JPS57188578A - N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same - Google Patents
N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the sameInfo
- Publication number
- JPS57188578A JPS57188578A JP7352081A JP7352081A JPS57188578A JP S57188578 A JPS57188578 A JP S57188578A JP 7352081 A JP7352081 A JP 7352081A JP 7352081 A JP7352081 A JP 7352081A JP S57188578 A JPS57188578 A JP S57188578A
- Authority
- JP
- Japan
- Prior art keywords
- thiazolyl
- expressed
- phenyl
- acid derivative
- carbamic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An N-(4-phenyl-2-thiazolyl)carbamic acid derivative expressed by formulaI(R1 is lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, NO2 or NH2; R2 is lower alkyl).
EXAMPLE: Ethyl N-(4-p-nitrophenyl-2-thiazolyl)carbamate.
USE: An immunogical regulating agent useful for the treatment of chronic rheumarthritis and viral diseases and the immunotherapy of cancer with little toxic action.
PROCESS: A 2-amino-4-phenylthiazole expressed by formula II is reacted with a dialkyl carbonate under heating preferably at ≥90°C or reacted with a halogenoformic ester expressed by formula III (X is halogen) to afford the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7352081A JPS57188578A (en) | 1981-05-18 | 1981-05-18 | N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same |
IT25957/81A IT1142649B (en) | 1981-01-08 | 1981-12-31 | N 4 Phenyl 2 thiazolyl carbamate derivs. |
EP82900226A EP0068033B1 (en) | 1981-01-08 | 1982-01-08 | N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same |
US06/417,115 US4511574A (en) | 1981-01-08 | 1982-01-08 | N-(4-Phenyl-2-thiazolyl)carbamate derivatives |
DE8282900226T DE3264595D1 (en) | 1981-01-08 | 1982-01-08 | N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same |
PCT/JP1982/000003 WO1982002384A1 (en) | 1981-01-08 | 1982-01-08 | Their preparation,and medicinal composition containing same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7352081A JPS57188578A (en) | 1981-05-18 | 1981-05-18 | N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57188578A true JPS57188578A (en) | 1982-11-19 |
JPH0260672B2 JPH0260672B2 (en) | 1990-12-17 |
Family
ID=13520596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7352081A Granted JPS57188578A (en) | 1981-01-08 | 1981-05-18 | N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57188578A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5461172A (en) * | 1977-10-19 | 1979-05-17 | Fabre Sa Pierre | Novel 44phenyll22aminothiazole derivative* its manufacture and immunity stimulant containing it |
-
1981
- 1981-05-18 JP JP7352081A patent/JPS57188578A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5461172A (en) * | 1977-10-19 | 1979-05-17 | Fabre Sa Pierre | Novel 44phenyll22aminothiazole derivative* its manufacture and immunity stimulant containing it |
Also Published As
Publication number | Publication date |
---|---|
JPH0260672B2 (en) | 1990-12-17 |
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