JPS57159493A - Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester - Google Patents

Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester

Info

Publication number
JPS57159493A
JPS57159493A JP4540781A JP4540781A JPS57159493A JP S57159493 A JPS57159493 A JP S57159493A JP 4540781 A JP4540781 A JP 4540781A JP 4540781 A JP4540781 A JP 4540781A JP S57159493 A JPS57159493 A JP S57159493A
Authority
JP
Japan
Prior art keywords
aminoglutaric
ester
enzyme
hydrolyzing
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4540781A
Other languages
Japanese (ja)
Inventor
Hamao Umezawa
Masaji Ono
Hiroshi Mori
Kyoichi Sakakibara
Koichi Dobashi
Shigeo Yoshizaki
Toshito Mori
Hideo Tani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP4540781A priority Critical patent/JPS57159493A/en
Publication of JPS57159493A publication Critical patent/JPS57159493A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare the titled substance in high yield by easy operations, by treating an enzyme capable of hydrolyzing a β-aminoglutaric dialkyl ester with an immobilized enzyme capable of hydrolyzing a carboxylic ester.
CONSTITUTION: An enzyme, capable of hydrolyzing a carboxylic ester, and extracted from a liver of a pig or cattle is supported on a high polymer, or the extract therefrom is crosslinked, gelatinized and immobilized to prepare an enzyme capable of hydrolyzing the carboxylic ester. The resultant enzyme is then packed in a clumn, and an aqueous solution of a β-aminoglutaric dialkyl ester raw material expressed by formulaI(R1 is lower alkyl; R2 is H, protecting group of the amino group, etc.) is passed through the column or the enzyme is reacted with the raw material to give optically active β-(R or S)-aminoglutaric monoalkyl ester expressed by formula II. The resultant ester is isolated and purified by the filtration, extraction, chromatography, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP4540781A 1981-03-30 1981-03-30 Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester Pending JPS57159493A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4540781A JPS57159493A (en) 1981-03-30 1981-03-30 Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4540781A JPS57159493A (en) 1981-03-30 1981-03-30 Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester

Publications (1)

Publication Number Publication Date
JPS57159493A true JPS57159493A (en) 1982-10-01

Family

ID=12718393

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4540781A Pending JPS57159493A (en) 1981-03-30 1981-03-30 Preparation of optically active beta-(r or s)-aminoglutaric monoalkyl ester

Country Status (1)

Country Link
JP (1) JPS57159493A (en)

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