JPS5770814A - Oral preparation of blood clotting eighth factor - Google Patents

Oral preparation of blood clotting eighth factor

Info

Publication number
JPS5770814A
JPS5770814A JP55144508A JP14450880A JPS5770814A JP S5770814 A JPS5770814 A JP S5770814A JP 55144508 A JP55144508 A JP 55144508A JP 14450880 A JP14450880 A JP 14450880A JP S5770814 A JPS5770814 A JP S5770814A
Authority
JP
Japan
Prior art keywords
factor
ribosome
blood clotting
oral preparation
enclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55144508A
Other languages
Japanese (ja)
Other versions
JPH03366B2 (en
Inventor
Isamu Horikoshi
Nobuo Sakuragawa
Masaharu Ueno
Kaoru Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP55144508A priority Critical patent/JPS5770814A/en
Priority to GB8130122A priority patent/GB2085729B/en
Priority to US06/309,269 priority patent/US4348384A/en
Priority to DE19813141223 priority patent/DE3141223A1/en
Priority to FR8119522A priority patent/FR2492260A1/en
Priority to ES506320A priority patent/ES8306323A1/en
Publication of JPS5770814A publication Critical patent/JPS5770814A/en
Publication of JPH03366B2 publication Critical patent/JPH03366B2/ja
Granted legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

PURPOSE: An oral preparation that is made by preparing the blood clotting eight factor with ribosome and an enteric capsule, thus being well absorbed through intestinal mucous membrane and used for curing hemophilia.
CONSTITUTION: An aqueous solution of the blood clotting either factor or a combination thereof with a wide-range tyrpsin inhibitor such as aprotinin is enclosed into ribosome. The enclosed product itself, or its freeze-dried product, or a mixture of separately dried components of the eights factor, the trypsin inhibitor and ribosome membrane-constituting components is filled in an enteric capsule to give the objective oral preparation. Ribosome and the trypsin ihibitor act to prevent the active component from being decomposed and deactivated in intestinal tracts.
COPYRIGHT: (C)1982,JPO&Japio
JP55144508A 1980-10-17 1980-10-17 Oral preparation of blood clotting eighth factor Granted JPS5770814A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP55144508A JPS5770814A (en) 1980-10-17 1980-10-17 Oral preparation of blood clotting eighth factor
GB8130122A GB2085729B (en) 1980-10-17 1981-10-06 Pharmaceutical composition for oral administration containing coagulation factor viii
US06/309,269 US4348384A (en) 1980-10-17 1981-10-07 Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
DE19813141223 DE3141223A1 (en) 1980-10-17 1981-10-16 "ORAL-AVAILABLE MEDICINES FOR THERAPY AND PROPHYLAXIS OF HAEMOPHILIA A"
FR8119522A FR2492260A1 (en) 1980-10-17 1981-10-16 PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION CONTAINING COAGULATION FACTOR VIII
ES506320A ES8306323A1 (en) 1980-10-17 1981-10-16 Pharmaceutical composition for oral administration containing coagulation factor VIII

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55144508A JPS5770814A (en) 1980-10-17 1980-10-17 Oral preparation of blood clotting eighth factor

Publications (2)

Publication Number Publication Date
JPS5770814A true JPS5770814A (en) 1982-05-01
JPH03366B2 JPH03366B2 (en) 1991-01-07

Family

ID=15363986

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55144508A Granted JPS5770814A (en) 1980-10-17 1980-10-17 Oral preparation of blood clotting eighth factor

Country Status (5)

Country Link
JP (1) JPS5770814A (en)
DE (1) DE3141223A1 (en)
ES (1) ES8306323A1 (en)
FR (1) FR2492260A1 (en)
GB (1) GB2085729B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056918A (en) * 1983-08-03 1985-04-02 ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア Liposome containing frustose-1,6-diphosphoric acid
JPS6069027A (en) * 1983-06-27 1985-04-19 クイ−ンズ　ユニバ−シテイ　アツト　キングストン Blood stopping drug composition
JPS6150912A (en) * 1984-08-16 1986-03-13 Shionogi & Co Ltd Production of liposome preparation
JP2001514209A (en) * 1997-09-04 2001-09-11 バイオゾーン ラボラトリーズ，インコーポレイテッド Oral liposome delivery system

