JPS56158758A - Preparation of isothiocyanate ester - Google Patents
Preparation of isothiocyanate esterInfo
- Publication number
- JPS56158758A JPS56158758A JP6180380A JP6180380A JPS56158758A JP S56158758 A JPS56158758 A JP S56158758A JP 6180380 A JP6180380 A JP 6180380A JP 6180380 A JP6180380 A JP 6180380A JP S56158758 A JPS56158758 A JP S56158758A
- Authority
- JP
- Japan
- Prior art keywords
- component
- reacted
- cyanamide
- dithiocarbamate
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a synthetic raw material for a tetrazole which is a raw material for cephalosporin antibiotic industrially and advantageously, by reacting a dithiocarbamate with cyanamide.
CONSTITUTION: (A) A dithiocarbamate expressed by the formula (R is alkyl, aralkyl or aromatic group) is reacted with (B) cyanamide to give the titled compound. In the process, (a) carbon disulfide and (b) a primary amine expressed by the formula R-NH2 which are synthetic raw materials for the component (A) are reacted with the component (B) preferably in one stage. Thus, the component (B) and the component (a) are dissolved in a solvent, e.g. acetone, and an aqueous solution of the component (b) is dopped to the resultant solution and reacted at 0W50°C. After completing the reaction, the deposited thiourea is filtered, and the solvent is distilled off. The reaction mixture is then subjected to the vacuum distillation to give the aimed compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6180380A JPS56158758A (en) | 1980-05-12 | 1980-05-12 | Preparation of isothiocyanate ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6180380A JPS56158758A (en) | 1980-05-12 | 1980-05-12 | Preparation of isothiocyanate ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56158758A true JPS56158758A (en) | 1981-12-07 |
JPH0124789B2 JPH0124789B2 (en) | 1989-05-15 |
Family
ID=13181607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6180380A Granted JPS56158758A (en) | 1980-05-12 | 1980-05-12 | Preparation of isothiocyanate ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56158758A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014136690A1 (en) * | 2013-03-05 | 2014-09-12 | 旭化成ケミカルズ株式会社 | Isothiocyanate production method, composition for transporting and storing n-substituted o-substituted thiocarbamate, and isothiocyanate composition |
-
1980
- 1980-05-12 JP JP6180380A patent/JPS56158758A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014136690A1 (en) * | 2013-03-05 | 2014-09-12 | 旭化成ケミカルズ株式会社 | Isothiocyanate production method, composition for transporting and storing n-substituted o-substituted thiocarbamate, and isothiocyanate composition |
CN105026367A (en) * | 2013-03-05 | 2015-11-04 | 旭化成化学株式会社 | Isothiocyanate production method, composition for transporting and storing N-substituted O-substituted thiocarbamate, and isothiocyanate composition |
JPWO2014136690A1 (en) * | 2013-03-05 | 2017-02-09 | 旭化成株式会社 | Method for producing isothiocyanate, composition for transporting and storing N-substituted-O-substituted thiocarbamates, and isothiocyanate composition |
CN105026367B (en) * | 2013-03-05 | 2019-05-21 | 旭化成株式会社 | The manufacturing method of isothiocyanates |
US10308601B2 (en) | 2013-03-05 | 2019-06-04 | Asahi Kasei Chemicals Corporation | Isothiocyanate production method, composition for transporting and storing N-substituted O-substituted thiocarbamate, and isothiocyanate composition |
US11046645B2 (en) | 2013-03-05 | 2021-06-29 | Asahi Kasei Chemicals Corporation | Isothiocyanate production method, composition for transporting and storing N-substituted O-substituted thiocarbamate, and isothiocyanate composition |
CN113880741A (en) * | 2013-03-05 | 2022-01-04 | 旭化成株式会社 | Method for producing isothiocyanate |
Also Published As
Publication number | Publication date |
---|---|
JPH0124789B2 (en) | 1989-05-15 |
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