JPS5759881A - 1alpha,25-dihydroxyvitamin d3-26,23-lactone - Google Patents
1alpha,25-dihydroxyvitamin d3-26,23-lactoneInfo
- Publication number
- JPS5759881A JPS5759881A JP13527680A JP13527680A JPS5759881A JP S5759881 A JPS5759881 A JP S5759881A JP 13527680 A JP13527680 A JP 13527680A JP 13527680 A JP13527680 A JP 13527680A JP S5759881 A JPS5759881 A JP S5759881A
- Authority
- JP
- Japan
- Prior art keywords
- dihydroxyvitamin
- lactone
- dogs
- rats
- 1alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:1,25-Dihydroxyvitamin D3-26,23-lactone of the formula.
USE: It has an activity of controlling the level of 1α,25-dihydroxycholecarciferol in vivo and is expected to be used as a medicine.
PREPARATION: A toxically permissible amount of 1α-hydroxyvitamin D3 or 1α, 25-dihydroxyvitamin D3 are given orally, intravenously or intramuscularly to rats or dogs. After 2W50hr, the fat-soluble part of the plasma from the rats or dogs is subjected to column chromatography or high-speed liquid chromatography to isolate the objective compound as a metabolite of the vitamin D3 given.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13527680A JPS5759881A (en) | 1980-09-30 | 1980-09-30 | 1alpha,25-dihydroxyvitamin d3-26,23-lactone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13527680A JPS5759881A (en) | 1980-09-30 | 1980-09-30 | 1alpha,25-dihydroxyvitamin d3-26,23-lactone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5759881A true JPS5759881A (en) | 1982-04-10 |
JPS6140231B2 JPS6140231B2 (en) | 1986-09-08 |
Family
ID=15147916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13527680A Granted JPS5759881A (en) | 1980-09-30 | 1980-09-30 | 1alpha,25-dihydroxyvitamin d3-26,23-lactone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5759881A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59148775A (en) * | 1983-02-14 | 1984-08-25 | Teijin Ltd | 25-hydroxyvitamin d3-26,23-lactone derivative and its preparation |
US4632784A (en) * | 1983-01-28 | 1986-12-30 | Hoffmann-La Roche Inc. | Process for the preparation of 1α,23,25-trihydroxycholecalciferol-26-oic acid 23,26-lactone |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0531861A (en) * | 1991-07-26 | 1993-02-09 | Sumitomo Bakelite Co Ltd | Hermetically sealed container |
-
1980
- 1980-09-30 JP JP13527680A patent/JPS5759881A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4632784A (en) * | 1983-01-28 | 1986-12-30 | Hoffmann-La Roche Inc. | Process for the preparation of 1α,23,25-trihydroxycholecalciferol-26-oic acid 23,26-lactone |
JPS59148775A (en) * | 1983-02-14 | 1984-08-25 | Teijin Ltd | 25-hydroxyvitamin d3-26,23-lactone derivative and its preparation |
Also Published As
Publication number | Publication date |
---|---|
JPS6140231B2 (en) | 1986-09-08 |
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