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581543B1 (en) * 1985-05-09 1989-07-07 Tressens Dominique PHARMACOTECHNIE ALLOWING THE PRODUCTION OF AN ORAL ACTIVE INSULIN PREPARATION
DE3625090A1 (en) * 1986-07-24 1988-01-28 Behringwerke Ag AGENT FOR THE THERAPY FACTOR VIII-RESISTANT HAEMOPHILY A AND METHOD FOR THE PRODUCTION THEREOF
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
GB9007052D0 (en) * 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
DE4115453A1 (en) * 1991-05-11 1992-11-12 Knoll Ag NEW ACTIVE COMPOUND
WO1994028876A1 (en) * 1993-06-07 1994-12-22 Advanced Therapies, Inc. Liposome powders
FR2706302B1 (en) * 1993-06-18 1995-08-18 Franche Comte Universite Basifying product in gastro-resistant form.
DE4416166C2 (en) * 1994-05-06 1997-11-20 Immuno Ag Stable preparation for the treatment of blood clotting disorders
DE4416180C2 (en) * 1994-05-06 1997-08-14 Immuno Ag Stable preparation for the treatment of blood coagulation disorders and method for producing this preparation
US6017891A (en) * 1994-05-06 2000-01-25 Baxter Aktiengesellschaft Stable preparation for the treatment of blood coagulation disorders
CH689139A5 (en) * 1995-04-03 1998-10-30 Cerbios Pharma Sa Process for the preparation of a liposomal, in water dispersable, orally administrable, solid, dry therapeutic formulation.
PT2130554E (en) 1999-02-22 2012-11-19 Univ Connecticut Albumin-free factor viii formulations
US20100168018A1 (en) 2008-11-07 2010-07-01 Baxter International Inc. Factor viii formulations
DE102009001334B4 (en) 2009-03-04 2017-02-23 Stefan Brosig Simple enteric encapsulation, e.g. of ginger and other delicate substances
CN109316599A (en) * 2018-08-24 2019-02-12 上海交通大学医学院附属瑞金医院 A kind of Aprotinin or its mutant, derivative, analog or its application for forming segment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2249552A1 (en) * 1971-10-12 1973-05-30 Inchema S A PROCESS FOR THE INCAPSULATION OF IN PARTICULAR WATER-SOLUBLE COMPOUNDS
NL7900459A (en) * 1979-01-19 1980-07-22 Hendrik Coenraad Hemker Prof D PHARMACEUTICAL PREPARATION AND METHOD OF PREPARATION THEREOF.

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6069027A (en) * 1983-06-27 1985-04-19 クイ−ンズ　ユニバ−シテイ　アツト　キングストン Blood stopping drug composition
JPS6056918A (en) * 1983-08-03 1985-04-02 ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア Liposome containing frustose-1,6-diphosphoric acid
JPS6150912A (en) * 1984-08-16 1986-03-13 Shionogi & Co Ltd Production of liposome preparation
JPH0545568B2 (en) * 1984-08-16 1993-07-09 Shionogi Seiyaku Kk
JP2001514209A (en) * 1997-09-04 2001-09-11 バイオゾーン ラボラトリーズ，インコーポレイテッド Oral liposome delivery system
JP2010001317A (en) * 1997-09-04 2010-01-07 Biozone Lab Inc Oral liposome delivery system

Also Published As

Publication number Publication date
GB2085729A (en) 1982-05-06
FR2492260A1 (en) 1982-04-23
JPH03366B2 (en) 1991-01-07
FR2492260B1 (en) 1984-07-27
ES506320A0 (en) 1983-05-16
GB2085729B (en) 1984-04-18
ES8306323A1 (en) 1983-05-16
DE3141223A1 (en) 1982-06-24

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