JPS56123999A - Cundurango glycoside, its preparation and antitumor agent comprising it - Google Patents

Cundurango glycoside, its preparation and antitumor agent comprising it

Info

Publication number
JPS56123999A
JPS56123999A JP2769780A JP2769780A JPS56123999A JP S56123999 A JPS56123999 A JP S56123999A JP 2769780 A JP2769780 A JP 2769780A JP 2769780 A JP2769780 A JP 2769780A JP S56123999 A JPS56123999 A JP S56123999A
Authority
JP
Japan
Prior art keywords
cundurango
glycoside
formula
antitumor agent
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2769780A
Other languages
Japanese (ja)
Other versions
JPS6251277B2 (en
Inventor
Hiroshi Mihashi
Denichi Mizuno
Koji Hayashi
Shigeru Abe
Muneaki Takase
Toshiharu Narita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Priority to JP2769780A priority Critical patent/JPS56123999A/en
Priority to US06/179,001 priority patent/US4320120A/en
Priority to PL22636980A priority patent/PL226369A1/xx
Priority to NL8004751A priority patent/NL8004751A/en
Priority to GB8027337A priority patent/GB2060379A/en
Priority to FR8018419A priority patent/FR2463620A1/en
Priority to ES494468A priority patent/ES494468A0/en
Priority to SE8005919A priority patent/SE8005919L/en
Priority to CA000358853A priority patent/CA1144917A/en
Priority to DE19803031745 priority patent/DE3031745A1/en
Priority to IT68313/80A priority patent/IT1141617B/en
Priority to IT8167295A priority patent/IT1144136B/en
Priority to BE0/204013A priority patent/BE887793A/en
Priority to PCT/JP1981/000045 priority patent/WO1981002577A1/en
Priority to AU67800/81A priority patent/AU6780081A/en
Priority to DE19813137612 priority patent/DE3137612A1/en
Priority to GB8209580A priority patent/GB2093032B/en
Priority to CH7326/81A priority patent/CH647533A5/en
Priority to EP19810900551 priority patent/EP0054570A4/en
Priority to CA000372389A priority patent/CA1169852A/en
Priority to US06/320,974 priority patent/US4452786A/en
Priority to NL8120043A priority patent/NL8120043A/en
Publication of JPS56123999A publication Critical patent/JPS56123999A/en
Priority to SE8202140A priority patent/SE8202140L/en
Publication of JPS6251277B2 publication Critical patent/JPS6251277B2/ja
Granted legal-status Critical Current

