JPS57169476A - Novel preparation of benzothiazepine derivative - Google Patents
Novel preparation of benzothiazepine derivativeInfo
- Publication number
- JPS57169476A JPS57169476A JP5600081A JP5600081A JPS57169476A JP S57169476 A JPS57169476 A JP S57169476A JP 5600081 A JP5600081 A JP 5600081A JP 5600081 A JP5600081 A JP 5600081A JP S57169476 A JPS57169476 A JP S57169476A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- useful
- novel
- stenocardiac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
PURPOSE: To obtain the titled compound useful for improving the stenocardiac pain advantageously in four steps, by passing through two novel substances from 2-(4-benzyloxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one.
CONSTITUTION: A compound of formula II is reacted with a dimethylaminoethyl halide, preferably chloride or hydrochloride, in the presence of an alkali metallic compound in a suitable solvent at room temperature W under heating to give a novel compound of formula III, which is then acetylated by the well-known method to afford a novel compound of formula IV. The resultant compound of formula IV is debenzylated in a solution of hydrogen bromide in acetic acid of an adequate concentration to give a compound of formula V, which is alkylated to afford a compound of formulaI(R is alkyl) useful for improving the stenocardiac parin in the angina of effort, etc. from an easily available raw material in high yield. The compound of formula IV or V is also useful for a coronary vasodilator.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5600081A JPS57169476A (en) | 1981-04-13 | 1981-04-13 | Novel preparation of benzothiazepine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5600081A JPS57169476A (en) | 1981-04-13 | 1981-04-13 | Novel preparation of benzothiazepine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57169476A true JPS57169476A (en) | 1982-10-19 |
Family
ID=13014799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5600081A Pending JPS57169476A (en) | 1981-04-13 | 1981-04-13 | Novel preparation of benzothiazepine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57169476A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62161776A (en) * | 1986-01-07 | 1987-07-17 | Tanabe Seiyaku Co Ltd | Production of 1,5-benzothiazepine derivative |
-
1981
- 1981-04-13 JP JP5600081A patent/JPS57169476A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62161776A (en) * | 1986-01-07 | 1987-07-17 | Tanabe Seiyaku Co Ltd | Production of 1,5-benzothiazepine derivative |
JPH0573749B2 (en) * | 1986-01-07 | 1993-10-15 | Tanabe Seiyaku Co |
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