JPS57108020A - Stable kallidinogenase composition and its preparation - Google Patents
Stable kallidinogenase composition and its preparationInfo
- Publication number
- JPS57108020A JPS57108020A JP55183816A JP18381680A JPS57108020A JP S57108020 A JPS57108020 A JP S57108020A JP 55183816 A JP55183816 A JP 55183816A JP 18381680 A JP18381680 A JP 18381680A JP S57108020 A JPS57108020 A JP S57108020A
- Authority
- JP
- Japan
- Prior art keywords
- kallidinogenase
- albumin
- composition
- drying
- spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
PURPOSE: To obtain a kallidinogenase composition having high stability and useful as a remedy for cerebral vascular lesion, coronary cardiopathy, etc., by adding less than the active amount of albumin to kallidinogenase.
CONSTITUTION: A kallidinogenase solution is mixed with less than the active amount of albumin (about 38g of albumin per 1,500,000 units of kallidinogenase) and a saccharide diluent (e.g. mannitol, lactose, sucrose, etc.), and the mixture is spray-dried at an inlet temperature of 110W120°C, an outlet temperature of 50W 60°C, and the speed of spindle rotation of 20,000W40,000rpm to obtain the objective stable kallidinogenase composition. Kallidinogenase is extremely unstable enzyme distributed widely in the living body. The lowering of the activity can be inhibited by using albumin as a stabilizer. The spray-drying is industrially advantageous as the final stage drying compared with the conventional freeze-drying.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55183816A JPS57108020A (en) | 1980-12-26 | 1980-12-26 | Stable kallidinogenase composition and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55183816A JPS57108020A (en) | 1980-12-26 | 1980-12-26 | Stable kallidinogenase composition and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57108020A true JPS57108020A (en) | 1982-07-05 |
JPH0210808B2 JPH0210808B2 (en) | 1990-03-09 |
Family
ID=16142357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55183816A Granted JPS57108020A (en) | 1980-12-26 | 1980-12-26 | Stable kallidinogenase composition and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57108020A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60161925A (en) * | 1984-02-02 | 1985-08-23 | Sanwa Kagaku Kenkyusho:Kk | Stable pharmaceutical preparation of kallidinogenase |
JPS61180723A (en) * | 1985-02-06 | 1986-08-13 | Sanwa Kagaku Kenkyusho:Kk | Composition for formulating easily absorbable kallidinogenase |
US4684615A (en) * | 1983-06-06 | 1987-08-04 | Ciba Corning Diagnostics Corp. | Stabilized isoenzyme control products |
WO1988006457A1 (en) * | 1987-03-04 | 1988-09-07 | Nippon Hypox Laboratories Incorporated | Medicinal composition containing albumin as carrier and process for its preparation |
FR2754269A1 (en) * | 1996-10-04 | 1998-04-10 | Rhodia Chimie Sa | Drying of heat-sensitive substances, especially enzymes |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56115723A (en) * | 1980-02-15 | 1981-09-11 | Green Cross Corp:The | Medical kallikrein preparation |
-
1980
- 1980-12-26 JP JP55183816A patent/JPS57108020A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56115723A (en) * | 1980-02-15 | 1981-09-11 | Green Cross Corp:The | Medical kallikrein preparation |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4684615A (en) * | 1983-06-06 | 1987-08-04 | Ciba Corning Diagnostics Corp. | Stabilized isoenzyme control products |
JPS60161925A (en) * | 1984-02-02 | 1985-08-23 | Sanwa Kagaku Kenkyusho:Kk | Stable pharmaceutical preparation of kallidinogenase |
JPH0452252B2 (en) * | 1984-02-02 | 1992-08-21 | Sanwa Kagaku Kenkyusho Co | |
JPS61180723A (en) * | 1985-02-06 | 1986-08-13 | Sanwa Kagaku Kenkyusho:Kk | Composition for formulating easily absorbable kallidinogenase |
WO1988006457A1 (en) * | 1987-03-04 | 1988-09-07 | Nippon Hypox Laboratories Incorporated | Medicinal composition containing albumin as carrier and process for its preparation |
US5051406A (en) * | 1987-03-04 | 1991-09-24 | Nippon Hypox Laboratories Incorporated | Pharmaceutical composition using albumin as a carrier and process for producing the same |
FR2754269A1 (en) * | 1996-10-04 | 1998-04-10 | Rhodia Chimie Sa | Drying of heat-sensitive substances, especially enzymes |
Also Published As
Publication number | Publication date |
---|---|
JPH0210808B2 (en) | 1990-03-09 |
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