JPS56158758A - Preparation of isothiocyanate ester - Google Patents

Preparation of isothiocyanate ester

Info

Publication number
JPS56158758A
JPS56158758A JP6180380A JP6180380A JPS56158758A JP S56158758 A JPS56158758 A JP S56158758A JP 6180380 A JP6180380 A JP 6180380A JP 6180380 A JP6180380 A JP 6180380A JP S56158758 A JPS56158758 A JP S56158758A
Authority
JP
Japan
Prior art keywords
component
reacted
cyanamide
dithiocarbamate
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6180380A
Other languages
Japanese (ja)
Other versions
JPH0124789B2 (en
Inventor
Masanori Sasaki
Kazuyoshi Miyata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Carbide Industries Co Inc
Original Assignee
Nippon Carbide Industries Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Carbide Industries Co Inc filed Critical Nippon Carbide Industries Co Inc
Priority to JP6180380A priority Critical patent/JPS56158758A/en
Publication of JPS56158758A publication Critical patent/JPS56158758A/en
Publication of JPH0124789B2 publication Critical patent/JPH0124789B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a synthetic raw material for a tetrazole which is a raw material for cephalosporin antibiotic industrially and advantageously, by reacting a dithiocarbamate with cyanamide.
CONSTITUTION: (A) A dithiocarbamate expressed by the formula (R is alkyl, aralkyl or aromatic group) is reacted with (B) cyanamide to give the titled compound. In the process, (a) carbon disulfide and (b) a primary amine expressed by the formula R-NH2 which are synthetic raw materials for the component (A) are reacted with the component (B) preferably in one stage. Thus, the component (B) and the component (a) are dissolved in a solvent, e.g. acetone, and an aqueous solution of the component (b) is dopped to the resultant solution and reacted at 0W50°C. After completing the reaction, the deposited thiourea is filtered, and the solvent is distilled off. The reaction mixture is then subjected to the vacuum distillation to give the aimed compound.
COPYRIGHT: (C)1981,JPO&Japio
JP6180380A 1980-05-12 1980-05-12 Preparation of isothiocyanate ester Granted JPS56158758A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6180380A JPS56158758A (en) 1980-05-12 1980-05-12 Preparation of isothiocyanate ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6180380A JPS56158758A (en) 1980-05-12 1980-05-12 Preparation of isothiocyanate ester

Publications (2)

Publication Number Publication Date
JPS56158758A true JPS56158758A (en) 1981-12-07
JPH0124789B2 JPH0124789B2 (en) 1989-05-15

Family

ID=13181607

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6180380A Granted JPS56158758A (en) 1980-05-12 1980-05-12 Preparation of isothiocyanate ester

Country Status (1)

Country Link
JP (1) JPS56158758A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014136690A1 (en) * 2013-03-05 2014-09-12 旭化成ケミカルズ株式会社 Isothiocyanate production method, composition for transporting and storing n-substituted o-substituted thiocarbamate, and isothiocyanate composition

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014136690A1 (en) * 2013-03-05 2014-09-12 旭化成ケミカルズ株式会社 Isothiocyanate production method, composition for transporting and storing n-substituted o-substituted thiocarbamate, and isothiocyanate composition
CN105026367A (en) * 2013-03-05 2015-11-04 旭化成化学株式会社 Isothiocyanate production method, composition for transporting and storing N-substituted O-substituted thiocarbamate, and isothiocyanate composition
JPWO2014136690A1 (en) * 2013-03-05 2017-02-09 旭化成株式会社 Method for producing isothiocyanate, composition for transporting and storing N-substituted-O-substituted thiocarbamates, and isothiocyanate composition
CN105026367B (en) * 2013-03-05 2019-05-21 旭化成株式会社 The manufacturing method of isothiocyanates
US10308601B2 (en) 2013-03-05 2019-06-04 Asahi Kasei Chemicals Corporation Isothiocyanate production method, composition for transporting and storing N-substituted O-substituted thiocarbamate, and isothiocyanate composition
US11046645B2 (en) 2013-03-05 2021-06-29 Asahi Kasei Chemicals Corporation Isothiocyanate production method, composition for transporting and storing N-substituted O-substituted thiocarbamate, and isothiocyanate composition
CN113880741A (en) * 2013-03-05 2022-01-04 旭化成株式会社 Method for producing isothiocyanate

Also Published As

Publication number Publication date
JPH0124789B2 (en) 1989-05-15

Similar Documents

Publication Publication Date Title
DE2852538C2 (en)
JPS56158758A (en) Preparation of isothiocyanate ester
US5574155A (en) Process for the synthesis of the disodium salt hemiheptahydrate of ceftriaxone
PT79118B (en) CEPHALOSPORINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
JPS54128591A (en) Cephalosporin analog
EP0300966B1 (en) Process for the selective n-acylation of amino-hydraxamic and derivates and starting compounds therefor
SE7907320L (en) 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION
SU415874A3 (en)
DE69232776T2 (en) Process for the preparation of cephalosporins and intermediates in this process
GB1505020A (en) Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides
US4311647A (en) Process for preparation of (hydrocarbonthio)oxamides
EP0108034B1 (en) Deacylation of amides
IE46287L (en) Production of haloacylamides
JPS56127369A (en) Nevel piperazine compound, its preparation and utilization
JPS5612395A (en) Oxazolinoazetidinone derivative
JPS55102589A (en) Preparation of organo-silicon isocyanates
FR2551751B1 (en) NOVEL PROCESS FOR PREPARING A PYROGLUTAMIC DERIVATIVE, NOVEL PYROGLUTAMIC DERIVATIVES, NOVEL SYNTHESIS FOR PREPARING THE SAME AND USE OR APPLICATION OF PYROGLUTAMIC DERIVATIVES AS ANTIBACTERIAL OR ANTIFUNGAL AGENTS
JPS55139387A (en) Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids
IE780206L (en) Production of vinyl and isopropenyl chloroformate and¹thiochloroformate
JPS55164692A (en) Preparation of tertiary dichlorophosphine
GB913415A (en) Alkoxyphenyl and alkenyloxyphenyl esters of n-methylcarbamic acid and method of preparation
GB1038727A (en) Vulcanisation process and novel bis(dithiocarbamates) for use therein
ATE16706T1 (en) METHODS FOR PRODUCTION OF CEPHALOSPORIN COMPOUNDS.
ES8206522A1 (en) Process for the Preparation of Apovincaminic Acid Esters
JPS55153790A (en) Preparation of 7-amino-3-heterocyclic thiomethyl-delta3- cephem-4-carboxylic acid