JPS56128764A - Quinolinecarboxylic acid derivative and its preparation - Google Patents
Quinolinecarboxylic acid derivative and its preparationInfo
- Publication number
- JPS56128764A JPS56128764A JP3236980A JP3236980A JPS56128764A JP S56128764 A JPS56128764 A JP S56128764A JP 3236980 A JP3236980 A JP 3236980A JP 3236980 A JP3236980 A JP 3236980A JP S56128764 A JPS56128764 A JP S56128764A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- lower alkyl
- acid derivative
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Quinoline Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I (R1 is H or lower alkyl; R2 is lower alkyl or acyl; X and X1 are H or halogen; however, are not H at the same time).
EXAMPLE: Ethyl 6-fluoro-4-hydroxy-7-(4-acetyl-1-piperazinyl)quinoline-3-carboxylate
USE: A synthetic intermediate for a quinolonecarboxylic acid derivative which is an antimicrobial agent.
PROCESS: A compound of formula II (R3 is lower alkyl) is subjected to the ring closure in the absence of a solvent or in the pressure of a high-boiling inert solvent, e.g. tetralin or diphenyl, or the ring closure in the presence of a cyclizing agent, e.g. acetic anhydride, sulfuric acid or polyphosphoric acid, to give the compound of formula I. The reaction is carried out at a temperature in the range of room temperature to 300°C.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3236980A JPS56128764A (en) | 1980-03-14 | 1980-03-14 | Quinolinecarboxylic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3236980A JPS56128764A (en) | 1980-03-14 | 1980-03-14 | Quinolinecarboxylic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56128764A true JPS56128764A (en) | 1981-10-08 |
Family
ID=12357023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3236980A Pending JPS56128764A (en) | 1980-03-14 | 1980-03-14 | Quinolinecarboxylic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56128764A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4398029A (en) * | 1981-02-19 | 1983-08-09 | Kyorin Seiyaku Kabushiki Kaisha | Quinoline carboxylic acid derivatives and process for the preparation |
JPS59212474A (en) * | 1983-05-18 | 1984-12-01 | バイエル・アクチエンゲゼルシヤフト | 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4- oxoquinoline carboxylic acid |
US4730000A (en) * | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
US4774246A (en) * | 1984-01-26 | 1988-09-27 | Abbott Laboratories | Quinoline antibacterial compounds |
US5409933A (en) * | 1992-06-09 | 1995-04-25 | Kim; Wan J. | Quinoline derivatives and processes for preparing the same |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4982671A (en) * | 1972-12-18 | 1974-08-08 | ||
JPS5365887A (en) * | 1976-11-22 | 1978-06-12 | Kyorin Seiyaku Kk | Substituted quinoline*arboxylate and process for preparing same |
JPS5466686A (en) * | 1977-09-20 | 1979-05-29 | Dainippon Pharmaceut Co Ltd | Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same |
-
1980
- 1980-03-14 JP JP3236980A patent/JPS56128764A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4982671A (en) * | 1972-12-18 | 1974-08-08 | ||
JPS5365887A (en) * | 1976-11-22 | 1978-06-12 | Kyorin Seiyaku Kk | Substituted quinoline*arboxylate and process for preparing same |
JPS5466686A (en) * | 1977-09-20 | 1979-05-29 | Dainippon Pharmaceut Co Ltd | Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4398029A (en) * | 1981-02-19 | 1983-08-09 | Kyorin Seiyaku Kabushiki Kaisha | Quinoline carboxylic acid derivatives and process for the preparation |
JPS59212474A (en) * | 1983-05-18 | 1984-12-01 | バイエル・アクチエンゲゼルシヤフト | 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4- oxoquinoline carboxylic acid |
US4774246A (en) * | 1984-01-26 | 1988-09-27 | Abbott Laboratories | Quinoline antibacterial compounds |
US4730000A (en) * | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
US5409933A (en) * | 1992-06-09 | 1995-04-25 | Kim; Wan J. | Quinoline derivatives and processes for preparing the same |
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