JPS5750894A - Preparation of ml-236b derivative - Google Patents

Preparation of ml-236b derivative

Info

Publication number
JPS5750894A
JPS5750894A JP12438580A JP12438580A JPS5750894A JP S5750894 A JPS5750894 A JP S5750894A JP 12438580 A JP12438580 A JP 12438580A JP 12438580 A JP12438580 A JP 12438580A JP S5750894 A JPS5750894 A JP S5750894A
Authority
JP
Japan
Prior art keywords
genus
derivative
syncephalosporum
absidia
cunninghamella
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12438580A
Other languages
Japanese (ja)
Other versions
JPS6254476B2 (en
Inventor
Akira Terahara
Minoru Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP12438580A priority Critical patent/JPS5750894A/en
Priority to DK247081A priority patent/DK149080C/en
Priority to MX819478U priority patent/MX7065E/en
Priority to FR8111190A priority patent/FR2483912B1/en
Priority to IE1257/81A priority patent/IE51270B1/en
Priority to CH3722/81A priority patent/CH655090A5/en
Priority to SE8103560A priority patent/SE453389B/en
Priority to FI811762A priority patent/FI71168C/en
Priority to ES502827A priority patent/ES8300353A1/en
Priority to IT67777/81A priority patent/IT1144598B/en
Priority to NL8102737A priority patent/NL191738C/en
Priority to KR1019810002023A priority patent/KR840001055B1/en
Priority to AU71376/81A priority patent/AU549988B2/en
Priority to US06/270,846 priority patent/US4346227A/en
Priority to DE19813122499 priority patent/DE3122499A1/en
Priority to CA000379232A priority patent/CA1150170A/en
Priority to GB8117450A priority patent/GB2077264B/en
Priority to AT0256781A priority patent/AT374495B/en
Priority to BE0/205046A priority patent/BE889150A/en
Priority to US06/351,974 priority patent/US4410629A/en
Priority to US06/351,975 priority patent/US4448979A/en
Publication of JPS5750894A publication Critical patent/JPS5750894A/en
Publication of JPS6254476B2 publication Critical patent/JPS6254476B2/ja
Priority to MX9203563A priority patent/MX9203563A/en
Priority to NL960028C priority patent/NL960028I2/en
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the titled derivative either by culturing microorganisms belonging to Absidia genus, cunninghamella genus, Syncephalosporum genus, etc. in a medium containing ML-236B, or by contacting extract or microbial enzyme with ML-236B.
CONSTITUTION: The titled derivative is prepared either by culturing microorganisms belonging to Absidia genus (e.g. Absidia coerulea IFO4423), Cunninghamella genus (e.g. Cunninghamella echinulata IFO4445), syncephalosporum genus (e.g. Syncephalosporum racemosum IFO4814), or Streptomyces genus in a medium containing ML-236B, or by contacting the extract of the enzyme of the above microorganisms with ML-236B. ML-236B is converted by the treatment to the objective ML-236B derivative of formula (I) (R1 is H, lower alkyl, etc.; R2 is group of formula II, etc.) or its ring-closed lactone.
COPYRIGHT: (C)1982,JPO&Japio
JP12438580A 1980-06-06 1980-09-08 Preparation of ml-236b derivative Granted JPS5750894A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP12438580A JPS5750894A (en) 1980-09-08 1980-09-08 Preparation of ml-236b derivative
DK247081A DK149080C (en) 1980-06-06 1981-06-04 METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES
MX819478U MX7065E (en) 1980-06-06 1981-06-04 A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
KR1019810002023A KR840001055B1 (en) 1980-06-06 1981-06-05 Process for preparing ml-236 b decivatives
DE19813122499 DE3122499A1 (en) 1980-06-06 1981-06-05 NEW DERIVATIVES OF ML-236B, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT PREPARATIONS CONTAINING THESE DERIVATIVES
CH3722/81A CH655090A5 (en) 1980-06-06 1981-06-05 HEXAHYDRONAPHTHALINE DERIVATIVES AND THEIR PRODUCTION.
SE8103560A SE453389B (en) 1980-06-06 1981-06-05 HYDROXICARBOXYLIC ACIDS, CIRCULATED LAKTONES, SALTS AND ESTERS THEREOF, AND PROCEDURE FOR THE PREPARATION OF THESE COMPOUNDS
FI811762A FI71168C (en) 1980-06-06 1981-06-05 FOERFARANDE FOER FRAMSTAELLNING AV ML-236B-DERIVAT VILKA ANVAENDS SOM CEEEMEDELEL
ES502827A ES8300353A1 (en) 1980-06-06 1981-06-05 ML-236B Derivatives and their preparation
IT67777/81A IT1144598B (en) 1980-06-06 1981-06-05 PHARMACEUTICAL COMPOUNDS SUITABLE TO INHIBIT THE BIOSYNTHESIS OF CHOLESTEROL AND PROCEDURE FOR THEIR PREPARATION
NL8102737A NL191738C (en) 1980-06-06 1981-06-05 ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives.
FR8111190A FR2483912B1 (en) 1980-06-06 1981-06-05 HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
AU71376/81A AU549988B2 (en) 1980-06-06 1981-06-05 Hydroxy esters
US06/270,846 US4346227A (en) 1980-06-06 1981-06-05 ML-236B Derivatives and their preparation
IE1257/81A IE51270B1 (en) 1980-06-06 1981-06-05 Ml-236b derivatives and their preparation
CA000379232A CA1150170A (en) 1980-06-06 1981-06-08 Ml-236b derivatives and their preparation
GB8117450A GB2077264B (en) 1980-06-06 1981-06-08 Ml-236b derivatives and their preparation
AT0256781A AT374495B (en) 1980-06-06 1981-06-09 METHOD FOR PRODUCING NEW DERIVATIVES OF ML-236B
BE0/205046A BE889150A (en) 1980-06-06 1981-06-09 HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
US06/351,974 US4410629A (en) 1980-06-06 1982-02-24 ML-236B Derivatives and their preparation
US06/351,975 US4448979A (en) 1980-06-06 1982-02-24 ML-236B Derivatives
MX9203563A MX9203563A (en) 1980-06-06 1992-06-26 DERIVATIVES OF ML-236B AND ITS PREPARATION.
NL960028C NL960028I2 (en) 1980-06-06 1996-11-18 ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12438580A JPS5750894A (en) 1980-09-08 1980-09-08 Preparation of ml-236b derivative

