JPS5679666A - Erythro 1- 4-benzyloxyphenyl -2- 4-benzylpiperidino propanol and its preparation - Google Patents

Erythro 1- 4-benzyloxyphenyl -2- 4-benzylpiperidino propanol and its preparation

Info

Publication number
JPS5679666A
JPS5679666A JP15637279A JP15637279A JPS5679666A JP S5679666 A JPS5679666 A JP S5679666A JP 15637279 A JP15637279 A JP 15637279A JP 15637279 A JP15637279 A JP 15637279A JP S5679666 A JPS5679666 A JP S5679666A
Authority
JP
Japan
Prior art keywords
formula
benzylpiperidino
propanol
benzyloxyphenyl
erythro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15637279A
Other languages
Japanese (ja)
Other versions
JPS6330895B2 (en
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Nagatoshi Azuma
Toshitaka Kohagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP15637279A priority Critical patent/JPS5679666A/en
Publication of JPS5679666A publication Critical patent/JPS5679666A/en
Publication of JPS6330895B2 publication Critical patent/JPS6330895B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Erythro 1-(4-benzyloxyphenyl)-2-(4-benzylpiperidyl)propanol shown by the formula I.
USE: An improving agent for cerebrovascular stream, remedy for sequela of cerebral infract, and an intermediate for synthesizing a drug for circulatory organs[etythro 2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)propanol].
PROCESS: A compound shown by the formula IV is halogenated with bromine, etc. in a solvent, e.g., glacial acetic acid, etc., to given an α-halogenated propiophenone shown by the formula V. This compound is condensed with 4-benzylpiperidine, to give 4'-benzyloxy-2-(4-benzylpiperidino)propiophenone shown by the formula II, which is in the state of a salt reduced with sodium boron hydride or in the presence of an acidic substance, to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP15637279A 1979-12-04 1979-12-04 Erythro 1- 4-benzyloxyphenyl -2- 4-benzylpiperidino propanol and its preparation Granted JPS5679666A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15637279A JPS5679666A (en) 1979-12-04 1979-12-04 Erythro 1- 4-benzyloxyphenyl -2- 4-benzylpiperidino propanol and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15637279A JPS5679666A (en) 1979-12-04 1979-12-04 Erythro 1- 4-benzyloxyphenyl -2- 4-benzylpiperidino propanol and its preparation

Publications (2)

Publication Number Publication Date
JPS5679666A true JPS5679666A (en) 1981-06-30
JPS6330895B2 JPS6330895B2 (en) 1988-06-21

Family

ID=15626306

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15637279A Granted JPS5679666A (en) 1979-12-04 1979-12-04 Erythro 1- 4-benzyloxyphenyl -2- 4-benzylpiperidino propanol and its preparation

Country Status (1)

Country Link
JP (1) JPS5679666A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62201867A (en) * 1985-07-24 1987-09-05 Grelan Pharmaceut Co Ltd Circulation improver

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4867234A (en) * 1971-12-15 1973-09-13
JPS5951940A (en) * 1982-09-18 1984-03-26 Mitsubishi Petrochem Co Ltd Ring opening polymer composition having improved mechanical characteristics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4867234A (en) * 1971-12-15 1973-09-13
JPS5951940A (en) * 1982-09-18 1984-03-26 Mitsubishi Petrochem Co Ltd Ring opening polymer composition having improved mechanical characteristics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62201867A (en) * 1985-07-24 1987-09-05 Grelan Pharmaceut Co Ltd Circulation improver
JPH0811730B2 (en) * 1985-07-24 1996-02-07 グレラン製薬株式会社 Circulation improver

Also Published As

Publication number Publication date
JPS6330895B2 (en) 1988-06-21

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