JPS57188578A - N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same - Google Patents

N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same

Info

Publication number
JPS57188578A
JPS57188578A JP7352081A JP7352081A JPS57188578A JP S57188578 A JPS57188578 A JP S57188578A JP 7352081 A JP7352081 A JP 7352081A JP 7352081 A JP7352081 A JP 7352081A JP S57188578 A JPS57188578 A JP S57188578A
Authority
JP
Japan
Prior art keywords
thiazolyl
expressed
phenyl
acid derivative
carbamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7352081A
Other languages
Japanese (ja)
Other versions
JPH0260672B2 (en
Inventor
Isao Sakano
Tatsuro Yokoyama
Seitaro Kajitani
Yutaka Okazaki
Hiroshi Tokuda
Hiroshi Kawamo
Mikio Kumakura
Takuo Nakano
Akira Awaya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP7352081A priority Critical patent/JPS57188578A/en
Priority to IT25957/81A priority patent/IT1142649B/en
Priority to EP82900226A priority patent/EP0068033B1/en
Priority to US06/417,115 priority patent/US4511574A/en
Priority to DE8282900226T priority patent/DE3264595D1/en
Priority to PCT/JP1982/000003 priority patent/WO1982002384A1/en
Publication of JPS57188578A publication Critical patent/JPS57188578A/en
Publication of JPH0260672B2 publication Critical patent/JPH0260672B2/ja
Granted legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An N-(4-phenyl-2-thiazolyl)carbamic acid derivative expressed by formulaI(R1 is lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, NO2 or NH2; R2 is lower alkyl).
EXAMPLE: Ethyl N-(4-p-nitrophenyl-2-thiazolyl)carbamate.
USE: An immunogical regulating agent useful for the treatment of chronic rheumarthritis and viral diseases and the immunotherapy of cancer with little toxic action.
PROCESS: A 2-amino-4-phenylthiazole expressed by formula II is reacted with a dialkyl carbonate under heating preferably at ≥90°C or reacted with a halogenoformic ester expressed by formula III (X is halogen) to afford the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP7352081A 1981-01-08 1981-05-18 N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same Granted JPS57188578A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP7352081A JPS57188578A (en) 1981-05-18 1981-05-18 N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same
IT25957/81A IT1142649B (en) 1981-01-08 1981-12-31 N 4 Phenyl 2 thiazolyl carbamate derivs.
EP82900226A EP0068033B1 (en) 1981-01-08 1982-01-08 N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same
US06/417,115 US4511574A (en) 1981-01-08 1982-01-08 N-(4-Phenyl-2-thiazolyl)carbamate derivatives
DE8282900226T DE3264595D1 (en) 1981-01-08 1982-01-08 N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same
PCT/JP1982/000003 WO1982002384A1 (en) 1981-01-08 1982-01-08 Their preparation,and medicinal composition containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7352081A JPS57188578A (en) 1981-05-18 1981-05-18 N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same

Publications (2)

Publication Number Publication Date
JPS57188578A true JPS57188578A (en) 1982-11-19
JPH0260672B2 JPH0260672B2 (en) 1990-12-17

Family

ID=13520596

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7352081A Granted JPS57188578A (en) 1981-01-08 1981-05-18 N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same

Country Status (1)

Country Link
JP (1) JPS57188578A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5461172A (en) * 1977-10-19 1979-05-17 Fabre Sa Pierre Novel 44phenyll22aminothiazole derivative* its manufacture and immunity stimulant containing it

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5461172A (en) * 1977-10-19 1979-05-17 Fabre Sa Pierre Novel 44phenyll22aminothiazole derivative* its manufacture and immunity stimulant containing it

Also Published As

Publication number Publication date
JPH0260672B2 (en) 1990-12-17

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