JPS5795976A - Piperidinophenylcarboxylic acid derivative and its preparation - Google Patents

Piperidinophenylcarboxylic acid derivative and its preparation

Info

Publication number
JPS5795976A
JPS5795976A JP55170918A JP17091880A JPS5795976A JP S5795976 A JPS5795976 A JP S5795976A JP 55170918 A JP55170918 A JP 55170918A JP 17091880 A JP17091880 A JP 17091880A JP S5795976 A JPS5795976 A JP S5795976A
Authority
JP
Japan
Prior art keywords
formula
chloro
piperidinophenylcarboxylic
acid derivative
formulai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55170918A
Other languages
Japanese (ja)
Inventor
Motoo Mutsuto
Shin Yamada
Kazutaka Arai
Yasuo Takakuwa
Genichi Dobashi
Shuichi Mitamura
Katsuyuki Ogura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP55170918A priority Critical patent/JPS5795976A/en
Publication of JPS5795976A publication Critical patent/JPS5795976A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A piperidinophenylcarboxylic acid derivative shown by the formulaI(Z is a group shown by the formula II or III.
EXAMPLE: α-Hydroxy-α-(chloro-piperidinophenyl)-propionic acid.
USE: A raw material for preparing a-(3-chloro-4-piperidino phenyl)propionic acid having improved antiphlogistic and analgesic action.
PROCESS: 3-Chloro-4-piperidinoacetophenone shown by the formula IV is reacted with a halaform shown by the formula V (X1 is Cl or Br) preferably in a nonproton polar solvent in the presence of a catalyst transferring between phases, to bive a compound shown by the formulaI. The compound shown by the formula IV is synthesized by reacting 4-aminoacetophenone with 1,5-dihalopentane shown by the formula VI (X2 and X3 are halogen) in the presence of a base to give 4- piperidionoacetophenone, which is chlorinated in an organic solvent.
COPYRIGHT: (C)1982,JPO&Japio
JP55170918A 1980-12-05 1980-12-05 Piperidinophenylcarboxylic acid derivative and its preparation Pending JPS5795976A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55170918A JPS5795976A (en) 1980-12-05 1980-12-05 Piperidinophenylcarboxylic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55170918A JPS5795976A (en) 1980-12-05 1980-12-05 Piperidinophenylcarboxylic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5795976A true JPS5795976A (en) 1982-06-15

Family

ID=15913757

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55170918A Pending JPS5795976A (en) 1980-12-05 1980-12-05 Piperidinophenylcarboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5795976A (en)

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