JPS5764695A - Novel cephalotaxine derivative - Google Patents
Novel cephalotaxine derivativeInfo
- Publication number
- JPS5764695A JPS5764695A JP14039780A JP14039780A JPS5764695A JP S5764695 A JPS5764695 A JP S5764695A JP 14039780 A JP14039780 A JP 14039780A JP 14039780 A JP14039780 A JP 14039780A JP S5764695 A JPS5764695 A JP S5764695A
- Authority
- JP
- Japan
- Prior art keywords
- cephalotaxine
- compound
- derivative
- novel
- formulai
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The compound of formulaI[R1is -(CH2)i(i is integer 1W8) or -(CH2)j-C6H4-(CH2)k-j and k are O or integers 1W8); R2 is -(CH2)l-(l is O or integer 1W8) or -(CH2)m-CHY(CH2)n-(Y is H or ester group; m and n are O or integers 1W8); R3 is H or iodine].
EXAMPLE: 3-0-Succinylcephalotaxine(iodotyrosine methyl ester)amide.
USE: Labelling hapten for the radioimmunoassay of cephalotaxines.
PROCESS: For example, cephalotaxine of formula II is made to react with a dicarboxylic acid such as succinic anhydride to obtain 3-0-succsnylcephalotaxine, which is reacted with the compound of formula III, etc. in the presence of triethylamine, dicyclohexylcarbodiimide, etc. to afford the objective compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14039780A JPS5764695A (en) | 1980-10-09 | 1980-10-09 | Novel cephalotaxine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14039780A JPS5764695A (en) | 1980-10-09 | 1980-10-09 | Novel cephalotaxine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5764695A true JPS5764695A (en) | 1982-04-19 |
Family
ID=15267834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14039780A Pending JPS5764695A (en) | 1980-10-09 | 1980-10-09 | Novel cephalotaxine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5764695A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002507615A (en) * | 1998-03-20 | 2002-03-12 | オンコファーム、コーポレーション | Novel cephalotaxane derivatives and their production |
EP2260041A4 (en) * | 2008-03-03 | 2012-04-25 | Sloan Kettering Inst Cancer | Cephalotaxus esters, methods of synthesis, and uses thereof |
-
1980
- 1980-10-09 JP JP14039780A patent/JPS5764695A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002507615A (en) * | 1998-03-20 | 2002-03-12 | オンコファーム、コーポレーション | Novel cephalotaxane derivatives and their production |
JP4942871B2 (en) * | 1998-03-20 | 2012-05-30 | ケムジェネックス、ファーマシューティカルズ、リミテッド | Novel cephalotaxane derivatives and methods for their preparation |
EP2260041A4 (en) * | 2008-03-03 | 2012-04-25 | Sloan Kettering Inst Cancer | Cephalotaxus esters, methods of synthesis, and uses thereof |
US8466142B2 (en) | 2008-03-03 | 2013-06-18 | Sloan-Kettering Institute For Cancer Research | Cephalotaxus esters, methods of synthesis, and uses thereof |
US9006231B2 (en) | 2008-03-03 | 2015-04-14 | Sloan-Kettering Institute For Cancer Research | Cephalotaxus esters, methods of synthesis, and uses thereof |
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