JPS57156421A - Malaria vaccine and its preparation - Google Patents
Malaria vaccine and its preparationInfo
- Publication number
- JPS57156421A JPS57156421A JP56042778A JP4277881A JPS57156421A JP S57156421 A JPS57156421 A JP S57156421A JP 56042778 A JP56042778 A JP 56042778A JP 4277881 A JP4277881 A JP 4277881A JP S57156421 A JPS57156421 A JP S57156421A
- Authority
- JP
- Japan
- Prior art keywords
- malaria
- erythrocyte
- attenuated
- protozoan
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PURPOSE: To obtain a malaria vaccine, by attenuating a malaria protozoan, inoculating it to a vertebrate animal of thymus imcompetence, collecting the erythrocyte containing the attenuated malaria protozoan.
CONSTITUTION: A mouse, aotus, etc. is infected by a malaria protozoan (e.g., plasmodium berghei, plasmodium falciparum, etc.), the erythrocyte is irradiated with X-rays and the malaria protozoan is attenuated. It is then inculated into a vertebrate animal (e.g., mouse, aotus, etc.) of thymus incompetence. Preferably 15W40 days after the inoculation, its erythrocyte is separated and collected. The prepared erythrocyte containing the attenuated malaria notozoan is directly preserved at preferably -100W-50°C, and used as a vaccine. A dose is 104W 107 (erythrocyte)/kg weight one W twice in intravenous, intraperitoneal, intramuscular, and hypodermic medication.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56042778A JPS57156421A (en) | 1981-03-24 | 1981-03-24 | Malaria vaccine and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56042778A JPS57156421A (en) | 1981-03-24 | 1981-03-24 | Malaria vaccine and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57156421A true JPS57156421A (en) | 1982-09-27 |
JPH0224806B2 JPH0224806B2 (en) | 1990-05-30 |
Family
ID=12645418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56042778A Granted JPS57156421A (en) | 1981-03-24 | 1981-03-24 | Malaria vaccine and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57156421A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002917A1 (en) * | 1983-01-28 | 1984-08-02 | Inst Medical W & E Hall | EXPRESSION OF PLASMODIUM FALCIPARUM POLYPEPTIDES FROM CLONED cDNA |
US8802919B2 (en) * | 2002-04-05 | 2014-08-12 | Sanaria Inc. | Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production |
US8821896B2 (en) | 2009-01-16 | 2014-09-02 | Sanaria Inc. | Purified Plasmodium and vaccine composition |
US9278125B2 (en) | 2011-05-11 | 2016-03-08 | Sanaria Inc. | Pharmaceutical compositions comprising attenuated Plasmodium sporozoites and glycolipid adjuvants |
US9764016B2 (en) | 2013-01-25 | 2017-09-19 | Sanaria Inc. | Genetic attenuation of Plasmodium by B9 gene disruption |
-
1981
- 1981-03-24 JP JP56042778A patent/JPS57156421A/en active Granted
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002917A1 (en) * | 1983-01-28 | 1984-08-02 | Inst Medical W & E Hall | EXPRESSION OF PLASMODIUM FALCIPARUM POLYPEPTIDES FROM CLONED cDNA |
US8802919B2 (en) * | 2002-04-05 | 2014-08-12 | Sanaria Inc. | Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production |
US8821896B2 (en) | 2009-01-16 | 2014-09-02 | Sanaria Inc. | Purified Plasmodium and vaccine composition |
US8992944B2 (en) | 2009-01-16 | 2015-03-31 | Sanaria Inc. | Purified Plasmodium and vaccine composition |
US9241982B2 (en) | 2009-01-16 | 2016-01-26 | Sanaria Inc. | Purified plasmodium and vaccine compositions |
US9616115B2 (en) | 2009-01-16 | 2017-04-11 | Sanaria Inc. | Purified plasmodium and vaccine compositions |
US10272146B2 (en) | 2009-01-16 | 2019-04-30 | Sanaria Inc. | Purified plasmodium and vaccine compositions |
US9278125B2 (en) | 2011-05-11 | 2016-03-08 | Sanaria Inc. | Pharmaceutical compositions comprising attenuated Plasmodium sporozoites and glycolipid adjuvants |
US9642909B2 (en) | 2011-05-11 | 2017-05-09 | Sanaria Inc. | Pharmaceutical compositions comprising attenuated Plasmodium sporozoites and glycolipid adjuvants |
US9764016B2 (en) | 2013-01-25 | 2017-09-19 | Sanaria Inc. | Genetic attenuation of Plasmodium by B9 gene disruption |
US9931389B2 (en) | 2013-01-25 | 2018-04-03 | Sanaria Inc. | Genetic attenuation of plasmodium by B9 gene disruption |
Also Published As
Publication number | Publication date |
---|---|
JPH0224806B2 (en) | 1990-05-30 |
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