JPS5795976A - Piperidinophenylcarboxylic acid derivative and its preparation - Google Patents
Piperidinophenylcarboxylic acid derivative and its preparationInfo
- Publication number
- JPS5795976A JPS5795976A JP55170918A JP17091880A JPS5795976A JP S5795976 A JPS5795976 A JP S5795976A JP 55170918 A JP55170918 A JP 55170918A JP 17091880 A JP17091880 A JP 17091880A JP S5795976 A JPS5795976 A JP S5795976A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- chloro
- piperidinophenylcarboxylic
- acid derivative
- formulai
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A piperidinophenylcarboxylic acid derivative shown by the formulaI(Z is a group shown by the formula II or III.
EXAMPLE: α-Hydroxy-α-(chloro-piperidinophenyl)-propionic acid.
USE: A raw material for preparing a-(3-chloro-4-piperidino phenyl)propionic acid having improved antiphlogistic and analgesic action.
PROCESS: 3-Chloro-4-piperidinoacetophenone shown by the formula IV is reacted with a halaform shown by the formula V (X1 is Cl or Br) preferably in a nonproton polar solvent in the presence of a catalyst transferring between phases, to bive a compound shown by the formulaI. The compound shown by the formula IV is synthesized by reacting 4-aminoacetophenone with 1,5-dihalopentane shown by the formula VI (X2 and X3 are halogen) in the presence of a base to give 4- piperidionoacetophenone, which is chlorinated in an organic solvent.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55170918A JPS5795976A (en) | 1980-12-05 | 1980-12-05 | Piperidinophenylcarboxylic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55170918A JPS5795976A (en) | 1980-12-05 | 1980-12-05 | Piperidinophenylcarboxylic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5795976A true JPS5795976A (en) | 1982-06-15 |
Family
ID=15913757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55170918A Pending JPS5795976A (en) | 1980-12-05 | 1980-12-05 | Piperidinophenylcarboxylic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5795976A (en) |
-
1980
- 1980-12-05 JP JP55170918A patent/JPS5795976A/en active Pending
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