JPS5748998A - Novel condurango glycoside, its preparation and antitumor agent containing the same - Google Patents

Novel condurango glycoside, its preparation and antitumor agent containing the same

Info

Publication number
JPS5748998A
JPS5748998A JP12517580A JP12517580A JPS5748998A JP S5748998 A JPS5748998 A JP S5748998A JP 12517580 A JP12517580 A JP 12517580A JP 12517580 A JP12517580 A JP 12517580A JP S5748998 A JPS5748998 A JP S5748998A
Authority
JP
Japan
Prior art keywords
condurango
formula
glycoside
condurango glycoside
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12517580A
Other languages
Japanese (ja)
Other versions
JPS6256160B2 (en
Inventor
Hiroshi Mihashi
Denichi Mizuno
Koji Hayashi
Shigeru Abe
Muneaki Takase
Toshiharu Narita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Priority to JP12517580A priority Critical patent/JPS5748998A/en
Priority to IT8167295A priority patent/IT1144136B/en
Priority to BE0/204013A priority patent/BE887793A/en
Priority to DE19813137612 priority patent/DE3137612A1/en
Priority to GB8209580A priority patent/GB2093032B/en
Priority to EP19810900551 priority patent/EP0054570A4/en
Priority to AU67800/81A priority patent/AU6780081A/en
Priority to CA000372389A priority patent/CA1169852A/en
Priority to CH7326/81A priority patent/CH647533A5/en
Priority to PCT/JP1981/000045 priority patent/WO1981002577A1/en
Priority to US06/320,974 priority patent/US4452786A/en
Publication of JPS5748998A publication Critical patent/JPS5748998A/en
Priority to SE8202140A priority patent/SE8202140L/en
Publication of JPS6256160B2 publication Critical patent/JPS6256160B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Condurango glycoside of formula I (R1 is methoxy; R2 is methyl; or R1 is methyl; R2 is hydroxyl).
EXAMPLE: 20-Iso-O-methyl-condurango glycoside D.
USE: Antitumor agnet.
PREPARATION: Condurango glycoside of formula II is subjected to alcoholysis and the resultant reaction mixture is concentrated under reduced pressure to dryness. The residue is subjected to ordinary-phase HPLC, then reversed-phase HPLC to effect isolation and purification to obtain the compound of formula II. Further, the compound of formula II is hydrolyzed and subjected to the same treatment as above to give the compound of formula I (condurango glycoside Do) where R1 is mathyl and R2 is hydroxyl. The condurango glycoside Bo of formual II is obtained by subjecting a fraction from crushed condurango suluble in methanol and chloroform but insoluble n-hexane to HPLC for isolation and purification.
COPYRIGHT: (C)1982,JPO&Japio
JP12517580A 1980-03-05 1980-09-09 Novel condurango glycoside, its preparation and antitumor agent containing the same Granted JPS5748998A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP12517580A JPS5748998A (en) 1980-09-09 1980-09-09 Novel condurango glycoside, its preparation and antitumor agent containing the same
IT8167295A IT1144136B (en) 1980-03-05 1981-03-03 GLUCOSIDES OF CONDUCT ANTI-CANCER AGENTS INCLUDING THEM AND PROCEDURE FOR THEIR PREPARATION
BE0/204013A BE887793A (en) 1980-03-05 1981-03-04 NOVEL CONDURANGO-GLYCOSIDES, ANTI-TUMOR AGENTS COMPRISING SAME, AND PROCESS FOR PREPARING THE SAME
CA000372389A CA1169852A (en) 1980-03-05 1981-03-05 Condurango glycoside compounds, antitumor agents comprising them and processes for their preparation
GB8209580A GB2093032B (en) 1980-03-05 1981-03-05 Novel condurango glycosides process for their preparation antineoplastic agent and composition containing same
EP19810900551 EP0054570A4 (en) 1980-03-05 1981-03-05 Novel condurango glycosides, process for their preparation, antineoplastic agent, and composition containing same.
AU67800/81A AU6780081A (en) 1980-03-05 1981-03-05 Novel cundurango glycosides, process for their preparation, antineoplastic agent, and composition containing same
DE19813137612 DE3137612A1 (en) 1980-03-05 1981-03-05 NOVEL CUNDURANGO GLYCOSIDES, PROCESS FOR THEIR PREPARATION, ANTINEOPLASTIC AGENT, AND COMPOSITION CONTAINING SAME
CH7326/81A CH647533A5 (en) 1980-03-05 1981-03-05 CUNDURANGO-GLYCOSIDE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND TUMOR-FIGHTING AGENTS CONTAINING THESE COMPOUNDS.
PCT/JP1981/000045 WO1981002577A1 (en) 1980-03-05 1981-03-05 Novel cundurango glycosides,process for their preparation,antineoplastic agent,and composition containing same
US06/320,974 US4452786A (en) 1980-03-05 1981-03-05 Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions
SE8202140A SE8202140L (en) 1980-03-05 1982-04-02 NEW CONDURANGO-GLYCOSIDE ASSOCIATIONS, PROCEDURES FOR THEIR PREPARATION, ANTITUMORS THAT INCLUDE THEM AND COMPOSITIONS WHICH THEY CONTAIN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12517580A JPS5748998A (en) 1980-09-09 1980-09-09 Novel condurango glycoside, its preparation and antitumor agent containing the same

Publications (2)

Publication Number Publication Date
JPS5748998A true JPS5748998A (en) 1982-03-20
JPS6256160B2 JPS6256160B2 (en) 1987-11-24

Family

ID=14903741

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12517580A Granted JPS5748998A (en) 1980-03-05 1980-09-09 Novel condurango glycoside, its preparation and antitumor agent containing the same

Country Status (1)

Country Link
JP (1) JPS5748998A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5797600U (en) * 1980-12-08 1982-06-15

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5797600U (en) * 1980-12-08 1982-06-15
JPS588314Y2 (en) * 1980-12-08 1983-02-15 株式会社 タカラ toy hammer

Also Published As

Publication number Publication date
JPS6256160B2 (en) 1987-11-24

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