩衝液、炭酸緩衝液
など化粧品への配合上問題とならないものも使用できる
。In this example, the buffer was M/201J buffer (
・Although pi-18,5) was used, it is also possible to use phosphate buffers, glycine-chloride buffers, NmOH buffers, carbonate buffers, etc. that do not cause problems when blended into cosmetics.
実施例２
緩衝液としてＭ／６０リン酸緩衝液（ｐＨ８，０４）、
ハラヘン類（防腐剤）としてメチルパラベン、エチルパ
ラベン、プロピルパラベン各０．０３３％、ｔなわち、
合計パラベン濃度が０．１％になるよう用いた他は、実
施例１と同様の条件で、化粧用エラスチン液を製造した
。このエラスチン液を噴霧乾燥すると微粉末のエラスチ
ンが得られた。この乾燥エラスチンは水に易溶であり、
所望の濃度のエラスチン溶液゛が得られ、化粧品への配
合の場合も使用上便利になることが多い。Example 2 M/60 phosphate buffer (pH 8,04) as a buffer solution,
Methylparaben, ethylparaben, propylparaben each 0.033% as halachens (preservatives), i.e.,
A cosmetic elastin liquid was produced under the same conditions as in Example 1, except that the total paraben concentration was 0.1%. When this elastin liquid was spray-dried, fine powder elastin was obtained. This dried elastin is easily soluble in water,
An elastin solution with a desired concentration can be obtained, and it is often convenient to use when incorporated into cosmetics.
この実施例で行った噴霧乾燥以外番こ、真空乾燥、凍結
乾燥など他の乾燥法でも同様の品質のエラスチン粉末が
得られる。Elastin powder of similar quality can be obtained by drying methods other than the spray drying used in this example, such as drying, vacuum drying, and freeze drying.
実施例６
実施例１で得られたエラスチン溶液を以下の配合により
ローションを作成した。Example 6 A lotion was prepared using the elastin solution obtained in Example 1 according to the following formulation.
成 分 量（重量％）
（１）ｎ製氷 ９４１８＋２１
ＤＬ−アラニン ０５０に（１グ
リチルリチン酸ジカリウム ０．１０（４）パ
ラオキシ安濤香酸 ０１０（５）エラスチ
ン溶液（１０チ） ５．００（６）香料
００２（７）ホ！Ｊオキシエ
チレン硬化ヒマシ油（６０モル）ｏ、ｉ。Component Amount (wt%)
(1)n ice making 9418+21
DL-alanine 050 (1 dipotassium glycyrrhizinate 0.10 (4) paraoxybenzoic acid 010 (5) elastin solution (10) 5.00 (6) fragrance
002 (7) Ho! J oxyethylene hydrogenated castor oil (60 mol) o, i.
精製水（１１を７５０に加熱後、バラオキシ安息香酸（
４）を加え溶解した。この溶液に常温にて成分（２）、
＋３１、＋５１． ＋６１および（７）を順次加え攪拌
溶解した。Purified water (11) was heated to 750℃, then roseoxybenzoic acid (
4) was added and dissolved. Add component (2) to this solution at room temperature,
+31, +51. +61 and (7) were sequentially added and dissolved with stirring.
この乳液は皮膚の保湿に効果がある。This emulsion is effective in moisturizing the skin.
実施例４
実施例２で得られたエラスチン粉末と特願昭５３−１６
７５０に述べられている方法で作られたアテロコラーゲ
ンを以下の割合で配合し、クリーム乳液を製造した。Example 4 Elastin powder obtained in Example 2 and patent application 1984-16
A cream emulsion was prepared by blending atelocollagen prepared by the method described in No. 750 in the following proportions.
成 分 量（重量嗟）ｔｌ
）スクワラン ９００（
２）コレステロール ０．５
０（３）レシチン ０．
２０（４）セタノール
５．００（５）自己乳化型モノステアリン酸グリセリン
５００（６）バラオキシ安息香酸プロピル
０．１０（７）精製水
７６．４０ｔ８）ＤＬ−アラニン
０．５０（９）エラスチン粉末
１．００θＧアテロコラーゲン（２１Ｇ）
２００ａυ香料
０．３０成分＋１）〜（６１ｆ７５ｔ：’
で溶解し均一化したこの溶液に、７５ｔｌ：：の成分（
７）〜（９）を加え乳化した。この乳液に、３５Ｃ以下
で成分（１１を加え均一化し、更ｉこ成分０υを加えた
。Ingredients Quantity (weight) tl
) Squalane 900 (
2) Cholesterol 0.5
0 (3) Lecithin 0.
