JPS57127406A - Production of crystalline freeze dried powder - Google Patents

Production of crystalline freeze dried powder

Info

Publication number
JPS57127406A
JPS57127406A JP1076481A JP1076481A JPS57127406A JP S57127406 A JPS57127406 A JP S57127406A JP 1076481 A JP1076481 A JP 1076481A JP 1076481 A JP1076481 A JP 1076481A JP S57127406 A JPS57127406 A JP S57127406A
Authority
JP
Japan
Prior art keywords
org
dissolve
crystalline
solvent
hard
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1076481A
Other languages
Japanese (ja)
Other versions
JPS6344001B2 (en
Inventor
Yoshikatsu Naganami
Shigeru Tachibana
Shinichi Ejima
Michio Harada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP1076481A priority Critical patent/JPS57127406A/en
Publication of JPS57127406A publication Critical patent/JPS57127406A/en
Publication of JPS6344001B2 publication Critical patent/JPS6344001B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To produce crystalline dry powder contg. no foreign matter by adding an org. solvent which is easy to dissolve in water and is hard to dissolve in org. compounds and an org. solvent which is hard to dissolve in water to an aq. crystalline org. compound soln. for medical use, and dispersing, cooling and freeze-drying these.
CONSTITUTION: First, an org. solvent which is easy to dissolve in water and is hard to dissolve in crystalline org. compound, for example, methanol or the like, and an org. solvent which is hard to dissolve in water, for example, dichloromethane or the like are added into an aq. soln. of a crystalline org. compound, for example, sodium cephapyrine under sterile operation. Thence, an org. solvent which is hard to dissolve in water is dispersed thoroughly in an aq. soln. of the crystalline org. compound. This treating soln. is filled in a vial and is quickly cooled to about ≤-30°C in a freeze dryer, after which it is heated slowly up to about -20W-5°C, whereby the crystallization is completed. Further, if it is cooled to about -40°C or around the same and vacuum drying is progressed carefully under elevation of tray temp., the product of the crystalline powder contained in the vial is obtained.
COPYRIGHT: (C)1982,JPO&Japio
JP1076481A 1981-01-29 1981-01-29 Production of crystalline freeze dried powder Granted JPS57127406A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1076481A JPS57127406A (en) 1981-01-29 1981-01-29 Production of crystalline freeze dried powder

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1076481A JPS57127406A (en) 1981-01-29 1981-01-29 Production of crystalline freeze dried powder

Publications (2)

Publication Number Publication Date
JPS57127406A true JPS57127406A (en) 1982-08-07
JPS6344001B2 JPS6344001B2 (en) 1988-09-02

Family

ID=11759391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1076481A Granted JPS57127406A (en) 1981-01-29 1981-01-29 Production of crystalline freeze dried powder

Country Status (1)

Country Link
JP (1) JPS57127406A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007037330A1 (en) * 2005-09-28 2007-04-05 Daiichi Sankyo Company, Limited Method for production of quinolone-containing lyophilized preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007037330A1 (en) * 2005-09-28 2007-04-05 Daiichi Sankyo Company, Limited Method for production of quinolone-containing lyophilized preparation
US8129533B2 (en) 2005-09-28 2012-03-06 Dalichi Sankyo Company, Limited Method for production of quinolone-containing lyophilized preparation

Also Published As

Publication number Publication date
JPS6344001B2 (en) 1988-09-02

Similar Documents

Publication Publication Date Title
GB2004182A (en) Process for preparing pharmaceutical cosmetic or diagnostic formulations
SU593656A3 (en) Method of manufacturing porous ceramic material
EP0384480A2 (en) Process for continously drying paste material for a high-density detergent
JPS57127406A (en) Production of crystalline freeze dried powder
DE69203220D1 (en) Continuous freeze dryer.
US4002434A (en) Process for the production of abrasion resistant perborate monohydrate
JPS57125676A (en) Preparation of powdered calcium compound used as a food additive
SE8203212L (en) PROCEDURE FOR THE PREPARATION OF A CORNY SUBSTRATE, IN PARTICULAR FOR HYDROCULTURES AND AS A BASIC BODY FOR HYDROCULTURES SUITABLE SUBSTRATE
JPS5658465A (en) Preparation of rice cake
JPS56131526A (en) Base material for rectal administration preparation
JPS5515722A (en) Production of whipped cream
SU362631A1 (en) METHOD FOR OBTAINING GRANULAR FERTILIZERS
DE1801470B1 (en) Process for dewatering sodium perborate tetrahydrate
JPS55127389A (en) 3-(1-imidazolyl)isoindolin-1-one
SU454236A1 (en) Method for surface modification of polycarbane products
JPS5684628A (en) Gypsum desiccating agent
JPS57122985A (en) Treatment of waste coating material
SU827482A1 (en) Method of preparing thymoquinonedioxime
US3890380A (en) Process for increasing the bulk density of salts of 2-(3-phenoxyphenyl)propionic acid
JPS52109501A (en) Method for controling temperature of equipment for preparing preheated coal
JPS57192399A (en) Composition containing s-adenosyl-l-methionine and its preparation
JPS5395109A (en) Controlling method for temperature of rotary kiln
JPS55118380A (en) Preparation of green water oat tea containing mineral
JPS5686165A (en) Pyrazolidin-3-one derivative and its preparation
JPS5667599A (en) Treatment for sludge such as waste sand containing organic components