JPS5753500A - Manufacture of 6 alpha-fluoro-delta1,4-3- ketosteroid - Google Patents
Manufacture of 6 alpha-fluoro-delta1,4-3- ketosteroidInfo
- Publication number
- JPS5753500A JPS5753500A JP56114340A JP11434081A JPS5753500A JP S5753500 A JPS5753500 A JP S5753500A JP 56114340 A JP56114340 A JP 56114340A JP 11434081 A JP11434081 A JP 11434081A JP S5753500 A JPS5753500 A JP S5753500A
- Authority
- JP
- Japan
- Prior art keywords
- delta1
- ketosteroid
- fluoro
- alpha
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/170,790 US4340538A (en) | 1980-07-21 | 1980-07-21 | Process for producing 6α-fluoro-Δ1,4 -3-keto steroids |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2076552A Division JPH02275896A (ja) | 1980-07-21 | 1990-03-26 | 6―フルオロー△↑1’↑5―3―ケトステロイドおよびその製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5753500A true JPS5753500A (en) | 1982-03-30 |
JPH0250919B2 JPH0250919B2 (ja) | 1990-11-05 |
Family
ID=22621267
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56114340A Granted JPS5753500A (en) | 1980-07-21 | 1981-07-21 | Manufacture of 6 alpha-fluoro-delta1,4-3- ketosteroid |
JP2076552A Granted JPH02275896A (ja) | 1980-07-21 | 1990-03-26 | 6―フルオロー△↑1’↑5―3―ケトステロイドおよびその製造方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2076552A Granted JPH02275896A (ja) | 1980-07-21 | 1990-03-26 | 6―フルオロー△↑1’↑5―3―ケトステロイドおよびその製造方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US4340538A (ja) |
JP (2) | JPS5753500A (ja) |
CH (1) | CH651306A5 (ja) |
DE (1) | DE3126942A1 (ja) |
FR (1) | FR2487360A1 (ja) |
GB (1) | GB2080307B (ja) |
IT (1) | IT1211076B (ja) |
NL (1) | NL8103267A (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63141211U (ja) * | 1987-03-04 | 1988-09-16 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0097328B1 (en) * | 1982-06-21 | 1987-08-26 | Dainippon Ink And Chemicals, Inc. | Process for preparation of steroids |
IT1319654B1 (it) * | 2000-11-15 | 2003-10-23 | Farmabios S R L Ora Farmabios | Processo di isomerizzazione di 6beta-fluoro steroidi neicorrispondenti 6alfa-fluoro derivati. |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1052223A (ja) * | ||||
US2841600A (en) * | 1957-01-18 | 1958-07-01 | Upjohn Co | 6alpha-fluoro delta-cortisone and 6alpha-fluoro delta'-hydrocortisone and the 21-acylates thereof |
US2989523A (en) * | 1958-06-09 | 1961-06-20 | Upjohn Co | 2-methyl-6-fluoro compounds of the pregnane series |
US2838543A (en) * | 1957-11-29 | 1958-06-10 | Upjohn Co | 6-fluoro steroids and process |
US2876219A (en) * | 1958-06-09 | 1959-03-03 | Upjohn Co | 6-fluoro-9alpha-halo-11-oxygenated-4-pregnenes and 6-fluoro-9alpha-halo-11-oxygenated-1,4-pregnadienes |
US2838538A (en) * | 1957-11-29 | 1958-06-10 | Upjohn Co | 6-fluoro steroids and process for preparing same |
US2838537A (en) * | 1957-11-29 | 1958-06-10 | Upjohn Co | 6-fluoro steroids and process |
US2838542A (en) * | 1957-11-29 | 1958-06-10 | Upjohn Co | 6-fluoro steroids and process |
US2877240A (en) * | 1958-06-09 | 1959-03-10 | Upjohn Co | 6-fluoro-17beta-hydroxy-17alpha-lower aliphatic hydrocarbon-1, 4-androstadienes and 6-fluoro-17alpha-lower aliphatic hydrocarbon estradiols |
GB882604A (en) * | 1957-11-29 | 1961-11-15 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
US3004044A (en) * | 1958-06-09 | 1961-10-10 | Upjohn Co | 1-dehydro-6-fluoro-11-oxygenated progesterones |
US3239540A (en) * | 1958-06-09 | 1966-03-08 | Upjohn Co | 1-dehydro-6-fluoroprogesterones |
US2880205A (en) * | 1958-06-09 | 1959-03-31 | Upjohn Co | 6-fluoro-9alpha-halo-11-oxygenated-4-pregnenes and 6-fluoro-9alpha-halo-11-oxygenated-, 4-pregnadienes |
US3127428A (en) * | 1963-01-16 | 1964-03-31 | Schering Corp | Process for converting a 3-keto-delta-steroid to the corresponding 3-keto delta-compound |
