JPS577481A - Novel benzopyran derivative - Google Patents

Novel benzopyran derivative

Info

Publication number
JPS577481A
JPS577481A JP8084180A JP8084180A JPS577481A JP S577481 A JPS577481 A JP S577481A JP 8084180 A JP8084180 A JP 8084180A JP 8084180 A JP8084180 A JP 8084180A JP S577481 A JPS577481 A JP S577481A
Authority
JP
Japan
Prior art keywords
compound
formula
agent
nitrated
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8084180A
Other languages
Japanese (ja)
Other versions
JPS6054317B2 (en
Inventor
Shozo Shirato
Noboru Shimizu
Hiromichi Shigyo
Yoshinori Kyotani
Hisashi Kunieda
Kiyoshi Kawamura
Seiichi Sato
Toshihiro Akashi
Masahiko Nagakura
Hisatoshi Sawada
Yasuyoshi Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP8084180A priority Critical patent/JPS6054317B2/en
Priority to US06/271,927 priority patent/US4394382A/en
Priority to AU71652/81A priority patent/AU543347B2/en
Priority to CA000379656A priority patent/CA1178598A/en
Priority to IE1312/81A priority patent/IE52067B1/en
Priority to FI811856A priority patent/FI79307C/en
Priority to EP81302700A priority patent/EP0042299B1/en
Priority to NO812042A priority patent/NO154495C/en
Priority to ES503091A priority patent/ES8300104A1/en
Priority to ZA814042A priority patent/ZA814042B/en
Priority to DK264181A priority patent/DK154557C/en
Priority to DE8181302700T priority patent/DE3166300D1/en
Priority to SU813300799A priority patent/SU1212325A3/en
Priority to CS814509A priority patent/CS226731B2/en
Priority to AT81302700T priority patent/ATE9582T1/en
Priority to MX10178081U priority patent/MX6885E/en
Priority to KR1019810002196A priority patent/KR850000193B1/en
Priority to DD81230894A priority patent/DD160453A5/en
Priority to HU178481A priority patent/HU188061B/en
Priority to PL1981231734A priority patent/PL130537B1/en
Publication of JPS577481A publication Critical patent/JPS577481A/en
Publication of JPS6054317B2 publication Critical patent/JPS6054317B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (P is 3,4-dihydro-2H-1-benzopyran ring; A is direct bond or -O-CH2; B is direct bond, alkylene, etc.; R is H, halogen, lower alkyl,alkoxyl,alkyleneoxy, etc.; R1 and R2 are H, alkyl, hydroxyalkyl, etc.; R3 is H or nitro; m and n are 1 or 2).
EXAMPLE: 3,4-Dihydro-8-[ (2-hydroxy-3-isopropylamino)propoxy ]-3-nitratomethyl- 2H-1-benzopyran.
USE: An antistenocaridiac agent, hypotensive agent, ameliorant of cerebral circulation and antiarrhythmic agent.
PROCESS: A compound of formula II (Q is OH, ethoxycarbonyloxy, acetoxy, etc.) is nitrated and converted into an aminoalkanol derivative thereof to give a compound of formula III. The resultant compound is then nitrated at room temperature to 90°C to afford the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8084180A 1980-06-17 1980-06-17 New benzopyran derivatives Expired JPS6054317B2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
JP8084180A JPS6054317B2 (en) 1980-06-17 1980-06-17 New benzopyran derivatives
US06/271,927 US4394382A (en) 1980-06-17 1981-06-09 Dihydrobenzopyran compounds and pharmaceutical composition comprising said compounds
AU71652/81A AU543347B2 (en) 1980-06-17 1981-06-11 Benzopyrans
CA000379656A CA1178598A (en) 1980-06-17 1981-06-12 Benzopyran compound, process for production thereof, and pharmaceutical composition comprising said compound
IE1312/81A IE52067B1 (en) 1980-06-17 1981-06-12 Benzopyrans,their production and pharmaceutical compositions containing them
FI811856A FI79307C (en) 1980-06-17 1981-06-15 FOR EXAMINATION OF THERAPEUTIC ANALYTICAL BAR 3,4-DIHYDRO-8- (2-HYDROXI-3-ALKYLAMINO) PROPOXI-2H-1-BENZOPYRANDERS.
EP81302700A EP0042299B1 (en) 1980-06-17 1981-06-16 Benzopyrans, their production and pharmaceutical compositions containing them
NO812042A NO154495C (en) 1980-06-17 1981-06-16 ANALOGY PROCEDURE FOR PREPARING A BENZOPYRAN COMPOUND.
ES503091A ES8300104A1 (en) 1980-06-17 1981-06-16 Benzopyrans, their production and pharmaceutical compositions containing them.
ZA814042A ZA814042B (en) 1980-06-17 1981-06-16 Benzopyran compound,process for production thereof,and pharmaceutical composition comprising said compound
DK264181A DK154557C (en) 1980-06-17 1981-06-16 METHOD OF ANALOGUE FOR THE PREPARATION OF 3,4-DIHYDRO-8 - ((2-HYDROXY-3-ALKYLAMINO) -PROPOXY) -2H-1-BENZOPYRANDER DERIVATIVES OR A PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALT
DE8181302700T DE3166300D1 (en) 1980-06-17 1981-06-16 Benzopyrans, their production and pharmaceutical compositions containing them
SU813300799A SU1212325A3 (en) 1980-06-17 1981-06-16 Method of producing derivatives of benzopyran
CS814509A CS226731B2 (en) 1980-06-17 1981-06-16 Method of preparing benzopyrane compounds
AT81302700T ATE9582T1 (en) 1980-06-17 1981-06-16 BENZOPYRANS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
MX10178081U MX6885E (en) 1980-06-17 1981-06-16 PROCEDURE FOR PREPARING DIHYDROBENZOPYRAN COMPOUNDS
KR1019810002196A KR850000193B1 (en) 1980-06-17 1981-06-16 Process for preparing benzopyran compounds
DD81230894A DD160453A5 (en) 1980-06-17 1981-06-17 METHOD FOR PRODUCING BENZOPYRANE COMPOUNDS
HU178481A HU188061B (en) 1980-06-17 1981-06-17 Process for the preparation of benzopyrane derivatives and pharmaceutical compositions containing said compounds as active ingredients
PL1981231734A PL130537B1 (en) 1980-06-17 1981-06-17 Method of manufacture of novel aminoalcohols,derivative of benzopyrane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8084180A JPS6054317B2 (en) 1980-06-17 1980-06-17 New benzopyran derivatives

