JPS57108020A - Stable kallidinogenase composition and its preparation - Google Patents

Stable kallidinogenase composition and its preparation

Info

Publication number
JPS57108020A
JPS57108020A JP55183816A JP18381680A JPS57108020A JP S57108020 A JPS57108020 A JP S57108020A JP 55183816 A JP55183816 A JP 55183816A JP 18381680 A JP18381680 A JP 18381680A JP S57108020 A JPS57108020 A JP S57108020A
Authority
JP
Japan
Prior art keywords
kallidinogenase
albumin
composition
drying
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55183816A
Other languages
Japanese (ja)
Other versions
JPH0210808B2 (en
Inventor
Akiji Kuwayama
Akio Sugiyama
Naohisa Ninomiya
Makoto Sato
Yoshio Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanwa Kagaku Kenkyusho Co Ltd
Original Assignee
Sanwa Kagaku Kenkyusho Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co Ltd filed Critical Sanwa Kagaku Kenkyusho Co Ltd
Priority to JP55183816A priority Critical patent/JPS57108020A/en
Publication of JPS57108020A publication Critical patent/JPS57108020A/en
Publication of JPH0210808B2 publication Critical patent/JPH0210808B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PURPOSE: To obtain a kallidinogenase composition having high stability and useful as a remedy for cerebral vascular lesion, coronary cardiopathy, etc., by adding less than the active amount of albumin to kallidinogenase.
CONSTITUTION: A kallidinogenase solution is mixed with less than the active amount of albumin (about 38g of albumin per 1,500,000 units of kallidinogenase) and a saccharide diluent (e.g. mannitol, lactose, sucrose, etc.), and the mixture is spray-dried at an inlet temperature of 110W120°C, an outlet temperature of 50W 60°C, and the speed of spindle rotation of 20,000W40,000rpm to obtain the objective stable kallidinogenase composition. Kallidinogenase is extremely unstable enzyme distributed widely in the living body. The lowering of the activity can be inhibited by using albumin as a stabilizer. The spray-drying is industrially advantageous as the final stage drying compared with the conventional freeze-drying.
COPYRIGHT: (C)1982,JPO&Japio
JP55183816A 1980-12-26 1980-12-26 Stable kallidinogenase composition and its preparation Granted JPS57108020A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55183816A JPS57108020A (en) 1980-12-26 1980-12-26 Stable kallidinogenase composition and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55183816A JPS57108020A (en) 1980-12-26 1980-12-26 Stable kallidinogenase composition and its preparation

Publications (2)

Publication Number Publication Date
JPS57108020A true JPS57108020A (en) 1982-07-05
JPH0210808B2 JPH0210808B2 (en) 1990-03-09

Family

ID=16142357

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55183816A Granted JPS57108020A (en) 1980-12-26 1980-12-26 Stable kallidinogenase composition and its preparation

Country Status (1)

Country Link
JP (1) JPS57108020A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60161925A (en) * 1984-02-02 1985-08-23 Sanwa Kagaku Kenkyusho:Kk Stable pharmaceutical preparation of kallidinogenase
JPS61180723A (en) * 1985-02-06 1986-08-13 Sanwa Kagaku Kenkyusho:Kk Composition for formulating easily absorbable kallidinogenase
US4684615A (en) * 1983-06-06 1987-08-04 Ciba Corning Diagnostics Corp. Stabilized isoenzyme control products
WO1988006457A1 (en) * 1987-03-04 1988-09-07 Nippon Hypox Laboratories Incorporated Medicinal composition containing albumin as carrier and process for its preparation
FR2754269A1 (en) * 1996-10-04 1998-04-10 Rhodia Chimie Sa Drying of heat-sensitive substances, especially enzymes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56115723A (en) * 1980-02-15 1981-09-11 Green Cross Corp:The Medical kallikrein preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56115723A (en) * 1980-02-15 1981-09-11 Green Cross Corp:The Medical kallikrein preparation

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684615A (en) * 1983-06-06 1987-08-04 Ciba Corning Diagnostics Corp. Stabilized isoenzyme control products
JPS60161925A (en) * 1984-02-02 1985-08-23 Sanwa Kagaku Kenkyusho:Kk Stable pharmaceutical preparation of kallidinogenase
JPH0452252B2 (en) * 1984-02-02 1992-08-21 Sanwa Kagaku Kenkyusho Co
JPS61180723A (en) * 1985-02-06 1986-08-13 Sanwa Kagaku Kenkyusho:Kk Composition for formulating easily absorbable kallidinogenase
WO1988006457A1 (en) * 1987-03-04 1988-09-07 Nippon Hypox Laboratories Incorporated Medicinal composition containing albumin as carrier and process for its preparation
US5051406A (en) * 1987-03-04 1991-09-24 Nippon Hypox Laboratories Incorporated Pharmaceutical composition using albumin as a carrier and process for producing the same
FR2754269A1 (en) * 1996-10-04 1998-04-10 Rhodia Chimie Sa Drying of heat-sensitive substances, especially enzymes

Also Published As

Publication number Publication date
JPH0210808B2 (en) 1990-03-09

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