JPS57176987A - Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative - Google Patents
Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivativeInfo
- Publication number
- JPS57176987A JPS57176987A JP56063170A JP6317081A JPS57176987A JP S57176987 A JPS57176987 A JP S57176987A JP 56063170 A JP56063170 A JP 56063170A JP 6317081 A JP6317081 A JP 6317081A JP S57176987 A JPS57176987 A JP S57176987A
- Authority
- JP
- Japan
- Prior art keywords
- compound shown
- pyrrolo
- quinoline
- carboxylic acid
- formulai
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56063170A JPS57176987A (en) | 1981-04-24 | 1981-04-24 | Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative |
NO813726A NO156828C (no) | 1980-11-10 | 1981-11-04 | Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser. |
AT0474881A AT395150B (de) | 1980-11-10 | 1981-11-05 | Verfahren zur herstellung von neuen benzoheterozyklischen verbindungen |
DK495281A DK160940C (da) | 1980-11-10 | 1981-11-09 | Analogifremgangsmaade til fremstilling af benzoheterocycliske forbindelser eller farmaceutisk acceptable salte deraf |
IT49656/81A IT1171646B (it) | 1980-11-10 | 1981-11-09 | Composti benzoeterociclici e procedimento per prepararli |
SU813354800A SU1366055A3 (ru) | 1980-11-10 | 1981-11-09 | Способ получения пиперазинилбензогетероциклических соединений |
PT73957A PT73957B (en) | 1980-11-10 | 1981-11-09 | Process for preparing piperazinylbenzoheterocyclic compounds |
SE8106642A SE448542B (sv) | 1980-11-10 | 1981-11-09 | Bensoheterocykliska foreningar, forfarande for deras framstellning och farmaceutisk komposition derav |
DE3153221A DE3153221C2 (ja) | 1981-04-24 | 1981-11-09 | |
FI813526A FI71141C (fi) | 1980-11-10 | 1981-11-09 | Foerfarande foer framstaellning av nya som antibakteriella aemnen anvaendbara 6,7-dihydro-1-oxo-benzo/ij/-kinolizin-2-karboxylsyror och 1,2-dihydro-6-oxo-pyrrolo/3,2,1-ij/-kinolin-5-karboxylsyror |
DE2000175035 DE10075035I2 (de) | 1980-11-10 | 1981-11-09 | Benzo¬ij¾chinolizinderivate Verfahren zu deren Herstellung und bakteriostatische Mittel welche diese enthalten |
DE19813144455 DE3144455A1 (de) | 1980-11-10 | 1981-11-09 | Benzoheterozyklische verbindungen, verfahren zu deren herstellung und bakteriostatische mittel, welche diese enthalten |
PH26477A PH16685A (en) | 1980-11-10 | 1981-11-10 | Benzoheterocyclic compounds and antibacterial composition containing same |
FR8121100A FR2493849A1 (fr) | 1980-11-10 | 1981-11-10 | Composes benzoheterocycliques utiles comme medicaments antimicrobiens et procedes de leur preparation |
ES507493A ES507493A0 (es) | 1980-11-10 | 1981-11-10 | Procedimiento de preparar compuestos benzoheterociclicos. |
CH7200/81A CH648845A5 (de) | 1980-11-10 | 1981-11-10 | Benzoheterozyklische verbindungen, verfahren zu deren herstellung und bakteriostatische mittel, welche diese enthalten. |
MX785781A MX155102A (es) | 1980-11-10 | 1981-11-10 | Procedimiento para preparar derivados del acido benzo(i j)-quinolizina-2-carboxilico y derivados del acido pirrolo-(3,2,1-i j)-quinolin-5-carboxilico |
GB8133890A GB2086905B (en) | 1980-11-10 | 1981-11-10 | Benzoheterocyclic compounds and process for preparing same |
AU77335/81A AU546358B2 (en) | 1980-11-10 | 1981-11-10 | Piperazinylbenzoheterocyclic compounds |
NL8105075A NL193457C (nl) | 1980-11-10 | 1981-11-10 | Benzoheterocyclische verbindingen en farmaceutisch preparaat dat een dergelijke verbinding bevat. |
CA000389769A CA1179341A (en) | 1980-11-10 | 1981-11-10 | Piperazinylbenzoheterocyclic compounds and process for preparing same |
