JPS5732215A - Powdery pharmacological composition and powder for application to internasal mucous membrane - Google Patents

Powdery pharmacological composition and powder for application to internasal mucous membrane

Info

Publication number
JPS5732215A
JPS5732215A JP10775080A JP10775080A JPS5732215A JP S5732215 A JPS5732215 A JP S5732215A JP 10775080 A JP10775080 A JP 10775080A JP 10775080 A JP10775080 A JP 10775080A JP S5732215 A JPS5732215 A JP S5732215A
Authority
JP
Japan
Prior art keywords
drug
composition
powder
cellulose
mucous membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10775080A
Other languages
Japanese (ja)
Other versions
JPS607965B2 (en
Inventor
Yoshiki Suzuki
Hiroshi Igura
Gentaro Yamashita
Tsuneji Nagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP10775080A priority Critical patent/JPS607965B2/en
Publication of JPS5732215A publication Critical patent/JPS5732215A/en
Publication of JPS607965B2 publication Critical patent/JPS607965B2/en
Expired legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: The titled composition and powder, consisting of a lower alkyl ether of cellulose having a specific viscosity of an aqueous solution thereof under specifed conditions and a pharmacologically effective amount of a drug, having a specific particle diameter, and capable of exhibiting the prolonged release of the drug and a high drug utilization efficiency.
CONSTITUTION: A composition consisting of a lower alkyl ether of cellulose, particularly hydroxypropyl cellulose, having a viscosity of about 5cps or above, preferably about 5W5,000cps, in a 2wt% aqueous solution thereof at about 37°C and a pharamacologically effective amount of a drug, preferably a remedy or preventing agent for nasal diseases. 90wt% or more particles have an effective particle diameter of about 20W250μ, particularly about 20W150μ. The composition adheres to the intranasal mucous membrane to absorb water and become a liquid state having a suitable tackiness and fluidity by the administration to the intranasal cavity. The administered composition moves slowly on the nasal mucous membrance as a flowing surface and imparts the prolonged release of the drug and a high drug utilization efficiency.
COPYRIGHT: (C)1982,JPO&Japio
JP10775080A 1980-08-07 1980-08-07 Method for manufacturing powder for nasal mucosal administration Expired JPS607965B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10775080A JPS607965B2 (en) 1980-08-07 1980-08-07 Method for manufacturing powder for nasal mucosal administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10775080A JPS607965B2 (en) 1980-08-07 1980-08-07 Method for manufacturing powder for nasal mucosal administration

Publications (2)

Publication Number Publication Date
JPS5732215A true JPS5732215A (en) 1982-02-20
JPS607965B2 JPS607965B2 (en) 1985-02-28

Family

ID=14467012

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10775080A Expired JPS607965B2 (en) 1980-08-07 1980-08-07 Method for manufacturing powder for nasal mucosal administration

Country Status (1)

Country Link
JP (1) JPS607965B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59163313A (en) * 1983-03-09 1984-09-14 Teijin Ltd Peptide hormone composition for nasal administration
US4579858A (en) * 1983-01-21 1986-04-01 Aktiebolaget Leo Smoking substitutes for nasal administration-I
WO1993025198A1 (en) * 1992-06-12 1993-12-23 Teijin Limited Ultrafine powder for inhalation and production thereof
WO1997031626A1 (en) * 1996-02-27 1997-09-04 Teijin Limited Powdery composition for nasal administration
US6572893B2 (en) 1996-12-31 2003-06-03 Inhale Therapeutic Systems, Inc. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
JP2007504129A (en) * 2003-08-29 2007-03-01 デルサイト バイオテクノロジーズ， インコーポレイテッド Physiological drug delivery in situ gels containing anionic polysaccharides

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5171102B2 (en) * 2007-05-02 2013-03-27 東亜薬品株式会社 Nasal absorption sleep inducer

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579858A (en) * 1983-01-21 1986-04-01 Aktiebolaget Leo Smoking substitutes for nasal administration-I
JPS6237016B2 (en) * 1983-03-09 1987-08-10 Teijin Ltd
JPS59163313A (en) * 1983-03-09 1984-09-14 Teijin Ltd Peptide hormone composition for nasal administration
US5972388A (en) * 1992-06-12 1999-10-26 Teijin Limited Ultrafine particle power for inhalation and method for production thereof
WO1993025198A1 (en) * 1992-06-12 1993-12-23 Teijin Limited Ultrafine powder for inhalation and production thereof
AU722319B2 (en) * 1996-02-27 2000-07-27 Teijin Limited Powdery composition for nasal administration
WO1997031626A1 (en) * 1996-02-27 1997-09-04 Teijin Limited Powdery composition for nasal administration
US6881423B2 (en) 1996-02-27 2005-04-19 Teijin Limited Powdery composition for nasal administration
US7731990B2 (en) 1996-02-27 2010-06-08 Teijin Limited Powdery composition for nasal administration
US8206748B2 (en) 1996-02-27 2012-06-26 Teijin Limited Powdery composition for nasal administration
US6572893B2 (en) 1996-12-31 2003-06-03 Inhale Therapeutic Systems, Inc. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
JP2007504129A (en) * 2003-08-29 2007-03-01 デルサイト バイオテクノロジーズ， インコーポレイテッド Physiological drug delivery in situ gels containing anionic polysaccharides
JP4765020B2 (en) * 2003-08-29 2011-09-07 ナノセラピューティクス・インコーポレイテッド Physiological drug delivery in situ gels containing anionic polysaccharides

Also Published As

Publication number Publication date
JPS607965B2 (en) 1985-02-28

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