20(4) Setanol
5.00(5) Self-emulsifying glyceryl monostearate 500(6) Propyl roseoxybenzoate
0.10 (7) Purified water
76.40t8) DL-alanine
0.50(9) Elastin powder
1.00θG atelocollagen (21G)
200aυ fragrance
0.30 component + 1) ~ (61f75t:'
To this solution, which was dissolved and homogenized with
7) to (9) were added and emulsified. Ingredient (11) was added to this emulsion at 35C or lower to homogenize it, and then 0μ of the ingredient was added.
このクリーム乳液は皮膚の保験改善に効果がある。This cream emulsion is effective in improving skin care.
実施例５
実施例１で製造されたエラスチン溶液と、特願昭５３−
１０２１７８で製造されたアテロコラーゲンＳＳ及びヒ
アルロン酸を同時に含むスキンクリームを以下の配合で
調製した。Example 5 The elastin solution produced in Example 1 and the patent application 1973-
A skin cream simultaneously containing atelocollagen SS manufactured by No. 102178 and hyaluronic acid was prepared with the following formulation.
成 分 童（重量−
〕ｆｌ［動パラフィン
１５．００（２）ミリスチン酸イソプロピル
１５．００（３）ミツロウ
１１００（４）オ
リーブ油
１２．ＯＤ（５）ラノリン
２．００（６）セタノール
２．００＋７
）−７ウリルアルコール
２００（８）テトラオレイン酸ポリオキシエチ
レンツルピント（４０Ｅｏ ） ３．５０（９）テ
トラオレイン酸ポリオキシエチレンソルビット（６０Ｅ
ｏ） ３．５００１プロピルパラベン
０．１０Ｉ精製水
１１７゜０３工ラスチン
溶液１０ｍ！ ５．００
０ヒアルロン酸溶液５嘩
５．００Ｑ４１ｒ）−、つ砂
０．７０Ｑ９ヒドロキ
シエチルセルロース ０．２０Ｑ
ｅメチルパラベン ０１０ａ７
）香料 ０．２０
Ｑ１７７０＝１ラーゲ７８８（２＄１１） ５
．００成分＋１１〜０Ｑを７５Ｃで溶解し均一化した。Ingredients (weight -
] fl [dynamic paraffin
15.00 (2) Isopropyl myristate
15.00 (3) Beeswax
1100 (4) Olive oil
12. OD(5) Lanolin
2.00 (6) Setanol
2.00+7
)-7 uryl alcohol
200(8) Polyoxyethylene sorbitol tetraoleate (40Eo) 3.50(9) Polyoxyethylene sorbitol tetraoleate (60Eo)
o) 3.5001 Propylparaben
0.10I purified water
117゜03 engineering Rustin solution 10m! 5.00
0 hyaluronic acid solution 5
5.00Q41r)-, Tsusuna
0.70Q9 Hydroxyethyl cellulose 0.20Q
eMethylparaben 010a7
)Fragrance 0.20
Q1770=1Lage788 (2$11) 5
．． 00 components +11 to 0Q were dissolved and homogenized at 75C.
別に１成分ａυ〜ＯＱを７５Ｃに加温し均一化しておき
、成分（１）〜（ＩＩからなる溶液に攪拌下で徐々に加
えた。Separately, one component aυ~OQ was heated to 75C and homogenized, and gradually added to the solution consisting of components (1) to (II) under stirring.
これを４０〜４５Ｃに冷却して成分Ｉｎを加え、更に３
５Ｃ以下で成分αＳを加えて混合した。Cool this to 40-45C, add component In, and further
At 5C or less, component αS was added and mixed.
このスキンクリームは、皮膚のｇＡｍ改曹１特に保湿に
効果を示す。This skin cream is particularly effective in moisturizing the skin.