Publications (2)

Publication Number Publication Date
JPS577481A true JPS577481A (en) 1982-01-14
JPS6054317B2 JPS6054317B2 (en) 1985-11-29

Family

ID=13729581

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8084180A Expired JPS6054317B2 (en) 1980-06-17 1980-06-17 New benzopyran derivatives

Country Status (2)

Country Link
JP (1) JPS6054317B2 (en)
HU (1) HU188061B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60181083A (en) * 1984-02-29 1985-09-14 Kowa Co Novel racemic compound and its conversion
JPS60208973A (en) * 1984-03-31 1985-10-21 Kowa Co Novel optically active compound, its preparation, and drug containing it
JPWO2004037246A1 (en) * 2002-10-24 2006-02-23 興和株式会社 Nerve fiber regeneration promoter
JP2006315993A (en) * 2005-05-12 2006-11-24 Tokuyama Corp Method for producing dihydrobenzopyran compound

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0160514U (en) * 1987-10-14 1989-04-17
AU2008220104B2 (en) 2007-02-28 2012-09-27 Asahi Kasei Pharma Corporation Sulfonamide derivative
WO2019198472A1 (en) 2018-04-13 2019-10-17 有限会社エコ・テクノ Bone-conduction earphone microphone

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60181083A (en) * 1984-02-29 1985-09-14 Kowa Co Novel racemic compound and its conversion
JPS60208973A (en) * 1984-03-31 1985-10-21 Kowa Co Novel optically active compound, its preparation, and drug containing it
JPH0422887B2 (en) * 1984-03-31 1992-04-20 Kowa Co
JPWO2004037246A1 (en) * 2002-10-24 2006-02-23 興和株式会社 Nerve fiber regeneration promoter
JP4675232B2 (en) * 2002-10-24 2011-04-20 興和株式会社 Nerve fiber regeneration promoter
JP2006315993A (en) * 2005-05-12 2006-11-24 Tokuyama Corp Method for producing dihydrobenzopyran compound

Also Published As

Publication number Publication date
HU188061B (en) 1986-03-28
JPS6054317B2 (en) 1985-11-29

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