JPS58161911A - Manufacture of beta-form calcium tertiary phosphate - Google Patents
Manufacture of beta-form calcium tertiary phosphateInfo
- Publication number
- JPS58161911A JPS58161911A JP4545482A JP4545482A JPS58161911A JP S58161911 A JPS58161911 A JP S58161911A JP 4545482 A JP4545482 A JP 4545482A JP 4545482 A JP4545482 A JP 4545482A JP S58161911 A JPS58161911 A JP S58161911A
- Authority
- JP
- Japan
- Prior art keywords
- neutralization reaction
- calcination
- calcium phosphate
- temperature
- carried out
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【発明の詳細な説明】
この発明は、酸化カルシウムとリン酸の中和反応により
ハイドロオキシアパタイトリン酸カルシウムを得、これ
を焼成してβ型第３リン酸カルシウムに変換するβ型第
３リン酸カルシウムの製造方法に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing β-type tribasic calcium phosphate, which involves obtaining hydroxyapatite calcium phosphate through a neutralization reaction between calcium oxide and phosphoric acid, and converting it into β-type tribasic calcium phosphate by firing. .
β型第３リン酸カルシウムは、近年窯業関係の原料とし
て多量に用いられるよう番こなり、高純度で且つ安価な
ものが求められている。従来、この化合物は、酸化カル
シウムとリン酸の中和反応を６０℃以上特に１００℃前
後の温度で行ない、得られたハイドロオキシアパタイト
リン酸カルシウムの焼成を９００℃以上特に１２００℃
前後の高温で数時間特に６時間前後行なうことにより製
造されていた。しかしこの場合、中和反応の温度が高い
ため、中間体ハイドロオキシアパタイトリン酸カルシウ
ムの焼成（こ高温および長時間を要して、熱コスト的に
はなはだ不経済である上に、変換率が低くて中間体ハイ
ドロオキシアパタイトリン酸カルシウムが残留し、この
点でも製品のコスト高をまねくという問題があった。In recent years, β-type tertiary calcium phosphate has been used in large quantities as a raw material for ceramics, and there is a demand for high purity and low cost. Conventionally, this compound has been produced by carrying out a neutralization reaction of calcium oxide and phosphoric acid at a temperature of 60°C or higher, especially around 100°C, and then firing the obtained hydroxyapatite calcium phosphate at a temperature of 900°C or higher, especially 1200°C.
It was manufactured by performing the process at a high temperature for several hours, especially around 6 hours. However, in this case, since the temperature of the neutralization reaction is high, the calcination of the intermediate hydroxyapatite calcium phosphate (this requires high temperature and a long time, is very uneconomical in terms of heat cost, and the conversion rate is low, resulting in intermediate There is a problem in that hydroxyapatite calcium phosphate remains in the body, which also increases the cost of the product.
この発明は、上記のような問題を克服すべくなされたも
ので、焼成温度を低くし且つ焼成時間を短縮し、高収率
で高純度の製品を得ることができ、その結果製造原価の
低廉化を果すことのできるβ厘第３リン酸カルシウムの
製造方法を提供することを目的とする。This invention was made to overcome the above-mentioned problems, and it is possible to lower the firing temperature and shorten the firing time, thereby obtaining a high-yield and high-purity product, and as a result, the manufacturing cost can be reduced. An object of the present invention is to provide a method for producing β-tribasic calcium phosphate, which can achieve the following effects.
この発明Ｃζよるβ型第３リン酸カルシウムの製造方法
は、酸化カルシウムの水性懸濁液に撹拌下にリン酸液を
徐々に添加して中和反応を行ない、得られたハイドロオ
キシアパタイトリン酸カルシウムを焼成してβ型第３リ
ン酸カルシウムに変換するに当り、中和反応を６０℃以
下の温度で行ない、焼成を７５０℃以上の温度で行なう
ことを特徴とする。The method for producing β-type tertiary calcium phosphate according to this invention Cζ involves gradually adding a phosphoric acid solution to an aqueous suspension of calcium oxide under stirring to carry out a neutralization reaction, and calcining the obtained hydroxyapatite calcium phosphate. When converting into β-type tertiary calcium phosphate, the neutralization reaction is carried out at a temperature of 60°C or lower, and the calcination is carried out at a temperature of 750°C or higher.
中和反応において、反応温度が６０℃以下に限定される
理由は、温度が６０℃を越えると、得られた中間体ハイ
ドロオキシアパタイトリン酸カルシウムの焼成に高温お
よび長時間を要するからである。最適反応温度は室温〜
４５℃である。中和反応の時間は約２時間で十分である
。The reason why the reaction temperature in the neutralization reaction is limited to 60°C or lower is that if the temperature exceeds 60°C, it will take a high temperature and a long time to calcinate the obtained intermediate hydroxyapatite calcium phosphate. Optimal reaction temperature is room temperature ~
The temperature is 45°C. Approximately 2 hours is sufficient for the neutralization reaction.
中間体ハイドロオキシアパタイトリン酸カルシウムの焼
成において、焼成温度が７５０℃以上に限定される理由
は、７５０℃未満ではハイドロオキシアパタイトリン酸
カルシウムからβ型第３リン酸カルシウムへの変換が十
分になされないからである。最適温度は８００℃以上で
ある。焼成時間は、温度とも関連するが、約３０分で十
分である。In the firing of the intermediate hydroxyapatite calcium phosphate, the reason why the firing temperature is limited to 750°C or higher is that at lower than 750°C, sufficient conversion from hydroxyapatite calcium phosphate to β-type tertiary calcium phosphate is not achieved. The optimum temperature is 800°C or higher. The firing time is related to the temperature, but about 30 minutes is sufficient.