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  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A cundurango glycoside shown by the formula I (R is O or group shown by the formula II).
EXAMPLE: A cundurango glycoside Ao.
USE: An antitumor agent. In the case of oral administration, a does is 0.6W6mg/kg/ day (cundurango glycoside Ao), and 10W30mg/kg/day (cundurango glycoside Co).
PROCESS: A condurango extract soluble in lower alcohols and chlorinated hydrocarbons excluding CCl4 and insoluble in aliphatic hydrocarbons, CCl4 or aromatic hydrocarbons is obtained from Marsdenia cundurango Reichenbach fil, preferably its bark, and the extract is subjected to high-speed liquid chromatography and separated, to give a cundurago glycoside shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP2769780A 1979-08-23 1980-03-05 Cundurango glycoside, its preparation and antitumor agent comprising it Granted JPS56123999A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP2769780A JPS56123999A (en) 1980-03-05 1980-03-05 Cundurango glycoside, its preparation and antitumor agent comprising it
US06/179,001 US4320120A (en) 1979-10-22 1980-08-18 Extracts of Marsdenia cundurango Reichenbach fil
PL22636980A PL226369A1 (en) 1979-08-23 1980-08-22
NL8004751A NL8004751A (en) 1979-08-23 1980-08-22 METHOD FOR PREPARING A MEDICINAL AGAINST CANCER, THE MEDICINE PREPARED AND A PROCESS FOR PREPARING THE ACTIVE SUBSTANCE FROM A PLANT REST.
GB8027337A GB2060379A (en) 1979-08-23 1980-08-22 Extracts of Marsdenia cundurango Reichenbach fil
FR8018419A FR2463620A1 (en) 1979-08-23 1980-08-22 MARSDENIA CINDURANGO REICHENBACH FIL EXTRACTS, PREPARATION METHODS THEREOF, ANTI-TUMOR AGENTS CONTAINING SAME, AND COMPOSITIONS CONTAINING SAME
ES494468A ES494468A0 (en) 1979-08-23 1980-08-22 A PROCEDURE FOR OBTAINING AN EXTRACT FROM MARSDE-NIA CUNDURANGO REICHENBACH FIL.
SE8005919A SE8005919L (en) 1979-08-23 1980-08-22 EXTRACT OF MARSDENIA CUNDURANGO REICHENBACH FILE
CA000358853A CA1144917A (en) 1979-08-23 1980-08-22 Extracts of marsdenia cundurango reichenbach fil
DE19803031745 DE3031745A1 (en) 1979-08-23 1980-08-22 MARSDENIA CUNDURANGO REICHENBACH FIL EXTRACTS, METHOD FOR THE PRODUCTION THEREOF, ANTITUARY AND MEDICINAL PRODUCTS CONTAINING THESE EXTRACTS, AND APPLICATION OF THE EXTRACTS FOR THE TREATMENT OF TUMORS
IT68313/80A IT1141617B (en) 1979-08-23 1980-08-25 MARSDENIA EXTRACTS CONDURANGO REICHENBACH SON
IT8167295A IT1144136B (en) 1980-03-05 1981-03-03 GLUCOSIDES OF CONDUCT ANTI-CANCER AGENTS INCLUDING THEM AND PROCEDURE FOR THEIR PREPARATION
BE0/204013A BE887793A (en) 1980-03-05 1981-03-04 NOVEL CONDURANGO-GLYCOSIDES, ANTI-TUMOR AGENTS COMPRISING SAME, AND PROCESS FOR PREPARING THE SAME
EP19810900551 EP0054570A4 (en) 1980-03-05 1981-03-05 Novel condurango glycosides, process for their preparation, antineoplastic agent, and composition containing same.
AU67800/81A AU6780081A (en) 1980-03-05 1981-03-05 Novel cundurango glycosides, process for their preparation, antineoplastic agent, and composition containing same
DE19813137612 DE3137612A1 (en) 1980-03-05 1981-03-05 NOVEL CUNDURANGO GLYCOSIDES, PROCESS FOR THEIR PREPARATION, ANTINEOPLASTIC AGENT, AND COMPOSITION CONTAINING SAME
GB8209580A GB2093032B (en) 1980-03-05 1981-03-05 Novel condurango glycosides process for their preparation antineoplastic agent and composition containing same
CH7326/81A CH647533A5 (en) 1980-03-05 1981-03-05 CUNDURANGO-GLYCOSIDE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND TUMOR-FIGHTING AGENTS CONTAINING THESE COMPOUNDS.
PCT/JP1981/000045 WO1981002577A1 (en) 1980-03-05 1981-03-05 Novel cundurango glycosides,process for their preparation,antineoplastic agent,and composition containing same
CA000372389A CA1169852A (en) 1980-03-05 1981-03-05 Condurango glycoside compounds, antitumor agents comprising them and processes for their preparation
US06/320,974 US4452786A (en) 1980-03-05 1981-03-05 Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions
NL8120043A NL8120043A (en) 1980-03-05 1981-03-05 Antitumour condurango glycoside derivs. - prepd. by extracting Marsdenia condurango
SE8202140A SE8202140L (en) 1980-03-05 1982-04-02 NEW CONDURANGO-GLYCOSIDE ASSOCIATIONS, PROCEDURES FOR THEIR PREPARATION, ANTITUMORS THAT INCLUDE THEM AND COMPOSITIONS WHICH THEY CONTAIN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2769780A JPS56123999A (en) 1980-03-05 1980-03-05 Cundurango glycoside, its preparation and antitumor agent comprising it

Publications (2)

Publication Number Publication Date
JPS56123999A true JPS56123999A (en) 1981-09-29
JPS6251277B2 JPS6251277B2 (en) 1987-10-29

Family

ID=12228164

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2769780A Granted JPS56123999A (en) 1979-08-23 1980-03-05 Cundurango glycoside, its preparation and antitumor agent comprising it

Country Status (1)

Country Link
JP (1) JPS56123999A (en)

Also Published As

Publication number Publication date
JPS6251277B2 (en) 1987-10-29

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