Publications (2)

Publication Number Publication Date
JPS5750894A true JPS5750894A (en) 1982-03-25
JPS6254476B2 JPS6254476B2 (en) 1987-11-16

Family

ID=14884092

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12438580A Granted JPS5750894A (en) 1980-06-06 1980-09-08 Preparation of ml-236b derivative

Country Status (1)

Country Link
JP (1) JPS5750894A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946270B1 (en) 1999-01-20 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing HMG-CoA reductase inhibitors
US7049111B1 (en) 1999-01-29 2006-05-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing HMG-CoA reductase inhibitor
WO2007063866A1 (en) 2005-11-29 2007-06-07 Kyowa Hakko Kogyo Co., Ltd. Novel protein and dna encoding the protein

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006412B2 (en) 2008-10-06 2015-04-14 Microbiopharm Japan Co., Ltd. Expression vector for pseudonocardia autotrophica

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946270B1 (en) 1999-01-20 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing HMG-CoA reductase inhibitors
US7049111B1 (en) 1999-01-29 2006-05-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing HMG-CoA reductase inhibitor
US7897370B2 (en) 1999-01-29 2011-03-01 Kyowa Hakko Bio Co., Ltd. Process for producing HMG-CoA reductase inhibitor
WO2007063866A1 (en) 2005-11-29 2007-06-07 Kyowa Hakko Kogyo Co., Ltd. Novel protein and dna encoding the protein
US8058037B2 (en) 2005-11-29 2011-11-15 Kyowa Hakko Bio Co., Ltd. Protein and DNA encoding the protein

Also Published As

Publication number Publication date
JPS6254476B2 (en) 1987-11-16

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