JPS57159493A - Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester - Google Patents
Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl esterInfo
- Publication number
- JPS57159493A JPS57159493A JP4540781A JP4540781A JPS57159493A JP S57159493 A JPS57159493 A JP S57159493A JP 4540781 A JP4540781 A JP 4540781A JP 4540781 A JP4540781 A JP 4540781A JP S57159493 A JPS57159493 A JP S57159493A
- Authority
- JP
- Japan
- Prior art keywords
- aminoglutaric
- ester
- enzyme
- hydrolyzing
- optically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare the titled substance in high yield by easy operations, by treating an enzyme capable of hydrolyzing a β-aminoglutaric dialkyl ester with an immobilized enzyme capable of hydrolyzing a carboxylic ester.
CONSTITUTION: An enzyme, capable of hydrolyzing a carboxylic ester, and extracted from a liver of a pig or cattle is supported on a high polymer, or the extract therefrom is crosslinked, gelatinized and immobilized to prepare an enzyme capable of hydrolyzing the carboxylic ester. The resultant enzyme is then packed in a clumn, and an aqueous solution of a β-aminoglutaric dialkyl ester raw material expressed by formulaI(R1 is lower alkyl; R2 is H, protecting group of the amino group, etc.) is passed through the column or the enzyme is reacted with the raw material to give optically active β-(R or S)-aminoglutaric monoalkyl ester expressed by formula II. The resultant ester is isolated and purified by the filtration, extraction, chromatography, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4540781A JPS57159493A (en) | 1981-03-30 | 1981-03-30 | Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4540781A JPS57159493A (en) | 1981-03-30 | 1981-03-30 | Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57159493A true JPS57159493A (en) | 1982-10-01 |
Family
ID=12718393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4540781A Pending JPS57159493A (en) | 1981-03-30 | 1981-03-30 | Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57159493A (en) |
-
1981
- 1981-03-30 JP JP4540781A patent/JPS57159493A/en active Pending
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