JPS5695158A - Preparation of n-carbamoyl-p-hydroxyphenylglycine - Google Patents
Preparation of n-carbamoyl-p-hydroxyphenylglycineInfo
- Publication number
- JPS5695158A JPS5695158A JP15291979A JP15291979A JPS5695158A JP S5695158 A JPS5695158 A JP S5695158A JP 15291979 A JP15291979 A JP 15291979A JP 15291979 A JP15291979 A JP 15291979A JP S5695158 A JPS5695158 A JP S5695158A
- Authority
- JP
- Japan
- Prior art keywords
- water
- titled compound
- salt
- acid
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as intermediate for producing β- lactam antibiotics readily and directly in high yield and in high purity, by reacting p-hydroxymandelic acid or its salt with an inexpensive urea.
CONSTITUTION: p-Hydroxymandelic acid, or its salt is reacted with urea in water, water-containing organic solvent, or organic solvent, in pH1.5W11, preferably in pH2W8, to give the titled compound. Water is preferable as the solvent from economical point of view, and in the use of water the reaction solution is optionally concentrated and adjusted with an acid to pH1W2. The adjusted solution is cooled to deposit precipitated, which are filtered to isolate the titled compound.
EFFECT: D-Isomer of p-hydrophenylglycine is useful as a raw material for antibiotics, and the titled compound can be transferred directly to the process of optical resolution by using an optical active amine.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15291979A JPS5695158A (en) | 1979-11-28 | 1979-11-28 | Preparation of n-carbamoyl-p-hydroxyphenylglycine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15291979A JPS5695158A (en) | 1979-11-28 | 1979-11-28 | Preparation of n-carbamoyl-p-hydroxyphenylglycine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5695158A true JPS5695158A (en) | 1981-08-01 |
Family
ID=15551009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15291979A Pending JPS5695158A (en) | 1979-11-28 | 1979-11-28 | Preparation of n-carbamoyl-p-hydroxyphenylglycine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5695158A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103360412A (en) * | 2013-06-08 | 2013-10-23 | 苏州中联化学制药有限公司 | A kind of synthetic method of S 578 |
-
1979
- 1979-11-28 JP JP15291979A patent/JPS5695158A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103360412A (en) * | 2013-06-08 | 2013-10-23 | 苏州中联化学制药有限公司 | A kind of synthetic method of S 578 |
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