JPS57131725A - Remedy for immune complex disease - Google Patents

Remedy for immune complex disease

Info

Publication number
JPS57131725A
JPS57131725A JP56018429A JP1842981A JPS57131725A JP S57131725 A JPS57131725 A JP S57131725A JP 56018429 A JP56018429 A JP 56018429A JP 1842981 A JP1842981 A JP 1842981A JP S57131725 A JPS57131725 A JP S57131725A
Authority
JP
Japan
Prior art keywords
acid
remedy
human urine
acid protease
buffer solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56018429A
Other languages
Japanese (ja)
Other versions
JPS6237611B2 (en
Inventor
Haruo Onishi
Koji Kojiyaku
Yasuo Suzuki
Suguru Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Priority to JP56018429A priority Critical patent/JPS57131725A/en
Priority to CA000395742A priority patent/CA1181005A/en
Priority to SE8200748A priority patent/SE455163B/en
Priority to AU80290/82A priority patent/AU531314B2/en
Priority to CH782/82A priority patent/CH653557A5/en
Priority to GB8203682A priority patent/GB2095993B/en
Priority to EP82100973A priority patent/EP0059346B1/en
Priority to FR8202145A priority patent/FR2499409A1/en
Priority to DE19823204631 priority patent/DE3204631A1/en
Priority to IT47761/82A priority patent/IT1154280B/en
Priority to DE8282100973T priority patent/DE3273953D1/en
Priority to NL8200509A priority patent/NL8200509A/en
Priority to US06/365,465 priority patent/US4540569A/en
Publication of JPS57131725A publication Critical patent/JPS57131725A/en
Publication of JPS6237611B2 publication Critical patent/JPS6237611B2/ja
Granted legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To provide the titled remedy having high safety and remedying effect, by using acid protease existing in human urine, as active component.
CONSTITUTION: Acid protease existing in human urine is used as an active component of a remedy for immune complex diseases represented by rheumatoid arthristis, systemic lupus erythematosus and lupus nephritis. The acid protesease can be obtained by (1) passing human urine through a column packed with DEAE-cellulose equilibrated with 0.1M acetate buffer solution (pH 5.3), (2) eluting the adsorbed acid protease with said buffer solution containing 0.3M NaCl, (3) concentrating the eluate, (4) purifying by gel chromatography using sepahdex G-100 swollen with 0.9% physiological saline water, and (5) treating the product with an acid. Administered at a dose of 1W1,000mg dialy for each person in the form of injection such as freeze-dried preparation, peroral agent such as capsule, absorbing agent, or rectal suppository.
COPYRIGHT: (C)1982,JPO&Japio
JP56018429A 1981-02-10 1981-02-10 Remedy for immune complex disease Granted JPS57131725A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP56018429A JPS57131725A (en) 1981-02-10 1981-02-10 Remedy for immune complex disease
CA000395742A CA1181005A (en) 1981-02-10 1982-02-08 Therapeutic agent for treatment of allergic diseases, immune complex diseases and tumors
SE8200748A SE455163B (en) 1981-02-10 1982-02-09 UROPEPSIN FOR USE AS A THERAPEUTIC AGAINST ALLERGIC DISEASES, IMMUNE COMPLEX DISEASES AND TUMORS
AU80290/82A AU531314B2 (en) 1981-02-10 1982-02-09 Therapeutic agent containing human urinary acid protease
CH782/82A CH653557A5 (en) 1981-02-10 1982-02-09 THERAPEUTIC AGENT SUITABLE FOR TREATING ALLERGIC CONDITIONS, IMMUNE COMPLEX DISEASES AND TUMORS.
GB8203682A GB2095993B (en) 1981-02-10 1982-02-09 Compositions containing human urinary acid protease
EP82100973A EP0059346B1 (en) 1981-02-10 1982-02-10 Therapeutic agent containing a human urinary pepsin
FR8202145A FR2499409A1 (en) 1981-02-10 1982-02-10 THERAPEUTIC AGENT BASED ON ACIDIC PROTEASE FOR THE TREATMENT OF ALLERGIC DISORDERS, IMMUNOCOMPLEX DISEASES AND TUMORS
DE19823204631 DE3204631A1 (en) 1981-02-10 1982-02-10 THERAPEUTIC AGENT AND ITS USE
IT47761/82A IT1154280B (en) 1981-02-10 1982-02-10 PROTEA-BASED THERAPEUTIC AGENT ACIDS AND ITS USE IN PATIENTS WITH ALLERGIC DISORDERS, IMMUNE-COMPLEX DISEASES AND CANCERS
DE8282100973T DE3273953D1 (en) 1981-02-10 1982-02-10 Therapeutic agent containing a human urinary pepsin
NL8200509A NL8200509A (en) 1981-02-10 1982-02-10 MEDICINAL PRODUCT FOR ALLERGY DISEASES, IMMUNE COMPLEX DISEASES AND TUMORS; METHOD FOR TREATING PATIENTS SUFFERING FROM THIS
US06/365,465 US4540569A (en) 1981-02-10 1982-04-05 Method for treatment of allergic disorders and immune complex diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56018429A JPS57131725A (en) 1981-02-10 1981-02-10 Remedy for immune complex disease

Publications (2)

Publication Number Publication Date
JPS57131725A true JPS57131725A (en) 1982-08-14
JPS6237611B2 JPS6237611B2 (en) 1987-08-13

Family

ID=11971396

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56018429A Granted JPS57131725A (en) 1981-02-10 1981-02-10 Remedy for immune complex disease

Country Status (1)

Country Link
JP (1) JPS57131725A (en)

Also Published As

Publication number Publication date
JPS6237611B2 (en) 1987-08-13

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