JPS5731640A - Dicarboxylic acid and its preparation - Google Patents

Dicarboxylic acid and its preparation

Info

Publication number
JPS5731640A
JPS5731640A JP10354180A JP10354180A JPS5731640A JP S5731640 A JPS5731640 A JP S5731640A JP 10354180 A JP10354180 A JP 10354180A JP 10354180 A JP10354180 A JP 10354180A JP S5731640 A JPS5731640 A JP S5731640A
Authority
JP
Japan
Prior art keywords
activity
formula
compound
dicarboxylic acid
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10354180A
Other languages
Japanese (ja)
Inventor
Takuya Kodama
Kenjun Takeshima
Mariko Hayashi
Hinako Murota
Mutsuko Maekawa
Masami Enomoto
Mariko Nakayama
Nobuko Asai
Hiroko Miwa
Yasuyuki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP10354180A priority Critical patent/JPS5731640A/en
Publication of JPS5731640A publication Critical patent/JPS5731640A/en
Pending legal-status Critical Current

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Landscapes

  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A dicarboxylic acid of formula I (X is alkylene substituted with carboxyl group; m is 0W2; n is 1W3; R is alkyl, halogen-substituted alkyl, aryl, cycloalkyl, alkoxy, aryloxy, etc.; when 2 is 2 or 3, the two Rs bonded to adjacent C atoms may together from methylenedioxy or phenyl ring), and its salt.
EXAMPLE: 2-(3-Carboxyphenyl)-3-(2-butoxyphenyl)propionic acid.
USE: The compound exhibits excellent activity to promote and normalize the immunological function, antirheumatic activity, hepatic function improving activity, antiulcer activity, etc., and is useful as pharmaceuticals.
PROCESS: The compound of formula I is prepared, e.g. by reducing the compound of formula II (X1 is carbonyl-substituted alkenylene, etc.) at 0W80°C in the presence of a catalyst.
COPYRIGHT: (C)1982,JPO&Japio
JP10354180A 1980-07-30 1980-07-30 Dicarboxylic acid and its preparation Pending JPS5731640A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10354180A JPS5731640A (en) 1980-07-30 1980-07-30 Dicarboxylic acid and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10354180A JPS5731640A (en) 1980-07-30 1980-07-30 Dicarboxylic acid and its preparation

Publications (1)

Publication Number Publication Date
JPS5731640A true JPS5731640A (en) 1982-02-20

Family

ID=14356696

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10354180A Pending JPS5731640A (en) 1980-07-30 1980-07-30 Dicarboxylic acid and its preparation

Country Status (1)

Country Link
JP (1) JPS5731640A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985003287A1 (en) * 1984-01-19 1985-08-01 Pharmacia Ab Novel arylacetic acid derivatives
WO2002014262A1 (en) * 2000-08-11 2002-02-21 Kaken Pharmaceutical Co.,Ltd. 2,3-diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985003287A1 (en) * 1984-01-19 1985-08-01 Pharmacia Ab Novel arylacetic acid derivatives
WO2002014262A1 (en) * 2000-08-11 2002-02-21 Kaken Pharmaceutical Co.,Ltd. 2,3-diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage
US7335673B2 (en) 2000-08-11 2008-02-26 Kaken Pharmaceutical Co., Ltd. 2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage
JP5046466B2 (en) * 2000-08-11 2012-10-10 科研製薬株式会社 2,3-Diphenylpropionic acid derivative or salt thereof, pharmaceutical and cell adhesion inhibitor using the same, and method of using the same

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