JPS5788141A - Preparation of optically active tetralin derivative - Google Patents
Preparation of optically active tetralin derivativeInfo
- Publication number
- JPS5788141A JPS5788141A JP16517180A JP16517180A JPS5788141A JP S5788141 A JPS5788141 A JP S5788141A JP 16517180 A JP16517180 A JP 16517180A JP 16517180 A JP16517180 A JP 16517180A JP S5788141 A JPS5788141 A JP S5788141A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- optically active
- formula
- amalgam
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled substance useful as a synthetic intermediate of a carcino-static anthracycline derivative, economically, from an optically active tetralincarboxylic acid ester derivative, keeping the optical activity of the starting compound, by reacting the derivative with an alkyl metal derivative, and then with an amalgam in the presence of water.
CONSTITUTION: An optically active tetralincarboxylic acid ester derivative of formulaI(R1 is H, lower alkyl, benzyl or acetyl; R2 is lower alkyl) is made to react with an alkyl metal derivative of formula II (M is alkali metal atom or alkaline earth metal atom; n is 1 or 2) in a solvent such as dimethylformamide at 0W100°C to obtain the optically active tetralin derivative of formula III, which is converted to the objective compound of formula IV by the reductive desulfurization with an amalgam in the presence of water or with zinc, tin or aluminum under alkaline conditions.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16517180A JPS5788141A (en) | 1980-11-21 | 1980-11-21 | Preparation of optically active tetralin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16517180A JPS5788141A (en) | 1980-11-21 | 1980-11-21 | Preparation of optically active tetralin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5788141A true JPS5788141A (en) | 1982-06-01 |
Family
ID=15807202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16517180A Pending JPS5788141A (en) | 1980-11-21 | 1980-11-21 | Preparation of optically active tetralin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5788141A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106316807A (en) * | 2016-08-20 | 2017-01-11 | 福建师范大学 | Preparation method for alpha-hydroxycyclopentadecanone |
-
1980
- 1980-11-21 JP JP16517180A patent/JPS5788141A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106316807A (en) * | 2016-08-20 | 2017-01-11 | 福建师范大学 | Preparation method for alpha-hydroxycyclopentadecanone |
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