この発明によるβ型第３リン酸カルシウムの製造方法は
、以上のとおり構成されているので、焼成温度を低くし
且つ焼成時間を短縮し、高収率で高純度の製品を得るこ
とができ、その結果製造原価の低廉化を果すことができ
る。Since the method for producing β-type tertiary calcium phosphate according to the present invention is configured as described above, it is possible to lower the calcination temperature and shorten the calcination time, and obtain a high-yield and high-purity product. Manufacturing costs can be reduced.
実施例
００ｖに、リン酸−←中→ｖ２を含む２５チ水溶液を撹
拌下に徐々に添加し、反応温度を３０℃に保って、中和
反応を２時間行なった。生成したハイドロオキシアパタ
イトリン酸カルシウム沈殿物を沖取し、乾燥した後、温
度８００℃で１時間焼成した。β型第３リン酸カルシウ
ム４２１（収率９７％）が得られた。粉末Ｘ線回折分析
の結果、製品中にはハイドロオキシアバタイ）ＩＪン酸
カルシウムの残留は認められず、高純度のβ型ｉＪ３リ
ン酸カルシウムが得られたことが確認された。To Example 00v, a 25% aqueous solution containing phosphoric acid -←middle→v2 was gradually added under stirring, and the reaction temperature was maintained at 30°C, and the neutralization reaction was carried out for 2 hours. The produced hydroxyapatite calcium phosphate precipitate was collected, dried, and then fired at a temperature of 800° C. for 1 hour. β-type tertiary calcium phosphate 421 (yield 97%) was obtained. As a result of powder X-ray diffraction analysis, no residual calcium hydroxyabatai)IJ3 phosphate was found in the product, confirming that highly pure β-type iJ3 calcium phosphate was obtained.
以 上 特許出願人 太平化学産業株式会社 外４名that's all Patent applicant: Taihei Kagaku Sangyo Co., Ltd. 4 people outside
Claims (1)
酸液を徐々に添加して中和反応を行ない、得られたハイ
ドロオキシアパタイトリン酸カルシウムを焼成してβ型
ｇＪ３リン酸カルシウムに変換するに当り、中和反応を
６０℃以下の温度で行ない、焼成を７５０℃以上の温度
で行なうことを特徴とするβ型第３リン酸カルシウムの
製造方法。 （２＋ 中和反応を室温〜４５℃で行なう特許請求の
範囲第１項記載の方法。 （３） 中和反応を約２時間行なう特許請求の範囲第
１または２項記載の方法。 （４）焼成を８００℃以上で行なう特許請求の範囲第１
〜３項のうちいずれか１項記載の方法。 （５） 焼成を約３０分間行なう輸許請求の範囲第１
〜４項のうちいずれか１項記載の方法。[Scope of Claims] (1) A phosphoric acid solution is gradually added to an aqueous suspension of calcium oxide while stirring to perform a neutralization reaction, and the obtained hydroxyapatite calcium phosphate is calcined to obtain β-type gJ3 calcium phosphate. 1. A method for producing β-type tricalcium phosphate, which comprises carrying out a neutralization reaction at a temperature of 60°C or lower and calcination at a temperature of 750°C or higher. (2+ The method according to claim 1, in which the neutralization reaction is carried out at room temperature to 45°C. (3) The method according to claim 1 or 2, in which the neutralization reaction is carried out for about 2 hours. (4) Claim 1 in which firing is performed at 800°C or higher
The method according to any one of 3 to 3. (5) The first patent claim in which firing is performed for about 30 minutes
4. The method according to any one of 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4545482A JPS58161911A (en) | 1982-03-19 | 1982-03-19 | Manufacture of beta-form calcium tertiary phosphate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4545482A JPS58161911A (en) | 1982-03-19 | 1982-03-19 | Manufacture of beta-form calcium tertiary phosphate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS58161911A true JPS58161911A (en) | 1983-09-26 |
Family
ID=12719790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4545482A Pending JPS58161911A (en) | 1982-03-19 | 1982-03-19 | Manufacture of beta-form calcium tertiary phosphate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58161911A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04321507A (en) * | 1991-04-23 | 1992-11-11 | Mitsubishi Materials Corp | Production of calcium tertiary phosphate and hydraulic calcium phosphate cement |
| JP2020105060A (en) * | 2018-12-28 | 2020-07-09 | 株式会社バイオアパタイト | HYDROXYAPATITE, ITS PRODUCTION METHOD AND METHOD FOR PRODUCING β-TCP |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5645814A (en) * | 1979-09-25 | 1981-04-25 | Kureha Chem Ind Co Ltd | Hydroxyapatite, its ceramic material and its manufacture |
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
-
1982
- 1982-03-19 JP JP4545482A patent/JPS58161911A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5645814A (en) * | 1979-09-25 | 1981-04-25 | Kureha Chem Ind Co Ltd | Hydroxyapatite, its ceramic material and its manufacture |
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04321507A (en) * | 1991-04-23 | 1992-11-11 | Mitsubishi Materials Corp | Production of calcium tertiary phosphate and hydraulic calcium phosphate cement |
| JP2020105060A (en) * | 2018-12-28 | 2020-07-09 | 株式会社バイオアパタイト | HYDROXYAPATITE, ITS PRODUCTION METHOD AND METHOD FOR PRODUCING β-TCP |
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