JPS57193437A - Amino acid derivative - Google Patents

Amino acid derivative

Info

Publication number
JPS57193437A
JPS57193437A JP56076906A JP7690681A JPS57193437A JP S57193437 A JPS57193437 A JP S57193437A JP 56076906 A JP56076906 A JP 56076906A JP 7690681 A JP7690681 A JP 7690681A JP S57193437 A JPS57193437 A JP S57193437A
Authority
JP
Japan
Prior art keywords
acid
amino
formulai
phenylalanine
tyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56076906A
Other languages
Japanese (ja)
Inventor
Hiroshi Takeuchi
Tadashi Suyama
Masaru Okutsu
Yasuo Ariyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP56076906A priority Critical patent/JPS57193437A/en
Publication of JPS57193437A publication Critical patent/JPS57193437A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An amino acid derivative expressed by formulaI[R1 is formula II or III (X1 is H or OH; X2 is H, halogen, OH or amino); R2 is OH, lower alkyloxy, amino, etc.; R3 is cyclohexyl or phenyl].
EXAMPLE: N-β-Cyclohexylpropionyl-L-tyrosine.
USE: An analgesic, hypotensive, psychotoropic, anticancer and antiviral agents, capable of powerfully inhibiting the excitability of nervous cells (by the use of cytomegalic nervous cells of a snail), and having the interferon inducing ability.
PROCESS: An N-hydroxysuccinimide ester of β-phenylpropionic acid, phenylacetic acid, caproic acid, β-cyclohexylpropionic acid cinnamic acid or Z-D-phenylalanine is prepared and then condensed with phenylalanine, tyrosine, tryptophan or a derivative thereof by the conventional method of peptide synthesis to give the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56076906A 1981-05-21 1981-05-21 Amino acid derivative Pending JPS57193437A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56076906A JPS57193437A (en) 1981-05-21 1981-05-21 Amino acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56076906A JPS57193437A (en) 1981-05-21 1981-05-21 Amino acid derivative

Publications (1)

Publication Number Publication Date
JPS57193437A true JPS57193437A (en) 1982-11-27

Family

ID=13618706

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56076906A Pending JPS57193437A (en) 1981-05-21 1981-05-21 Amino acid derivative

Country Status (1)

Country Link
JP (1) JPS57193437A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004154A1 (en) * 1986-01-03 1987-07-16 The University Of Melbourne Melphalan derivatives
EP0312898A2 (en) * 1987-10-19 1989-04-26 Abbott Laboratories Phenylacetylglutamine (pag) analytical test
EP1108428A2 (en) * 1991-10-21 2001-06-20 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Compositions for and uses thereof for treating viral disease with phenylacetate and derivatives thereof
WO2006101422A1 (en) * 2005-03-25 2006-09-28 Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004154A1 (en) * 1986-01-03 1987-07-16 The University Of Melbourne Melphalan derivatives
US5075108A (en) * 1986-01-03 1991-12-24 Consolidated Pharmaceuticals, Limited Melphalan derivatives
EP0312898A2 (en) * 1987-10-19 1989-04-26 Abbott Laboratories Phenylacetylglutamine (pag) analytical test
EP1108428A2 (en) * 1991-10-21 2001-06-20 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Compositions for and uses thereof for treating viral disease with phenylacetate and derivatives thereof
EP1108427A2 (en) * 1991-10-21 2001-06-20 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Compositions for and uses thereof for altering gene expression with phenylacetate and derivatives thereof
EP1108427A3 (en) * 1991-10-21 2004-01-07 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Compositions for and uses thereof for altering gene expression with phenylacetate and derivatives thereof
EP1108428A3 (en) * 1991-10-21 2004-01-07 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Compositions for and uses thereof for treating viral disease with phenylacetate and derivatives thereof
WO2006101422A1 (en) * 2005-03-25 2006-09-28 Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof
JP2008534495A (en) * 2005-03-25 2008-08-28 オブシェストヴォス オグラニチェンノイ オトヴェツトヴェンノスティユ “ファルメンテルプリセス” Phenyl-N-acyl derivatives of amines and amino acids, methods for their preparation, their pharmaceutical compositions and uses
EA013644B1 (en) * 2005-03-25 2010-06-30 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Phenyl-containing n-acyl amines and aminoacids derivatives, a method for the producing thereof, a pharmaceutical composition and the use thereof
US8309766B2 (en) 2005-03-25 2012-11-13 Obschestvo S. Organichennoi Otvetstvennostiyu Pharmenterprises Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof
US8546612B2 (en) 2005-03-25 2013-10-01 Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises Phenyl-N-acyl derivatives of amines and amino acids, a process for the preparation thereof, a pharmaceutical composition and use thereof

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