US3127430A (en) * | 1963-01-16 | 1964-03-31 | Schering Corp | 17alpha-methyl-1, 5-androstadienes-17beta-ol-3-one and derivatives thereof |
BE642575A (ja) * | 1963-01-16 | |||
US3221033A (en) * | 1964-07-07 | 1965-11-30 | Schering Corp | Novel process for the preparation of 1,5-bis-dehydro steroids |
US4011315A (en) * | 1975-07-07 | 1977-03-08 | Syntex (U.S.A.) Inc. | 21-acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation |
US4198403A (en) * | 1978-04-05 | 1980-04-15 | Syntex (U.S.A.) Inc. | 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes |
AR224124A1 (es) * | 1978-04-05 | 1981-10-30 | Syntex Inc | Procedimiento para preparar 4-halo-pregna-1,4-dieno-3,20-dionas |
-
1980
- 1980-07-21 US US06/170,790 patent/US4340538A/en not_active Expired - Lifetime
-
1981
- 1981-07-01 GB GB8120351A patent/GB2080307B/en not_active Expired
- 1981-07-06 CH CH4447/81A patent/CH651306A5/de not_active IP Right Cessation
- 1981-07-08 DE DE3126942A patent/DE3126942A1/de active Granted
- 1981-07-08 NL NL8103267A patent/NL8103267A/nl not_active Application Discontinuation
- 1981-07-08 IT IT8122819A patent/IT1211076B/it active
- 1981-07-20 FR FR8114077A patent/FR2487360A1/fr active Granted
- 1981-07-21 JP JP56114340A patent/JPS5753500A/ja active Granted
-
1990
- 1990-03-26 JP JP2076552A patent/JPH02275896A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63141211U (ja) * | 1987-03-04 | 1988-09-16 |
Also Published As
Publication number | Publication date |
---|---|
CH651306A5 (de) | 1985-09-13 |
NL8103267A (nl) | 1982-02-16 |
DE3126942A1 (de) | 1982-06-03 |
IT8122819A0 (it) | 1981-07-08 |
GB2080307B (en) | 1984-12-05 |
JPH02275896A (ja) | 1990-11-09 |
DE3126942C2 (ja) | 1992-12-03 |
JPH0518838B2 (ja) | 1993-03-15 |
US4340538A (en) | 1982-07-20 |
IT1211076B (it) | 1989-09-29 |
JPH0250919B2 (ja) | 1990-11-05 |
FR2487360A1 (fr) | 1982-01-29 |
FR2487360B1 (ja) | 1984-02-24 |
GB2080307A (en) | 1982-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5799565A (en) | Manufacture of 2,3-dichlorosulfonyl- acrylonitrile | |
GB2087383B (en) | Preparation of 1,1,1,3,3,-hexafluoropropane-2-ol | |
JPS57165367A (en) | Manufacture of 2,3-dichloro-5-trichloromethylpyridine | |
JPS56161356A (en) | Manufacture of 1-aminopropanediol-2,3 | |
JPS57120536A (en) | Manufacture of 1,2-dichloroethane | |
JPS56154460A (en) | Manufacture of 2,2,6,6-tetramethylpiperidone-4 | |
JPS56161357A (en) | Manufacture of 1-aminopropanediol-2,3 | |
JPS577469A (en) | Manufacture of 2,3,5-trichloropyridine | |
JPS56161355A (en) | Manufacture of 1-aminopropanediol-2,3 | |
JPS5781473A (en) | Manufacture of 1,2,4-triazole | |
JPS57108059A (en) | Manufacture of 1,4-diamino-anthraquinone-2- sulfonic acid | |
JPS5732234A (en) | Manufacture of 1,2-dichloroethane | |
JPS56161367A (en) | Manufacture of 3-mercapto-propanediol-(1,2) | |
JPS56123960A (en) | Manufacture of 1*44diaminoo2*33dicyanoanthraquinone | |
JPS57150637A (en) | Manufacture of m,m'-dinitrobenzophenone | |
JPS5777647A (en) | Manufacture of alpha-benzamide-alpha'- halogeno-1,1'-dianthraimide | |
JPS56128738A (en) | Manufacture of n,n,n',n'-tetraalkylimino-bis- alkylamine | |
JPS5753500A (en) | Manufacture of 6 alpha-fluoro-delta1,4-3- ketosteroid | |
JPS57120583A (en) | Manufacture of 3,4-dihydro-alpha-pyrone | |
JPS5721376A (en) | Manufacture of 4-amino-6-tert-butyl-3-mercapto- 1,2,4-triazine-5-one | |
NZ193642A (en) | Manufacture of 2,2-dichloro-5-methyl-1,1,1-trifluorohex-4-ene | |
JPS5777632A (en) | Manufacture of 1-brom-3,5-dichlorobenzole | |
JPS57108044A (en) | Manufacture of 3,5-dimethylaniline | |
JPS57193492A (en) | Manufacture of o,s-dialkylphosphoroamidothioates | |
JPS5759838A (en) | Manufacture of substituted 4,4'-diaminodiphenylene |