JPS57130925A - Novel synthesis of carboxylate - Google Patents
Novel synthesis of carboxylateInfo
- Publication number
- JPS57130925A JPS57130925A JP56017725A JP1772581A JPS57130925A JP S57130925 A JPS57130925 A JP S57130925A JP 56017725 A JP56017725 A JP 56017725A JP 1772581 A JP1772581 A JP 1772581A JP S57130925 A JPS57130925 A JP S57130925A
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- trialkylsilyldiazomethane
- methanol
- room temperature
- high yield
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000007942 carboxylates Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 150000001735 carboxylic acids Chemical class 0.000 abstract 4
- ONDSBJMLAHVLMI-UHFFFAOYSA-N trimethylsilyldiazomethane Chemical compound C[Si](C)(C)[CH-][N+]#N ONDSBJMLAHVLMI-UHFFFAOYSA-N 0.000 abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 238000004817 gas chromatography Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
PURPOSE: To obtain a methyl carboxylate under mild conditions of neutrality at ≤ room temperature simply in short time in high yield, by reacting a carboxylic acid with a trialkylsilyldiazomethane in the presence of methanol.
CONSTITUTION: 1mol Carboxylic acid is reacted with 1W3mol trialkylsilyldiazomethane shown by the formula R3'SiCHN2 (R' is 1W4C straight-chain or branched-chain similar or different alkyl), especially trimethylsilyldiazomethane, in the presence of methanol at ≤ room temperature, to give a corresponding methyl ester in high yield. By this method, not only a common carboxylic acid but also a fatty acid or bile acid can be easily subjected to methyl esterification, so that it is useful as pretreatment of a carboxylic acid before gas chromatography determination. The raw material compound is stable, safe, handled easily, and capable of being stored for a long time.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56017725A JPS5932445B2 (en) | 1981-02-09 | 1981-02-09 | New synthesis method for carboxylic acid esters |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56017725A JPS5932445B2 (en) | 1981-02-09 | 1981-02-09 | New synthesis method for carboxylic acid esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57130925A true JPS57130925A (en) | 1982-08-13 |
| JPS5932445B2 JPS5932445B2 (en) | 1984-08-09 |
Family
ID=11951715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56017725A Expired JPS5932445B2 (en) | 1981-02-09 | 1981-02-09 | New synthesis method for carboxylic acid esters |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5932445B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111875494A (en) * | 2020-07-20 | 2020-11-03 | 无锡极电光能科技有限公司 | Benzoyl butyrate derivative and preparation method thereof |
-
1981
- 1981-02-09 JP JP56017725A patent/JPS5932445B2/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111875494A (en) * | 2020-07-20 | 2020-11-03 | 无锡极电光能科技有限公司 | Benzoyl butyrate derivative and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5932445B2 (en) | 1984-08-09 |
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