JPS5750894A - Preparation of ml-236b derivative - Google Patents
Preparation of ml-236b derivativeInfo
- Publication number
- JPS5750894A JPS5750894A JP12438580A JP12438580A JPS5750894A JP S5750894 A JPS5750894 A JP S5750894A JP 12438580 A JP12438580 A JP 12438580A JP 12438580 A JP12438580 A JP 12438580A JP S5750894 A JPS5750894 A JP S5750894A
- Authority
- JP
- Japan
- Prior art keywords
- genus
- derivative
- syncephalosporum
- absidia
- cunninghamella
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled derivative either by culturing microorganisms belonging to Absidia genus, cunninghamella genus, Syncephalosporum genus, etc. in a medium containing ML-236B, or by contacting extract or microbial enzyme with ML-236B.
CONSTITUTION: The titled derivative is prepared either by culturing microorganisms belonging to Absidia genus (e.g. Absidia coerulea IFO4423), Cunninghamella genus (e.g. Cunninghamella echinulata IFO4445), syncephalosporum genus (e.g. Syncephalosporum racemosum IFO4814), or Streptomyces genus in a medium containing ML-236B, or by contacting the extract of the enzyme of the above microorganisms with ML-236B. ML-236B is converted by the treatment to the objective ML-236B derivative of formula (I) (R1 is H, lower alkyl, etc.; R2 is group of formula II, etc.) or its ring-closed lactone.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12438580A JPS5750894A (en) | 1980-09-08 | 1980-09-08 | Preparation of ml-236b derivative |
DK247081A DK149080C (en) | 1980-06-06 | 1981-06-04 | METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES |
MX819478U MX7065E (en) | 1980-06-06 | 1981-06-04 | A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B |
KR1019810002023A KR840001055B1 (en) | 1980-06-06 | 1981-06-05 | Process for preparing ml-236 b decivatives |
DE19813122499 DE3122499A1 (en) | 1980-06-06 | 1981-06-05 | NEW DERIVATIVES OF ML-236B, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT PREPARATIONS CONTAINING THESE DERIVATIVES |
CH3722/81A CH655090A5 (en) | 1980-06-06 | 1981-06-05 | HEXAHYDRONAPHTHALINE DERIVATIVES AND THEIR PRODUCTION. |
SE8103560A SE453389B (en) | 1980-06-06 | 1981-06-05 | HYDROXICARBOXYLIC ACIDS, CIRCULATED LAKTONES, SALTS AND ESTERS THEREOF, AND PROCEDURE FOR THE PREPARATION OF THESE COMPOUNDS |
FI811762A FI71168C (en) | 1980-06-06 | 1981-06-05 | FOERFARANDE FOER FRAMSTAELLNING AV ML-236B-DERIVAT VILKA ANVAENDS SOM CEEEMEDELEL |
ES502827A ES8300353A1 (en) | 1980-06-06 | 1981-06-05 | ML-236B Derivatives and their preparation |
IT67777/81A IT1144598B (en) | 1980-06-06 | 1981-06-05 | PHARMACEUTICAL COMPOUNDS SUITABLE TO INHIBIT THE BIOSYNTHESIS OF CHOLESTEROL AND PROCEDURE FOR THEIR PREPARATION |
NL8102737A NL191738C (en) | 1980-06-06 | 1981-06-05 | ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives. |
FR8111190A FR2483912B1 (en) | 1980-06-06 | 1981-06-05 | HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
AU71376/81A AU549988B2 (en) | 1980-06-06 | 1981-06-05 | Hydroxy esters |
US06/270,846 US4346227A (en) | 1980-06-06 | 1981-06-05 | ML-236B Derivatives and their preparation |
IE1257/81A IE51270B1 (en) | 1980-06-06 | 1981-06-05 | Ml-236b derivatives and their preparation |
CA000379232A CA1150170A (en) | 1980-06-06 | 1981-06-08 | Ml-236b derivatives and their preparation |
GB8117450A GB2077264B (en) | 1980-06-06 | 1981-06-08 | Ml-236b derivatives and their preparation |
AT0256781A AT374495B (en) | 1980-06-06 | 1981-06-09 | METHOD FOR PRODUCING NEW DERIVATIVES OF ML-236B |
BE0/205046A BE889150A (en) | 1980-06-06 | 1981-06-09 | HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
US06/351,974 US4410629A (en) | 1980-06-06 | 1982-02-24 | ML-236B Derivatives and their preparation |
US06/351,975 US4448979A (en) | 1980-06-06 | 1982-02-24 | ML-236B Derivatives |
MX9203563A MX9203563A (en) | 1980-06-06 | 1992-06-26 | DERIVATIVES OF ML-236B AND ITS PREPARATION. |
NL960028C NL960028I2 (en) | 1980-06-06 | 1996-11-18 | ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12438580A JPS5750894A (en) | 1980-09-08 | 1980-09-08 | Preparation of ml-236b derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5750894A true JPS5750894A (en) | 1982-03-25 |
JPS6254476B2 JPS6254476B2 (en) | 1987-11-16 |
Family
ID=14884092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12438580A Granted JPS5750894A (en) | 1980-06-06 | 1980-09-08 | Preparation of ml-236b derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5750894A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6946270B1 (en) | 1999-01-20 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitors |
US7049111B1 (en) | 1999-01-29 | 2006-05-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitor |
WO2007063866A1 (en) | 2005-11-29 | 2007-06-07 | Kyowa Hakko Kogyo Co., Ltd. | Novel protein and dna encoding the protein |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006412B2 (en) | 2008-10-06 | 2015-04-14 | Microbiopharm Japan Co., Ltd. | Expression vector for pseudonocardia autotrophica |
-
1980
- 1980-09-08 JP JP12438580A patent/JPS5750894A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6946270B1 (en) | 1999-01-20 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitors |
US7049111B1 (en) | 1999-01-29 | 2006-05-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitor |
US7897370B2 (en) | 1999-01-29 | 2011-03-01 | Kyowa Hakko Bio Co., Ltd. | Process for producing HMG-CoA reductase inhibitor |
WO2007063866A1 (en) | 2005-11-29 | 2007-06-07 | Kyowa Hakko Kogyo Co., Ltd. | Novel protein and dna encoding the protein |
US8058037B2 (en) | 2005-11-29 | 2011-11-15 | Kyowa Hakko Bio Co., Ltd. | Protein and DNA encoding the protein |
Also Published As
Publication number | Publication date |
---|---|
JPS6254476B2 (en) | 1987-11-16 |
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