JPS5685298A - Preparation of 7-aminocephem compound - Google Patents
Preparation of 7-aminocephem compoundInfo
- Publication number
- JPS5685298A JPS5685298A JP16158279A JP16158279A JPS5685298A JP S5685298 A JPS5685298 A JP S5685298A JP 16158279 A JP16158279 A JP 16158279A JP 16158279 A JP16158279 A JP 16158279A JP S5685298 A JPS5685298 A JP S5685298A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- ion exchange
- exchange resin
- immobilized enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare the titled compound in high productivity, by treating a specific compound with immobilized enzyme obtained by adsorbing acid amidase to a porous ion exchange resin.
CONSTITUTION: An acid amidase is adsorbed to e.g. a strongly basic anion exchange resin (e.g. Amberlite IRA904) having a specific surface area of about 40W60m2/g, prove volume of about 0.85W0.9ml/g, mode pore diameter of about 650W750Å, and ion exchange group of -N-(CH3)3-X, and the adsorption is fortified with a polyfunctional protein crosslinking agent such as glutaraldehyde. A compound of formula I (R is -COOH, etc.; X is nucleophilic residue such as H) is passed through a column packed with the above immobilized enzyme to obtain the 7-amino-cephem compound of formula II by enzymatic reaction. The reaction is carried out in an aqueous medium in the presence of pH-buffering agent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16158279A JPS5685298A (en) | 1979-12-14 | 1979-12-14 | Preparation of 7-aminocephem compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16158279A JPS5685298A (en) | 1979-12-14 | 1979-12-14 | Preparation of 7-aminocephem compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5685298A true JPS5685298A (en) | 1981-07-11 |
JPS6258716B2 JPS6258716B2 (en) | 1987-12-07 |
Family
ID=15737857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16158279A Granted JPS5685298A (en) | 1979-12-14 | 1979-12-14 | Preparation of 7-aminocephem compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5685298A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
EP0524604A3 (en) * | 1991-07-26 | 1994-05-04 | Lonza Ag | |
WO2002086143A3 (en) * | 2001-04-19 | 2003-01-09 | Bioferma Murcia S A | Enzymatic process for preparing cephalosporin derivatives |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5359095A (en) * | 1976-11-05 | 1978-05-27 | Asahi Chem Ind Co Ltd | Preparation of 7-aminocephem cpds. |
JPS53139791A (en) * | 1977-05-02 | 1978-12-06 | Asahi Chem Ind Co Ltd | Preparation of 7-aminocephem compounds |
-
1979
- 1979-12-14 JP JP16158279A patent/JPS5685298A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5359095A (en) * | 1976-11-05 | 1978-05-27 | Asahi Chem Ind Co Ltd | Preparation of 7-aminocephem cpds. |
JPS53139791A (en) * | 1977-05-02 | 1978-12-06 | Asahi Chem Ind Co Ltd | Preparation of 7-aminocephem compounds |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
EP0524604A3 (en) * | 1991-07-26 | 1994-05-04 | Lonza Ag | |
WO2002086143A3 (en) * | 2001-04-19 | 2003-01-09 | Bioferma Murcia S A | Enzymatic process for preparing cephalosporin derivatives |
WO2002085914A3 (en) * | 2001-04-19 | 2003-02-06 | Bioferma Murcia S A | ENZYMATIC PROCESS FOR PREPARING CEPHALOSPORANIC ACID DERIVATIVES USING α-KETOACID DERIVATIVES |
US6642020B2 (en) | 2001-04-19 | 2003-11-04 | Bioferma Murcia S.A. | Process for preparing cephalosporin derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6258716B2 (en) | 1987-12-07 |
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