JPS5714586A - Substituted benzaldehyde - Google Patents
Substituted benzaldehydeInfo
- Publication number
- JPS5714586A JPS5714586A JP8854980A JP8854980A JPS5714586A JP S5714586 A JPS5714586 A JP S5714586A JP 8854980 A JP8854980 A JP 8854980A JP 8854980 A JP8854980 A JP 8854980A JP S5714586 A JPS5714586 A JP S5714586A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- reacting
- bromo
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Epoxy Compounds (AREA)
Abstract
NEW MATERIAL:A 3-bromo-4-(2,3-epoxypropoxy) benzaldehyde of fomula I.
USE: A synthetic intermediate for medicines, capable of synthesizing a propanolamine having β-blocking action by reacting the compound of formula I with an amine and also a substituted benzylidenehydrazinophthalazine having the β-blocking action and vasodilator action at the same time by reacting the amine with a hydrazone obtained by reacting the compound of formula I with hydrazine.
PROCESS: A 3-bromo-4-hydroxybenzaldehyde of formula II is reacted with an epihalohydrin of formula III (X is halogen) to give the compound of formula I. The reaction is completed in the presence of an aqueous solvent, e.g. H2O or methanol, at room temperature for 1W24hr. Preferably, the compound of formula III is used in a molar amount of 2W10 times that of the compound of formula II, and the amount of an acid binder, e.g. NaOH or KOH, is used in an equivalent amount of about 1W1.5 times that of the compound of formula II.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8854980A JPS5714586A (en) | 1980-07-01 | 1980-07-01 | Substituted benzaldehyde |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8854980A JPS5714586A (en) | 1980-07-01 | 1980-07-01 | Substituted benzaldehyde |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5714586A true JPS5714586A (en) | 1982-01-25 |
Family
ID=13945932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8854980A Pending JPS5714586A (en) | 1980-07-01 | 1980-07-01 | Substituted benzaldehyde |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5714586A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4661644A (en) * | 1985-09-09 | 1987-04-28 | The Dow Chemical Company | Brominated epoxyaromatic compounds |
US5130482A (en) * | 1989-12-27 | 1992-07-14 | Daiso Company, Ltd. | Process for producing optically active atenolol and intermediate thereof |
US5223646A (en) * | 1989-12-27 | 1993-06-29 | Daiso Company, Ltd. | Process for producing optically active atenolol and intermediate thereof |
-
1980
- 1980-07-01 JP JP8854980A patent/JPS5714586A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4661644A (en) * | 1985-09-09 | 1987-04-28 | The Dow Chemical Company | Brominated epoxyaromatic compounds |
US5130482A (en) * | 1989-12-27 | 1992-07-14 | Daiso Company, Ltd. | Process for producing optically active atenolol and intermediate thereof |
US5223646A (en) * | 1989-12-27 | 1993-06-29 | Daiso Company, Ltd. | Process for producing optically active atenolol and intermediate thereof |
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