JPS5718610A - Immunizator - Google Patents
ImmunizatorInfo
- Publication number
- JPS5718610A JPS5718610A JP9169280A JP9169280A JPS5718610A JP S5718610 A JPS5718610 A JP S5718610A JP 9169280 A JP9169280 A JP 9169280A JP 9169280 A JP9169280 A JP 9169280A JP S5718610 A JPS5718610 A JP S5718610A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- immunizator
- immunity
- ahpa
- bestatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: An immunizator that contains 3-amino-2-hydroxy-4-phenylbutyric acid and its derivative as major active principles, thus being suitably used for immunotherapy and infection immunity, because it can increase cellular immunity with a low-dose administration.
CONSTITUTION: The objective immunizator contains as major active principles 3-amino-2-hydroxy-4-phenylbutyric acid (AHPA) of the formula (R1 is H, hydroxyl; R2 is hydroxyl, alkoxy, benzyloxy, amino, substituted amino) and its derivatve. The compound of the formula has strong immunization activity, i.e., greatly increases cellular immunity with an extremely low-dose adminitration compared with bestatin that is known as an immunologically carcinostatic agent. Therefore, it can find broad appliction in the fields of immunotherapy and infection immunity. (2S,3R)-AHPA is otained by acidic hydrolysis of bestatin through the known process.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9169280A JPS5718610A (en) | 1980-07-07 | 1980-07-07 | Immunizator |
US06/272,211 US4370318A (en) | 1980-07-07 | 1981-06-10 | Bestatin-related compounds as immunopotentiator |
GB8119397A GB2083046B (en) | 1980-07-07 | 1981-06-24 | Bestatin-related compounds |
DE3153030A DE3153030C2 (en) | 1980-07-07 | 1981-07-06 | Use of (2S, 3R) -3-amino-2-hydroxy-4-phenylbutanoic acid compounds as immune boosting agents |
CA000381174A CA1178610A (en) | 1980-07-07 | 1981-07-06 | Bestatin-related compounds as immunopotentiator |
IT09465/81A IT1167937B (en) | 1980-07-07 | 1981-07-06 | COMPOUNDS LINKED TO THE SKEWER AS AN IMMUNOPOTENTIATOR |
DE3126606A DE3126606C2 (en) | 1980-07-07 | 1981-07-06 | (2S, 3R) -3-Amino-2-hydroxy-4-phenylbutanoic acid amides and peptides and pharmaceuticals containing them |
IT1981A09465A IT8109465A1 (en) | 1980-07-07 | 1981-07-06 | COMPOUNDS CONNECTED TO BABY AS AN IMMUNOPOTENTIATOR |
FR8113332A FR2485924A1 (en) | 1980-07-07 | 1981-07-07 | NOVEL IMMUNOPOTENTIALIZING PHARMACEUTICAL COMPOSITIONS, AND NOVEL BESTATIN-RELATED COMPOUNDS ENTERING THESE COMPOSITIONS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9169280A JPS5718610A (en) | 1980-07-07 | 1980-07-07 | Immunizator |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5718610A true JPS5718610A (en) | 1982-01-30 |
JPS646165B2 JPS646165B2 (en) | 1989-02-02 |
Family
ID=14033554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9169280A Granted JPS5718610A (en) | 1980-07-07 | 1980-07-07 | Immunizator |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5718610A (en) |
-
1980
- 1980-07-07 JP JP9169280A patent/JPS5718610A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS646165B2 (en) | 1989-02-02 |
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