JPS5639794A - Preparation of interferon - Google Patents

Preparation of interferon

Info

Publication number
JPS5639794A
JPS5639794A JP11322579A JP11322579A JPS5639794A JP S5639794 A JPS5639794 A JP S5639794A JP 11322579 A JP11322579 A JP 11322579A JP 11322579 A JP11322579 A JP 11322579A JP S5639794 A JPS5639794 A JP S5639794A
Authority
JP
Japan
Prior art keywords
interferon
cluture
incubated
fluid
human lymphoblastic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11322579A
Other languages
Japanese (ja)
Inventor
Tomonori Minagawa
Nobuhiro Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP11322579A priority Critical patent/JPS5639794A/en
Publication of JPS5639794A publication Critical patent/JPS5639794A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To mass-produce interferon without the stimulation of an interferon inducer, by incubating a human lymphoblastic cell from prolonged infection with measles virus in a nutrient culture medium, and collecting interferon from the culture fluid.
CONSTITUTION: An incubated human lymphoblastic cell is inoculated with an attenuated variant of measles virus in an amount of 10W102 infection value per 103 cells, and incubated in a nutrient cluture medium containing 10% a bovine fetal serum to give a stable human lymphoblastic cell from prolonged infection with measles virus. The human lymphoblastic cell from prolonged infectio with meales virus is incubated in a culture medium usually used for the tissue culture of an animal, and the interferon is separated and collected from the resultant cluture fluid by the well-known separation means, e.g. separation of the cell from th cluture fluid through centrifugation, treatment with a surfactant, and salting out. The addition of a serum, e.g. the bovine fetal serum, to the nutrient culture medium improves the production of the interferon.
COPYRIGHT: (C)1981,JPO&Japio
JP11322579A 1979-09-04 1979-09-04 Preparation of interferon Pending JPS5639794A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11322579A JPS5639794A (en) 1979-09-04 1979-09-04 Preparation of interferon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11322579A JPS5639794A (en) 1979-09-04 1979-09-04 Preparation of interferon

Publications (1)

Publication Number Publication Date
JPS5639794A true JPS5639794A (en) 1981-04-15

Family

ID=14606730

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11322579A Pending JPS5639794A (en) 1979-09-04 1979-09-04 Preparation of interferon

Country Status (1)

Country Link
JP (1) JPS5639794A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57188524A (en) * 1981-05-15 1982-11-19 Thomae Gmbh Dr K Interferon
JPS61135598A (en) * 1984-12-04 1986-06-23 Green Cross Corp:The Production of interferon-alpha

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57188524A (en) * 1981-05-15 1982-11-19 Thomae Gmbh Dr K Interferon
JPS61135598A (en) * 1984-12-04 1986-06-23 Green Cross Corp:The Production of interferon-alpha

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