JPS5695158A - Preparation of n-carbamoyl-p-hydroxyphenylglycine - Google Patents

Preparation of n-carbamoyl-p-hydroxyphenylglycine

Info

Publication number
JPS5695158A
JPS5695158A JP15291979A JP15291979A JPS5695158A JP S5695158 A JPS5695158 A JP S5695158A JP 15291979 A JP15291979 A JP 15291979A JP 15291979 A JP15291979 A JP 15291979A JP S5695158 A JPS5695158 A JP S5695158A
Authority
JP
Japan
Prior art keywords
water
titled compound
salt
acid
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15291979A
Other languages
Japanese (ja)
Inventor
Rinzo Nishizawa
Masao Takei
Kazuteru Hagita
Masao Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP15291979A priority Critical patent/JPS5695158A/en
Publication of JPS5695158A publication Critical patent/JPS5695158A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as intermediate for producing β- lactam antibiotics readily and directly in high yield and in high purity, by reacting p-hydroxymandelic acid or its salt with an inexpensive urea.
CONSTITUTION: p-Hydroxymandelic acid, or its salt is reacted with urea in water, water-containing organic solvent, or organic solvent, in pH1.5W11, preferably in pH2W8, to give the titled compound. Water is preferable as the solvent from economical point of view, and in the use of water the reaction solution is optionally concentrated and adjusted with an acid to pH1W2. The adjusted solution is cooled to deposit precipitated, which are filtered to isolate the titled compound.
EFFECT: D-Isomer of p-hydrophenylglycine is useful as a raw material for antibiotics, and the titled compound can be transferred directly to the process of optical resolution by using an optical active amine.
COPYRIGHT: (C)1981,JPO&Japio
JP15291979A 1979-11-28 1979-11-28 Preparation of n-carbamoyl-p-hydroxyphenylglycine Pending JPS5695158A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15291979A JPS5695158A (en) 1979-11-28 1979-11-28 Preparation of n-carbamoyl-p-hydroxyphenylglycine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15291979A JPS5695158A (en) 1979-11-28 1979-11-28 Preparation of n-carbamoyl-p-hydroxyphenylglycine

Publications (1)

Publication Number Publication Date
JPS5695158A true JPS5695158A (en) 1981-08-01

Family

ID=15551009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15291979A Pending JPS5695158A (en) 1979-11-28 1979-11-28 Preparation of n-carbamoyl-p-hydroxyphenylglycine

Country Status (1)

Country Link
JP (1) JPS5695158A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360412A (en) * 2013-06-08 2013-10-23 苏州中联化学制药有限公司 A kind of synthetic method of S 578

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360412A (en) * 2013-06-08 2013-10-23 苏州中联化学制药有限公司 A kind of synthetic method of S 578

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