JPS57127406A - Production of crystalline freeze dried powder - Google Patents
Production of crystalline freeze dried powderInfo
- Publication number
- JPS57127406A JPS57127406A JP1076481A JP1076481A JPS57127406A JP S57127406 A JPS57127406 A JP S57127406A JP 1076481 A JP1076481 A JP 1076481A JP 1076481 A JP1076481 A JP 1076481A JP S57127406 A JPS57127406 A JP S57127406A
- Authority
- JP
- Japan
- Prior art keywords
- org
- dissolve
- crystalline
- solvent
- hard
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To produce crystalline dry powder contg. no foreign matter by adding an org. solvent which is easy to dissolve in water and is hard to dissolve in org. compounds and an org. solvent which is hard to dissolve in water to an aq. crystalline org. compound soln. for medical use, and dispersing, cooling and freeze-drying these.
CONSTITUTION: First, an org. solvent which is easy to dissolve in water and is hard to dissolve in crystalline org. compound, for example, methanol or the like, and an org. solvent which is hard to dissolve in water, for example, dichloromethane or the like are added into an aq. soln. of a crystalline org. compound, for example, sodium cephapyrine under sterile operation. Thence, an org. solvent which is hard to dissolve in water is dispersed thoroughly in an aq. soln. of the crystalline org. compound. This treating soln. is filled in a vial and is quickly cooled to about ≤-30°C in a freeze dryer, after which it is heated slowly up to about -20W-5°C, whereby the crystallization is completed. Further, if it is cooled to about -40°C or around the same and vacuum drying is progressed carefully under elevation of tray temp., the product of the crystalline powder contained in the vial is obtained.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1076481A JPS57127406A (en) | 1981-01-29 | 1981-01-29 | Production of crystalline freeze dried powder |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1076481A JPS57127406A (en) | 1981-01-29 | 1981-01-29 | Production of crystalline freeze dried powder |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57127406A true JPS57127406A (en) | 1982-08-07 |
JPS6344001B2 JPS6344001B2 (en) | 1988-09-02 |
Family
ID=11759391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1076481A Granted JPS57127406A (en) | 1981-01-29 | 1981-01-29 | Production of crystalline freeze dried powder |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57127406A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007037330A1 (en) * | 2005-09-28 | 2007-04-05 | Daiichi Sankyo Company, Limited | Method for production of quinolone-containing lyophilized preparation |
-
1981
- 1981-01-29 JP JP1076481A patent/JPS57127406A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007037330A1 (en) * | 2005-09-28 | 2007-04-05 | Daiichi Sankyo Company, Limited | Method for production of quinolone-containing lyophilized preparation |
US8129533B2 (en) | 2005-09-28 | 2012-03-06 | Dalichi Sankyo Company, Limited | Method for production of quinolone-containing lyophilized preparation |
Also Published As
Publication number | Publication date |
---|---|
JPS6344001B2 (en) | 1988-09-02 |
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