JPS57193437A - Amino acid derivative - Google Patents
Amino acid derivativeInfo
- Publication number
- JPS57193437A JPS57193437A JP56076906A JP7690681A JPS57193437A JP S57193437 A JPS57193437 A JP S57193437A JP 56076906 A JP56076906 A JP 56076906A JP 7690681 A JP7690681 A JP 7690681A JP S57193437 A JPS57193437 A JP S57193437A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- amino
- formulai
- phenylalanine
- tyrosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An amino acid derivative expressed by formulaI[R1 is formula II or III (X1 is H or OH; X2 is H, halogen, OH or amino); R2 is OH, lower alkyloxy, amino, etc.; R3 is cyclohexyl or phenyl].
EXAMPLE: N-β-Cyclohexylpropionyl-L-tyrosine.
USE: An analgesic, hypotensive, psychotoropic, anticancer and antiviral agents, capable of powerfully inhibiting the excitability of nervous cells (by the use of cytomegalic nervous cells of a snail), and having the interferon inducing ability.
PROCESS: An N-hydroxysuccinimide ester of β-phenylpropionic acid, phenylacetic acid, caproic acid, β-cyclohexylpropionic acid cinnamic acid or Z-D-phenylalanine is prepared and then condensed with phenylalanine, tyrosine, tryptophan or a derivative thereof by the conventional method of peptide synthesis to give the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56076906A JPS57193437A (en) | 1981-05-21 | 1981-05-21 | Amino acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56076906A JPS57193437A (en) | 1981-05-21 | 1981-05-21 | Amino acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57193437A true JPS57193437A (en) | 1982-11-27 |
Family
ID=13618706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56076906A Pending JPS57193437A (en) | 1981-05-21 | 1981-05-21 | Amino acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57193437A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987004154A1 (en) * | 1986-01-03 | 1987-07-16 | The University Of Melbourne | Melphalan derivatives |
EP0312898A2 (en) * | 1987-10-19 | 1989-04-26 | Abbott Laboratories | Phenylacetylglutamine (pag) analytical test |
EP1108428A2 (en) * | 1991-10-21 | 2001-06-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Compositions for and uses thereof for treating viral disease with phenylacetate and derivatives thereof |
WO2006101422A1 (en) * | 2005-03-25 | 2006-09-28 | Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises | Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof |
-
1981
- 1981-05-21 JP JP56076906A patent/JPS57193437A/en active Pending
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987004154A1 (en) * | 1986-01-03 | 1987-07-16 | The University Of Melbourne | Melphalan derivatives |
US5075108A (en) * | 1986-01-03 | 1991-12-24 | Consolidated Pharmaceuticals, Limited | Melphalan derivatives |
EP0312898A2 (en) * | 1987-10-19 | 1989-04-26 | Abbott Laboratories | Phenylacetylglutamine (pag) analytical test |
EP1108428A2 (en) * | 1991-10-21 | 2001-06-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Compositions for and uses thereof for treating viral disease with phenylacetate and derivatives thereof |
EP1108427A2 (en) * | 1991-10-21 | 2001-06-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Compositions for and uses thereof for altering gene expression with phenylacetate and derivatives thereof |
EP1108427A3 (en) * | 1991-10-21 | 2004-01-07 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Compositions for and uses thereof for altering gene expression with phenylacetate and derivatives thereof |
EP1108428A3 (en) * | 1991-10-21 | 2004-01-07 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Compositions for and uses thereof for treating viral disease with phenylacetate and derivatives thereof |
WO2006101422A1 (en) * | 2005-03-25 | 2006-09-28 | Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises | Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof |
JP2008534495A (en) * | 2005-03-25 | 2008-08-28 | オブシェストヴォス オグラニチェンノイ オトヴェツトヴェンノスティユ “ファルメンテルプリセス” | Phenyl-N-acyl derivatives of amines and amino acids, methods for their preparation, their pharmaceutical compositions and uses |
EA013644B1 (en) * | 2005-03-25 | 2010-06-30 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Phenyl-containing n-acyl amines and aminoacids derivatives, a method for the producing thereof, a pharmaceutical composition and the use thereof |
US8309766B2 (en) | 2005-03-25 | 2012-11-13 | Obschestvo S. Organichennoi Otvetstvennostiyu Pharmenterprises | Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof |
US8546612B2 (en) | 2005-03-25 | 2013-10-01 | Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises | Phenyl-N-acyl derivatives of amines and amino acids, a process for the preparation thereof, a pharmaceutical composition and use thereof |
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