JPS56128764A - Quinolinecarboxylic acid derivative and its preparation - Google Patents

Quinolinecarboxylic acid derivative and its preparation

Info

Publication number
JPS56128764A
JPS56128764A JP3236980A JP3236980A JPS56128764A JP S56128764 A JPS56128764 A JP S56128764A JP 3236980 A JP3236980 A JP 3236980A JP 3236980 A JP3236980 A JP 3236980A JP S56128764 A JPS56128764 A JP S56128764A
Authority
JP
Japan
Prior art keywords
compound
formula
lower alkyl
acid derivative
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3236980A
Other languages
Japanese (ja)
Inventor
Tsutomu Irikura
Seigo Suzue
Hiroshi Koga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to JP3236980A priority Critical patent/JPS56128764A/en
Publication of JPS56128764A publication Critical patent/JPS56128764A/en
Pending legal-status Critical Current

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  • Quinoline Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 is H or lower alkyl; R2 is lower alkyl or acyl; X and X1 are H or halogen; however, are not H at the same time).
EXAMPLE: Ethyl 6-fluoro-4-hydroxy-7-(4-acetyl-1-piperazinyl)quinoline-3-carboxylate
USE: A synthetic intermediate for a quinolonecarboxylic acid derivative which is an antimicrobial agent.
PROCESS: A compound of formula II (R3 is lower alkyl) is subjected to the ring closure in the absence of a solvent or in the pressure of a high-boiling inert solvent, e.g. tetralin or diphenyl, or the ring closure in the presence of a cyclizing agent, e.g. acetic anhydride, sulfuric acid or polyphosphoric acid, to give the compound of formula I. The reaction is carried out at a temperature in the range of room temperature to 300°C.
COPYRIGHT: (C)1981,JPO&Japio
JP3236980A 1980-03-14 1980-03-14 Quinolinecarboxylic acid derivative and its preparation Pending JPS56128764A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3236980A JPS56128764A (en) 1980-03-14 1980-03-14 Quinolinecarboxylic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3236980A JPS56128764A (en) 1980-03-14 1980-03-14 Quinolinecarboxylic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS56128764A true JPS56128764A (en) 1981-10-08

Family

ID=12357023

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3236980A Pending JPS56128764A (en) 1980-03-14 1980-03-14 Quinolinecarboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56128764A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4398029A (en) * 1981-02-19 1983-08-09 Kyorin Seiyaku Kabushiki Kaisha Quinoline carboxylic acid derivatives and process for the preparation
JPS59212474A (en) * 1983-05-18 1984-12-01 バイエル・アクチエンゲゼルシヤフト 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4- oxoquinoline carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
US5409933A (en) * 1992-06-09 1995-04-25 Kim; Wan J. Quinoline derivatives and processes for preparing the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4982671A (en) * 1972-12-18 1974-08-08
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
JPS5466686A (en) * 1977-09-20 1979-05-29 Dainippon Pharmaceut Co Ltd Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4982671A (en) * 1972-12-18 1974-08-08
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
JPS5466686A (en) * 1977-09-20 1979-05-29 Dainippon Pharmaceut Co Ltd Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4398029A (en) * 1981-02-19 1983-08-09 Kyorin Seiyaku Kabushiki Kaisha Quinoline carboxylic acid derivatives and process for the preparation
JPS59212474A (en) * 1983-05-18 1984-12-01 バイエル・アクチエンゲゼルシヤフト 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4- oxoquinoline carboxylic acid
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US5409933A (en) * 1992-06-09 1995-04-25 Kim; Wan J. Quinoline derivatives and processes for preparing the same

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