JPS57179192A - Ethylene glycol derivative - Google Patents
Ethylene glycol derivativeInfo
- Publication number
- JPS57179192A JPS57179192A JP17677181A JP17677181A JPS57179192A JP S57179192 A JPS57179192 A JP S57179192A JP 17677181 A JP17677181 A JP 17677181A JP 17677181 A JP17677181 A JP 17677181A JP S57179192 A JPS57179192 A JP S57179192A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- ethylene glycol
- formulai
- react
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:An ethylene glycol derivative of formulaI(n is 1W15; R1 is residue of aliphatic hydrocarbon of 3W26 carbon atoms; R2WR4 are H, lower alkyl) or its salt.
EXAMPLE: 3,6,9,12,15-Pentaoxaheptadecyl-2-pyridinium ethyl phosphate.
USE: Antitumor agent, anntibacterial for agricultural purpose: it shows activities of proliferation inhibition and differentiation induction (removal of cancers) of tumor cells such as cells of mouse spontaneous leukemia and remarkable life- prolonging effect on patients with malignant tumors such as leukemia or solid cancers. Further, it shows antimycotic activity.
PREPARATION: A compound of formula II reacts with another compound of formula III(X, Y are halogen) to form a compound of formula IV, which is made to react with water to give a compound of formula V. The product is made to react with a compound of formula VI to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/257,771 US4551532A (en) | 1980-05-08 | 1981-04-27 | Ethylene glycol derivatives having anti-protozoan, anti-fungal and anti-tumor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57179192A true JPS57179192A (en) | 1982-11-04 |
Family
ID=22977683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17677181A Pending JPS57179192A (en) | 1981-04-27 | 1981-11-03 | Ethylene glycol derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57179192A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0592876A1 (en) * | 1992-10-10 | 1994-04-20 | Beiersdorf Aktiengesellschaft | Antimycotic dermatological and cosmetic compositions |
| JP2001262184A (en) * | 2000-03-15 | 2001-09-26 | Toyobo Co Ltd | Surfactant |
| JP2001354679A (en) * | 2000-06-09 | 2001-12-25 | Nof Corp | Phosphorylcholine derivative, intermediate, method for producing the same and use |
| WO2010150761A1 (en) * | 2009-06-24 | 2010-12-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Pyridine derivative having ((phosphonooxy)methyl)pyridinium ring and anti-fungal agent comprising same |
| US8188119B2 (en) | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| US8507530B2 (en) | 2007-04-27 | 2013-08-13 | Eisai R&D Management Co., Ltd. | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| US8841327B2 (en) | 2005-10-31 | 2014-09-23 | Eisai R&D Management Co., Ltd. | Heterocycles substituted pyridine derivatives and antifungal agent containing thereof |
-
1981
- 1981-11-03 JP JP17677181A patent/JPS57179192A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0592876A1 (en) * | 1992-10-10 | 1994-04-20 | Beiersdorf Aktiengesellschaft | Antimycotic dermatological and cosmetic compositions |
| JP2001262184A (en) * | 2000-03-15 | 2001-09-26 | Toyobo Co Ltd | Surfactant |
| JP2001354679A (en) * | 2000-06-09 | 2001-12-25 | Nof Corp | Phosphorylcholine derivative, intermediate, method for producing the same and use |
| US8841327B2 (en) | 2005-10-31 | 2014-09-23 | Eisai R&D Management Co., Ltd. | Heterocycles substituted pyridine derivatives and antifungal agent containing thereof |
| US8507530B2 (en) | 2007-04-27 | 2013-08-13 | Eisai R&D Management Co., Ltd. | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| US8188119B2 (en) | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| WO2010150761A1 (en) * | 2009-06-24 | 2010-12-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Pyridine derivative having ((phosphonooxy)methyl)pyridinium ring and anti-fungal agent comprising same |
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