JPS57131725A - Remedy for immune complex disease - Google Patents
Remedy for immune complex diseaseInfo
- Publication number
- JPS57131725A JPS57131725A JP56018429A JP1842981A JPS57131725A JP S57131725 A JPS57131725 A JP S57131725A JP 56018429 A JP56018429 A JP 56018429A JP 1842981 A JP1842981 A JP 1842981A JP S57131725 A JPS57131725 A JP S57131725A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- remedy
- human urine
- acid protease
- buffer solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE: To provide the titled remedy having high safety and remedying effect, by using acid protease existing in human urine, as active component.
CONSTITUTION: Acid protease existing in human urine is used as an active component of a remedy for immune complex diseases represented by rheumatoid arthristis, systemic lupus erythematosus and lupus nephritis. The acid protesease can be obtained by (1) passing human urine through a column packed with DEAE-cellulose equilibrated with 0.1M acetate buffer solution (pH 5.3), (2) eluting the adsorbed acid protease with said buffer solution containing 0.3M NaCl, (3) concentrating the eluate, (4) purifying by gel chromatography using sepahdex G-100 swollen with 0.9% physiological saline water, and (5) treating the product with an acid. Administered at a dose of 1W1,000mg dialy for each person in the form of injection such as freeze-dried preparation, peroral agent such as capsule, absorbing agent, or rectal suppository.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56018429A JPS57131725A (en) | 1981-02-10 | 1981-02-10 | Remedy for immune complex disease |
CA000395742A CA1181005A (en) | 1981-02-10 | 1982-02-08 | Therapeutic agent for treatment of allergic diseases, immune complex diseases and tumors |
SE8200748A SE455163B (en) | 1981-02-10 | 1982-02-09 | UROPEPSIN FOR USE AS A THERAPEUTIC AGAINST ALLERGIC DISEASES, IMMUNE COMPLEX DISEASES AND TUMORS |
AU80290/82A AU531314B2 (en) | 1981-02-10 | 1982-02-09 | Therapeutic agent containing human urinary acid protease |
CH782/82A CH653557A5 (en) | 1981-02-10 | 1982-02-09 | THERAPEUTIC AGENT SUITABLE FOR TREATING ALLERGIC CONDITIONS, IMMUNE COMPLEX DISEASES AND TUMORS. |
GB8203682A GB2095993B (en) | 1981-02-10 | 1982-02-09 | Compositions containing human urinary acid protease |
EP82100973A EP0059346B1 (en) | 1981-02-10 | 1982-02-10 | Therapeutic agent containing a human urinary pepsin |
FR8202145A FR2499409A1 (en) | 1981-02-10 | 1982-02-10 | THERAPEUTIC AGENT BASED ON ACIDIC PROTEASE FOR THE TREATMENT OF ALLERGIC DISORDERS, IMMUNOCOMPLEX DISEASES AND TUMORS |
DE19823204631 DE3204631A1 (en) | 1981-02-10 | 1982-02-10 | THERAPEUTIC AGENT AND ITS USE |
IT47761/82A IT1154280B (en) | 1981-02-10 | 1982-02-10 | PROTEA-BASED THERAPEUTIC AGENT ACIDS AND ITS USE IN PATIENTS WITH ALLERGIC DISORDERS, IMMUNE-COMPLEX DISEASES AND CANCERS |
DE8282100973T DE3273953D1 (en) | 1981-02-10 | 1982-02-10 | Therapeutic agent containing a human urinary pepsin |
NL8200509A NL8200509A (en) | 1981-02-10 | 1982-02-10 | MEDICINAL PRODUCT FOR ALLERGY DISEASES, IMMUNE COMPLEX DISEASES AND TUMORS; METHOD FOR TREATING PATIENTS SUFFERING FROM THIS |
US06/365,465 US4540569A (en) | 1981-02-10 | 1982-04-05 | Method for treatment of allergic disorders and immune complex diseases |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56018429A JPS57131725A (en) | 1981-02-10 | 1981-02-10 | Remedy for immune complex disease |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57131725A true JPS57131725A (en) | 1982-08-14 |
JPS6237611B2 JPS6237611B2 (en) | 1987-08-13 |
Family
ID=11971396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56018429A Granted JPS57131725A (en) | 1981-02-10 | 1981-02-10 | Remedy for immune complex disease |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57131725A (en) |
-
1981
- 1981-02-10 JP JP56018429A patent/JPS57131725A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6237611B2 (en) | 1987-08-13 |
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