JPS56147766A - Preparation of lactam - Google Patents
Preparation of lactamInfo
- Publication number
- JPS56147766A JPS56147766A JP5135980A JP5135980A JPS56147766A JP S56147766 A JPS56147766 A JP S56147766A JP 5135980 A JP5135980 A JP 5135980A JP 5135980 A JP5135980 A JP 5135980A JP S56147766 A JPS56147766 A JP S56147766A
- Authority
- JP
- Japan
- Prior art keywords
- lactam
- formula
- high yield
- pyrrolidin
- benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
PURPOSE: To obtain a lactam useful as a remedy for peptic ulcer, etc. and an intermediate for other medicines in high yield industrially and efficiently, by reacting a 1-benzoyl-pyrrolidin-5-one-2-carboxylic acid halide with a secondary amine.
CONSTITUTION: N-Benzoylglutamic acid is reacted with a phosphorus halide under mild reaction conditions to give a 1-benzoyl-pyrrolidin-5-one-2-carboxylic acid halide of formula I (X is halogen) in high yield. The resultant compound of formula I is then preferably without isolation from the reaction mixture reacted with an amine of formula II (R1 and R2 are 1W6C alkyl or together with the adjacent N link to form a heterocyclic ring) under mild condition in the absence of a solvent in a short time of about 1W2hr to give a lactam of formula III almost quantitatively. According to the method, the lactam of formula III can be prepared in high yield by using the conventional reactor with saved energy.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5135980A JPS56147766A (en) | 1980-04-17 | 1980-04-17 | Preparation of lactam |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5135980A JPS56147766A (en) | 1980-04-17 | 1980-04-17 | Preparation of lactam |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56147766A true JPS56147766A (en) | 1981-11-16 |
Family
ID=12884732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5135980A Pending JPS56147766A (en) | 1980-04-17 | 1980-04-17 | Preparation of lactam |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56147766A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2597100A1 (en) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | PYROGLUTAMIDE DERIVATIVES |
-
1980
- 1980-04-17 JP JP5135980A patent/JPS56147766A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2597100A1 (en) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | PYROGLUTAMIDE DERIVATIVES |
FR2613366A1 (en) * | 1986-01-21 | 1988-10-07 | Nippon Shinyaku Co Ltd | PYROGLUTAMIDE DERIVATIVES |
BE1003248A5 (en) * | 1986-01-21 | 1992-02-11 | Nippon Shinyaku Co Ltd | PYROGLUTAMIDE DERIVATIVES. |
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