US06/320,027 US4399134A (en) | 1980-11-10 | 1981-11-10 | Pyrroloquinoline and benzoquinolizine compounds and antimicrobial compositions |
KR1019810004344A KR880001625B1 (ko) | 1980-11-10 | 1981-11-10 | 벤조헤테로사이클 화합물의 제조방법 |
ES516523A ES8401035A1 (es) | 1980-11-10 | 1982-10-15 | "metodo de preparar compuestos benzoheterociclicos". |
SU823527501A SU1277896A3 (ru) | 1980-11-10 | 1982-12-27 | Способ получени производных тетрагидрохинолина или их фармацевтически приемлемых солей |
US06/497,914 US4552879A (en) | 1980-11-10 | 1983-05-25 | Benzoheterocyclic compounds and pharmaceutical composition thereof |
AT2887/89A AT393383B (de) | 1980-11-10 | 1989-12-20 | Verfahren zur herstellung von neuen benzoheterozyklischen verbindungen |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56063170A JPS57176987A (en) | 1981-04-24 | 1981-04-24 | Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57176987A true JPS57176987A (en) | 1982-10-30 |
JPH0222074B2 JPH0222074B2 (ja) | 1990-05-17 |
Family
ID=13221505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56063170A Granted JPS57176987A (en) | 1980-11-10 | 1981-04-24 | Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS57176987A (ja) |
DE (1) | DE3153221C2 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59137482A (ja) * | 1983-01-26 | 1984-08-07 | Otsuka Pharmaceut Co Ltd | ピロロ〔3,2,1,−ij〕キノリン−5−カルボン酸誘導体 |
US6514986B2 (en) | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
US7164023B2 (en) | 2003-09-04 | 2007-01-16 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
US7247642B2 (en) | 1999-05-07 | 2007-07-24 | Wockhardt Limited | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55149284A (en) * | 1980-05-02 | 1980-11-20 | Otsuka Pharmaceut Co Ltd | Piperazinylbenzo heterocyclic derivative |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2953974C2 (ja) * | 1978-04-12 | 1992-06-25 | Otsuka Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp | |
JPS6019910B2 (ja) * | 1979-10-11 | 1985-05-18 | 大塚製薬株式会社 | ベンゾ〔ij〕キノリジン−2−カルボン酸誘導体及びその製造法 |
JPS5630964A (en) * | 1979-08-22 | 1981-03-28 | Kyorin Pharmaceut Co Ltd | Novel substituted quinolinecarboxylic acid and its preparation |
-
1981
- 1981-04-24 JP JP56063170A patent/JPS57176987A/ja active Granted
- 1981-11-09 DE DE3153221A patent/DE3153221C2/de not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55149284A (en) * | 1980-05-02 | 1980-11-20 | Otsuka Pharmaceut Co Ltd | Piperazinylbenzo heterocyclic derivative |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0321031B2 (ja) * | 1983-01-26 | 1991-03-20 | Otsuka Pharma Co Ltd | |
JPS59137482A (ja) * | 1983-01-26 | 1984-08-07 | Otsuka Pharmaceut Co Ltd | ピロロ〔3,2,1,−ij〕キノリン−5−カルボン酸誘導体 |
US7247642B2 (en) | 1999-05-07 | 2007-07-24 | Wockhardt Limited | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment |
US6753333B2 (en) | 1999-12-14 | 2004-06-22 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
US6514986B2 (en) | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7393957B2 (en) | 2001-04-25 | 2008-07-01 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7626032B2 (en) | 2001-04-25 | 2009-12-01 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7132541B2 (en) | 2002-05-28 | 2006-11-07 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US7164023B2 (en) | 2003-09-04 | 2007-01-16 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
Also Published As
Publication number | Publication date |
---|---|
JPH0222074B2 (ja) | 1990-05-17 |
DE3153221C2 (ja) | 1991-07-04 |
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