JPS568384A - Preparation of descysteaminothienamycin having protecting group - Google Patents
Preparation of descysteaminothienamycin having protecting groupInfo
- Publication number
- JPS568384A JPS568384A JP8418679A JP8418679A JPS568384A JP S568384 A JPS568384 A JP S568384A JP 8418679 A JP8418679 A JP 8418679A JP 8418679 A JP8418679 A JP 8418679A JP S568384 A JPS568384 A JP S568384A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- reacted
- protecting group
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a raw material for an intibiotic, in a retained absolute configuration, by decomposing the acetal group of a specific phosphorane compound with an acid.
CONSTITUTION: A novel azetidinone compound of formula III is reacted with a protecting group-forming reagent to form a compound of formula IV having a protected hydroxyl group, which is then reacted with a glyoxylate hemiacetal, e.g. o- nitrobenzyl glyoxylate ethyl hemiacetal, to give a compound of formula V. The alcohol derivative of formula V is chlorinated and reacted with triphenylphosphine to form a phosphorane derivative of formula VI, which is decomposed with an acid and subjected to the intramolecular Wittig reaction to afford the objective compound of formula II is high yield.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8418679A JPS568384A (en) | 1979-07-03 | 1979-07-03 | Preparation of descysteaminothienamycin having protecting group |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8418679A JPS568384A (en) | 1979-07-03 | 1979-07-03 | Preparation of descysteaminothienamycin having protecting group |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS568384A true JPS568384A (en) | 1981-01-28 |
Family
ID=13823440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8418679A Pending JPS568384A (en) | 1979-07-03 | 1979-07-03 | Preparation of descysteaminothienamycin having protecting group |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS568384A (en) |
-
1979
- 1979-07-03 JP JP8418679A patent/JPS568384A/en active Pending
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