JPS568384A - Preparation of descysteaminothienamycin having protecting group - Google Patents

Preparation of descysteaminothienamycin having protecting group

Info

Publication number
JPS568384A
JPS568384A JP8418679A JP8418679A JPS568384A JP S568384 A JPS568384 A JP S568384A JP 8418679 A JP8418679 A JP 8418679A JP 8418679 A JP8418679 A JP 8418679A JP S568384 A JPS568384 A JP S568384A
Authority
JP
Japan
Prior art keywords
formula
compound
reacted
protecting group
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8418679A
Other languages
Japanese (ja)
Inventor
Tetsuji Kametani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP8418679A priority Critical patent/JPS568384A/en
Publication of JPS568384A publication Critical patent/JPS568384A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a raw material for an intibiotic, in a retained absolute configuration, by decomposing the acetal group of a specific phosphorane compound with an acid.
CONSTITUTION: A novel azetidinone compound of formula III is reacted with a protecting group-forming reagent to form a compound of formula IV having a protected hydroxyl group, which is then reacted with a glyoxylate hemiacetal, e.g. o- nitrobenzyl glyoxylate ethyl hemiacetal, to give a compound of formula V. The alcohol derivative of formula V is chlorinated and reacted with triphenylphosphine to form a phosphorane derivative of formula VI, which is decomposed with an acid and subjected to the intramolecular Wittig reaction to afford the objective compound of formula II is high yield.
COPYRIGHT: (C)1981,JPO&Japio
JP8418679A 1979-07-03 1979-07-03 Preparation of descysteaminothienamycin having protecting group Pending JPS568384A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8418679A JPS568384A (en) 1979-07-03 1979-07-03 Preparation of descysteaminothienamycin having protecting group

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8418679A JPS568384A (en) 1979-07-03 1979-07-03 Preparation of descysteaminothienamycin having protecting group

Publications (1)

Publication Number Publication Date
JPS568384A true JPS568384A (en) 1981-01-28

Family

ID=13823440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8418679A Pending JPS568384A (en) 1979-07-03 1979-07-03 Preparation of descysteaminothienamycin having protecting group

Country Status (1)

Country Link
JP (1) JPS568384A (en)

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