代理人 上屋 勝 ｌ 常包芳男 ｌ 杉 浦 俊 貴Agent Katsu Ueya l Yoshio Tsuneko l Takashi Ura
Claims (1)
物に、エチレンオキサイドガスで消毒したエラスターゼ
で無菌的に可溶化し、９０Ｃ〜１００Ｃに加熱後濾過し
て得られることを特徴とする化粧用エラスチン。 ２、その化粧用エラスチンが溶液かまたは粉末状である
ことを特徴とする特許請求の範１１Ｉｇｉ項に記載の化
粧用エラスチン。 ６、ハラペン類がメチルパラベン、エチルパラベン、プ
ロピルパラベンもしくはブチルパラベンまたはその混合
物であることを特徴とする特許請求の範囲第１項または
第２項に記載の化粧用エラスチン。 ４、不溶性エラスチンｔよびパラベン類からなる組成物
に、エチレンオキサイドガスで消毒したエラスターゼで
無菌的に可溶化し、９０Ｃ〜１００Ｃに加熱後濾過して
得られる化粧用エラスチンを含有することを特徴とする
化粧用組成物。 ５、 更にコラーゲンを含有することを特徴とする特許
請求の範囲第４項に記載の組成物。 ６ 更にムコ多糖類を含有することを特徴とする特許請
求の範囲第４項に記載の組成物。 Ｚ ムコ多糖類がフンドロイチン硫酸、デルマタンｖＬ
酸、またはヒアルロン酸であることを特徴とする特許請
求の範囲第６項に記載の組成物。 ８ 更にコラーゲンおよびムコ多糖類とを含有すること
を特徴とする特許請求の範囲第４項に記載の組成物。[Claims] 1. It is characterized in that it is obtained by aseptically solubilizing a composition consisting of insoluble elastin and parabens with elastase disinfected with ethylene oxide gas, heating it to 90C to 100C, and then filtering it. Cosmetic elastin. 2. The cosmetic elastin according to claim 11Igi, wherein the cosmetic elastin is in the form of a solution or powder. 6. Cosmetic elastin according to claim 1 or 2, wherein the halapen is methylparaben, ethylparaben, propylparaben, butylparaben, or a mixture thereof. 4. It is characterized by containing cosmetic elastin obtained by aseptically solubilizing a composition consisting of insoluble elastin T and parabens with elastase disinfected with ethylene oxide gas, heating to 90C to 100C, and then filtering. Cosmetic composition. 5. The composition according to claim 4, further comprising collagen. 6. The composition according to claim 4, further comprising a mucopolysaccharide. Z Mucopolysaccharides are fundroitin sulfate and dermatan vL
The composition according to claim 6, which is an acid or hyaluronic acid. 8. The composition according to claim 4, further comprising collagen and mucopolysaccharide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7435382A JPS58192812A (en) | 1982-04-30 | 1982-04-30 | Elastin for cosmetic and its composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7435382A JPS58192812A (en) | 1982-04-30 | 1982-04-30 | Elastin for cosmetic and its composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS58192812A true JPS58192812A (en) | 1983-11-10 |
Family
ID=13544671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7435382A Pending JPS58192812A (en) | 1982-04-30 | 1982-04-30 | Elastin for cosmetic and its composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58192812A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037803A (en) * | 1987-03-04 | 1991-08-06 | Jean Gueyne | Product comprising a silicon organic compound combined with a cosmetically active substance |
| GB2264058A (en) * | 1990-10-25 | 1993-08-18 | Narhex Ltd | Methods and compositions for amelioration of skin wrinkles |
| AU653368B2 (en) * | 1990-10-25 | 1994-09-29 | Narhex Limited | Methods and compositions for amelioration of skin wrinkles |
| RU2762199C1 (en) * | 2020-12-22 | 2021-12-16 | Общество с ограниченной ответственностью "ЛАОНА ЛАБ" | Method for obtaining elastin mono-product (options) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2353282A1 (en) * | 1976-06-02 | 1977-12-30 | Invap Etablissement | APPLICATION OF ELASTIN AND ITS DERIVATIVES IN COSMETICS |
-
1982
- 1982-04-30 JP JP7435382A patent/JPS58192812A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2353282A1 (en) * | 1976-06-02 | 1977-12-30 | Invap Etablissement | APPLICATION OF ELASTIN AND ITS DERIVATIVES IN COSMETICS |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037803A (en) * | 1987-03-04 | 1991-08-06 | Jean Gueyne | Product comprising a silicon organic compound combined with a cosmetically active substance |
| GB2264058A (en) * | 1990-10-25 | 1993-08-18 | Narhex Ltd | Methods and compositions for amelioration of skin wrinkles |
| GB2264058B (en) * | 1990-10-25 | 1994-08-10 | Narhex Ltd | Anti-wrinkle compositions comprising low molecular weight elastin |
| AU653368B2 (en) * | 1990-10-25 | 1994-09-29 | Narhex Limited | Methods and compositions for amelioration of skin wrinkles |
| RU2762199C1 (en) * | 2020-12-22 | 2021-12-16 | Общество с ограниченной ответственностью "ЛАОНА ЛАБ" | Method for obtaining elastin mono-product (options) |
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